Chapter 10 : The Genus

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spp. have been isolated from superficial abscesses, wounds, ocular or urethral discharges, lung, and liver of marine mammals. Although it is now an established pathogen, at one time was believed to be completely innocuous. In England and Wales, bacteremia reports increased by 13.2% between 2000 and 2001. Patients with urinary tract infections (UTIs) and indwelling catheters or colonized or infected respiratory tracts are the most common reservoirs; spread occurs primarily via the hands of hospital personnel. bacteremia is relatively uncommon; accounted for only 2% of bloodstream infections reported to the National Nosocomial Infections Surveillance System (NNIS). Cholangitis, osteomyelitis, ruptured diverticuli, and premature ruptured membranes have also been reported as sources of bacteremia. fails to produce DNase, lipase, or gelatinase, all hallmark traits of the genus . The majority of pigmented strains belonged to environmental serotype O6:K14 and were serum resistant, a trait previously determined to be associated with this serotype and not believed to be important in human serratia infection. Strains that are initially susceptible rapidly become resistant during antimicrobial therapy. The current literature indicates that 88 to 93% of serratiae are susceptible to ciprofloxacin. Susceptibilities to various cephalosporins and other antimicrobials are reported.

Citation: Janda J, Abbott S. 2006. The Genus , p 137-150. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch10

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Shiga Toxin 2
Serratia marcescens
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1. Ajithkumar, B.,, V. P. Ajithkumar,, R. Iriye,, Y. Doi,, and T. Sakai. 2003. Spore-forming Serratia marcescens subsp. sakuensis subsp. nov., isolated from a domestic wastewater treatment tank. Int. J. Syst. Evol. Microbiol. 53:253258.
2. Al Hazzaa, S. A. F.,, K. F. Tabbara,, and J. A. Gammon. 1992. Pink hypopyon: a sign of Serratia marcescens endophthalmitis. Br. J. Ophthalmol. 76:764765.
3. Anahory, T.,, H. Darbas,, O. Ongaro,, H. Jean-Pierre,, and P. Mion. 1998. Serratia ficaria: a misidentified or unidentified rare cause of human infection in fig tree culture zones. J. Clin. Microbiol. 36:32663272.
4. Arribas, J. R.,, A. Dominguez,, M. D. Folgueria,, P. Pena,, S. Luengo,, J. M. Pena,, and J. J. Vazquez. 1990. Prognostic factors in Serratia bacteremia. Rev. Infect. Dis. 12:563564.
5.ASCP Susceptibility Testing Group (1995). 1996. United States geographic bacteria susceptibility patterns. Am. J. Clin. Pathol. 106:275281.
6. Ashelford, K. E.,, J. C. Fry,, M. J. Bailey,, and M. J. Day. 2002. Characterization of Serratia isolates from soil, ecological implications and transfer of Serratia proteamaculans subsp. quinovora Grimont et al. 1983 to Serratia quinivorans corrig., sp. nov. Int. J. Syst. Evol. Microbiol. 52:22812289.
7. Aucken, H. L. M.,, S. G. Wilkinson,, and T. L. Pitt. 1997. Identification of capsular antigens in Serratia marcescens. J. Clin. Microbiol. 35:5963.
8. Badenoch, P. R.,, A. L. Thom,, and D. J. Coster. 2002. Serratia ficaria endophthalmitis. J. Clin. Microbiol. 40:15631564.
9. Bagattini, M.,, M. Crispino,, F. Gentile,, E. Barretta,, D. Schiavone,, M. C. Boccia,, M. Triassi,, and R. Zarrilli. 2004. A nosocomial outbreak of Serratia marcescens producing inducible Amp C-type beta-lactamase enzyme and carrying antimicrobial resistance genes within a class 1 integron. J. Hosp. Infect. 56:2936.
10. Bale, M.,, M. Sanford,, R. Hollis,, and M. A. Pfaller. 1993. Application of a biotyping system and DNA restriction fragment analysis to the study of Serratia marcescens from hospitalized patients. Diagn. Microbiol. Infect. Dis. 16:17.
11. Bangert, R. L.,, A. C. S. Ward,, E. H. Stauber,, B. R. Cho,, and P. R. Widders. 1988. A survey of the aerobic bacteria in the feces of captive raptors. Avian Dis. 32:5362.
12. Bantar, C.,, A. Famiglietti,, M. Goldberg, the Antimicrobial Committee, and the National Surveillance Program (SIR) Participants Group. 2000. Three-year surveillance study of nosocomial bacterial resistance in Argentina. Int. J. Infect. Dis. 4:8590.
13. Bennett, J. W.,, and R. Bentley. 2000. Seeing red: the story of prodigiosin. Adv. Appl. Microbiol. 47:132.
14. Berkowitz, F. E.,, and B. Metchock. 1995. Third generation cephalothin-resistant gram-negative bacilli in the feces of hospitalized children. Pediatr. Infect. Dis. J. 14:97100.
15. Blaylock, R. S. M. 2001. Normal oral bacterial flora from some southern African snakes. Onderstepoort J. Vet. Res. 68:175182.
