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Abstract:

The main species that cause infections in animals belongs to the genera and . In veterinary medicine the most commonly used antimicrobial agents are fluoroquinolones, macrolides, tetracyclines, and tiamulin. Susceptibility testing for can, as for all other bacterial species, be performed by agar or broth dilution or disk diffusion. Susceptibility testing of mycoplasmas requires special media because of their slow growth and fastidious medium requirements. Worldwide, there have been very few reports on the antimicrobial susceptibility of the different species. is intrinsically resistant to erythromycin and flumequin. Most studied strains are susceptible to josamycin, spiramycin, lincomycin, tylosin, tilmicosin, tiamulin, danofloxacin, and enrofloxacin. The genetic background for resistance has been studied only with mycoplasmas causing infections in humans. A high frequency of tetracycline resistance has been reported in several species. Quinolones interfere with DNA replication by binding to DNA gyrase or topoisomerase IV. Resistance to quinolones is caused mainly by mutations in the genes encoding DNA gyrase or topoisomerase IV. Mutations at positions 83, 87, and 119 in have been frequently found to be associated with quinolone resistance in several gram-negative bacterial species, whereas changes at positions 81 and 84 seem to be infrequently found. There are only a very limited number of reports on the antimicrobial susceptibility of the different species pathogenic for animals, and there is an obvious need for standardization of methods and interpretation.

Citation: Aarestrup F, Kempf I. 2006. , p 239-248. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch14

Key Concept Ranking

Mycoplasma hyopneumoniae
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Mycoplasma agalactiae
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References

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Tables

Generic image for table
Table 1.

Pathogenic and species, animal hosts, diseases caused, and antimicrobial agents of importance in controlling infections

Citation: Aarestrup F, Kempf I. 2006. , p 239-248. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch14
Generic image for table
Table 2.

Recommendations for susceptibility testing of veterinary mycoplasmas

Citation: Aarestrup F, Kempf I. 2006. , p 239-248. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch14
Generic image for table
Table 3.

Mutations in 23S rRNA genes conferring macrolide resistance in spp.

Citation: Aarestrup F, Kempf I. 2006. , p 239-248. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch14
Generic image for table
Table 4.

Amino acid substitutions associated with fluoroquinolone resistance in spp.

Citation: Aarestrup F, Kempf I. 2006. , p 239-248. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch14

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