1887

Chapter 2 : Functions of Antibodies

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in
Zoomout

Functions of Antibodies, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555817411/9781555817350_Chap02-1.gif /docserver/preview/fulltext/10.1128/9781555817411/9781555817350_Chap02-2.gif

Abstract:

In the setting of infectious diseases, antibody function refers to the biological effect that an antibody has on a pathogen or its toxin. Thus, assays that measure antibody function are differentiated from those that strictly measure the ability of an antibody to bind to its cognate antigen. Examples of antibody functions include neutralization of infectivity, phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and complement-mediated lysis of pathogens or of infected cells.

Citation: Forthal D. 2015. Functions of Antibodies, p 25-48. In Crowe J, Boraschi D, Rappuoli R (ed), Antibodies for Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.AID-0019-2014
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

References

/content/book/10.1128/9781555817411.chap2
1. Hessell AJ,, Hangartner L,, Hunter M,, Havenith CE,, Beurskens FJ,, Bakker JM,, Lanigan CM,, Landucci G,, Forthal DN,, Parren PW,, Marx PA,, Burton DR . 2007. Fc receptor but not complement binding is important in antibody protection against HIV. Nature 449 : 101 104.[PubMed] [CrossRef]
2. Brandtzaeg P . 2007. Induction of secretory immunity and memory at mucosal surfaces. Vaccine 25 : 5467 5484.[PubMed] [CrossRef]
3. Phalipon A,, Cardona A,, Kraehenbuhl JP,, Edelman L,, Sansonetti PJ,, Corthesy B . 2002. Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity 17 : 107 115.[PubMed] [CrossRef]
4. Brioen P,, Dekegel D,, Boeye A . 1983. Neutralization of poliovirus by antibody-mediated polymerization. Virology 127 : 463 468.[CrossRef]
5. Thomas AA,, Vrijsen R,, Boeye A . 1986. Relationship between poliovirus neutralization and aggregation. J Virol 59 : 479 485.[PubMed]
6. Lin TL,, Clark TG,, Dickerson H . 1996. Passive immunization of channel catfish (Ictalurus punctatus) against the ciliated protozoan parasite Ichthyophthirius multifiliis by use of murine monoclonal antibodies. Infect Immun 64 : 4085 4090.[PubMed]
7. Campodonico VL,, Llosa NJ,, Grout M,, Doring G,, Maira-Litran T,, Pier GB . 2010. Evaluation of flagella and flagellin of Pseudomonas aeruginosa as vaccines. Infect Immun 78 : 746 755.[PubMed] [CrossRef]
8. Bishop AL,, Schild S,, Patimalla B,, Klein B,, Camilli A . 2010. Mucosal immunization with Vibrio cholerae outer membrane vesicles provides maternal protection mediated by antilipopolysaccharide antibodies that inhibit bacterial motility. Infect Immun 78 : 4402 4420.[PubMed] [CrossRef]
9. Hope T . 2010. Defining the interaction of HIV with the mucosal barriers to gain insights into the mechanisms of sexual transmission. Abstr. AIDS Vaccine Conference 2010, Atlanta, GA.
10. McCullough KC,, Smale CJ,, Carpenter WC,, Crowther JR,, Brocchi E,, De Simone F . 1987. Conformational alteration in foot-and-mouth disease virus virion capsid structure after complexing with monospecific antibody. Immunology 60 : 75 82.[PubMed]
11. Hernandez R,, Paredes A,, Brown DT . 2008. Sindbis virus conformational changes induced by a neutralizing anti-E1 monoclonal antibody. J Virol 82 : 5750 5760.[PubMed] [CrossRef]
12. Klasse PJ,, Sattentau QJ . 2002. Occupancy and mechanism in antibody-mediated neutralization of animal viruses. J Gen Virol 83 : 2091 2108.[PubMed]
13. LaRocca TJ,, Holthausen DJ,, Hsieh C,, Renken C,, Mannella CA,, Benach JL . 2009. The bactericidal effect of a complement-independent antibody is osmolytic and specific to Borrelia. Proc Natl Acad Sci USA 106 : 10752 10757.[PubMed] [CrossRef]
14. Matthews RC,, Rigg G,, Hodgetts S,, Carter T,, Chapman C,, Gregory C,, Illidge C,, Burnie J . 2003. Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90. Antimicrob Agents Chemother 47 : 2208 2216.[PubMed] [CrossRef]
15. Pachl J,, Svoboda P,, Jacobs F,, Vandewoude K,, van der Hoven B,, Spronk P,, Masterson G,, Malbrain M,, Aoun M,, Garbino J,, Takala J,, Drgona L,, Burnie J,, Matthews R . 2006. A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis. Clin Infect Dis 42 : 1404 1413.[PubMed] [CrossRef]
16. Nooney L,, Matthews RC,, Burnie JP . 2005. Evaluation of Mycograb, amphotericin B, caspofungin, and fluconazole in combination against Cryptococcus neoformans by checkerboard and time-kill methodologies. Diagn Microbiol Infect Dis 51 : 19 29.[PubMed] [CrossRef]
17. McClelland EE,, Nicola AM,, Prados-Rosales R,, Casadevall A . 2010. Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism. J Clin Invest 120 : 1355 1361.[PubMed] [CrossRef]
18. Watanabe M,, Blobel G . 1989. Site-specific antibodies against the PrlA (secY) protein of Escherichia coli inhibit protein export by interfering with plasma membrane binding of preproteins. Proc Natl Acad Sci USA 86 : 1895 1899.[PubMed] [CrossRef]
