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Chapter 96 : Hantaviruses

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Hantaviruses, Page 1 of 2

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Abstract:

Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) are rodent-borne zoonoses caused by certain members of the virus family , genus . Both syndromes are characterized by a febrile prodrome, thromobocytopenia, leakage of fluid from capillaries, and shock. Early diagnosis is critical to the successful management of HFRS and HPS, and—in the case of HPS caused by Andes virus—implementation of appropriate isolation procedures to prevent virus transmission to health care providers. Laboratory assays for evidence of hantaviral infections in HFRS cases and HPS cases during the acute phase of illness should include μ-capture enzyme-linked immunosorbent assay (ELISA) for anti-hantavirus IgM, ELISA for anti-hantavirus IgG, and RT-PCR assays for hantaviral RNA. Immunohistochemistry assays for hantaviral antigens in lung and other solid tissues often reveal widespread infection in the endothelium of the microvasculature. The results of assays for hantaviral RNA should be supported by the results of tests for hantavirus-specific antibodies or antigen. The proper controls for μ-capture ELISA, IgG ELISA, and immunohistochemistry assays are essential for correct interpretation of the results of these assays. Local laboratories usually do not have direct access to these materials. Thus, diagnostic testing is often limited to federal laboratories, reference laboratories, and a small number of commercial laboratories. Recovery from severe disease is absolutely dependent upon carefully managed supportive care, in particular the judicious administration of intravenous fluids during the hypotensive phase in HFRS and the cardiopulmonary phase in HPS.

Citation: Fulhorst C, Bowen M. 2015. Hantaviruses, p 1660-1668. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch96
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FIGURE 1

Electron micrograph of negatively stained Sin Nombre virus (2% phosphotungstic acid stain, pH 6.5). Courtesy of Charles Humphrey, Centers for Disease Control and Prevention. doi:10.1128/9781555817381.ch96.f1

Citation: Fulhorst C, Bowen M. 2015. Hantaviruses, p 1660-1668. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch96
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Image of FIGURE 2
FIGURE 2

Photomicrograph of human lung tissue showing hantaviral antigen in pulmonary microvasculature, with hantaviral antigen stained in red by using immunohistochemistry. Courtesy of Sherif Zaki, Centers for Disease Control and Prevention. doi:10.1128/9781555817381.ch96.f2

Citation: Fulhorst C, Bowen M. 2015. Hantaviruses, p 1660-1668. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch96
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References