16. Bollet, C.,, P. Grimont,, M. Gainnier,, A. Geissler,, J. Sainty,, and P. De Micco. 1993. Fatal pneumonia due to Serratia proteamaculans subsp. quinovora. J. Clin. Microbiol. 31:444445.
17. Bornstein, P. F.,, A. M. Ditto,, and G. A. Noskin. 1992. Serratia marcescens cellulitis in a patient on hemodialysis. Am. J. Nephrol. 12:374376.
18. Bourbeau, P. P.,, and B. J. Heiter. 1998. Comparison of Vitek GNI and GNI+ cards for identification of gram-negative bacteria. J. Clin. Microbiol. 36:27752777.
19. Boyd, R. S.,, and J. DeMaio. 1991. Serratia plymuthica nosocomial pneumonia in an immunocompromised patient. Lab. Med. 22:861863.
20. Brouillard, J. A.,, W. Hansen,, and A. Compere. 1984. Isolation of Serratia ficaria from human clinical specimens. J. Clin. Microbiol. 19:902904.
21. Buenviaje, G. N.,, P. W. Ladds,, L. Melville,, and S. C. Manolis. 1994. Disease-husbandry associations in farmed crocodiles in Queensland and the Northern Territory. Aust. Vet. J. 71: 165173.
22. Campbell, J. R.,, T. Diacovo,, and C. J. Baker. 1992. Serratia marcescens meningitis in neonates. Pediatr. Infect. Dis. J. 11: 881886.
23. Carbonell, G. V.,, H. H. M. Della Colleta,, T. Yano,, A. L. C. Darini,, C. E. Levy,, and B. A. L. Fonseca. 2000. Clinical relevance and virulence factors of pigmented Serratia marcescens. FEMS Immunol. Med. Microbiol. 28:143149.
24. Carbonell, G. V.,, R. Falcon,, A. T. Yamada,, B. A. L. da Fonseca,, and T. Yano. 2004. Morphological and intracellular alterations induced by Serratia marcescens cytotoxin. Res. Microbiol. 155:2530.
25. Carrero, P.,, J. A. Garrote,, S. Pacheco,, A. I. García,, R. Gil,, and S. G. Carbajosa. 1995. Report of six cases of human infection by Serratia plymuthica. J. Clin. Microbiol. 33:275276.
26. Chartrand, S. A.,, K. J. Thompson,, and C. C. Sanders. 1996. Antibiotic-resistant, gram-negative bacillary infections. Pediatr. Infect. Dis. 7:187203.
27. Chetoui, H.,, E. Delhalle,, P. Melin,, M. J. Struelens,, R. De Ryck,, P. Osterrieth,, and P. De Mol. 1998. Typing of nosocomial strains of Serratia marcescens: comparison of pulsed-field gel electrophoresis of macrorestriction fragments with biotyping, esterase typing and ribotyping. Res. Microbiol. 149:137143.
28. Chmel, H. 1988. Serratia odorifera biogroup l causing an invasive human infection. J. Clin. Microbiol. 26:12441245.
29. Clark, R. B.,, and J. M. Janda. 1985. Isolation of Serratia plymuthica from a human burn site. J. Clin. Microbiol. 21:656657.
30. Cockerill, F. R.III,, J. G. Hughes,, E. A. Vetter,, R. A. Mueller,, A. L. Weaver,, D. M. Ilstrup,, J. E. Rosenblatt,, and W. R. Wilson. 1997. Analysis of 281,797 consecutive blood cultures performed over an eight-year period: trends in microorganisms isolated and the value of anaerobic culture of blood. Clin. Infect. Dis. 24:403418.
31. Cooper, R.,, and J. Mills. 1980. Serratia endocarditis. Arch. Intern. Med. 140:199202.
32. Cullen, J. C. 1994. The miracle of Bolsena. ASM News 60: 187191.
33. Darbas, H. J.,, H. Jean-Pierre,, and J. Paillisson. 1994. Case report and review of septicemia due to Serratia ficaria. J. Clin. Microbiol. 32:22852288.
34. Dauga, C.,, F. Grimont,, and P. A. D. Grimont. 1990. Nucleotide sequences of 16S rRNA from ten Serratia species. Res. Microbiol. 141:11391149.
35. Domingo, D.,, A. Limia,, T. Alarcon,, J. C. Sanz,, M. C. Del Rey,, and M. Lopez-Brea. 1994. Nosocomial septicemia caused by Serratia plymuthica. J. Clin. Microbiol. 32:575577.
36. Ewing, W. H.,, B. R. Davis,, M. A. Fife,, and E. F. Lessel. 1973. Biochemical characterization of Serratia liquefaciens (Grimes and Hennerty) Bascomb et al. (formerly Enterobacter liquefaciens) and Serratia rubidaea (Stapp) comb. nov. and designation of type and neotype strains. Int. J. Syst. Bacteriol. 23:217225.