19. Gregory RL,, Michalek SM,, Shechmeister IL,, McGhee JR . 1984. Function of anti- Streptococcus mutans antibodies: anti-ribosomal antibodies inhibit acid production, growth, and glucose phosphotransferase activity. Infect Immun 45 : 286 289.[PubMed]
20. Casadevall A,, Pirofski LA . 2012. Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases. Cell Host Microbe 11 : 447 456.[PubMed] [CrossRef]
21. Klasse PJ,, Sanders RW,, Cerutti A,, Moore JP . 2012. How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development? AIDS Res Hum Retroviruses 28 : 1 15.[PubMed] [CrossRef]
22. He RT,, Innis BL,, Nisalak A,, Usawattanakul W,, Wang S,, Kalayanarooj S,, Anderson R . 1995. Antibodies that block virus attachment to Vero cells are a major component of the human neutralizing antibody response against dengue virus type 2. J Med Virol 45 : 451 461.[CrossRef]
23. Iorio RM,, Glickman RL,, Riel AM,, Sheehan JP,, Bratt MA . 1989. Functional and neutralization profile of seven overlapping antigenic sites on the HN glycoprotein of Newcastle disease virus: monoclonal antibodies to some sites prevent viral attachment. Virus Res 13 : 245 261.[CrossRef]
24. Booy FP,, Roden RB,, Greenstone HL,, Schiller JT,, Trus BL . 1998. Two antibodies that neutralize papillomavirus by different mechanisms show distinct binding patterns at 13 A resolution. J Mol Biol 281 : 95 106.[PubMed] [CrossRef]
25. Ruggeri FM,, Greenberg HB . 1991. Antibodies to the trypsin cleavage peptide VP8 neutralize rotavirus by inhibiting binding of virions to target cells in culture. J Virol 65 : 2211 2219.[PubMed]
26. Smith TJ,, Olson NH,, Cheng RH,, Liu H,, Chase ES,, Lee WM,, Leippe DM,, Mosser AG,, Rueckert RR,, Baker TS . 1993. Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibody. J Virol 67 : 1148 1158.[PubMed]
27. Della-Porta AJ,, Westaway EG . 1978. A multi-hit model for the neutralization of animal viruses. J Gen Virol 38 : 1 19.[PubMed] [CrossRef]
28. Platt EJ,, Gomes MM,, Kabat D . 2012. Kinetic mechanism for HIV-1 neutralization by antibody 2G12 entails reversible glycan binding that slows cell entry. Proc Natl Acad Sci USA 109 : 7829 7834.[PubMed] [CrossRef]
29. Reading SA,, Dimmock NJ . 2007. Neutralization of animal virus infectivity by antibody. Arch Virol 152 : 1047 1059.[PubMed] [CrossRef]
30. Klemm P,, Vejborg RM,, Hancock V . 2010. Prevention of bacterial adhesion. Appl Microbiol Biotechnol 88 : 451 459.[PubMed] [CrossRef]
31. Cegelski L,, Marshall GR,, Eldridge GR,, Hultgren SJ . 2008. The biology and future prospects of antivirulence therapies. Nat Rev Microbiol 6 : 17 27.[PubMed] [CrossRef]
32. Smani Y,, McConnell MJ,, Pachón J . 2012. Role of fibronectin in the adhesion of Acinetobacter baumannii to host cells. PLoS One 7 : e33073. doi:10.1371/journal.pone.0033073. [PubMed] [CrossRef]
33. Tsang TM,, Annis DS,, Kronshage M,, Fenno JT,, Usselman LD,, Mosher DF,, Krukonis ES . 2012. Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120-kDa region of fibronectin to facilitate cell binding by Yersinia pestis . J Biol Chem 287 : 16759 16767.[PubMed] [CrossRef]
34. Khan MN,, Pichichero ME . 2012. Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans. Vaccine 30 : 2900 2907.[PubMed] [CrossRef]
35. Langermann S,, Ballou WR . 2003. Development of a recombinant FimCH vaccine for urinary tract infections. Adv Exp Med Biol 539 : 635 648.[PubMed]
36. Langermann S,, Palaszynski S,, Barnhart M,, Auguste G,, Pinkner JS,, Burlein J,, Barren P,, Koenig S,, Leath S,, Jones CH,, Hultgren SJ . 1997. Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination. Science 276 : 607 611.[PubMed] [CrossRef]
37. Langermann S,, Mollby R,, Burlein JE,, Palaszynski SR,, Auguste CG,, DeFusco A,, Strouse R,, Schenerman MA,, Hultgren SJ,, Pinkner JS,, Winberg J,, Guldevall L,, Soderhall M,, Ishikawa K,, Normark S,, Koenig S . 2000. Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli . J Infect Dis 181 : 774 778.[PubMed] [CrossRef]
38. Kain R,, Exner M,, Brandes R,, Ziebermayr R,, Cunningham D,, Alderson CA,, Davidovits A,, Raab I,, Jahn R,, Ashour O,, Spitzauer S,, Sunder-Plassmann G,, Fukuda M,, Klemm P,, Rees AJ,, Kerjaschki D . 2008. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med 14 : 1088 1096.[PubMed] [CrossRef]
39. Manjarrez-Hernandez HA,, Gavilanes-Parra S,, Chavez-Berrocal E,, Navarro-Ocana A,, Cravioto A . 2000. Antigen detection in enteropathogenic Escherichia coli using secretory immunoglobulin A antibodies isolated from human breast milk. Infect Immun 68 : 5030 5036.[PubMed] [CrossRef]
40. Schlesinger LS,, Hull SR,, Kaufman TM . 1994. Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages. J Immunol 152 : 4070 4079.[PubMed]
41. Kornspan JD,, Tarshis M,, Rottem S . 2011. Adhesion and biofilm formation of Mycoplasma pneumoniae on an abiotic surface. Arch Microbiol 193 : 833 836.[PubMed] [CrossRef]
42. Holder AA,, Freeman RR . 1981. Immunization against blood-stage rodent malaria using purified parasite antigens. Nature 294 : 361 364.[PubMed] [CrossRef]