/content/book/10.1128/9781555817381.mcm11.ch96
1. Plyusnin A,, Beaty BJ,, Elliott RM,, Goldbach R,, Kormelink R,, Lundkvist Å,, Schmaljohn CS,, Tesh RB,. 2012. Family Bunyaviridae, p 725741. In King AMQ,, Lefkowitz EJ,, Adams MJ,, Carstens EB (ed), Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses (ICTV). Elsevier Academic Press, San Diego, CA.
2. Song JW,, Baek LJ,, Schmaljohn CS,, Yanagihara R. 2007. Thottapalayam virus, a prototype shrewborne hantavirus. Emerg Infect Dis 13:980985.
3. Kang HJ,, Bennett SN,, Sumibcay L,, Arai S,, Hope AG,, Mocz G,, Song JW,, Cook JA,, Yanagihara R. 2009. Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One 4:e6149. doi:10.1371/journal.pone.0006149.
4. Martin ML,, Lindsey-Regnery H,, Sasso DR,, McCormick JB,, Palmer E. 1985. Distinction between Bunyaviridae genera by surface structure and comparison with Hantaan virus using negative stain electron microscopy. Arch Virol 86:1728.
5. Jääskeläinen KM,, Kaukinen P,, Minskaya ES,, Plyusnina A,, Vapalahti O,, Elliott RM,, Weber F,, Vaheri A,, Plyusnin A. 2007. Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter. J Med Virol 79:15271536.
6. Roig IL,, Musher DM,, Tweardy DJ. 2012. Severe pulmonary involvement in a case attributed to domestically acquired Seoul hantavirus in the United States. Clin Infect Dis 54:9194.
7. Vapalahti O,, Mustonen J,, Lundkvist A,, Henttonen H,, Plyusnin A,, Vaheri A. 2003. Hantavirus infections in Europe. Lancet Infect Dis 3:653661.
8. Yashina LN,, Patrushev NA,, Ivanov LI,, Slonova RA,, Mishin VP,, Kompanez GG,, Zdanovskaya NI,, Kuzina,II,, Safronov PF,, Chizhikov VE,, Schmaljohn C,, Netesov SV. 2000. Genetic diversity of hantaviruses associated with hemorrhagic fever with renal syndrome in the far east of Russia. Virus Res 70:3144.
9. Watson DC,, Sargianou M,, Papa A,, Chra P,, Starakis I,, Panos G. 2013. Epidemiology of hantavirus infections in humans: a comprehensive, global overview. Crit Rev Microbiol 40:261272.
10. MacNeil A,, Ksiazek TG,, Rollin PE. 2011. Hantavirus pulmonary syndrome, United States, 1993–2009. Emerg Infect Dis 17:11951201.
11. Bellomo C,, Nudelman J,, Kwaszka R,, Vazquez G,, Cantoni G,, Weinzettel B,, Larrieu EG,, Padula P. 2009. (Geographic expansion of hantavirus pulmonary syndrome in Argentina. The southernest case report). Medicina (Buenos Aires) 69:647650. (In Spanish.)
12. Kawamata J,, Yamanouchi T,, Dohmae K,, Miyamoto H,, Takahaski M,, Yamanishi K,, Kurata T,, Lee HW. 1987. Control of laboratory acquired hemorrhagic fever with renal syndrome (HFRS) in Japan. Lab Anim Sci 37:431436.
13. Tsai TF. 1987. Hemorrhagic fever with renal syndrome: mode of transmission to humans. Lab Anim Sci 37:428430.
14. Padula PJ,, Edelstein A,, Miguel SD,, Lopez NM,, Rossi CM,, Rabinovich RD. 1998. Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology 241:323330.
15. Armstrong LR,, Zaki SR,, Goldoft MJ,, Todd RL,, Khan AS,, Khabbaz RF,, Ksiazek TG,, Peters CJ. 1995. Hantavirus pulmonary syndrome associated with entering or cleaning rarely used, rodent-infested structures. J Infect Dis 172:1166.
16. Crowcroft NS,, Infuso A,, Ilef D,, Le Guenno B,, Desenclos JC,, Van Loock F,, Clement J. 1999. Risk factors for human hantavirus infection: Franco-Belgian collaborative case-control study during 1995-6 epidemic. Brit Med J 318:17371738.
17. Mills JN,, Corneli A,, Young JC,, Garrison LE,, Khan AS,, Ksiazek TG. 2002. Hantavirus pulmonary syndrome—United States: updated recommendations for risk reduction. MMWR Recomm Rep 51:112.
18. Roehr B. 2012. US officials warn 39 countries about risk of hantavirus among travellers to Yosemite. BMJ 345:e6054. doi:10.1136/bmj.e6054.
