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Chapter 12 : The Genus Citrobacter

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Abstract:

By the late 1960s and early 1970s, three major groups of biochemically defined citrobacteria were recognized, namely, , which dated back to the original work of Braak in 1928; , described by Frederiksen in 1970; and , an organism which was originally placed in the genus by Young and coworkers. A recently identified new subspecies or possibly even a new species was given the general name of Centers for Disease Control and Prevention (CDC) enteric group 137 because of uncertainty regarding the taxonomic (genus) status of named species within this group, based upon 16S rRNA analysis. species are not common agents of human disease. Although they are resident commensal flora in the gastrointestinal tract, they are infrequently implicated as primary pathogens. A study performed by researchers at the CDC since the recent taxonomic revisions within the genus suggests that many commercial systems should be able to identify these newly described species with only minor adjustments to their current algorithms. Biotyping is a technique primarily used for epidemiologic purposes. Two biotypes of are distinguished in the older literature, based upon the ability of citrobacteria to produce HS on triple sugar iron (TSI) slants.

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12

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Clustering of species into distinct groups, based upon phylogenetic analysis of 16S rRNA sequences (158).

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
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1. Aldová, E.,, J. Schindler,, J. šourek,, A. Nemec,, and P. Urbášková. 1997. Detection and identification of Citrobacter sedlakiiin the Czech republic. Zentbl. Bakteriol. 285: 389 396.
2. Arens, S.,, J. Verhaegen,, and L. Verbist. 1997. Differentiation and susceptibility of Citrobacter isolates from patients in a university hospital. Clin. Microbiol. Infect. 3: 53 57.
3. Badger, J. L.,, M. F. Stins,, and K. S. Kim. 1999. Citrobacter freundii invades and replicates in human brain microvascular endothelial cells. Infect. Immun. 67: 4208 4215.
4. Bangert, R. L.,, A. C. S. Ward,, E. H. Stauber,, B. R. Cho,, and P. R. Widders. 1988. A survey of the aerobic bacteria in the feces of captive raptors. Avian Dis. 32: 53 62.
5. Bascomb, S.,, S. L. Abbott,, J. D. Bobolis,, D. A. Bruckner,, S. J. Connell,, S. K. Cullen,, M. Daugherty,, D. Glenn,, J. M. Janda,, S. J. Lentsch,, D. Lindquist,, P. B. Mayhew,, D. M. Nothaft,, J. R. Skinner,, G. B. Williams,, J. Wong,, and B. L. Zimmer. 1997. Multicenter evaluation of the MicroScan rapid gram-negative identification type 3 panel. J. Clin. Microbiol. 35: 2531 2536.
6. Bennett, A. R.,, S. MacPhee,, R. Betts,, and D. Post. 1999. Use of pyrrolidonyl peptidase to distinguish Citrobacter from Salmonella. Lett. Appl. Microbiol. 28: 175 178.
7. Bettelheim, K. A.,, H. Evangelidis,, J. L. Pearce,, E. Sowers,, and N. A. Strockbine. 1993. Isolation of a Citrobacter freundii strain which carries the Escherichia coli O157 antigen. J. Clin. Microbiol. 31: 760 761.
8. Bishara, J.,, B. Gabay,, Z. Samra,, E. Hodak,, and S. Pitlik. 1998. Cellulitis caused by Citrobacter diversus in a patient with multiple myeloma. Cutis 61: 158 159.
9. Blaylock, R. S. M. 2001. Normal oral bacterial flora from some southern African snakes. Onderstepoort J . Vet. Res. 68: 175 182.
10. Booth, L. V.,, J. D. Palmer,, J. Pateman,, and A. C Tuck. 1993. Citrobacter diversus ventriculitis and brain abscesses in an adult. J. Infect. 26: 207 209.
11. Brenner, D. J.,, P. A. D. Grimont,, A. G. Steigerwalt,, G. R. Fanning,, E. Ageron,, and C. F. Riddle. 1993. Classification of citrobacteria by DNA hybridization: designation of Citrobacter farmeri sp. nov., Citrobacter youngae sp. nov., Citrobacter braakii sp. nov., Citrobacter werkmanii sp. nov., Citrobacter sedlakii sp. nov., and three unnamed Citrobacter genomospecies. Int. J. Syst. Bacteriol. 43: 645 658.
