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Chapter 15.6 : Packing and Shipping Infectious Substances

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Packing and Shipping Infectious Substances, Page 1 of 2

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Abstract:

The information in this procedure is not intended to be an all-inclusive guide to packing and shipping regulations. The information is a summary of my interpretations of the current (as of 1 January 2009) requirements and regulations issued by the following: the International Civil Aviation Organization (ICAO; a specialized United Nations [UN] agency which promotes the international standardization of essentially all technical aspects of aviation, including the transport of dangerous goods), the International Air Transport Association (IATA; a commercial airline trade association), and the U.S. Department of Transportation (DOT; an agency of the federal government).

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Figures

Image of Figure 15.6-1
Figure 15.6-1

Algorithm for classifying infectious substances. Abbreviations: inact., inactivated; neut., neutralized.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-2
Figure 15.6-2

Labels which indicate an infectious substance (Class 6), proper shipping name, UN number, and quantity of substance.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-3
Figure 15.6-3

Markings which indicate a Biological Substance, Category B, and appropriate UN number.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-4
Figure 15.6-4

Labels which indicate a miscellaneous (Class 9) dangerous good (2 kg of dry ice).

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-5
Figure 15.6-5

Label which indicates correct orientation of package during shipping.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-6
Figure 15.6-6

Label which indicates that the substance must be transported only in cargo (not passenger) aircraft.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-7
Figure 15.6-7

Label which indicates that an overpack is used and inner packages comply with regulations.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-8
Figure 15.6-8

Label which indicates an Exempt Human Specimen.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-9
Figure 15.6-9

Example of a label which indicates that the outer container has met UNspecified manufacturing standards.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-10
Figure 15.6-10

Example of an appropriately labeled outer package. The primary container inside the package contains an Exempt Human Specimen and is packed according to IATA directions.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-11
Figure 15.6-11

A completely labeled outer package. The primary container inside the package contains a Biological Substance, Category B (diagnostic or clinical specimen), and is packed according to PI 650.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-12
Figure 15.6-12

A completely labeled outer package. The primary container inside the package contains a Category A infectious substance and is packed according to PI 602.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-13
Figure 15.6-13

Shipper's Declaration for Dangerous Goods showing 13 sections which must be completed by the shipper.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Image of Figure 15.6-14
Figure 15.6-14

Completed Shipper's Declaration for Dangerous Goods.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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References