19. Fulhorst CF,, Koster FT,, Enría DA,, Peters CJ,. 2011. Hantavirus infections, p 470480. In Guerrant RL,, Walker DH,, Weller PF (ed), Tropical Infectious Diseases: Principles, Pathogens & Practice, 3rd ed. Elsevier Saunders, Philadelphia, PA.
20. Park SC,, Pyo HJ,, Soe JB,, Lee MS,, Kim YH,, Byun KS,, Kang KH,, Kim MJ,, Kim JS,, Lee HW. 1989. A clinical study of hemorrhagic fever with renal syndrome caused by Seoul virus infection. Korean J Intern Med 4:130135.
21. Lee HW,, van der Groen G. 1989. Hemorrhagic fever with renal syndrome. Prog Med Virol 36:62102.
22. Lukes R. 1954. The pathology of thirty-nine fatal cases of epidemic hemorrhagic fever. Am J Med 16:639650.
23. Nichol ST,, Spiropoulou CF,, Morzunov S,, Rollin PE,, Ksiazek TG,, Feldmann H,, Sanchez A,, Childs J,, Zaki S,, Peters CJ. 1993. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262:914917.
24. Duchin JS,, Koster FT,, Peters CJ,, Simpson GL,, Tempest B,, Zaki SR,, Ksiazek TG,, Rollin PE,, Nichol S,, Umland ET,, Moolenaar RL,, Reef SE,, Nolte KB,, Gallaher MM,, Butler JC,, Breiman RF. 1994. Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The Hantavirus Study Group. N Engl J Med 330:949955.
25. Kitsutani PT,, Denton RW,, Fritz CL,, Murray RA,, Todd RL,, Pape WJ,, Wyatt Frampton J,, Young JC,, Khan AS,, Peters CJ,, Ksiazek TG. 1999. Acute Sin Nombre hantavirus infection without pulmonary syndrome, United States. Emerg Infect Dis 5:701705.
26. Castillo C,, Naranjo J,, Sepulveda A,, Ossa G,, Levy H. 2001. Hantavirus pulmonary syndrome due to Andes virus in Temuco, Chile: clinical experience with 16 adults. Chest 120:548554.
27. Riquelme R,, Riquelme M,, Torres A,, Rioseco ML,, Vergara JA,, Scholz L,, Carriel A. 2003. Hantavirus pulmonary syndrome, southern Chile. Emerg Infect Dis 9:14381443.
28. Koster FT,, Levy H,. 2007. Hantavirus cardiopulmonary syndrome: a new twist to an established pathogen, p 5792. In Fong IW,, Alibek K (ed), New and Evolving Infections of the 21st Century. Springer, New York, NY.
29. Koster F,, Foucar K,, Hjelle B,, Scott A,, Chong YY,, Larson R,, McCabe M. 2001. Rapid presumptive diagnosis of hantavirus cardiopulmonary syndrome by peripheral blood smear review. Am J Clin Pathol 116:665672.
30. Nolte KB,, Feddersen RM,, Foucar K,, Zaki SR,, Koster FT,, Madar D,, Merlin TL,, McFeeley PJ,, Umland ET,, Zumwalt RE. 1995. Hantavirus pulmonary syndrome in the United States: a pathological description of a disease caused by a new agent. Hum Pathol 26:110120.
31. Zaki SR,, Greer PW,, Coffield LM,, Goldsmith CS,, Nolte KB,, Foucar K,, Feddersen RM,, Zumwalt RE,, Miller GL,, Khan AS,, Rollin PE,, Ksiazek TG,, Nichol ST,, Mahy BWJ,, Peters CJ. 1995. Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol 146:552579.
32. Huggins JW,, Hsiang CM,, Cosgriff TM,, Guang MY,, Smith JI,, Wu ZO,, LeDuc JW,, Zheng ZM,, Meegan JM,, Wang QN,, Oland DD,, Gui XE,, Gibbs PH,, Yuan GH,, Zhang TM. 1991. Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome. J Infect Dis 164:11191127.
33. Ye C,, Prescott J,, Nofchissey R,, Goade D,, Hjelle B. 2004. Neutralizing antibodies and Sin Nombre virus RNA after recovery from hantavirus cardiopulmonary syndrome. Emerg Infect Dis 10:478482.
34. Custer DM,, Thompson E,, Schmaljohn CS,, Ksiazek TG,, Hooper JW. 2003. Active and passive vaccination against hantavirus pulmonary syndrome with Andes virus M genome segment-based DNA vaccine. J Virol 77:98949905.
35. Maes P,, Clement J,, Van Ranst M. 2009. Recent approaches in hantavirus vaccine development. Expert Rev Vaccines 8:6776.
36. Cho HW,, Howard CR,, Lee HW. 2002. Review of an inactivated vaccine against hantaviruses. Intervirology 45:328333.
37. Park K,, Kim CS,, Moon KT. 2004. Protective effectiveness of hantavirus vaccine. Emerg Infect Dis 10:22182220.
