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Chapter 13 : Antimicrobial Drug Resistance in Fish Pathogens

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Abstract:

In the 1970s several reports of drug resistance in fish pathogens from Japanese fish farms linked antibiotic resistance to fish farming. In this report, the devastating effect of acquired sulfonamide resistance in the treatment of furunculosis was demonstrated in clinical trials. strains from Norway, including 10 isolates of sulfonamide-resistant atypical strains representing the various groups of a typical isolated in Norway, were screened for occurrence of class 1 integrons and sulfonamide resistance genes. In this study isolates from Switzerland, Finland, France, Japan, Scotland, and the United States were also studied. The study also characterized a third R plasmid of about 70 kb found in two isolates in 1974 in the United States. It is also of particular interest that one of the R plasmids of is very similar to the R plasmids of subsp. . Infections with multiple-drug-resistant occurred in farmed ayu in Japan in 1973. Several studies demonstrate transfer of R plasmids from fish pathogens to recipients. In many ways, fish pathogens represent possible intermediate vectors for shipping antibiotic resistance genes between the environment and human beings for further recombination.

Citation: Sørum H. 2006. Antimicrobial Drug Resistance in Fish Pathogens, p 213-238. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch13
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Figures

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Figure 1.

Comparison of the resistance-determining regions of pRAS1 and pAr-32. The areas of the plasmids that are the same as the sequences in Tn (EMBL accession number U12338), Tn (EMBL accession number X61367), pSa (EMBL accession number L06822), and of (EMBL accession number X53796) are indicated by the lines at the top. The areas of pRAS1 with similarities to In and Tn are indicated at the bottom. Reprinted from reference with permission of the publisher.

Citation: Sørum H. 2006. Antimicrobial Drug Resistance in Fish Pathogens, p 213-238. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch13
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Image of Figure 2.
Figure 2.

Schematic presentation of management and environmental factors in aquaculture that contribute to the spread of drug-resistant bacteria and their genetic factors.

Citation: Sørum H. 2006. Antimicrobial Drug Resistance in Fish Pathogens, p 213-238. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch13
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Tables

Generic image for table
Table 2.

Transferable R plasmids in Japanese fish culturing

Citation: Sørum H. 2006. Antimicrobial Drug Resistance in Fish Pathogens, p 213-238. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch13
Generic image for table
Table 1.

Global distribution of transferable R plasmids in aeromonads

Citation: Sørum H. 2006. Antimicrobial Drug Resistance in Fish Pathogens, p 213-238. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch13
Generic image for table
Table 5.

Conjugative transfer of pRAS1 measured by transfer frequencies

Citation: Sørum H. 2006. Antimicrobial Drug Resistance in Fish Pathogens, p 213-238. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch13
Generic image for table
Table 3.

Amino acid substitutions in the gyrA gene of fish-pathogenic bacteria causing quinolone resistance

Citation: Sørum H. 2006. Antimicrobial Drug Resistance in Fish Pathogens, p 213-238. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch13
Generic image for table
Table 4.

Resistance determinants in representative R plasmids of V. anguillarum from Japanese ayu (P. altivelis) farms

Citation: Sørum H. 2006. Antimicrobial Drug Resistance in Fish Pathogens, p 213-238. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch13

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