37. Farmer, J. J. III,, 1995. Enterobacteriaceae: introduction and identification, p. 438449. In P. R. Murray,, E. J. Baron,, M. A. Pfaller,, F. C. Tenover,, and R. H. Yolken (ed.), Manual of Clinical Microbiology, 6th ed. American Society for Microbiology, Washington, D.C.
38. Farmer, J. J. III,, B. R. Davis,, P. A. D. Grimont,, and F. Grimont. 1977. Source of American Serratia. Lancet ii:459460.
39. Farmer, J. J. III,, B. R. Davis,, and F. W. Hickman. 1976. Detection of Serratia outbreaks in hospital. Lancet ii:455459.
40. Farmer, J. J.III,, F. Silva,, and D. R. Williams. 1973. Isolation of Serratia marcescens on deoxyribonuclease-toluidine bluecephalothin agar. Appl. Microbiol. 25:151152.
41. Fleisch, F.,, U. Zimmermann-Baer,, R. Zbinden,, G. Bischoff,, K. Waldvogel,, D. Nadal,, and C. Ruef. 2002. Three consecutive outbreaks of Serratia marcescens in a neonatal intensive care unit. Clin. Infect. Dis. 34:767773.
42. Freney, J.,, M. O. Husson,, F. Gavini,, S. Madier,, A. Martra,, D. Izard,, H. Leclerc,, and J. Fleurette. 1988. Susceptibilities to antibiotics and antiseptics of new species of the family Enterobacteriaceae. Antimicrob. Agents Chemother. 32:873876.
43. Funke, G.,, and P. Funke-Kissling. 2004. Use of the BD PHOENIX automated microbiology system for direct identification and susceptibility testing of gram-negative rods from positive blood cultures in a three-phase trial. J. Clin. Microbiol. 42:14661470.
44. Gales, A. C.,, D. J. Biedenbach,, P. Winokur,, D. M. Hacek,, M. A. Pfaller,, and R. N. Jones. 2001. Carbapenem-resistant Serratia marcescens isolates producing Bush Group 2f β-lactamase (SME-1) in the United States: results from the MYSTIC Programme. Diagn. Microbiol. Infect. Dis. 39:125127.
45. Garcia, D. C.,, G. M. Woloj,, S. Pineiro,, S. Sordelli,, and S. Kaufman. 1995. An 8-year study of resistance to amikacin in gram-negative bacilli isolates from patients with nosocomial infection at one hospital in Argentina. J. Med. Microbiol. 42:283290.
46. Gaston, M. S.,, and T. L. Pitt. 1989. Improved O-serotyping method for Serratia marcescens. J. Clin. Microbiol. 27:27022705.
47. Gavini, F.,, C. Ferragut,, D. Izard,, P. A. Trinel,, H. Leclerc,, B. Lefebvre,, and D. A. A. Mossel. 1979. Serratia fonticola, a new species from water. Int. J. Syst. Bacteriol. 29:92101.
48. Gill, V. J.,, J. J. Farmer III,, P. A. D. Grimont,, M. A. Asbury,, and C. L. McIntosh. 1981. Serratia ficaria isolated from a human clinical specimen. J. Clin. Microbiol. 14:234236.
49. Glustein, J. Z.,, B. Rudensky,, and A. Abrahamov. 1994. Catheter-associated sepsis caused by Serratia odorifera biovar l in an adolescent patient. Eur. J. Clin. Microbiol. Infect. Dis. 13:183184.
50. Gonzalez-Rodriguez, M.-N.,, J.-J. Sanz,, J.-A. Santos,, A. Otero,, and M.-L. Garcia-Lopez. 2002. Numbers and types of microorganisms in vacuum-packed cold-smoked freshwater fish at the retail level. Int. J. Food Microbiol. 77:161168.
51. Goullet, P.,, and B. Picard. 1997. An epidemiological study of Serratia marcescens isolates from nosocomial infections by enzyme electrophoresis. J. Med. Microbiol. 46:10191028.
52. Grimont, F.,, and P. A. D. Grimont,. 1981. The genus Serratia, p. 28222848. In M. P. Starr,, H. Stolp,, H. G. Truper,, and H. G. Schlegel (ed.), The Prokaryotes: a Handbook on Habitats, Isolation and Identification of Bacteria. Springer-Verlag, Berlin, Germany.
53. Grimont, P. A. D.,, and F. Grimont. 1978. Biotyping of Serratia marcescens and its use in epidemiological studies. J. Clin. Microbiol. 8:7383.
54. Grimont, P. A. D.,, and F. Grimont,. 1984. Genus VIII. Serratia Bizio 1823, 288AL, p. 477484. In N. R. Krieg, and, J. G. Holt (ed.) Bergey’s Manual of Systematic Bacteriology. Williams & Wilkins, Baltimore, Md.
55. Grimont, P. A. D.,, F. Grimont,, and K. Irino. 1982. Biochemical characterization of Serratia liquefaciens sensu stricto, Serratia proteamaculans, and Serratia grimesii sp. nov. Curr. Microbiol. 7:6974.
