Chapter 9 : Antimicrobial Resistance in and spp. and other Anaerobes

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This chapter focuses on issues relating to antimicrobial resistance in some of the more commonly encountered anaerobic bacterial pathogens of animals. Most of the available data on specific antimicrobial resistance relate to type A, causing necrotic enteritis in broiler chickens, and to , causing swine dysentery. Some species are essentially nonpathogenic; others, such as , may act as opportunistic pathogens, occasionally causing disease; and others are classified as major pathogens. Recently, in vitro development of resistance to coumermycin A1 in was reported. The resistance was associated with single-nucleotide mutations in the (B) gene. Coumarins are not used for treatment of infections with spp. and this study was performed to evaluate this resistance as a selective marker for genetic studies. Recently, three different mutations in the ribosomal protein L3 gene and six mutations in the 23S rRNA gene that are associated with tiamulin resistance in and were described. Early studies on the in vitro susceptibility of 18 U.S. strains of indicated that penicillin was the most effective antimicrobial, followed by cefamandole, clindamycin, tetracycline, chloramphenicol, erythromycin, cefoxitin, tylosin, nitrofurazone, tinidazole, and dihydrostreptomycin.

Citation: Franklin A, Pringle M, Hampson D. 2006. Antimicrobial Resistance in and spp. and other Anaerobes, p 127-144. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch9

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Antibacterial Agents
Peptidyl Transferase Inhibitors
Porcine reproductive and respiratory syndrome virus
Gram-Positive Bacteria
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Figure 1

Distribution of MICs of tiamulin for 221 German field isolates of isolated between 1989 and 2001. Adapted from reference .

Citation: Franklin A, Pringle M, Hampson D. 2006. Antimicrobial Resistance in and spp. and other Anaerobes, p 127-144. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch9
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Table 1

Resistance to tetracycline and erythromycin or tylosin in of animal origin

Citation: Franklin A, Pringle M, Hampson D. 2006. Antimicrobial Resistance in and spp. and other Anaerobes, p 127-144. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch9
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Table 2

Antimicrobial resistance in isolates from horses, piglets, and dogs

Citation: Franklin A, Pringle M, Hampson D. 2006. Antimicrobial Resistance in and spp. and other Anaerobes, p 127-144. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch9

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