43. Perkins ME,, Rocco LJ . 1988. Sialic acid-dependent binding of Plasmodium falciparum merozoite surface antigen, Pf200, to human erythrocytes. J Immunol 141 : 3190 3196.[PubMed]
44. Bolad A,, Berzins K . 2000. Antigenic diversity of Plasmodium falciparum and antibody-mediated parasite neutralization. Scand J Immunol 52 : 233 239.[PubMed] [CrossRef]
45. Clausen TM,, Christoffersen S,, Dahlback M,, Langkilde AE,, Jensen KE,, Resende M,, Agerbaek MO,, Andersen D,, Berisha B,, Ditlev SB,, Pinto VV,, Nielsen MA,, Theander TG,, Larsen S,, Salanti A . 2012. Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria. J Biol Chem 287 : 23332 23345.[PubMed] [CrossRef]
46. Yun CH,, Lillehoj HS,, Lillehoj EP . 2000. Intestinal immune responses to coccidiosis. Dev Comp Immunol 24 : 303 324.[PubMed] [CrossRef]
47. Eckmann L . 2003. Mucosal defences against Giardia. Parasite Immunol 25 : 259 270.[PubMed] [CrossRef]
48. Negrao-Correa D . 2001. Importance of immunoglobulin E (IgE) in the protective mechanism against gastrointestinal nematode infection: looking at the intestinal mucosae. Rev Inst Med Trop Sao Paulo 43 : 291 299.[PubMed] [CrossRef]
49. Cevallos AM,, Zhang X,, Waldor MK,, Jaison S,, Zhou X,, Tzipori S,, Neutra MR,, Ward HD . 2000. Molecular cloning and expression of a gene encoding Cryptosporidium parvum glycoproteins gp40 and gp15. Infect Immun 68 : 4108 4116.[PubMed] [CrossRef]
50. Lopalco L,, Barassi C,, Pastori C,, Longhi R,, Burastero SE,, Tambussi G,, Mazzotta F,, Lazzarin A,, Clerici M,, Siccardi AG . 2000. CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 In vitro. J Immunol 164 : 3426 3433.[PubMed] [CrossRef]
51. Barassi C,, Soprana E,, Pastori C,, Longhi R,, Buratti E,, Lillo F,, Marenzi C,, Lazzarin A,, Siccardi AG,, Lopalco L . 2005. Induction of murine mucosal CCR5-reactive antibodies as an anti-human immunodeficiency virus strategy. J Virol 79 : 6848 6858.[PubMed] [CrossRef]
52. Wintachai P,, Wikan N,, Kuadkitkan A,, Jaimipuk T,, Ubol S,, Pulmanausahakul R,, Auewarakul P,, Kasinrerk W,, Weng WY,, Panyasrivanit M,, Paemanee A,, Kittisenachai S,, Roytrakul S,, Smith DR . 2012. Identification of prohibitin as a Chikungunya virus receptor protein. J Med Virol 84 : 1757 1770.[PubMed] [CrossRef]
53. Kondratowicz AS,, Lennemann NJ,, Sinn PL,, Davey RA,, Hunt CL,, Moller-Tank S,, Meyerholz DK,, Rennert P,, Mullins RF,, Brindley M,, Sandersfeld LM,, Quinn K,, Weller M,, McCray PB Jr,, Chiorini J,, Maury W . 2011. T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci USA 108 : 8426 8431.[PubMed] [CrossRef]
54. Bruno CJ,, Jacobson JM . 2010. Ibalizumab: an anti-CD4 monoclonal antibody for the treatment of HIV-1 infection. J Antimicrob Chemother 65 : 1839 1841.[PubMed] [CrossRef]
55. Meuleman P,, Hesselgesser J,, Paulson M,, Vanwolleghem T,, Desombere I,, Reiser H,, Leroux-Roels G . 2008. Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo. Hepatology 48 : 1761 1768.[PubMed] [CrossRef]
56. Silvie O,, Rubinstein E,, Franetich JF,, Prenant M,, Belnoue E,, Renia L,, Hannoun L,, Eling W,, Levy S,, Boucheix C,, Mazier D . 2003. Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Nat Med 9 : 93 96.[PubMed] [CrossRef]
57. Schubert A,, Zakikhany K,, Pietrocola G,, Meinke A,, Speziale P,, Eikmanns BJ,, Reinscheid DJ . 2004. The fibrinogen receptor FbsA promotes adherence of Streptococcus agalactiae to human epithelial cells. Infect Immun 72 : 6197 6205.[PubMed] [CrossRef]
58. Edwards MJ,, Dimmock NJ . 2001. Hemagglutinin 1-specific immunoglobulin G and Fab molecules mediate postattachment neutralization of influenza A virus by inhibition of an early fusion event. J Virol 75 : 10208 10218.[PubMed] [CrossRef]
59. de Rosny E,, Vassell R,, Jiang S,, Kunert R,, Weiss CD . 2004. Binding of the 2F5 monoclonal antibody to native and fusion-intermediate forms of human immunodeficiency virus type 1 gp41: implications for fusion-inducing conformational changes. J Virol 78 : 2627 2631.[PubMed] [CrossRef]
60. Lorizate M,, Cruz A,, Huarte N,, Kunert R,, Perez-Gil J,, Nieva JL . 2006. Recognition and blocking of HIV-1 gp41 pre-transmembrane sequence by monoclonal 4E10 antibody in a Raft-like membrane environment. J Biol Chem 281 : 39598 39606.[PubMed] [CrossRef]
61. Kaufmann B,, Nybakken GE,, Chipman PR,, Zhang W,, Diamond MS,, Fremont DH,, Kuhn RJ,, Rossmann MG . 2006. West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody. Proc Natl Acad Sci USA 103 : 12400 12404.[PubMed] [CrossRef]
62. Pierson TC,, Diamond MS . 2008. Molecular mechanisms of antibody-mediated neutralisation of flavivirus infection. Expert Rev Mol Med 10 : e12. doi:10.1017/S1462399408000665. [CrossRef]
63. Barbey-Martin C,, Gigant B,, Bizebard T,, Calder LJ,, Wharton SA,, Skehel JJ,, Knossow M . 2002. An antibody that prevents the hemagglutinin low pH fusogenic transition. Virology 294 : 70 74.[PubMed] [CrossRef]
64. Ekiert DC,, Bhabha G,, Elsliger MA,, Friesen RH,, Jongeneelen M,, Throsby M,, Goudsmit J,, Wilson IA . 2009. Antibody recognition of a highly conserved influenza virus epitope. Science 324 : 246 251.[PubMed] [CrossRef]