56. Grimont, P. A. D.,, F. Grimont,, C. Richard,, B. R. Davis,, A. G. Steigerwalt,, and D. J. Brenner. 1978. Deoxyribonucleic acid relatedness between Serratia plymuthica and other Serratia species, with a description of Serratia odorifera sp. nov. (type strain: ICPB 3995). Int. J. Syst. Bacteriol. 28:453463.
57. Grimont, P. A. D.,, F. Grimont,, and M. P. Starr. 1979. Serratia ficaria sp. nov., a bacterial species associated with Smyrna figs and the fig wasp Blastophaga psenes. Curr. Microbiol. 2:277282.
58. Grimont, P. A. D.,, F. Grimont,, and M. P. Starr. 1981. Comment on the request to the judicial commission to conserve the specific epithet Serratia liquefaciens over the specific epithet proteamaculans in the name of the organism currently known as Serratia liquefaciens. Int. J. Syst. Bacteriol. 31:211212.
59. Grimont, P. A. D.,, K. Irino,, and F. Grimont. 1982. The Serratia liquefaciens-S. proteamaculans-S. grimesii complex: DNA relatedness. Curr. Microbiol. 7:6368.
60. Grimont, P. A. D.,, T. A. Jackson,, E. Ageron,, and M. J. Noonan. 1988. Serratia entomophila sp. nov. associated with amber disease in the New Zealand grass grub Costelytra zealandica. Int. J. Syst. Bacteriol. 38:16.
61. Grohskopf, L. A.,, V. R. Roth,, D. R. Feikin,, M. J. Arduino,, L. A. Carson,, J. I. Takars,, S. C. Holt,, B. J. Jensen,, R. E. Hoffman,, and W. R. Jarvis. 2001. Serratia liquefaciens bloodstream infections from contamination of epoetin alfa at a hemodialysis center. N. Engl. J. Med. 344:14911497.
62. Helterberg, O.,, F. Skov,, P. Berner-Smidt,, H. J. Holmes,, E. Dybkjer,, E. Gutschik,, D. Jerne,, O. B. Jepsen,, M. Weischer,, W. Frederiksen,, and H. Sorensen. 1993. Nosocomial epidemic of Serratia marcescens septicemia ascribed to contaminated blood transfusion bags. Transfusion 33:221227.
63. Hengstler, K. A.,, R. Hammann,, and A.-M. Fahr. 1997. Evaluation of BBL CHROMagar orientation medium for detection and presumptive identification of urinary tract pathogens. J. Clin. Microbiol. 35:27732777.
64. Hertle, R.,, M. Hilger,, S. Weingardt-Kocher,, and I. Walev. 1999. Cytotoxic action of Serratia marcescens hemolysin on human epithelial cells. Infect. Immun. 67:817825.
65. Hindler, J. A. 1995. Antimicrobial susceptibility testing of gram-negative bacteria: meeting the challenge of increasing resistance and decreasing budget. Clin. Microbiol. Newsl. 17: 7780.
66. Hoban, D. J.,, S. K. Bouchillon,, J. L. Johnson,, G. G. Zhanel,, D. L. Butler,, L. A. Miller,, J. A. Poupard, and the Gemifloxacin Surveillance Study Research Group. 2001. Comparative in vitro activity of gemifloxacin, ciprofloxacin, levofloxacin and ofloxacin in a North American surveillance study. Diagn. Microbiol. Infect. Dis. 40:5157.
67. Hohl, P.,, J. Luthy-Hottenstein,, J. Zollinger-Iten,, and M. Altwegg. 1990. In vitro activities of fleroxacin, cefetamet, ciprofloxacin, ceftriaxone, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against rare members of the family Enterobacteriaceae primarily of human (clinical) origin. Antimicrob. Agents Chemother. 34:16051608.
68. Holmes, B.,, M. Costas,, M. Ganner,, S. L. W. On,, and M. Stevens. 1994. Evaluation of Biolog system for identification of some gram-negative bacteria of clinical importance. J. Clin. Microbiol. 32:19701975.
69. Horowitz, H. W.,, R. B. Nadelman,, K. G. Van Horn,, S. E. Weekes,, L. Goyburu,, and G. P. Wormser. 1987. Serratia plymuthica sepsis associated with infection of central venous catheter. J. Clin. Microbiol. 25:15621563.
70. Hoyen, C.,, L. Rice,, S. Conte,, M. R. Jacobs,, M. Walsh-Sukys,, and P. Toltzis. 1999. Use of real time pulsed-field gel electrophoresis to guide interventions during a nursery outbreak of Serratia marcescens infection. Pediatr. Infect. Dis. J. 18:357360.
71. Hsieh, S.,, and F. E. Babl. 1999. Serratia marcescens cellulitis following an iguana bite. Clin. Infect. Dis. 28:11811182.
72. Hume, E. B. H.,, M. D. P. Willcox,, D. F. Sweeney,, and B. A. Holden. 1996. An examination of the clonal variants of Serratia marcescens that infect the eye during contact lens wear. J. Med. Microbiol. 45:127132.
