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Chapter 7 : Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions

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Abstract:

According to the internationally accepted National Institutes of Health (NIH) classification, there are four prostatitis syndromes ( ). Category I is acute bacterial prostatitis that presents as an acute urinary tract infection, most commonly caused by . Category II is chronic bacterial prostatitis that presents as recurrent bacterial infections caused by the same bacterial species, most commonly . Category III is chronic prostatitis/chronic pelvic pain syndrome, the most common clinical syndrome, characterized by pelvic pain complaints in the absence of urinary tract infection recognized by standard testing. Category IV is asymptomatic prostatitis in which patients are diagnosed with prostatic inflammation in the absence of symptoms, for example, prostatic inflammation (pathologist’s definition of “prostatitis”) in an asymptomatic patient undergoing biopsy to evaluate possible prostate cancer.

Citation: Krieger J, Thumbikat P. 2017. Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions, p 121-134. In Mulvey M, Klumpp D, Stapleton A (ed), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.UTI-0004-2012
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Figures

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Figure 1

Geno- and phenotypic diversity of acute prostatitis strains. White and black denote the presence and absence, respectively, of virulence-associated genes or traits, as detected by PCR or phenotypic tests. CPE refers to cytopathic effect.

Citation: Krieger J, Thumbikat P. 2017. Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions, p 121-134. In Mulvey M, Klumpp D, Stapleton A (ed), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.UTI-0004-2012
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References