65. Cao Z,, Meng J,, Li X,, Wu R,, Huang Y,, He Y . 2012. The epitope and neutralization mechanism of AVFluIgG01, a broad-reactive human monoclonal antibody against H5N1 influenza virus. PLoS One 7 : e38126. doi:10.1371/journal.pone.0038126. [PubMed] [CrossRef]
66. Bai Y,, Ye L,, Tesar DB,, Song H,, Zhao D,, Bjorkman PJ,, Roopenian DC,, Zhu X . 2011. Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport. Proc Natl Acad Sci USA 108 : 18406 18411.[PubMed] [CrossRef]
67. Stewart PL,, Nemerow GR . 1997. Recent structural solutions for antibody neutralization of viruses. Trends Microbiol 5 : 229 233.[PubMed] [CrossRef]
68. Wien MW,, Filman DJ,, Stura EA,, Guillot S,, Delpeyroux F,, Crainic R,, Hogle JM . 1995. Structure of the complex between the Fab fragment of a neutralizing antibody for type 1 poliovirus and its viral epitope. Nat Struct Biol 2 : 232 243.[PubMed] [CrossRef]
69. Maciejewski JP,, Weichold FF,, Young NS,, Cara A,, Zella D,, Reitz MS Jr,, Gallo RC . 1995. Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro. Nat Med 1 : 667 673.[PubMed] [CrossRef]
70. Varghese R,, Mikyas Y,, Stewart PL,, Ralston R . 2004. Postentry neutralization of adenovirus type 5 by an antihexon antibody. J Virol 78 : 12320 12332.[PubMed] [CrossRef]
71. Ishii Y,, Tanaka K,, Kondo K,, Takeuchi T,, Mori S,, Kanda T . 2010. Inhibition of nuclear entry of HPV16 pseudovirus-packaged DNA by an anti-HPV16 L2 neutralizing antibody. Virology 406 : 181 188.[PubMed] [CrossRef]
72. Mazanec MB,, Kaetzel CS,, Lamm ME,, Fletcher D,, Nedrud JG . 1992. Intracellular neutralization of virus by immunoglobulin A antibodies. Proc Natl Acad Sci USA 89 : 6901 6905.[PubMed] [CrossRef]
73. Yan H,, Lamm ME,, Bjorling E,, Huang YT . 2002. Multiple functions of immunoglobulin A in mucosal defense against viruses: an in vitro measles virus model. J Virol 76 : 10972 10979.[PubMed] [CrossRef]
74. Mazanec MB,, Coudret CL,, Fletcher DR . 1995. Intracellular neutralization of influenza virus by immunoglobulin A anti-hemagglutinin monoclonal antibodies. J Virol 69 : 1339 1343.[PubMed]
75. Zhou D,, Zhang Y,, Li Q,, Chen Y,, He B,, Yang J,, Tu H,, Lei L,, Yan H . 2011. Matrix protein-specific IgA antibody inhibits measles virus replication by intracellular neutralization. J Virol 85 : 11090 11097.[PubMed] [CrossRef]
76. Bomsel M,, Heyman M,, Hocini H,, Lagaye S,, Belec L,, Dupont C,, Desgranges C . 1998. Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM. Immunity 9 : 277 287.[CrossRef]
77. Corthesy B,, Benureau Y,, Perrier C,, Fourgeux C,, Parez N,, Greenberg H,, Schwartz-Cornil I . 2006. Rotavirus anti-VP6 secretory immunoglobulin A contributes to protection via intracellular neutralization but not via immune exclusion. J Virol 80 : 10692 10699.[PubMed] [CrossRef]
78. Feng N,, Lawton JA,, Gilbert J,, Kuklin N,, Vo P,, Prasad BV,, Greenberg HB . 2002. Inhibition of rotavirus replication by a non-neutralizing, rotavirus VP6-specific IgA mAb. J Clin Invest 109 : 1203 1213.[PubMed] [CrossRef]
79. Thouvenin E,, Schoehn G,, Rey F,, Petitpas I,, Mathieu M,, Vaney MC,, Cohen J,, Kohli E,, Pothier P,, Hewat E . 2001. Antibody inhibition of the transcriptase activity of the rotavirus DLP: a structural view. J Mol Biol 307 : 161 172.[PubMed] [CrossRef]
80. Mallery DL,, McEwan WA,, Bidgood SR,, Towers GJ,, Johnson CM,, James LC . 2010. Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21). Proc Natl Acad Sci USA 107 : 19985 19990.[PubMed] [CrossRef]
81. Wang X,, Kikuchi T,, Rikihisa Y . 2006. Two monoclonal antibodies with defined epitopes of P44 major surface proteins neutralize Anaplasma phagocytophilum by distinct mechanisms. Infect Immun 74 : 1873 1882.[PubMed] [CrossRef]
82. Edelson BT,, Unanue ER . 2001. Intracellular antibody neutralizes Listeria growth. Immunity 14 : 503 512.[PubMed] [CrossRef]
83. Bout D,, Moretto M,, Dimier-Poisson I,, Gatel DB . 1999. Interaction between Toxoplasma gondii and enterocyte. Immunobiology 201 : 225 228.[PubMed] [CrossRef]
84. Mineo JR,, Khan IA,, Kasper LH . 1994. Toxoplasma gondii: a monoclonal antibody that inhibits intracellular replication. Exp Parasitol 79 : 351 361.[PubMed] [CrossRef]
85. Webster RG,, Laver WG . 1967. Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus. J Immunol 99 : 49 55.[PubMed]
86. Hughey PG,, Roberts PC,, Holsinger LJ,, Zebedee SL,, Lamb RA,, Compans RW . 1995. Effects of antibody to the influenza A virus M2 protein on M2 surface expression and virus assembly. Virology 212 : 411 421.[PubMed] [CrossRef]
87. Corboba P,, Grutadauria S,, Cuffini C,, Zapata M . 2000. Neutralizing monoclonal antibody to the E1 glycoprotein epitope of rubella virus mediates virus arrest in VERO cells. Viral Immunol 13 : 83 92.[PubMed] [CrossRef]
88. Murphy K,, Travers P,, Walport M . 2008. The complement system and innate immunity, p 61 80. Janeway’s Immunobiology, 7th ed. Garland Science, New York, NY.