73. Ito, H.,, Y. Arakawa,, S. Ohsuka,, R. Wacharotayankun,, N. Kato,, and M. Ohta. 1995. Plasmid-mediated dissemination of the metallo-β-lactamase gene blaIMP among clinically isolated strains of Serratia marcescens. Antimicrob. Agents Chemother. 39:824829.
74. Itskowitz, M. S.,, R. Watkins,, and V. Banks. 2004. Serratia brain abscess in a patient with diabetes mellitus. Infect. Med. 21:9092.
75. Jacoby, G. A.,, and A. A. Medeiros. More extended-spectrum β-lactamases. Antimicrob. Agents Chemother. 35:16971704.
76. Jones, R. N.,, E. N. Kehrberg,, M. E. Erwin,, S. C. Anderson, and the Fluoroquinolone Resistance Surveillance Group. 1994. Prevalence of important pathogens and antimicrobial activity of parenteral drugs at numerous medical centers in the United States. Diagn. Microbiol. Infect. Dis. 19:203215.
77. Jossart, M.-F.,, and R. J. Courcol. 1999. Evaluation of an automated system for identification of Enterobacteriaceae and nonfermenting bacilli. Eur. J. Clin. Microbiol. Infect. Dis. 18:902907.
78. Karlowsky, J. A.,, M. E. Jones,, D. C. Mayfield,, C. Thornsberry,, and D. F. Sahm. 2002. Ceftriaxone activity against gram-positive and gram-negative pathogens isolated in US clinical microbiology laboratories from 1996 to 2000: results from The Surveillance Network (TSN) database-USA. Int. J. Antimicrob. Agents 19:413426.
79. Karlowsky, J. A.,, M. E. Jones,, C. Thornsberry,, I. R. Friedland,, and D. F. Sahm. 2003. Trends in antimicrobial susceptibilities among Enterobacteriaceae isolated from hospitalized patients in the United States from 1998 to 2001. Antimicrob. Agents Chemother. 47:16721680.
80. Klein, N. C.,, and B. A. Cunha. 1995. Tetracyclines. Med. Clin. North Am. 79:789801.
81. Kunimoto, D.,, R. Rennie,, D. M. Citron,, and E. J. C. Goldstein. 2004. Bacteriology of a bear bite wound to a human: case report. J. Clin. Microbiol. 42:33743376.
82. Kurz, C. L.,, S. Chauvet,, E. Andres,, M. Aurouze,, I. Vallet,, G. P. F. Michel,, M. Uh,, J. Celli,, A. Filloux,, S. de Bentzman,, I. Steinmetz,, J. A. Hoffmann,, B. B. Finlay,, J.-P. Grovel,, D. Ferrandon,, and J. J. Ewbank. 2003. Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening. EMBO J. 22:14511460.
83. Kuzina, L. V.,, J. J. Peloquin,, D. C. Vacek,, and T. A. Miller. 2001. Isolation and identification of bacteria associated with adult laboratory Mexican fruit flies, Anastrepha ludens (Diptera: Tephritidae). Curr. Microbiol. 42:290294.
84. Lass, J. H.,, J. Haaf,, C. Foster,, and C. Belcher. 1981. Visual outcome in eight cases of Serratia marcescens keratitis. Am. J. Ophthalmol. 92:384390.
85. Lautenbach, E.,, B. L. Strom,, I. Nachamkin,, W. B. Bilker,, A. M. Marr,, L. A. Larosa,, and N. O. Fishman. 2004. Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, 1989-2000: difference in the emergence and epidemiology of resistance across organisms. Clin. Infect. Dis. 38:655662.
86. Letoffe, S.,, J. M. Ghigo,, and C. Wandersman. 1994. Iron acquisition from heme and hemoglobin by a Serratia marcescens extracellular protein. Proc. Natl. Acad. Sci. USA 91:98769880.
87. Libby, K. J. 1980. Infection with Serratia rubidaea. Clin. Microbiol. Newsl. 2:4.
88. Lindberg, A.-M.,, A. Ljungh,, S. Ahrne,, S. Lofdahl,, and G. Molin. 1998. Enterobactericeae found in high numbers in fish, minced meat and pasteurized milk or cream and the presence of toxin encoding genes. Int. J. Food Microbiol. 39: 1117.
89. Ling, T. K. W.,, P. C. Tam,, Z. K. Liu,, and A. F. B. Cheng. 2001. Evaluation of VITEK 2 Rapid identification and susceptibility testing system against gram-negative clinical isolates. J. Clin. Microbiol. 39:29642966.
90. Lortholary, O.,, M. Tod,, Y. Cohen,, and O. Petitjean. 1995. Aminoglycosides. Med. Clin. North Am. 79:761789.
91. Marre, R.,, J. Hacker,, and V. Braun. 1989. The cell-bound hemolysis of Serratia marcescens contributes to uropathogenicity. Microb. Pathog. 7:153157.
92. Marty, K. B.,, C. L. Williams,, L. J. Guynn,, M. J. Benedik,, and S. R. Blanke. 2002. Characterization of a cytotoxic factor in culture filtrates of Serratia marcescens. Infect. Immun. 70:11211128.