38. Sohn YM,, Rho HO,, Park MS,, Kim JS,, Summers PL. 2001. Primary humoral immune responses to formalin inactivated hemorrhagic fever with renal syndrome vaccine (Hantavax): consideration of active immunization in South Korea. Yonsei Med J 42:278284.
39. Centers for Disease Control and Prevention. 1994. Laboratory management of agents associated with hantavirus pulmonary syndrome: interim biosafety guidelines. MMWR Recomm Rep 43:17.
40. U. S. Department of Health and Human Services (Public Health Service, Centers for Disease Control and Prevention, and National Institutes of Health). 2009. Viral agents, p 200232. In Chosewood LC,, Wilson DE (ed), Biosafety in Microbiological and Biomedical Laboratories, 5th ed, HHS publication no. (CDC) 21-1112. Centers for Disease Control and Prevention, Atlanta, GA.
41. Saluzzo JF,, Leguenno B,, Van der Groen G. 1988. Use of heat inactivated viral haemorrhagic fever antigens in serological assays. J Virol Methods 22:165172.
42. Kraus AA,, Priemer C,, Heider H,, Kruger DH,, Ulrich R. 2005. Inactivation of Hantaan virus-containing samples for subsequent investigations outside biosafety level 3 facilities. Intervirology 48:255261.
43. Maes P,, Li S,, Verbeeck J,, Keyaerts E,, Clement J,, Van Ranst M. 2007. Evaluation of the efficacy of disinfectants against Puumala hantavirus by real-time RT-PCR. J Virol Methods 141:111115.
44. Hung T,, Zhou JY,, Tang YM,, Zhao TX,, Baek LJ,, Lee HW. 1992. Identification of Hantaan virus-related structures in kidneys of cadavers with haemorrhagic fever with renal syndrome. Arch Virol 122:187199.
45. Johnson AM,, Bowen MD,, Ksiazek TG,, Williams RJ,, Bryan RT,, Mills JN,, Peters CJ,, Nichol ST. 1997. Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology 238:115127.
46. Xiao SY,, Chu YK,, Knauert FK,, Lofts R,, Dalrymple JM,, LeDuc JW. 1992. Comparison of hantavirus isolates using a genus-reactive primer pair polymerase chain reaction. J Gen Virol 73(Pt. 3):567573.
47. Garin D,, Peyrefitte C,, Crance JM,, Le Faou A,, Jouan A,, Bouloy M. 2001. Highly sensitive Taqman PCR detection of Puumala hantavirus. Microbes Infect 3:739745.
48. Horling J,, Lundkvist A,, Persson K,, Mullaart M,, Dzagurova T,, Dekonenko A,, Tkachenko E,, Niklasson B. 1995. Detection and subsequent sequencing of Puumala virus from human specimens by PCR. J Clin Microbiol 33:277282.
49. Schwarz TF,, Zaki SR,, Morzunov S,, Peters CJ,, Nichol ST. 1995. Detection and sequence confirmation of Sin Nombre virus RNA in paraffin-embedded human tissues using one-step RT-PCR. J Virol Methods 51:349356.
50. Aitichou M,, Saleh SS,, McElroy AK,, Schmaljohn C,, Ibrahim MS. 2005. Identification of Dobrava, Hantaan, Seoul, and Puumala viruses by one-step real-time RT-PCR. J Virol Methods 124:2126.
51. Dzagurova TK,, Klempa B,, Tkachenko EA,, Slyusareva GP,, Morozov VG,, Auste B,, Kruger DH. 2009. Molecular diagnostics of hemorrhagic fever with renal syndrome during a Dobrava virus infection outbreak in the European part of Russia. J Clin Microbiol 47:40294036.
52. Evander M,, Eriksson I,, Pettersson L,, Juto P,, Ahlm C,, Olsson GE,, Bucht G,, Allard A. 2007. Puumala hantavirus viremia diagnosed by real-time reverse transcriptase PCR using samples from patients with hemorrhagic fever and renal syndrome. J Clin Microbiol 45:24912497.
53. Saksida A,, Duh D,, Korva M,, Avsic-Zupanc T. 2008. Dobrava virus RNA load in patients who have hemorrhagic fever with renal syndrome. J Infect Dis 197:681685.
54. Xiao R,, Yang S,, Koster F,, Ye C,, Stidley C,, Hjelle B. 2006. Sin Nombre viral RNA load in patients with hantavirus cardiopulmonary syndrome. J Infect Dis 194:14031409.
55. Galeno H,, Mora J,, Villagra E,, Fernandez J,, Hernandez J,, Mertz GJ,, Ramirez E. 2002. First human isolate of Hantavirus (Andes virus) in the Americas. Emerg Infect Dis 8:657661.