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1. Krieger JN,, Nyberg L Jr,, Nickel JC . 1999. NIH consensus definition and classification of prostatitis. JAMA 282 : 236237.[PubMed] [CrossRef]
2. Krieger JN,, Ross SO,, Simonsen JM . 1993. Urinary tract infections in healthy university men. J Urol 149 : 10461048.[PubMed]
3. Abarbanel J,, Engelstein D,, Lask D,, Livne PM . 2003. Urinary tract infection in men younger than 45 years of age: is there a need for urologic investigation? Urology 62 : 2729.[PubMed] [CrossRef]
4. Soto SM,, Smithson A,, Martinez JA,, Horcajada JP,, Mensa J,, Vila J . 2007. Biofilm formation in uropathogenic Escherichia coli strains: relationship with prostatitis, urovirulence factors and antimicrobial resistance. J Urol 177 : 365368.[PubMed] [CrossRef]
5. Terai A,, Yamamoto S,, Mitsumori K,, Okada Y,, Kurazono H,, Takeda Y,, Yoshida O . 1997. Escherichia coli virulence factors and serotypes in acute bacterial prostatitis. Int J Urol 4 : 289294.[PubMed] [CrossRef]
6. Parham NJ,, Pollard SJ,, Chaudhuri RR,, Beatson SA,, Desvaux M,, Russell MA,, Ruiz J,, Fivian A,, Vila J,, Henderson IR . 2005. Prevalence of pathogenicity island IICFT073 genes among extraintestinal clinical isolates of Escherichia coli . J Clin Microbiol 43 : 24252434.[PubMed] [CrossRef]
7. Johnson JR,, Scheutz F,, Ulleryd P,, Kuskowski MA,, O’Bryan TT,, Sandberg T . 2005. Host-pathogen relationships among Escherichia coli isolates recovered from men with febrile urinary tract infection. Clin Infect Dis 40 : 813822.[PubMed] [CrossRef]
8. Johnson JR,, Kuskowski MA,, Gajewski A,, Soto S,, Horcajada JP,, Jimenez de Anta MT,, Vila J . 2005. Extended virulence genotypes and phylogenetic background of Escherichia coli isolates from patients with cystitis, pyelonephritis, or prostatitis. J Infect Dis 191 : 4650.[PubMed] [CrossRef]
9. Dowling KJ,, Roberts JA,, Kaack MB . 1987. P-fimbriated Escherichia coli urinary tract infection: A clinical correlation. South Med J 80 : 15331536.[PubMed] [CrossRef]
10. Dalet F,, Segovia T,, Del Río G . 1991. Frequency and distribution of uropathogenic Escherichia coli adhesins: A clinical correlation over 2,000 cases. Eur Urol 19 : 295303.[PubMed]
11. Andreu A,, Stapleton AE,, Fennell C,, Lockman HA,, Xercavins M,, Fernandez F,, Stamm WE . 1997. Urovirulence determinants in Escherichia coli strains causing prostatitis. J Infect Dis 176 : 464469.[PubMed] [CrossRef]
12. Mitsumori K,, Terai A,, Yamamoto S,, Ishitoya S,, Yoshida O . 1999. Virulence characteristics of Escherichia coli in acute bacterial prostatitis. J Infect Dis 180 : 13781381.[PubMed] [CrossRef]
13. Ruiz J,, Simon K,, Horcajada JP,, Velasco M,, Barranco M,, Roig G,, Moreno-Martínez A,, Martínez JA,, Jiménez de Anta T,, Mensa J,, Vila J . 2002. Differences in virulence factors among clinical isolates of Escherichia coli causing cystitis and pyelonephritis in women and prostatitis in men. J Clin Microbiol 40 : 44454449.[PubMed] [CrossRef]
14. Ishitoya S,, Yamamoto S,, Kanamaru S,, Kurazono H,, Habuchi T,, Ogawa O,, Terai A . 2003. Distribution of afaE adhesins in Escherichia coli isolated from Japanese patients with urinary tract infection. J Urol 169 : 17581761.[PubMed] [CrossRef]
15. Turner JA,, Ciol MA,, Von Korff M,, Berger R . 2004. Prognosis of patients with new prostatitis/pelvic pain syndrome episodes. J Urol 172 : 538541.[PubMed] [CrossRef]
16. Kravchick S,, Cytron S,, Agulansky L,, Ben-Dor D . 2004. Acute prostatitis in middle-aged men: A prospective study. BJU Int 93 : 9396.[PubMed] [CrossRef]
17. Krieger JN,, Dobrindt U,, Riley DE,, Oswald E . 2011. Acute Escherichia coli prostatitis in previously health young men: bacterial virulence factors, antimicrobial resistance, and clinical outcomes. Urology 77 : 14201425.[PubMed] [CrossRef]