93. Mayhall, C. G. 2003. The epidemiology of burn wound infections: then and now. Clin. Infect. Dis. 37:543550.
94. McGeer, A.,, D. E. Low,, J. Penner,, J. Ng,, C. Goldman,, and A. E. Simor. 1990. Use of molecular typing to study the epidemiology of Serratia marcescens. J. Clin. Microbiol. 28:5558.
95. Mermel, L. A.,, and C. A. Spiegel. 1992. Nosocomial sepsis due to Serratia odorifera biovar l. Clin. Infect. Dis. 14:208210.
96. Nakashima, A. K.,, A. K. Highsmith,, and W. J. Martone. 1987. Survival of Serratia marcescens in benzalkonium chloride and in multiple-dose medication vials: relationship to epidemic septic arthritis. J. Clin. Microbiol 25:10191021.
97. Nakashima, A. K.,, M. McCarthy,, W. J. Martone,, and R. L. Anderson. 1987. Epidemic septic arthritis caused by Serratia marcescens and associated with a benzalkonium chloride antiseptic. J. Clin. Microbiol. 25:10141018.
98.. National Nosocomial Infection Surveillance System. 1998. http://www.cdc.gov/ncidod/hip/surveill/NNIS.htm.
99. Novak, S. S.,, and R. A. Seigel. 1986. Gram-negative septicemia in American alligators (Alligator mississippiensis) J. Wildl. Dis. 22:484487.
100. O’Hara, C. M.,, and J. M. Miller. 2000. Evaluation of the MicroScan Rapid Neg ID3 panel for identification of Enterobacteriaceae and some common gram-negative nonfermenters. J. Clin. Microbiol. 33:35773580.
101. O’Hara, C. M.,, and J. M. Miller. 2003. Evaluation of the Vitek 2 ID-GNB assay for identification of members of the family Enterobacteriaceae and other nonenteric gram-negative bacilli and comparison with the Vitek GNI+ card. J. Clin. Microbiol. 41:20962101.
102. Ohkusu, K. 2000. Cost-effective and rapid presumptive identification of gram-negative bacilli in routine urine, pus, and stool cultures: evaluation of the use of CHROMagar orientation medium in conjunction with simple biochemical tests. J. Clin. Microbiol. 38:45864592.
103. Osano, E.,, Y. Arakawa,, R. Wacharotayankun,, M. Ohta,, T. Horii,, H. Ito,, F. Yoshimura,, and N. Kato. 1994. Molecular characterization of an enterobacterial metallo-β-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. Antimicrob. Agents Chemother. 38:7178.
104. Osterblad, M.,, O. Pensala,, M. Peterzens,, H. Heleniusc,, and P. Huovinen. 1999. Antimicrobial susceptibility of Enterobacteriaceae isolated from vegetables. J. Antimicrob. Chemother. 43:503509.
105. Ostrowsky, B. E.,, C. Whitener,, H. K. Bredenberg,, L. A. Carson,, S. Holt,, L. Hutwagner,, M. J. Arduino,, and W. R. Jarvis. 2002. Serratia marcescens bacteremia traced to an infused narcotic. N. Engl. J. Med. 346:15291537.
106. Pancoast, S. J. 1988. Aminoglycoside antibiotics in clinical use. Med. Clin. North Am. 72:581612.
107. Parment, P. A.,, C. Svanborg-Eden,, and M. J. Chaknis. 1992. Hemagglutination (fimbriae) and hydrophobicity in adherence of Serratia marcescens to urinary tract epithelium and contact lenses. Curr. Microbiol. 25:113118.
108. Passaro, D. J.,, L. Waring,, R. Armstrong,, F. Bolding,, B. Bouvier,, J. Rosenberg,, A. W. Reingold,, M. McQuitty,, S. M. Philpott,, W. R. Jarvis,, S. B. Werner,, L. S. Tompkins,, and D. J. Vugia. 1997. Postoperative Serratia marcescens wound infections traced to an out-of-hospital source. J. Infect. Dis. 175:992995.
109. Patton, T. G.,, S. Katz,, R. J. Sobieski,, and S. S. Crupper. 2001. Genotyping of clinical Serratia marcescens isolates: a comparison of PCR-based methods. FEMS Microbiol. Lett. 194:1925.
110. Pfaller, M. A.,, and R. N. Jones. 1997. A review of the in vitro activity of meropenem and comparative antimicrobial agents tested against 30, 254 aerobic and anaerobic pathogens isolated world wide. Diagn. Microbiol. Infect. Dis. 28:157163.
111. Pfaller, M. A.,, R. N. Jones,, D. J. Biedenbach, and the MYSTIC Program Study Group (USA). 2001. Antimicrobial resistance trends in medical centers using carbapenems: report of 1999 and 2000 results from the MYSTIC Program (USA). Diagn. Microbiol. Infect. Dis. 41:177182.