56. Godoy P,, Marsac D,, Stefas E,, Ferrer P,, Tischler ND,, Pino K,, Ramdohr P,, Vial P,, Valenzuela PD,, Ferres M,, Veas F,, Lopez-Lastra M. 2009. Andes virus antigens are shed in urine of patients with acute hantavirus cardiopulmonary syndrome. J Virol 83:504655.
57. Vapalahti O,, Lundkvist A,, Fedorov V,, Conroy CJ,, Hirvonen S,, Plyusnina A,, Nemirov K,, Fredga K,, Cook JA,, Niemimaa J,, Kaikusalo A,, Henttonen H,, Vaheri A,, Plyusnin A. 1999. Isolation and characterization of a hantavirus from Lemmus sibiricus: evidence for host switch during hantavirus evolution. J Virol 73:55865592.
58. Bharadwaj M,, Nofchissey R,, Goade D,, Koster F,, Hjelle B. 2000. Humoral immune responses in the hantavirus cardiopulmonary syndrome. J Infect Dis 182:4348.
59. Gavrilovskaya IN,, Shepley M,, Shaw R,, Ginsberg MH,, Mackow ER. 1998. β3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci USA 95:70747079.
60. Heider H,, Ziaja B,, Priemer C,, Lundkvist A,, Neyts J,, Kruger DH,, Ulrich R. 2001. A chemiluminescence detection method of hantaviral antigens in neutralisation assays and inhibitor studies. J Virol Methods 96:1723.
61. Clement J,, McKenna P,, Groen J,, Osterhaus A,, Colson P,, Vervoot T,, van der Groen G,, Lee HW. 1995. Epidemiology and laboratory diagnosis of hantavirus (HTV) infections. Acta Clin Belg 50:919.
62. Jenison S,, Yamada T,, Morris C,, Anderson B,, Torrez-Martinez N,, Keller N,, Hjelle B. 1994. Characterization of human antibody responses to Four Corners hantavirus infections among patients with hantavirus pulmonary syndrome. J Virol 68:30003006.
63. Ksiazek TG,, Peters CJ,, Rollin PE,, Zaki S,, Nichol S,, Spiropoulou C,, Morzunov S,, Feldmann H,, Sanchez A,, Khan AS,, Mahy BWJ,, Wachsmuth K,, Butler JC. 1995. Identification of a new North American hantavirus that causes acute pulmonary insufficiency. Am J Trop Med Hyg 52:117123.
64. Niklasson B,, Kjelsson T. 1988. Detection of nephropathia epidemica (Puumala virus)-specific immunoglobulin M by enzyme-linked immunosorbent assay. J Clin Microbiol 26:15191523.
65. Bostik P,, Winter J,, Ksiazek TG,, Rollin PE,, Villinger F,, Zaki SR,, Peters CJ,, Ansari AA. 2000. Sin Nombre virus (SNV) Ig isotype antibody response during acute and convalescent phases of hantavirus pulmonary syndrome. Emerg Infect Dis 6:184187.
66. Elgh F,, Linderholm M,, Wadell G,, Tarnvik A,, Juto P. 1998. Development of humoral cross-reactivity to the nucleocapsid protein of heterologous hantaviruses in nephropathia epidemica. FEMS Immunol Med Microbiol 22:309315.
67. Elgh F,, Wadell G,, Juto P. 1995. Comparison of the kinetics of Puumala virus specific IgM and IgG antibody responses in nephropathia epidemica as measured by a recombinant antigen-based enzyme-linked immunosorbent assay and an immunofluorescence test. J Med Virol 45:146150.
68. Padula PJ,, Rossi CM,, Della Valle MO,, Martinez PV,, Colavecchia SB,, Edelstein A,, Miguel SD,, Rabinovich RD,, Segura EL. 2000. Development and evaluation of a solid-phase enzyme immunoassay based on Andes hantavirus recombinant nucleoprotein. J Med Microbiol 49:149155.
69. Feldmann H,, Sanchez A,, Morzunov S,, Spiropoulou CF,, Rollin PE,, Ksiazek TG,, Peters CJ,, Nichol ST. 1993. Utilization of autopsy RNA for the synthesis of the nucleocapsid antigen of a newly recognized virus associated with hantavirus pulmonary syndrome. Virus Res 30:351367.
70. Groen J,, Dalrymple J,, Fisher-Hoch S,, Jordans JG,, Clement JP,, Osterhaus AD. 1992. Serum antibodies to structural proteins of Hantavirus arise at different times after infection. J Med Virol 37:283287.
71. Hjelle B,, Chavez-Giles F,, Torrez-Martinez N,, Yamada T,, Sarisky J,, Ascher M,, Jenison S. 1994. Dominant glycoprotein epitope of Four Corners hantavirus is conserved across a wide geographical area. J Gen Virol 75(Pt. 11):28812888.