12. Brenner, D. J.,, C. M. O’Hara,, P. A. D. Grimont,, J. M. Janda,, E. Falsen,, E. Aldova,, E. Ageron,, J. Schindler,, S. L. Abbott,, and A. G. Steigerwalt. 1999. Biochemical identification of Citrobacter species defined by DNA hybridization and description of Citrobacter gillenii sp. nov. (formerly Citrobacter genomospecies 10) and Citrobacter murliniae sp. nov. (formerly Citrobacter genomospecies 11). J. Clin. Microbiol. 37: 2619 2624.
13. Brooks, D. E.,, E. R. Jacobson,, E. D. Wolf,, S. Clubb,, and J. M. Gaskin. 1983. Panophthalmitis and otitis interna in fire-bellied toads . J. Am. Vet. Med. Assoc. 183: 1198 1201.
14. Bruckner, D. A.,, P. Colonna,, D. Glenn,, S. L. Abbott,, and J. M. Janda. 1997. Citrobacter farmeri bacteremia in a child with short-bowel syndrome. J. Clin. Microbiol. 35: 3353 3354.
15. Bruehl, C. L.,, and R. Listernick. 1992. Citrobacter freundii septic arthritis. J. Paediatr. Child Health 28: 402 403.
16. Chart, H.,, G. A. Willshaw,, T. Cheasty,, and B. Rowe. 1993. Structure and antigenic properties of Citrobacter freundii lipolysaccharides. J. Appl. Bacteriol. 74: 583 587.
17. Chen, H.,, P. Gollnick,, and R. S. Phillips. 1995. Site-directed mutagenesis of His3436Ala in Citrobacter freundii tyrosine phenol-lyase. Effects on the kinetic mechanism and rate determining step. Eur. J. Biochem. 229: 540 549.
18. Chen, Y.-S.,, W.-W. Wong,, C.-P. Fung,, K.-W. Yu,, and C.-Y. Liu. 2002. Clinical features and antimicrobial susceptibility trends in Citrobacter freundii bacteremia. J. Microbiol. Immunol. Infect. 35: 109 114.
19. Chuang, A. W.,, J. B. Lewis,, E. B. Golden,, and S. K. Bhaskar. 1998. Citrobacter freundii empyema in a patient with occult pulmonary histoplasmosis. Am. J. Med. Sci. 315: 314 316.
20. Christo, G. G.,, J. Mathai,, B. Nalini,, M. Baliga,, and A. Venkatesh. 1990. Neonatal Citrobacter sepsis: clinical and epidemiological aspects. Ind. J. Pediatr. 57: 781 784.
21. Cockerill, F. R. III,, J. G. Hughes,, E. A. Vetter,, R. A. Mueller,, A. L. Weaver,, D. M. Ilstrup,, J. E. Rosenblatt,, and W. R. Wilson. 1997. Analysis of 281,797 consecutive blood cultures performed over an eight-year period: trends in microorganisms isolated and the value of anaerobic culture of blood. Clin. Infect. Dis. 24: 403 418.
22. Crosa, J. H.,, A. G. Steigerwalt,, G. R. Fanning,, and D. J. Brenner. 1974. Polynucleotide sequence divergence in the genus Citrobacter. J. Gen. Microbiol. 83: 271 282.
23. Dauga, C. 2002. Evolution of the gyrB gene and the molecular phylogeny of Enterobacteriaceae: a model molecule for molecular systematic studies. Int. J. Syst. Evol. Microbiol. 52: 531 547.
24. de la Puente-Redondo, V. A.,, C. B. Gutiérrez-Martin,, C. Pérez-Martínez,, N. García del Blanco,, M. J. García-Iglesias,, C. C. Pérez-García,, and E. F. Rodríguez-Ferri. 1999. Epidemic infection caused by Citrobacter rodentium in a gerbil colony. Vet. Rec. 145: 400 403.
25. Deng, W.,, B. A. Vallance,, Y. Li,, J. L. Puente,, and B. B. Finlay. 2003. Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice. Mol. Microbiol. 48: 95 115.
26. Doran, T. I. 1999. The role of Citrobacter in clinical disease of children: review. Clin. Infect. Dis. 28: 384 394.
27. Draper, C. S.,, R. D. Walker,, and H. E. Lawler. 1981. Patterns of oral bacterial infection in captive snakes. J. Am. Vet. Med. Assoc. 179: 1223 1226.