89. DiScipio RG,, Schraufstatter IU . 2007. The role of the complement anaphylatoxins in the recruitment of eosinophils. Int Immunopharmacol 7 : 1909 1923.[PubMed] [CrossRef]
90. Walport MJ . 2001. Complement. First of two parts. N Engl J Med 344 : 1058 1066.[PubMed] [CrossRef]
91. Prodinger WM,, Wurzner R,, Stoiber H,, Dierich MP, . 2003. Complement, p 1077 1103. In Paul W (ed), Fundamental Immunology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
92. Diamond MS,, Shrestha B,, Mehlhop E,, Sitati E,, Engle M . 2003. Innate and adaptive immune responses determine protection against disseminated infection by West Nile encephalitis virus. Viral Immunol 16 : 259 278.[PubMed] [CrossRef]
93. Vogt MR,, Dowd KA,, Engle M,, Tesh RB,, Johnson S,, Pierson TC,, Diamond MS . 2011. Poorly neutralizing cross-reactive antibodies against the fusion loop of West Nile virus envelope protein protect in vivo via Fcgamma receptor and complement-dependent effector mechanisms. J Virol 85 : 11567 11580.[PubMed] [CrossRef]
94. Kruijsen D,, Bakkers MJ,, van Uden NO,, Viveen MC,, van der Sluis TC,, Kimpen JL,, Leusen JH,, Coenjaerts FE,, van Bleek GM . 2010. Serum antibodies critically affect virus-specific CD4+/CD8+ T cell balance during respiratory syncytial virus infections. J Immunol 185 : 6489 6498.[PubMed] [CrossRef]
95. Terajima M,, Cruz J,, Co MD,, Lee JH,, Kaur K,, Wrammert J,, Wilson PC,, Ennis FA . 2011. Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies. J Virol 85 : 13463 13467.[PubMed] [CrossRef]
96. Frank AL,, Puck J,, Hughes BJ,, Cate TR . 1980. Microneutralization test for influenza A and B and parainfluenza 1 and 2 viruses that uses continuous cell lines and fresh serum enhancement. J Clin Microbiol 12 : 426 432.[PubMed]
97. Linscott WD,, Levinson WE . 1969. Complement components required for virus neutralization by early immunoglobulin antibody. Proc Natl Acad Sci USA 64 : 520 527.[PubMed] [CrossRef]
98. Yoshino K,, Taniguchi S . 1965. Studies on the neutralization of herpes simplex virus. I. Appearance of neutralizing antibodies having different grades of complement requirement. Virology 26 : 44 53.[PubMed] [CrossRef]
99. Ozaki Y,, Tabeyi K . 1967. Studies on the neutralization of Japanese encephalitis virus. I. Application of kinetic neutralization to the measurement of the neutralizing potency of antiserum. J Immunol 98 : 1218 1223.[PubMed]
100. Johnson JB,, Capraro GA,, Parks GD . 2008. Differential mechanisms of complement-mediated neutralization of the closely related paramyxoviruses simian virus 5 and mumps virus. Virology 376 : 112 123.[PubMed] [CrossRef]
101. Corbeil S,, Seguin C,, Trudel M . 1996. Involvement of the complement system in the protection of mice from challenge with respiratory syncytial virus Long strain following passive immunization with monoclonal antibody 18A2B2. Vaccine 14 : 521 525.[PubMed] [CrossRef]
102. Boere WA,, Benaissa-Trouw BJ,, Harmsen T,, Erich T,, Kraaijeveld CA,, Snippe H . 1986. The role of complement in monoclonal antibody-mediated protection against virulent Semliki Forest virus. Immunology 58 : 553 559.[PubMed]
103. Saifuddin M,, Parker CJ,, Peeples ME,, Gorny MK,, Zolla-Pazner S,, Ghassemi M,, Rooney IA,, Atkinson JP,, Spear GT . 1995. Role of virion-associated glycosylphosphatidylinositol-linked proteins CD55 and CD59 in complement resistance of cell line-derived and primary isolates of HIV-1. J Exp Med 182 : 501 509.[PubMed] [CrossRef]
104. Schmitz J,, Zimmer JP,, Kluxen B,, Aries S,, Bogel M,, Gigli I,, Schmitz H . 1995. Antibody-dependent complement-mediated cytotoxicity in sera from patients with HIV-1 infection is controlled by CD55 and CD59. J Clin Invest 96 : 1520 1526.[PubMed] [CrossRef]
105. Zhou ZH,, Wild T,, Xiong Y,, Sylvers P,, Zhang Y,, Zhang L,, Wahl L,, Wahl SM,, Kozlowski S,, Notkins AL . 2013. Polyreactive Antibodies Plus Complement Enhance the Phagocytosis of Cells Made Apoptotic by UV-Light or HIV. Sci Rep 3 : 2271. doi:10.1038/srep02271. [PubMed] [CrossRef]
106. Willey S,, Aasa-Chapman MM,, O’Farrell S,, Pellegrino P,, Williams I,, Weiss RA,, Neil SJ . 2011. Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection. Retrovirology 8 : 16. doi:10.1186/1742-4690-8-16. [PubMed] [CrossRef]
107. Stoiber H,, Banki Z,, Wilflingseder D,, Dierich MP . 2008. Complement-HIV interactions during all steps of viral pathogenesis. Vaccine 26 : 3046 3054.[PubMed] [CrossRef]
108. Huber G,, Banki Z,, Lengauer S,, Stoiber H . 2011. Emerging role for complement in HIV infection. Curr Opin HIV AIDS 6 : 419 426.[PubMed] [CrossRef]
109. Jayasekera JP,, Moseman EA,, Carroll MC . 2007. Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. J Virol 81 : 3487 3494.[PubMed] [CrossRef]
110. Carroll MC . 2004. The complement system in regulation of adaptive immunity. Nat Immunol 5 : 981 986.[PubMed] [CrossRef]
111. Stager S,, Alexander J,, Kirby AC,, Botto M,, Rooijen NV,, Smith DF,, Brombacher F,, Kaye PM . 2003. Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med 9 : 1287 1292.[PubMed] [CrossRef]
112. Lindorfer MA,, Hahn CS,, Foley PL,, Taylor RP . 2001. Heteropolymer-mediated clearance of immune complexes via erythrocyte CR1: mechanisms and applications. Immunol Rev 183 : 10 24.[PubMed] [CrossRef]
113. Nelson RA Jr . 1953. The immune-adherence phenomenon; an immunologically specific reaction between microorganisms and erythrocytes leading to enhanced phagocytosis. Science 118 : 733 737.[CrossRef]
114. Ram S,, Lewis LA,, Rice PA . 2010. Infections of people with complement deficiencies and patients who have undergone splenectomy. Clin Microbiol Rev 23 : 740 780.[PubMed] [CrossRef]
115. Amir J,, Scott MG,, Nahm MH,, Granoff DM . 1990. Bactericidal and opsonic activity of IgG1 and IgG2 anticapsular antibodies to Haemophilus influenzae type b. J Infect Dis 162 : 163 171.[PubMed] [CrossRef]