18. Wong ES,, Stamm WE . 1983. Sexual acquisition of urinary tract infection in a man. JAMA 250 : 30873088.[PubMed] [CrossRef]
19. Johnson JR,, Stell AL . 2000. Extended virulence genotypes of Escherichia coli strains from patients with urosepsis in relation to phylogeny and host compromise. J Infect Dis 181 : 261272.[PubMed] [CrossRef]
20. Schmidt H,, Knop C,, Franke S,, Aleksic S,, Heesemann J,, Karch H . 1995. Development of PCR for screening of enteroaggregative Escherichia coli . J Clin Microbiol 33 : 701705.[PubMed]
21. Müller D,, Greune L,, Heusipp G,, Karch H,, Fruth A,, Tschäpe H,, Schmidt MA . 2007. Identification of unconventional intestinal pathogenic Escherichia coli isolates expressing intermediate virulence factor profiles by using a novel single-step multiplex PCR. Appl Environ Microbiol 73 : 33803390.[PubMed] [CrossRef]
22. Zdziarski J,, Svanborg C,, Wullt B,, Hacker J,, Dobrindt U . 2008. Molecular basis of commensalism in the urinary tract: low virulence or virulence attenuation? Infect Immun 76 : 695703.[PubMed] [CrossRef]
23. Nougayrède JP,, Homburg S,, Taieb F,, Boury M,, Brzuszkiewicz E,, Gottschalk G,, Buchrieser C,, Hacker J,, Dobrindt U,, Oswald E . 2006. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science 313 : 848851.[PubMed] [CrossRef]
24. Oswald E,, Sugai M,, Labigne A,, Wu HC,, Fiorentini C,, Boquet P,, O’Brien AD . 1994. Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibers. Proc Natl Acad Sci U S A 91 : 38143818.[PubMed] [CrossRef]
25. Clermont O,, Bonacorsi S,, Bingen E . 2000. Rapid and simple determination of the Escherichia coli phylogenetic group. Appl Environ Microbiol 66 : 45554558.[PubMed] [CrossRef]
26. Boyd EF,, Hartl DL . 1998. Chromosomal regions specific to pathogenic isolates of Escherichia coli have a phylogenetically clustered distribution. J Bacteriol 180 : 11591165.[PubMed]
27. Jaureguy F,, Landreau L,, Passet V,, Diancourt L,, Frapy E,, Guigon G,, Carbonnelle E,, Lortholary O,, Clermont O,, Denamur E,, Picard B,, Nassif X,, Brisse S . 2008. Phylogenetic and genomic diversity of human bacteremic Escherichia coli strains. BMC Genomics 9 : 560. [PubMed] [CrossRef]
28. Johnson JR,, Russo TA . 2005. Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli . Int J Med Microbiol 295 : 383404.[PubMed] [CrossRef]
29. Oelschlaeger TA,, Dobrindt U,, Hacker J . 2002. Virulence factors of uropathogens. Curr Opin Urol 12 : 3338.[PubMed] [CrossRef]
30. Roos V,, Klemm P . 2006. Global gene expression profiling of the asymptomatic bacteriuria Escherichia coli strain 83972 in the human urinary tract. Infect Immun 74 : 35653575.[PubMed] [CrossRef]
31. Wallace-Gadsden F,, Johnson JR,, Wain J,, Okeke IN . 2007. Enteroaggregative Escherichia coli related to uropathogenic clonal group A. Emerg Infect Dis 13 : 757760.[PubMed] [CrossRef]
32. Russo TA,, Johnson JR . 2003. Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes Infect 5 : 449456.[PubMed] [CrossRef]
33. Aoki SK,, Pamma R,, Hernday AD,, Bickham JE,, Braaten BA,, Low DA . 2005. Contact-dependent inhibition of growth in Escherichia coli . Science 309 : 12451248.[PubMed] [CrossRef]
34. Gillor O,, Kirkup BC,, Riley MA . 2004. Colicins and microcins: the next generation antimicrobials. Adv Appl Microbiol 54 : 129146.[PubMed] [CrossRef]
35. Roesch PL,, Redford P,, Batchelet S,, Moritz RL,, Pellett S,, Haugen BJ,, Blattner FR,, Welch RA . 2003. Uropathogenic Escherichia coli use d-serine deaminase to modulate infection of the murine urinary tract. Mol Microbiol 49 : 5567.[PubMed] [CrossRef]