28. Drelichman, V.,, and J. D. Band. 1985. Bacteremias due to Citrobacter diversus and Citrobacter freundii. Arch. Intern. Med. 145: 1808 1810.
29. Dyer, J.,, K. C. Hayani,, W. M. Janda,, and P. C. Schreckenberger. 1997. Citrobacter sedlakii meningitis and brain abscess in a premature infant . J. Clin. Microbiol. 35: 2686 2688.
30. El Harrif-Heraud, C. Arpin, S. Benliman, and C. Quentin. 1997. Molecular epidemiology of a nosocomial outbreak due to SHV-4-producing strains of Citrobacter diversus. J. Clin. Microbiol. 35: 2561 2567.
31. Eppes, S. C.,, C. R. Woods,, A. S. Mayer,, and J. D. Klein. 1993. Recurring ventriculitis due to Citrobacter diversus: clinical and bacteriologic analysis. Clin. Infect. Dis. 17: 437 440.
32. Ewing, W. H.,, and B. R. Davis. 1972. Biochemical characterization of Citrobacter diversus (Burkey) Werkman and Gillen and designation of the neotype strain. Int. J. Syst. Bacteriol. 22: 12 18.
33. Farmer, J. J., III, 1981. The genus Citrobacter, p. 1140 1147. In M. P. Starr,, H. Stolp,, H. G. Trüper,, and H. G. Schlegel (ed.), The Prokaryotes: a Handbook on Habitats, Isolation, and Identification of Bacteria. Springer-Verlag, Berlin, Germany.
34. Farmer, J. J. III, 2003. Enterobacteriaceae: introduction and identification, p. 636 653. In P. R. Murray,, E. J. Baron,, J. H. Jorgensen,, M. A. Pfaller,, and R. H. Yolken (ed.), Manual of Clinical Microbiology, 8th ed. American Society for Microbiology, Washington, D.C.
35. Farmer, J. J. III,, B. R. Davis,, F. W. Hickman-Brenner,, A. McWhorter,, G. P. Huntley-Carter,, M. A. Asbury,, C. Riddle,, H. G. Wathen-Grady,, C. Elias,, G. R. Fanning,, A. G. Steigerwalt,, C. M. O’Hara,, G. K. Morris,, P. B. Smith,, and D. J. Brenner. 1985. Biochemical identification of new species and biogroups of Enterobacteriaceae isolated from clinical specimens. J. Clin. Microbiol. 21: 46 76.
36. Farr, R. W.,, R. A. Khakoo,, L. P. Maxwell,, and R. C. Hill. 1994. Citrobacter pericarditis secondary to a subphrenic abscess. Clin. Infect. Dis. 18: 838 839.
37. Ferrer, F. A.,, C. D. A. Herndon,, and P. H. McKenna. 1999. Citrobacter diversus urosepsis and cerebral abscess in a child with antenatal hydronephrosis. Urology 54: 1097v 1097vii.
38. Fields, B. N.,, M. M. Uwaydah,, L. J. Kunz,, and M. N. Swartz. 1967. The so-called “paracolon” bacteria. Am. J. Med. 42: 89 106.
39. Fincher, R.-M. E.,, M. W. Jackson,, and A. Q. Fischer. 1990. Case report: Citrobacter freundii: a newly reported cause of pyomyositis. Am. J. Med. Sci. 299: 331 333.
40. Finn, A.,, G. H. Talbot,, E. Anday,, M. Skros,, M. Provencher,, and C. Hoegg. 1988. Vertical transmission of Citrobacter diversus from mother to infant. Pediatr. Infect. Dis. J. 7: 293 294.
41. Fischer, C.,, M. Kallerhoff,, W. Weidner,, and R. H. Ringert. 1996. Citrobacter emphysematous pyelonephritis in a tuberculous kidney caused by Citrobacter. A case report in a diabetic patient. Ann. Urol. (Paris) 30: 108 111.
42. Flaherty, J. P.,, S. Garcia-Houchins,, S. Chudy,, and P. M. Arnow. 1993. An outbreak of gram-negative bacteremia traced to contaminated O-rings in reprocessed dialyzers. Ann. Intern. Med. 119: 1072 1078.
43. Flegg, P. J.,, and B. K. Mandal. 1989. Citrobacter freundii bacteraemia presenting as typhoid fever. J. Infect. 18: 171 173.