116. Frasch CE,, Borrow R,, Donnelly J . 2009. Bactericidal antibody is the immunologic surrogate of protection against meningococcal disease. Vaccine 27( Suppl 2) : B112 B116.[PubMed] [CrossRef]
117. Welsch JA,, Moe GR,, Rossi R,, Adu-Bobie J,, Rappuoli R,, Granoff DM . 2003. Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity. J Infect Dis 188 : 1730 1740.[PubMed] [CrossRef]
118. Plested JS,, Welsch JA,, Granoff DM . 2009. Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activity. Clin Vaccine Immunol 16 : 785 791.[PubMed] [CrossRef]
119. Granoff DM . 2009. Relative importance of complement-mediated bactericidal and opsonic activity for protection against meningococcal disease. Vaccine 27( Suppl 2) : B117 B125.[PubMed] [CrossRef]
120. Horwitz MA,, Silverstein SC . 1981. Interaction of the Legionnaires’ disease bacterium (Legionella pneumophila) with human phagocytes. I. L. pneumophila resists killing by polymorphonuclear leukocytes, antibody, and complement. J Exp Med 153 : 386 397.[PubMed] [CrossRef]
121. Lindow JC,, Fimlaid KA,, Bunn JY,, Kirkpatrick BD . 2011. Antibodies in action: role of human opsonins in killing Salmonella enterica serovar Typhi. Infect Immun 79 : 3188 3194.[PubMed] [CrossRef]
122. Cheng SC,, Sprong T,, Joosten LA,, van der Meer JW,, Kullberg BJ,, Hube B,, Schejbel L,, Garred P,, van Deuren M,, Netea MG . 2012. Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs. Eur J Immunol 42 : 993 1004.[PubMed] [CrossRef]
123. Han Y,, Kozel TR,, Zhang MX,, MacGill RS,, Carroll MC,, Cutler JE . 2001. Complement is essential for protection by an IgM and an IgG3 monoclonal antibody against experimental, hematogenously disseminated candidiasis. J Immunol 167 : 1550 1557.[PubMed] [CrossRef]
124. Zaragoza O,, Casadevall A . 2006. Monoclonal antibodies can affect complement deposition on the capsule of the pathogenic fungus Cryptococcus neoformans by both classical pathway activation and steric hindrance. Cell Microbiol 8 : 1862 1876.[PubMed] [CrossRef]
125. Zhong Z,, Pirofski LA . 1998. Antifungal activity of a human antiglucuronoxylomannan antibody. Clin Diagn Lab Immunol 5 : 58 64.[PubMed]
126. Taborda CP,, Casadevall A . 2002. CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans . Immunity 16 : 791 802.[CrossRef]
127. Ayi K,, Turrini F,, Piga A,, Arese P . 2004. Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait. Blood 104 : 3364 3371.[PubMed] [CrossRef]
128. Luzzi GA,, Merry AH,, Newbold CI,, Marsh K,, Pasvol G . 1991. Protection by alpha-thalassaemia against Plasmodium falciparum malaria: modified surface antigen expression rather than impaired growth or cytoadherence. Immunol Lett 30 : 233 240.[CrossRef]
129. Yuthavong Y,, Bunyaratvej A,, Kamchonwongpaisan S . 1990. Increased susceptibility of malaria-infected variant erythrocytes to the mononuclear phagocyte system. Blood Cells 16 : 591 597.[PubMed]
130. Cappadoro M,, Giribaldi G,, O’Brien E,, Turrini F,, Mannu F,, Ulliers D,, Simula G,, Luzzatto L,, Arese P . 1998. Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency. Blood 92 : 2527 2534.[PubMed]
131. Kumaratilake LM,, Ferrante A,, Jaeger T,, Morris-Jones SD . 1997. The role of complement, antibody, and tumor necrosis factor alpha in the killing of Plasmodium falciparum by the monocytic cell line THP-1. Infect Immun 65 : 5342 5345.[PubMed]
132. Salmon D,, Vilde JL,, Andrieu B,, Simonovic R,, Lebras J . 1986. Role of immune serum and complement in stimulation of the metabolic burst of human neutrophils by Plasmodium falciparum . Infect Immun 51 : 801 806.[PubMed]
133. Pang XL,, Horii T . 1998. Complement-mediated killing of Plasmodium falciparum erythrocytic schizont with antibodies to the recombinant serine repeat antigen (SERA). Vaccine 16 : 1299 1305.[PubMed] [CrossRef]
134. Healer J,, McGuinness D,, Hopcroft P,, Haley S,, Carter R,, Riley E . 1997. Complement-mediated lysis of Plasmodium falciparum gametes by malaria-immune human sera is associated with antibodies to the gamete surface antigen Pfs230. Infect Immun 65 : 3017 3023.[PubMed]
135. Read D,, Lensen AH,, Begarnie S,, Haley S,, Raza A,, Carter R . 1994. Transmission-blocking antibodies against multiple, non-variant target epitopes of the Plasmodium falciparum gamete surface antigen Pfs230 are all complement-fixing. Parasite Immunol 16 : 511 519.[PubMed] [CrossRef]
136. Rener J,, Graves PM,, Carter R,, Williams JL,, Burkot TR . 1983. Target antigens of transmission-blocking immunity on gametes of Plasmodium falciparum . J Exp Med 158 : 976 981.[PubMed] [CrossRef]
137. Roeffen W,, Geeraedts F,, Eling W,, Beckers P,, Wizel B,, Kumar N,, Lensen T,, Sauerwein R . 1995. Transmission blockade of Plasmodium falciparum malaria by anti-Pfs230-specific antibodies is isotype dependent. Infect Immun 63 : 467 471.[PubMed]
138. Macaskill JA,, Holmes PH,, Whitelaw DD,, McConnell I,, Jennings FW,, Urquhart GM . 1980. Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. II. Mechanisms in immune animals. Immunology 40 : 629 635.[PubMed]
139. Pan W,, Ogunremi O,, Wei G,, Shi M,, Tabel H . 2006. CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of tumor necrosis factor alpha and nitric oxide. Microbes Infect 8 : 1209 1218.[PubMed] [CrossRef]
140. Owuor BO,, Odhiambo CO,, Otieno WO,, Adhiambo C,, Makawiti DW,, Stoute JA . 2008. Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia. Mol Med 14 : 89 97.[PubMed] [CrossRef]
141. Patel SN,, Berghout J,, Lovegrove FE,, Ayi K,, Conroy A,, Serghides L,, Min-oo G,, Gowda DC,, Sarma JV,, Rittirsch D,, Ward PA,, Liles WC,, Gros P,, Kain KC . 2008. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med 205 : 1133 1143.[PubMed] [CrossRef]