72. Lundkvist A,, Bjorsten S,, Niklasson B. 1993. Immunoglobulin G subclass responses against the structural components of Puumala virus. J Clin Microbiol 31:368372.
73. Horling J,, Lundkvist A,, Huggins JW,, Niklasson B. 1992. Antibodies to Puumala virus in humans determined by neutralization test. J Virol Methods 39:139147.
74. Valdivieso F,, Vial P,, Ferres M,, Ye C,, Goade D,, Cuiza A,, Hjelle B. 2006. Neutralizing antibodies in survivors of Sin Nombre and Andes hantavirus infection. Emerg Infect Dis 12:166168.
75. Hujakka H,, Koistinen V,, Kuronen I,, Eerikainen P,, Parviainen M,, Lundkvist A,, Vaheri A,, Vapalahti O,, Narvanen A. 2003. Diagnostic rapid tests for acute hantavirus infections: specific tests for Hantaan, Dobrava and Puumala viruses versus a hantavirus combination test. J Virol Methods 108:117122.
76. Sjolander KB,, Lundkvist A. 1999. Dobrava virus infection: serological diagnosis and cross-reactions to other hantaviruses. J Virol Methods 80:137143.
77. Chu YK,, Rossi C,, Leduc JW,, Lee HW,, Schmaljohn CS,, Dalrymple JM. 1994. Serological relationships among viruses in the Hantavirus genus, family Bunyaviridae. Virology 198:196204.
78. Lundkvist A,, Hukic M,, Horling J,, Gilljam M,, Nichol S,, Niklasson B. 1997. Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera. J Med Virol 53:5159.
79. Prince HE,, Su X,, Hogrefe WR. 2007. Utilization of hantavirus antibody results over a five-year period to develop an improved serologic algorithm for detecting acute Sin Nombre virus infection. J Clin Lab Anal 21:713.
80. Ivanov A,, Vapalahti O,, Lankinen H,, Tkachenko E,, Vaheri A,, Niklasson B,, Lundkvist A. 1996. Biotin-labeled antigen: a novel approach for detection of Puumala virus-specific IgM. J Virol Methods 62:8792.
81. LeDuc JW,, Ksiazek TG,, Rossi CA,, Dalrymple JM. 1990. A retrospective analysis of sera collected by the Hemorrhagic Fever Commission during the Korean Conflict. J Infect Dis 162:11821184.
82. Iversson LB,, da Rosa AP,, Rosa MD,, Lomar AV,, Sasaki Mda G,, LeDuc JW. 1994. Human infection by Hantavirus in southern and southeastern Brazil. Rev Assoc Med Bras 40:8592. (In Portuguese.)
83. Khan AS,, Spiropoulou CF,, Morzunov S,, Zaki SR,, Kohn MA,, Nawas SR,, McFarland L,, Nichol ST. 1995. Fatal illness associated with a new hantavirus in Louisiana. J Med Virol 46:281286.
84. Lopez N,, Padula P,, Rossi C,, Lazaro ME,, Franze-Fernandez MT. 1996. Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology 220:223226.
85. Rusnak JM,, Byrne WR,, Chung KN,, Gibbs PH,, Kim TT,, Boudreau EF,, Cosgriff T,, Pittman P,, Kim KY,, Erlichman MS,, Rezvani DF,, Huggins JW. 2009. Experience with intravenous ribavirin in the treatment of hemorrhagic fever with renal syndrome in Korea. Antiviral Res 81:6876.
86. Safronetz D,, Haddock E,, Feldmann F,, Ebihara H,, Feldmann H. 2011. In vitro and in vivo activity of ribavirin against Andes virus infection. PLoS One 6:e23560. doi:10.1371/journal.pone.0023560.
87. Chapman LE,, Mertz GJ,, Peters CJ,, Jolson HM,, Khan AS,, Ksiazek TG,, Koster FT,, Baum KF,, Rollin PE,, Pavia AT,, Holman RC,, Christenson JC,, Rubin PJ,, Behrman RE,, Bell LJ,, Simpson GL,, Sadek RF. 1999. Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. Antivir Ther 4:211219.
88. Biel SS,, Donoso Mantke O,, Lemmer K,, Vaheri A,, Lundkvist A,, Emmerich P,, Hukic M,, Niedrig M. 2003. Quality control measures for the serological diagnosis of hantavirus infections. J Clin Virol 28:248256.

Tables

Generic image for table
TABLE 1

Hantaviral species associated with human disease

Citation: Fulhorst C, Bowen M. 2015. Hantaviruses, p 1660-1668. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch96

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