44. Fluit, A. C.,, F. J. Schmitz,, J. Verhoef, and the European SENTRY Participant Group. 2001. Frequency of isolation of pathogens from bloodstream, nosocomial pneumonia, skin and soft tissue, and urinary tract infections occurring in European patients. Eur. J. Clin. Microbiol. Infect. Dis. 20: 188 191.
45. Frederiksen, W. 1970. Citrobacter koseri (n. sp.) a new species within the genus Citrobacter, with a comment on the taxonomic position of Citrobacter intermedium (Werkman and Gillen). Publ. Fac. Sci. Univ. J. E. Purkyne Brno 47: 89 94.
46. Frederiksen, W. 1990. Correct names of the species Citrobacter koseri, Levinea malonatica, and Citrobacter diversus. Request for an opinion. Int. J. Syst. Bacteriol. 40: 107 108.
47. Frederiksen, W.,, and P. Søgaard,. 1991. The genus Citrobacter, p. 2744 2753. In A. Balows,, H. G. Trüper,, M. Dworkin,, W. Harder,, and K.-H. Schleifer (ed.), The Prokaryotes: a Handbook on the Biology of Bacteria. Ecophysiology, Isolation, Identification, Applications, 2nd ed. Springer-Verlag, Berlin, Germany.
48. Funke, G.,, D. Monnet,, C. deBernardis,, A. von Graevenitz,, and J. Freney. 1998. Evaluation of the VITEK 2 system for rapid identification of medically relevant gram-negative rods. J. Clin. Microbiol. 36: 1948 1952.
49. Galarneau, J. R.,, M. Fortin,, J. M. Lapointe,, and C. Girard. 2003. Citrobacter freundii septicemia in two dogs. J. Vet. Diagn. Investig. 15: 297 299.
50. Garcia, D. C.,, G. M. Woloj,, S. Piñeiro,, D. O. Sordelli,, and S. Kaufman. 1995. An 8-year study of resistance in gramnegative bacilli isolates from patients with nosocomial infection at one hospital in Argentina. J. Med. Microbiol. 42: 283 290.
51. Garcia-Bustinduy, M.,, M. Lecuona,, F. Guimera,, M. Saez,, S. Dorta,, R. Sanchez,, A. Noda,, and R. Garcia-Montelongo. 2002. Citrobacter koseri in scalp folliculitis. Cutis 69: 393 394.
52. Gill, M. A.,, and G. E. Schutze. 1999. Citrobacter urinary tract infections in children . Pediatr. Infect. Dis. J. 18: 889 892.
53. Goering, R. V.,, J. Ehrenkranz,, C. C. Sanders,, and W. E. Sanders, Jr. 1992. Long term epidemiological analysis of Citrobacter diversus in a neonatal intensive care unit. Pediatr. Infect. Dis. J. 11: 99 104.
54. Goldstein, E. J. C.,, E. O. Agyare,, A. E. Vagvolgyi,, and M. Halpern. 1981. Aerobic bacterial oral flora of garter snakes: development of normal flora and pathogenic potential for snakes and humans . J. Clin. Microbiol. 13: 954 956.
55. Gordon, D. M.,, and F. FitzGibbon. 1999. The distribution of enteric bacteria from Australian mammals: host and geographical effects. Microbiology 145: 2663 2671.
56. Graham, D. R.,, R. L. Anderson,, F. E. Ariel,, N. J. Ehrenkranz,, B. Rowe,, H. R. Boer,, and R. E. Dixon. 1981. Epidemic nosocomial meningitis due to Citrobacter diversus in neonates. J. Infect. Dis. 144: 203 209.
57. Graham, D. R.,, and J. D. Band. 1981. Citrobacter diversus brain abscess and meningitis in neonates. JAMA 245: 1923 1925.
58. Gross, R. J.,, and B. Rowe. 1975. Citrobacter koseri. I. An extended antigenic scheme for Citrobacter koseri (syn. C. diversus, Levinea malonatica). J. Hyg. Camb. 75: 121 127.
59. Gross, R. J.,, and B. Rowe. 1983. Citrobacter koseri (syn. C. diversus): biotype, serogroup and drug resistance patterns of 517 strains. J. Hyg. Camb. 90: 233 239.