142. Farrell HE,, Shellam GR . 1991. Protection against murine cytomegalovirus infection by passive transfer of neutralizing and non-neutralizing monoclonal antibodies. J Gen Virol 72( Pt 1) : 149 156.[PubMed] [CrossRef]
143. Horton RE,, Vidarsson G . 2013. Antibodies and their receptors: different potential roles in mucosal defense. Front Immunol 4 : 200. doi:10.3389/fimmu.2013.00200. [PubMed] [CrossRef]
144. Takai T . 2002. Roles of Fc receptors in autoimmunity. Nat Rev Immunol 2 : 580 592.[PubMed]
145. Clark MR,, Clarkson SB,, Ory PA,, Stollman N,, Goldstein IM . 1989. Molecular basis for a polymorphism involving Fc receptor II on human monocytes. J Immunol 143 : 1731 1734.[PubMed]
146. Warmerdam PA,, van de Winkel JG,, Vlug A,, Westerdaal NA,, Capel PJ . 1991. A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding. J Immunol 147 : 1338 1343.[PubMed]
147. Ravetch JV,, Perussia B . 1989. Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. J Exp Med 170 : 481 497.[PubMed] [CrossRef]
148. Ory PA,, Goldstein IM,, Kwoh EE,, Clarkson SB . 1989. Characterization of polymorphic forms of Fc receptor III on human neutrophils. J Clin Invest 83 : 1676 1681.[PubMed] [CrossRef]
149. Ory PA,, Clark MR,, Kwoh EE,, Clarkson SB,, Goldstein IM . 1989. Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils. J Clin Invest 84 : 1688 1691.[PubMed] [CrossRef]
150. Bruhns P,, Iannascoli B,, England P,, Mancardi DA,, Fernandez N,, Jorieux S,, Daeron M . 2009. Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Blood 113 : 3716 3725.[PubMed] [CrossRef]
151. Wiener E,, Jolliffe VM,, Scott HC,, Kumpel BM,, Thompson KM,, Melamed MD,, Hughes-Jones NC . 1988. Differences between the activities of human monoclonal IgG1 and IgG3 anti-D antibodies of the Rh blood group system in their abilities to mediate effector functions of monocytes. Immunology 65 : 159 163.[PubMed]
152. Shields RL,, Lai J,, Keck R,, O’Connell LY,, Hong K,, Meng YG,, Weikert SH,, Presta LG . 2002. Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity. J Biol Chem 277 : 26733 26740.[PubMed] [CrossRef]
153. Forthal DN,, Gach JS,, Landucci G,, Jez J,, Strasser R,, Kunert R,, Steinkellner H . 2010. Fc-glycosylation influences Fcgamma receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G12. J Immunol 185 : 6876 6882.[PubMed] [CrossRef]
154. Lux A,, Nimmerjahn F . 2011. Impact of differential glycosylation on IgG activity. Adv Exp Med Biol 780 : 113 124.[PubMed] [CrossRef]
155. Moldt B,, Shibata-Koyama M,, Rakasz EG,, Schultz N,, Kanda Y,, Dunlop DC,, Finstad SL,, Jin C,, Landucci G,, Alpert MD,, Dugast AS,, Parren PW,, Nimmerjahn F,, Evans DT,, Alter G,, Forthal DN,, Schmitz JE,, Iida S,, Poignard P,, Watkins DI,, Hessell AJ,, Burton DR . 2012. A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcgammaRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques. J Virol 86 : 6189 6196.[PubMed] [CrossRef]
156. Forthal DN,, Moog C . 2009. Fc receptor-mediated antiviral antibodies. Curr Opin HIV AIDS 4 : 388 393.[PubMed] [CrossRef]
157. Lyerly HK,, Reed DL,, Matthews TJ,, Langlois AJ,, Ahearne PA,, Petteway SR Jr,, Weinhold KJ . 1987. Anti-GP 120 antibodies from HIV seropositive individuals mediate broadly reactive anti-HIV ADCC. AIDS Res Hum Retroviruses 3 : 409 422.[PubMed] [CrossRef]
158. Torben W,, Ahmad G,, Zhang W,, Nash S,, Le L,, Karmakar S,, Siddiqui AA . 2012. Role of antibody dependent cell mediated cytotoxicity (ADCC) in Sm-p80-mediated protection against Schistosoma mansoni. Vaccine 30 : 6753 6758.[PubMed] [CrossRef]
159. Bouharoun-Tayoun H,, Oeuvray C,, Lunel F,, Druilhe P . 1995. Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. J Exp Med 182 : 409 418.[PubMed] [CrossRef]
160. Forthal DN,, Landucci G,, Daar ES . 2001. Antibody from patients with acute human immunodeficiency virus (HIV) infection inhibits primary strains of HIV type 1 in the presence of natural-killer effector cells. J Virol 75 : 6953 6961.[PubMed] [CrossRef]
161. Weber S,, Tian H,, van Rooijen N,, Pirofski LA . 2012. A serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibody requires Fcgamma receptor III and macrophages to mediate protection against pneumococcal pneumonia in mice. Infect Immun 80 : 1314 1322.[PubMed] [CrossRef]
162. Sun D,, Raisley B,, Langer M,, Iyer JK,, Vedham V,, Ballard JL,, James JA,, Metcalf J,, Coggeshall KM . 2012. Anti-peptidoglycan antibodies and Fcgamma receptors are the key mediators of inflammation in Gram-positive sepsis. J Immunol 189 : 2423 2431.[PubMed] [CrossRef]
163. Song X,, Tanaka S,, Cox D,, Lee SC . 2004. Fcgamma receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction. J Leukoc Biol 75 : 1147 1155.[PubMed] [CrossRef]
164. Porcherie A,, Mathieu C,, Peronet R,, Schneider E,, Claver J,, Commere PH,, Kiefer-Biasizzo H,, Karasuyama H,, Milon G,, Dy M,, Kinet JP,, Louis J,, Blank U,, Mecheri S . 2011. Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria. J Exp Med 208 : 2225 2236.[PubMed] [CrossRef]
165. Forthal DN,, Landucci G,, Phan TB,, Becerra J . 2005. Interactions between natural killer cells and antibody Fc result in enhanced antibody neutralization of human immunodeficiency virus type 1. J Virol 79 : 2042 2049.[PubMed] [CrossRef]
166. Brown BK,, Wieczorek L,, Kijak G,, Lombardi K,, Currier J,, Wesberry M,, Kappes JC,, Ngauy V,, Marovich M,, Michael N,, Ochsenbauer C,, Montefiori DC,, Polonis VR . 2012. The role of natural killer (NK) cells and NK cell receptor polymorphisms in the assessment of HIV-1 neutralization. PLoS One 7 : e29454. doi:10.1371/journal.pone.0029454. [CrossRef]
167. Holl V,, Peressin M,, Decoville T,, Schmidt S,, Zolla-Pazner S,, Aubertin AM,, Moog C . 2006. Nonneutralizing antibodies are able to inhibit human immunodeficiency virus type 1 replication in macrophages and immature dendritic cells. J Virol 80 : 6177 6181.[PubMed] [CrossRef]