112. Pfaller, M. A.,, R. N. Jones,, S. A. Marshall,, S. L. Coffman,, R. J. Hollis,, M. B. Edmond,, and R. P. Wenzel. 1997. Inducible Amp C β-lactamase producing gram-negative bacilli from blood stream infections: frequency, antimicrobial susceptibility, and molecular epidemiology in a national surveillance program (SCOPE). Diagn. Microbiol. Infect. Dis. 28:211219.
113. Pien, F. D.,, and J. J. Farmer III. 1983. Serratia ficaria isolated from a leg ulcer. South. Med. J. 76:15911592.
114.Public Health Laboratory Service. 2002. Klebsiella spp, Enterobacter spp, Serratia spp, and Citrobacter spp from bacteraemias, England and Wales 2001. Commun. Dis. Rep. CDR Wkly. [Online.] http://hpa.org.uk/cdr/PDFfiles/2002/cdr2002.pdf.
115. Quentin, C.,, C. Arpin,, V. Dubois,, C. Andre,, I. Lagrange,, I. Fischer,, J.-P. Brochet,, F. Grobost,, J. Julin,, B. Dutilh,, G. Larribet,, and P. Noury. 2004. Antibiotic resistance rates and phenotypes among isolates of Enterobacteriaceae in French extra-hospital practice. Eur. J. Clin. Microbiol. Infect. Dis. 23:185193.
116. Ramos, J. M.,, R. Fernandez-Roblas,, I. Gadea,, M. Cuenca-Estrella,, and F. Soriano. 1995. Nosocomially acquired bacteremia caused by Serratia plymuthica. Clin. Microbiol. Newsl. 17:156157.
117. Rasmussen, B. A.,, and K. Bush. 1997. Carbapenemhydrolyzing β-lactamases. Antimicrob. Agents Chemother. 41:223232.
118. Reina, J.,, N. Borrell,, and I. Llompart. 1992. Community-acquired bacteremia caused by Serratia plymuthica case report and review of the literature. Diagn. Microbiol. Infect. Dis. 15:449452.
119. Roberts, F. J.,, I. W. Geere,, and A. Coldman. 1991. A three-year study of positive blood cultures, with emphasis on prognosis. Rev. Infect. Dis. 13:3446.
120. Robinson, A.,, Y. S. McCarter,, and J. Tetreault. 1995. Comparison of Crystal Enteric/Nonfermenter system, API 20E system, and Vitek Automicrobic system for identification of gram-negative bacilli. J. Clin. Microbiol. 33:364370.
121. Saito, H.,, L. Elting,, G. P. Bodey,, and P. Berkey. 1989. Serratia bacteremia: review of 118 cases. Rev. Infect. Dis. 11:912920.
122. Sanders, C. C.,, and W. E. Sanders, Jr. 1992. β-Lactam resistance in gram-negative bacteria: global trends and clinical impact. Clin. Infect. Dis. 15:824839.
123. Schaberg, D. P.,, D. H. Culver,, and R. P. Gaynes. 1991. Major trends in the microbial etiology of nosocomial infection. Am. J. Med. 91(Suppl. 3B):72S75S.
124. Sherley, M.,, D. M. Gordon,, and P. J. Collingnon. 2003. Species differences in plasmid carriage in the Enterobacteriaceae. Plasmid 49:7985.
125. Sifuentes-Osornia, J.,, G. M. Ruiz-Palacios,, and D. H. M. Groschel. 1986. Analysis of epidemiologic markers of nosocomial Serratia marcescens isolates with special reference to the Grimont biotyping system. J. Clin. Microbiol. 23: 230234.
126. Sirot, D. L.,, F. W. Goldstein,, C.J. Soussy,, A. L. Courtieu,, M. O. Husson,, J. Lemozy,, M. Meyran,, C. Morel,, R. Perez,, C. Quentin-Noury,, M. E. Reverdy,, J. M. Scheftel,, M. Rosembaum,, and Y. Rezvani. 1992. Resistance to cefotaxime and seven other β-lactams in members of the family Enterobacteriaceae: a 3-year survey in France. Antimicrob. Agents Chemother. 36:1677168l.
127. Sokalski, S. J.,, M. A. Jewell,, A. C. Asmus-Shillington,, J. Mulcahy,, and J. Segreti. 1992. An outbreak of Serratia marcescens in 14 adult cardiac surgical patients associated with 12-lead electrocardiogram bulbs. Arch. Intern. Med. 152:841844.
128. Starr, M. P.,, P. A. D. Grimont,, F. Grimont,, and P. B. Starr. 1976. Caprylate-thallous agar medium for selectively isolating Serratia and its utility in the clinical laboratory. J. Clin. Microbiol. 4:270276.
129. Stephen, M.,, and M. K. Lalitha. 1993. An outbreak of Serratia marcescens infections among obstetric patients. Indian J. Med. Res. 97:202205.
130. Steppberger, K.,, S. Walter,, M. C. Claros,, F. B. Spencker,, W. Kiess,, A. C. Rodloff,, and C. Vogtmann. 2002. Nosocomial neonatal outbreak of Serratia marcescens—analysis of pathogens by pulsed-field gel electrophoresis and polymerase chain reaction. Infection 30:277281.