60. Gross, R. J.,, B. Rowe,, I. Sechter,, D. Cahan,, and G. Altman. 1981. Antigenic scheme for Citrobacter koseri (syn. C. diversus, Levinea malonatica): three new antigens recognized in strains from Israel. J. Hyg. Lond. 86: 111 115.
61. Guarino, A.,, G. Capano,, B. Malamisura,, M. Alessio,, S. Guandalini,, and A. Rubino. 1987. Production of Escherichia coli STa-like heat-stable enterotoxin by Citrobacter freundii isolated from humans. J. Clin. Microbiol. 25: 110 114.
62. Guarino, A.,, R. Giannella,, and M. R. Thompson. 1989. Citrobacter freundii produces an 18-amino-acid heat-stable enterotoxin identical to the 18-amino-acid Escherichia coli heat-stable enterotoxin (ST Ia). Infect. Immun. 57: 649 652.
63. Guerrant, R. L.,, M. D. Dickens,, R. P. Wenzel,, and A. Z. Kapikian. 1976. Toxigenic bacterial diarrhea: nursery outbreak involving multiple bacterial strains. J. Pediatr. 89: 885 891.
64. Harvey, B. S.,, T. Koeuth,, J. Versalovic,, C. R. Woods,, and J. R. Lupski. 1995. Vertical transmission of Citrobacter diversus documented by DNA fingerprinting. Infect. Control Hosp. Epidemiol. 16: 564 569.
65. Hess, P.,, N. Daryab,, K. Michaelis,, A. Reisenauer,, and T. A. Oelschlaeger. 2000. Type 1 pili of Citrobacter freundii mediate invasion into host cells. Adv. Exp. Med. Biol. 485: 225 235.
66. Hoban, D. J.,, S. K. Bouchillon,, J. L. Johnson,, G. G. Zhanel,, D. L. Butler,, L. A. Miller,, J. A. Poupard, and the Gemifloxacin Surveillance Study Research Group. 2001. Comparative in vitro activity of gemifloxacin, ciprofloxacin, levofloxacin and ofloxacin in a North American surveillance study. Diagn. Microbiol. Infect. Dis. 40: 51 57.
67. Hodges, G. R.,, C. E. Degener,, and W. G. Barnes. 1978. Clinical significance of Citrobacter isolates. Am. J. Clin. Pathol. 70: 37 40.
68. Holmes, B.,, M. Costas,, M. Ganner,, S. L. W. On,, and M. Stevens. 1994. Evaluation of Biolog system for identification of some gram-negative bacteria of clinical importance. J. Clin. Microbiol. 32: 1970 1975.
69. Holmes, B.,, M. Costas,, T. Thaker,, and M. Stevens. 1994. Evaluation of two BBL Crystal systems for identification of some clinically important gram-negative bacteria. J. Clin. Microbiol. 32: 2221 2224.
70. Inoue, K.,, K. Miki,, K. Tamura,, and R. Sakazaki. 1996. Evaluation of L-pyrrolidonyl peptidase paper strip test for differentiation of members of the family Enterobacteriaceae, particularly Salmonella spp. J. Clin. Microbiol. 34: 1811 1812.
71. Jacoby, G. A.,, and G. L. Archer. 1991. New mechanisms of bacterial resistance to antimicrobial agents. N. Engl. J. Med. 324: 601 612.
72. Janda, J. M.,, S. L. Abbott,, W. K. W. Cheung,, and D. F. Hanson. 1994. Biochemical identification of citrobacteria in the clinical laboratory. J. Clin. Microbiol. 32: 1850 1854.
73. Joaquin, A.,, S. Khan,, N. Russell,, and N. Al Fayez. 1991. Neonatal meningitis and bilateral cerebellar abscesses due to Citrobacter freundii. Pediatr. Neurosurg. 17: 23 24.
74. Jolivet-Gougeon, A.,, Z. Tamanai-Shacoori,, F. Sauvager,, and M. Cormier. 1997. Production of Escherichia coli group I-like heat-labile enterotoxin by Enterobacteriaceae isolated from environmental water. Microbios 90: 209 218.
75. Jones, R. N.,, E. N. Kehrberg,, M. E. Erwin,, S. C. Anderson, and the Fluoroquinolone Resistance Surveillance Group. 1994. Prevalence of important pathogens and antimicrobial activity of parenteral drugs at numerous medical centers in the United States. I. Study on the threat of emerging resistances: real or perceived? Diagn. Microbiol. Infect. Dis. 19: 203 215.
