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Chapter 17 : Antimicrobial Resistance in Nontyphoidal Salmonellae

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Abstract:

Epidemiologic data of a study of a multistate outbreak of food-borne salmonellosis due to resistant serovar Newport carrying a common ampicillin and tetracycline resistance plasmid, strongly associated hamburger meat originating from a single farm in South Dakota. Similarly, an outbreak study reported by a group used antimicrobial resistance and plasmid profiling to trace chloramphenicol-resistant serovar Newport from the incriminated hamburger meat back through the abattoir and to the dairy farm from which the meat was derived. As with many bacterial pathogens, antimicrobial resistance in nontyphoidal spp. is an international problem. Resistance associated with integrons has been studied extensively and is common in many multiple-drug resistance (MDR) serovars. An outbreak of quinolone-resistant DT104 in Denmark, originating in swine, resulted in 11 hospitalizations and the death of 2 patients due to therapeutic failure. The majority of AmpC β-lactamases belong to the CMY gene family, whose sequence similarity suggests an origin in . Food is an important vehicle for the national and international transmission of antimicrobial-resistant bacteria and antimicrobial resistance genes from food animals to humans. As food is distributed worldwide, attempts to control the spread of antimicrobial resistance must be approached internationally, in order to reduce or eliminate contamination by antimicrobial-resistant at the primary production site.

Citation: McDermott P. 2006. Antimicrobial Resistance in Nontyphoidal Salmonellae, p 293-314. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch17

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Figure 1.

Proportion of serovar Typhimurium isolates displaying DT104-like antimicrobial resistance in the United States. Adapted from references 45 and 95.

Citation: McDermott P. 2006. Antimicrobial Resistance in Nontyphoidal Salmonellae, p 293-314. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch17
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Image of Figure 2.
Figure 2.

Changes in phage types of multidrug-resistant serovar Typhimurium in England and Wales. Reprinted from reference 17a with permission from E. J. Threlfall.

Citation: McDermott P. 2006. Antimicrobial Resistance in Nontyphoidal Salmonellae, p 293-314. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch17
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