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1. Animal and Plant Inspection Service, U.S. Department of Agriculture. 2005. Agricultural bioterrorism protection act of 2002: possession, use, and transfer of biological agents and toxins; final rule (7 CFR Part 331; 9 CFR Part 121). Fed. Regist. 70:1324213292.
2a.. Centers for Disease Control and Prevention and the Office of the Inspector General, U.S. Department of Health and Human Services. 2005. Possession, use, and transfer of select agents and toxins; final rule (42 CFR Parts 72 and 73). Fed. Regist. 70:1329413325.
2b.. Centers for Disease Control and Prevention, U.S. Department of Health and Human Services. 2008. Possession, use, and transfer of select agents and toxins; final rule (42 CFR Part 73). Fed. Regist. 73:6136361366.
3. Centers for Disease Control and Prevention, U.S. Department of Health and Human Services. 2005. Possession, use, and transfer of select agents and toxins—reconstructed replication competent forms of the 1918 pandemic influenza virus containing any portion of the coding regions of all eight gene segments; interim final rule (42 CFR Part 73). Fed. Regist. 70:6104761049.
4. Denys, G. A.,, L. D. Gray,, and J. W. Snyder,. 2004. Cumitech 40, Packing and Shipping Diagnostic Specimens and Infectious Substances. Coordinating ed., D. L. Sewell. American Society for Microbiology, Washington, DC.
5. Gilchrist, M. J. R.,, W. P. McKinney,, J. M. Miller,, and A. S. Weissfeld,. 2000. Cumitech 33, Laboratory Safety, Management, and Diagnosis of Biological Agents Associated with Bioterrorism. Coordinating ed., J. W. Snyder. American Society for Microbiology, Washington, DC.
6. Gray, L. D.,, and J. W. Snyder,. 2006. Packing and shipping biological materials, p. 383401. In D. O. Fleming, and D. L. Hunt (ed.), Biological Safety: Principles and Practices, 4th ed. ASM Press, Washington, DC.
7.International Air Transport Association. 2009. Dangerous Goods Regulations, 50th ed. International Air Transport Association, Montreal, Quebec, Canada.
8. McKay, J.,, and D. O. Fleming,. 2000. Packaging and shipping biological materials, p. 411425. In D. O. Fleming, and D. L. Hunt (ed.), Biological Safety: Principles and Practices, 3rd ed. American Society for Microbiology, Washington, DC.
9. Snyder, J. W. 2002. Packaging and shipping of infectious substances. Clin. Microbiol. Newsl. 24:8993.
10.U.S. Department of Transportation, Pipeline and Hazardous Materials Safety Administration. 2005. Hazardous materials. Incorporation of statutory mandated revisions to the hazardous materials regulations. Fed. Regist. 70:73164.
11.U.S. Department of Transportation, Pipeline and Hazardous Materials Safety Administration. 2006. Hazardous materials: infectious substances; harmonization with the United Nations recommendations; final rule. Fed. Regist. 71:3224432263.
12.U.S. Department of Transportation, Research and Special Programs Administration. 2004. Hazardous materials. Miscellaneous changes to the hazardous communication requirements; final rule. Fed. Regist. 69:64468.
13.U.S. Department of Transportation, Research and Special Programs Administration. 2004. Harmonization with the United Nations Recommendations, International Maritime Dangerous Goods Code, and International Civil Aviation Organization’s Technical Instructions; final rule. Fed. Regist. 69:7604476187.
14.U.S. Postal Service. 2009. Domestic Mail Manual. http://pe.usps.com/text/dmm300/ dmm300_landing.htm. Accessed 25 June 2009.
15.World Health Organization. 2005. Guidance on Regulations for the Transport of Infectious Substances. World Health Organization, Geneva, Switzerland. http://www.who.int/csr/ resources/publications/biosafety/WHO_CDS_ CSR_LYO_2005_22/en..

Tables

Generic image for table
Table 15.6-1

Agencies governing transportation of dangerous goods

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
Generic image for table
Table 15.6-2

IATA-defined classes of dangerous goods

Addressed in detail in the text.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
Generic image for table
Table 15.6-3

Types and classifications of IATA Division 6.2 infectious substances

The only acceptable proper shipping name for Category B substances is Biological Substance, Category B. The proper shipping names Diagnostic Specimen and Clinical Specimen are no longer allowed.

Substance is not addressed in detail in this procedure.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Table 15.6-4

Examples of infectious substances (agents) included in Category A in any form unless otherwise indicated

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
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Table 15.6-5

Information provided for each proper shipping name in the IATA alphabetical and applicable to completing a Shipper's Declaration

Refers to the 14 columns in the IATA alphabetical .

NA, not applicable to infectious substances.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
Generic image for table
Table 15.6-6

The seven types of infectious substances in the IATA alphabetical

Pk gp, packing group; ltd, limited; qty, quantity; spec prov, special provisions; ERG, emergency response guide.

On the Shipper's Declaration but not on the outer package, the proper shipping name of the substance must be followed by the technical name (in parentheses) of the substance, e.g., Infectious Substance, Affecting Humans ().

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6
Generic image for table
Table 15.6-7

Comparison of IATA PI 650 and 602 and packing directions for exempt human specimens ( )

1° and 2° , primary and secondary, respectively.

Includes substances with minimal likelihood of causing disease in humans and animals, and substances not likely to contain pathogens (see text).

PI for Biological Substances, Category B.

PI for Category A infectious substances and other biological substances shipper considers to be an infectious danger to carrier personnel.

—, requirement not specified by the IATA or DOT.

Not required for solid substances such as tissue and solid agar medium cultures or slants.

Should be “of adequate strength for its intended capacity, mass, and intended use.”

May be placed either on the outer package or on the air waybill.

Citation: Garcia L. 2010. Packing and Shipping Infectious Substances, p 701-724. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch15.6

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