168. Holl V,, Hemmerter S,, Burrer R,, Schmidt S,, Bohbot A,, Aubertin AM,, Moog C . 2004. Involvement of Fc gamma RI (CD64) in the mechanism of HIV-1 inhibition by polyclonal IgG purified from infected patients in cultured monocyte-derived macrophages. J Immunol 173 : 6274 6283.[PubMed] [CrossRef]
169. Anderson DR,, Grillo-Lopez A,, Varns C,, Chambers KS,, Hanna N . 1997. Targeted anti-cancer therapy using rituximab, a chimaeric anti-CD20 antibody (IDEC-C2B8) in the treatment of non-Hodgkin’s B-cell lymphoma. Biochem Soc Trans 25 : 705 708.[PubMed]
170. Sliwkowski MX,, Lofgren JA,, Lewis GD,, Hotaling TE,, Fendly BM,, Fox JA . 1999. Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Semin Oncol 26 : 60 70.[PubMed]
171. Clynes RA,, Towers TL,, Presta LG,, Ravetch JV . 2000. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 6 : 443 446.[PubMed] [CrossRef]
172. Shore SL,, Nahmias AJ,, Starr SE,, Wood PA,, McFarlin DE . 1974. Detection of cell-dependent cytotoxic antibody to cells infected with herpes simplex virus. Nature 251 : 350 352.[PubMed] [CrossRef]
173. Balachandran N,, Bacchetti S,, Rawls WE . 1982. Protection against lethal challenge of BALB/c mice by passive transfer of monoclonal antibodies to five glycoproteins of herpes simplex virus type 2. Infect Immun 37 : 1132 1137.[PubMed]
174. Gorander S,, Harandi AM,, Lindqvist M,, Bergstrom T,, Liljeqvist JA . 2012. Glycoprotein G of herpes simplex virus 2 as a novel vaccine antigen for immunity to genital and neurological disease. J Virol 86 : 7544 7553.[PubMed] [CrossRef]
175. Chu CF,, Meador MG,, Young CG,, Strasser JE,, Bourne N,, Milligan GN . 2008. Antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by Fc gamma receptor-dependent and -independent mechanisms. J Reprod Immunol 78 : 58 67.[PubMed] [CrossRef]
176. Jegerlehner A,, Schmitz N,, Storni T,, Bachmann MF . 2004. Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity. J Immunol 172 : 5598 5605.[PubMed] [CrossRef]
177. Forthal D,, Hope TJ,, Alter G . 2013. New paradigms for functional HIV-specific nonneutralizing antibodies. Curr Opin HIV AIDS 8 : 392 400.[PubMed] [CrossRef]
178. Lowell GH,, Smith LF,, Artenstein MS,, Nash GS,, MacDermott RP Jr . 1979. Antibody-dependent cell-mediated antibacterial activity of human mononuclear cells. I. K lymphocytes and monocytes are effective against meningococi in cooperation with human imune sera. J Exp Med 150 : 127 137.[PubMed] [CrossRef]
179. Lowell GH,, MacDermott RP,, Summers PL,, Reeder AA,, Bertovich MJ,, Formal SB . 1980. Antibody-dependent cell-mediated antibacterial activity: K lymphocytes, monocytes, and granulocytes are effective against shigella. J Immunol 125 : 2778 2784.[PubMed]
180. Tagliabue A,, Nencioni L,, Villa L,, Keren DF,, Lowell GH,, Boraschi D . 1983. Antibody-dependent cell-mediated antibacterial activity of intestinal lymphocytes with secretory IgA. Nature 306 : 184 186.[PubMed] [CrossRef]
181. Tagliabue A,, Boraschi D,, Villa L,, Keren DF,, Lowell GH,, Rappuoli R,, Nencioni L . 1984. IgA-dependent cell-mediated activity against enteropathogenic bacteria: distribution, specificity, and characterization of the effector cells. J Immunol 133 : 988 992.[PubMed]
182. Sestini P,, Nencioni L,, Villa L,, Boraschi D,, Tagliabue A . 1988. IgA-driven antibacterial activity against Streptococcus pneumoniae by mouse lung lymphocytes. Am Rev Respir Dis 137 : 138 143.[PubMed] [CrossRef]
183. Messick JB,, Rikihisa Y . 1992. Presence of parasite antigen on the surface of P388D1 cells infected with Ehrlichia risticii . Infect Immun 60 : 3079 3086.[PubMed]
184. Koster FT,, Kirkpatrick TL,, Rowatt JD,, Baca OG . 1984. Antibody-dependent cellular cytotoxicity of Coxiella burnetii-infected J774 macrophage target cells. Infect Immun 43 : 253 256.
185. Galdiero F,, Romano Carratelli C,, Nuzzo I,, Folgore A . 1985. Cytotoxic antibody dependent cells in mice experimentally infected with Brucella abortus . Microbiologica 8 : 217 224.[PubMed]
186. Shannon JG,, Cockrell DC,, Takahashi K,, Stahl GL,, Heinzen RA . 2009. Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent. BMC Immunol 10 : 26. doi:10.1186/1471-2172-10-26. [CrossRef]
187. Kazura JW . 1981. Host defense mechanisms against nematode parasites: destruction of newborn Trichinella spiralis larvae by human antibodies and granulocytes. J Infect Dis 143 : 712 718.[PubMed] [CrossRef]
188. Venturiello SM,, Giambartolomei GH,, Costantino SN . 1993. Immune killing of newborn Trichinella larvae by human leucocytes. Parasite Immunol 15 : 559 564.[PubMed]
189. Gounni AS,, Lamkhioued B,, Ochiai K,, Tanaka Y,, Delaporte E,, Capron A,, Kinet JP,, Capron M . 1994. High-affinity IgE receptor on eosinophils is involved in defence against parasites. Nature 367 : 183 186.[PubMed] [CrossRef]
190. Capron M,, Capron A . 1994. Immunoglobulin E and effector cells in schistosomiasis. Science 264 : 1876 1877.[PubMed] [CrossRef]
191. Zhou S,, Liu S,, Song G,, Xu Y,, Sun W . 2000. Protective immunity induced by the full-length cDNA encoding paramyosin of Chinese Schistosoma japonicum . Vaccine 18 : 3196 3204.[PubMed] [CrossRef]
192. Capron A . 1998. Schistosomiasis: forty years’ war on the worm. Parasitol Today 14 : 379 384.[PubMed] [CrossRef]
193. Joseph M,, Auriault C,, Capron A,, Vorng H,, Viens P . 1983. A new function for platelets: IgE-dependent killing of schistosomes. Nature 303 : 810 812.[PubMed] [CrossRef]
194. Khalife J,, Capron M,, Capron A,, Grzych JM,, Butterworth AE,, Dunne DW,, Ouma JH . 1986. Immunity in human schistosomiasis mansoni. Regulation of protective immune mechanisms by IgM blocking antibodies. J Exp Med 164 : 1626 1640.[PubMed] [CrossRef]