36. Snyder JA,, Haugen BJ,, Buckles EL,, Lockatell CV,, Johnson DE,, Donnenberg MS,, Welch RA,, Mobley HL . 2004. Transcriptome of uropathogenic Escherichia coli during urinary tract infection. Infect Immun 72 : 63736381.[PubMed] [CrossRef]
37. Ochman H,, Selander RK . 1984. Standard reference strains of Escherichia coli from natural populations. J Bacteriol 157 : 690693.[PubMed]
38. Picard B,, Garcia JS,, Gouriou S,, Duriez P,, Brahimi N,, Bingen E,, Elion J,, Denamur E . 1999. The link between phylogeny and virulence in Escherichia coli extraintestinal infection. Infect Immun 67 : 546553.[PubMed]
39. Johnson JR,, Johnston B,, Kuskowski MA,, Nougayrède JP,, Oswald E . 2008. Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island. J Clin Microbiol 46 : 39063911.[PubMed] [CrossRef]
40. Le Gall T,, Clermont O,, Gouriou S,, Picard B,, Nassif X,, Denamur E,, Tenaillon O . 2007. Extraintestinal virulence is a coincidental by-product of commensalism in B2 phylogenetic group Escherichia coli strains. Mol Biol Evol 24 : 23732384.[PubMed] [CrossRef]
41. Krieger JN,, Lee SW,, Jeon J,, Cheah PY,, Liong ML,, Riley DE . 2008. Epidemiology of prostatitis. Int J Antimicrob Agents 31(Suppl 1): S8590.[PubMed] [CrossRef]
42. De Marzo AM,, Nakai Y,, Nelson WG . 2007. Inflammation, atrophy, and prostate carcinogenesis. Urol Oncol 25 : 398400.[PubMed] [CrossRef]
43. Collins MM,, Stafford RS,, O’Leary MP,, Barry MJ . 1998. How common is prostatitis? A national survey of physician visits. J Urol 159 : 12241228.[PubMed] [CrossRef]
44. Nickel JC,, Alexander RB,, Schaeffer AJ,, Landis JR,, Knauss JS,, Propert KJ ; Chronic Prostatitis Collaborative Research Network Study Group . 2003. Leukocytes and bacteria in men with chronic prostatitis/chronic pelvic pain syndrome compared to asymptomatic controls. J Urol 170 : 818822.[PubMed] [CrossRef]
45. Leskinen MJ,, Rantakokko-Jalava K,, Manninen R,, Leppilahti M,, Marttila T,, Kylmälä T,, Tammela TL . 2003. Negative bacterial polymerase chain reaction (PCR) findings in prostate tissue from patients with symptoms of chronic pelvic pain syndrome (CPPS) and localized prostate cancer. Prostate 55 : 105110.[PubMed] [CrossRef]
46. Krieger JN,, Riley DE,, Roberts MC,, Berger RE . 1996. Prokaryotic DNA sequences in patients with chronic idiopathic prostatitis. J Clin Microbiol 34 : 31203128.[PubMed]
47. Krieger JN,, Riley DE . 2002. Bacteria in the chronic prostatitis-chronic pelvic pain syndrome: molecular approaches to critical research questions. J Urol 167 : 25742583.[PubMed] [CrossRef]
48. Hochreiter WW,, Duncan JL,, Schaeffer AJ . 2000. Evaluation of the bacterial flora of the prostate using a 16S rRNA gene based polymerase chain reaction. J Urol 163 : 127130.[PubMed] [CrossRef]
49. Karatas OF,, Turkay C,, Bayrak O,, Cimentepe E,, Unal D . 2010. Helicobacter pylori seroprevalence in patients with chronic prostatitis: A pilot study. Scand J Urol Nephrol 44 : 9194.[PubMed] [CrossRef]
50. Motrich RD,, Cuffini C,, Oberti JP,, Maccioni M,, Rivero VE . 2006. Chlamydia trachomatis occurrence and its impact on sperm quality in chronic prostatitis patients. J Infect 53 : 175183.[PubMed] [CrossRef]
51. Mändar R,, Raukas E,, Türk S,, Korrovits P,, Punab M . 2005. Mycoplasmas in semen of chronic prostatitis patients. Scand J Urol Nephrol 39 : 479482.[PubMed] [CrossRef]
52. Potts JM,, Sharma R,, Pasqualotto F,, Nelson D,, Hall G,, Agarwal A . 2000. Association of Ureaplasma urealyticum with abnormal reactive oxygen species levels and absence of leukocytospermia. J Urol 163 : 17751778.[PubMed] [CrossRef]
53. Rudick CN,, Berry RE,, Johnson JR,, Johnston B,, Klumpp DJ,, Schaeffer AJ,, Thumbikat P . 2011. Uropathogenic Escherichia coli induces chronic pelvic pain. Infect Immun 79 : 628635.[PubMed] [CrossRef]
