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Chapter 9 : Blocking Transmission

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Blocking Transmission, Page 1 of 2

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Abstract:

The oldest and most effective public health measures have been interventions that prevented or reduced the transmission of malaria. An approach to blocking transmission is to reduce the infectivity of the human population itself by widespread distribution and use of antimalarial drugs. An alternative to the use of drugs to suppress human infectivity for mosquitoes is to develop and deploy vaccines designed to limit the transmission of human malaria infections to mosquitoes—a transmission-blocking vaccine (TBV). A malaria TBV would not prevent disease in newly infected individuals but would contribute to herd immunity: although it would not directly influence the course of infection in the vaccinated individual, it would affect the potential for infection in others. Thus, TBVs are sometimes called altruistic vaccines. The protein antigens that could be used for a malaria TBV were identified—at least for chicken malaria. The presence of these antigens in the gametocytes is the probable reason why these stages induce transmission-blocking immunity almost as effectively as do the gametes themselves. Those working on a TBV cite as the major strengths of the lead candidates Pfs25 and Pfs28 to be the following: (i) they are present in both and , (ii) they act synergistically in inducing transmission blocking immunity, and (iii) vaccination of humans induces the correct immune response.

Citation: Sherman I. 2009. Blocking Transmission, p 188-215. In The Elusive Malaria Vaccine. ASM Press, Washington, DC. doi: 10.1128/9781555817428.ch9
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