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Chapter 11 : Antibodies Targeting the Envelope of HIV-1
Category: Clinical Microbiology
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HIV continues to be a major global public health issue, with an estimated 35 million people living with the virus and more than 2 million new infections occurring yearly ( 1 ). As part of the natural immune response, antibodies (Abs) exert immune pressure on HIV and play a key role both in controlling the virus and in driving escape mutations in the viral envelope glycoproteins. Therefore, and because the elicitation of Abs is believed to be crucial for an effective vaccine against HIV, Abs targeting HIV have been the focus of intense research in the past years.