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Chapter 19 : The Clinical Importance of Animal-Related Resistance

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Abstract:

This chapter reviews the clinical and public health consequences of antimicrobial drug resistance in bacteria transferred from food animals to humans. To address the clinical importance of animal-related antimicrobial drug resistance, one must review how resistant bacteria may be a cause of increased morbidity and mortality. The chapter discusses the significance of increased transmission as a result of the unrelated use of antimicrobial agents to which a pathogen is resistant. It further covers reduced efficacy of treatment and increased virulence from a public health perspective, i.e., by summarizing observational studies that address the clinical and public health consequences of animal-related resistance. The food chain contains an abundance of antimicrobial drug-resistant pathogens, including Salmonella and Campylobacter. There is growing evidence that this has significant public health consequences. Mitigation of antimicrobial resistance in food-borne bacteria such as Salmonella and Campylobacter will likely benefit human health.

Citation: Mølbak K. 2006. The Clinical Importance of Animal-Related Resistance, p 329-337. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch19
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References

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Tables

Generic image for table
Table 1.

Mechanisms by which human health may be affected by the emergence of animal-related antimicrobial drug resistance in food-borne bacteria

Citation: Mølbak K. 2006. The Clinical Importance of Animal-Related Resistance, p 329-337. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch19
Generic image for table
Table 2.

Summary of selected epidemiological studies demonstrating that recent antimicrobial use is a risk factor for infection with drug-resistant salmonellae

Citation: Mølbak K. 2006. The Clinical Importance of Animal-Related Resistance, p 329-337. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch19
Generic image for table
Table 3.

Survival after infection with Salmonella serovar Typhimurium according to antimicrobial drug resistance

Citation: Mølbak K. 2006. The Clinical Importance of Animal-Related Resistance, p 329-337. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch19

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