54. Kanamaru S,, Kurazono H,, Ishitoya S,, Terai A,, Habuchi T,, Nakano M,, Ogawa O,, Yamamoto S . 2003. Distribution and genetic association of putative uropathogenic virulence factors iroN, iha, kpsMT, ompT and usp in Escherichia coli isolated from urinary tract infections in Japan. J Urol 170 : 24902493.[PubMed] [CrossRef]
55. Johnson JR . 2003. Microbial virulence determinants and the pathogenesis of urinary tract infection. Infect Dis Clin North Am 17 : 261278, viii.[PubMed] [CrossRef]
56. Yamamoto S . 2007. Molecular epidemiology of uropathogenic Escherichia coli . J Infect Chemother 13 : 6873.[PubMed] [CrossRef]
57. Kanamaru S,, Kurazono H,, Nakano M,, Terai A,, Ogawa O,, Yamamoto S . 2006. Subtyping of uropathogenic Escherichia coli according to the pathogenicity island encoding uropathogenic-specific protein: comparison with phylogenetic groups. Int J Urol 13 : 754760.[PubMed] [CrossRef]
58. Pontari MA,, Ruggieri MR . 2004. Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol 172 : 839845.[PubMed] [CrossRef]
59. Meares EM,, Stamey TA . 1968. Bacteriologic localization patterns in bacterial prostatitis and urethritis. Invest Urol 5 : 492518.[PubMed]
60. Herzer PJ,, Inouye S,, Inouye M,, Whittam TS . 1990. Phylogenetic distribution of branched RNA-linked multicopy single-stranded DNA among natural isolates of Escherichia coli . J Bacteriol 172 : 61756181.[PubMed]
61. Johnson JR,, Delavari P,, Kuskowski M,, Stell AL . 2001. Phylogenetic distribution of extraintestinal virulence-associated traits in Escherichia coli . J Infect Dis 183 : 7888.[PubMed] [CrossRef]
62. Costerton JW,, Stewart PS,, Greenberg EP . 1999. Bacterial biofilms: A common cause of persistent infections. Science 284 : 13181322.[PubMed] [CrossRef]
63. Berry RE,, Klumpp DJ,, Schaeffer AJ . 2009. Urothelial cultures support intracellular bacterial community formation by uropathogenic Escherichia coli . Infect Immun 77 : 27622772.[PubMed] [CrossRef]
64. Martinez JJ,, Mulvey MA,, Schilling JD,, Pinkner JS,, Hultgren SJ . 2000. Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. EMBO J 19 : 28032812.[PubMed] [CrossRef]
65. Kikutani H,, Makino S . 1992. The murine autoimmune diabetes model: NOD and related strains. Adv Immunol 51 : 285322.[CrossRef]

Tables

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TABLE 1

Studies of virulence factors in bacterial prostatitis

Citation: Krieger J, Thumbikat P. 2017. Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions, p 121-134. In Mulvey M, Klumpp D, Stapleton A (ed), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.UTI-0004-2012
Generic image for table
TABLE 2

Sequence types (ST), clonal complexes, phylogenetic groupings, and predominant pathotypes of 18 isolates from healthy young men with acute bacterial prostatitis

Citation: Krieger J, Thumbikat P. 2017. Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions, p 121-134. In Mulvey M, Klumpp D, Stapleton A (ed), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.UTI-0004-2012
Generic image for table
TABLE 3

Virulence-associated genes in 18 isolates from healthy young men with acute prostatitis

Citation: Krieger J, Thumbikat P. 2017. Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions, p 121-134. In Mulvey M, Klumpp D, Stapleton A (ed), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.UTI-0004-2012
Generic image for table
TABLE 4

Characteristics of study strains

Citation: Krieger J, Thumbikat P. 2017. Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions, p 121-134. In Mulvey M, Klumpp D, Stapleton A (ed), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.UTI-0004-2012

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