131. Stock, I.,, S. Burak,, K. J. Sherwood,, T. Gruger,, and B. Wiedemann. 2003. Natural antimicrobial susceptibilities of strains of ‘unusual’ Serratia species: S. ficaria, S. fonticola, S. odorifera, S. plymuthica, and S. rubidaea. J. Antimicrob. Chemother. 51:865885.
132. Szewzyk, U.,, R. Szewzyk,, and R. Stenstron. 1993. Growth and survival of Serratia marcescens under aerobic and anaerobic conditions in the presence of materials from blood bags. J. Clin. Microbiol. 31:18261830.
133. Theccanat, G.,, L. Hirschfield,, and H. Isenberg. 1991. Serratia marcescens meningitis. J. Clin. Microbiol. 29:822823.
134. Thornsberry, C. 1994. Susceptibility of clinical bacterial isolates to ciprofloxacin in the United States. Infection 22:S80S89.
135. Thornton, S. M.,, S. Nolan,, and F. M. D. Gulland 1998. Bacterial isolates from California sea lions (Zalophus californianus), harbor seals, (Phoca vitulina), and northern elephant seals (Mirounga angustirostris) admitted to a rehabilitation center along the central California coast, 1994-1995. J. Zoo Wildl. Med. 29:171176.
136. Tzouvelekis, L. S.,, E. Tzelepi,, A. F. Mentis,, and N. J. Legakis. 1995. In vitro activity of cefpirome against selected clinical enterobacterial isolates with β-lactamase-mediated resistance. Infection 23:384388.
137. Ursua, P. R.,, M. J. Unzaga,, P. Melera,, I. Iturbura,, C. Expeleta,, and R. Cisterna. 1996. Serratia rubidaea as an invasive pathogen. J. Clin. Microbiol. 34:216217.
138. Vandenbrouck-Grauls, C. M. J. E.,, A. C. M. Baars,, M. R. Visser,, P. F. Hulstaert,, and J. Verhoef. 1993. An outbreak of Serratia marcescens traced to a contaminated bronchoscope. J. Hosp. Infect. 23:263270.
139. Vartian, C. V.,, and E. J. Septimus. 1989. Septic bursitis caused by gram-negative bacilli. J. Infect. Dis. 160:908.
140. Viswanathan, P.,, and R. Kaur. 2001. Prevalence and growth of pathogens on salad vegetables, fruits and sprout. Int. J. Hyg. Environ. Health 203:205213.
141. Walker, G.,, R. Hertle,, and V. Braun. 2004. Activation of Serratia marcescens hemolysin through a conformational change. Infect. Immun. 72:611614.
142. Watanakunakorn, C. 1989. Serratia bacteremia: a review of 44 episodes. Scand. J. Infect. Dis. 21:477483.
143. Wisplinghoff, H.,, T. Bischoff,, S. M. Tallent,, H. Seifert,, R. P. Wenzel,, and M. B. Edmond. 2004. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis. 39:309317.
144. Woodfield, D. G. 1991. Transfusion acquired Serratia liquefaciens septicemia. N. Z. Med. J. 104:141.
145. Wright, C.,, S. D. Kominos,, and R. B. Yee. 1976. Enterobacteriaceae and Pseudomonas aeruginosa recovered from vegetable salads. Appl. Environ. Microbiol. 31:453454.
146. Yannelli, B.,, P. E. Schoch,, and B. A. Cunha. 1987. Serratia marcescens. Clin. Microbiol. Newsl. 9:157160.
147. Yoo, J.-H.,, J.-H. Choi,, W.-S. Shin,, D.-H. Huh,, Y.-K. Cho,, K.-M. Kim,, M.-Y. Kim,, and M.-W. Kang. 1999. Application of infrequent-restriction-site PCR to clinical isolates of Acinetobacter baumannii and Serratia marcescens. J. Clin. Microbiol. 37:31083112.
148. Yu, V. L. 1979. Serratia marcescens: historical perspective and clinical review. New Engl. J. Med. 300:887893.
149. Zaidi, M.,, J. Sifuentes,, M. Bobadilla,, D. Moncada,, and S. Ponce de Leon. 1989. Epidemic of Serratia marcescens bacteremia and meningitis in a neonatal unit in Mexico City. Infect. Control Hosp. Epidemiol. 10:1420.
150. Zbinden, R.,, and R. Blass. 1988. Serratia plymuthica osteomyelitis following a motorcycle accident. J. Clin. Microbiol. 26:14091410.
151. Zipper, R. P.,, M. A. Bustamante,, and R. Khatib. 1996. Serratia marcescens: a single pathogen in necrotizing fasciitis. Clin. Infect. Dis. 23:648649.


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Table 1

Members of the genus

Citation: Janda J, Abbott S. 2006. The Genus , p 137-150. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch10
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Table 2

Susceptibility of to selected antimicrobials

Citation: Janda J, Abbott S. 2006. The Genus , p 137-150. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch10

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