76. Jossart, M.-F.,, and R. J. Courcol. 1999. Evaluation of an automated system for identification of Enterobacteriaceae and nonfermenting bacilli. Eur. J. Clin. Microbiol. Infect. Dis. 18: 902 907.
77. Karasawa, T.,, H. Ito,, T. Tsukamoto,, S. Yamasaki,, H. Kurazono,, S. M. Faruque,, G. B. Nair,, M. Nishibuchi,, and Y. Takeda. 2002. Cloning and characterization of genes encoding homologues of the B subunit of cholera toxin and the Escherichia coli heat-labile enterotoxin from clinical isolates of Citrobacter freundii and E. coli. Infect. Immun. 70: 7153 7155.
78. Karlowsky, J. A.,, M. E. Jones,, C. Thornsberry,, I. R. Friedland,, and D. F. Sahm. 2003. Trends in antimicrobial susceptibilities among Enterobacteriaceae isolated from hospitalized patients in the United States from 1998 to 2001. Antimicrob. Agents Chemother. 47: 1672 1680.
79. Kelly, M. T.,, and C. Leicester. 1992. Evaluation of the Autoscan Walkaway system for rapid identification and susceptibility testing of gram-negative bacilli. J. Clin. Microbiol. 30: 1568 1571.
80. Khan, A.,, R. K. Nandi,, S. C. Das,, T. Ramamurthy,, J. Khanam,, T. Shimizu,, S. Yamasaki,, S. K. Bhattacharya,, W. Chaicumpa,, Y. Takeda,, and G. B. Nair. 2003. Environmental isolates of Citrobacter braakii that agglutinate with Escherichia coli O157 antiserum but do not possess the genes responsible for the biosynthesis of O157 somatic antigen. Epidemiol. Infect. 130: 179 186.
81. Khashe, S.,, and J. M. Janda. 1996. Iron utilization studies in Citrobacter species. FEMS Microbiol. Lett. 137: 141 146.
82. Kitch, T. T.,, M. R. Jacobs,, and P. C. Appelbaum. 1994. Evaluation of RapID onE system for identification of 379 strains in the family Enterobacteriaceae and oxidase-negative, gramnegative nonfermenters. J. Clin. Microbiol. 32: 931 934.
83. Kline, M. W. 1988. Citrobacter meningitis and brain abscess in infancy: epidemiology, pathogenesis, and treatment. J. Pediatr. 113: 430 434.
84. Kline, M. W.,, S. L. Kaplan,, E. P. Hawkins,, and E. O. Mason, Jr. 1988. Pathogenesis of brain abscess formation in an infant rat model of Citrobacter diversus bacteremia and meningitis. J. Infect. Dis. 157: 106 112.
85. Kline, M. W.,, E. O. Mason, Jr.,, and S. L. Kaplan. 1988. Characterization of Citrobacter diversus strains causing neonatal meningitis. J. Infect. Dis. 157: 101 105.
86. Kline, M. W.,, E. O. Mason, Jr.,, and S. L. Kaplan. 1989. Epidemiologic marker system for Citrobacter diversus using outer membrane protein profiles. J. Clin. Microbiol. 27: 1793 1796.
87. Kocharova, N. A.,, Y. A. Knirel,, E. S. Stanislavsky,, E. V. Kholodkova,, C. Lugowski,, W. Jachymek,, and E. Romanowska. 1996. Structural and serological studies of lipopolysaccharides of Citrobacter O35 and O38 antigenically related to Salmonella. FEMS Microbiol. Immunol. 13: 1 8.
88. Kueh, C. S. W.,, P. Kutarski,, and M. Brunton. 1992. Contaminated marine wounds-the risk of acquiring acute bacterial infection from marine recreational beaches. J. Appl. Bacteriol. 73: 412 420.
89. Lew, P. D.,, A. S. Baker,, L. J. Kunz,, and R. C. Moellering, Jr. 1984. Intra-abdominal Citrobacter infections: association with biliary or upper gastrointestinal source. Surgery 95: 398 403.
90. Li, J.,, J. M. Musser,, P. Beltran,, M. W. Kline,, and R. K. Selander. 1990. Genotypic heterogeneity of strains of Citrobacter diversus expressing a 32-kilodalton outer membrane protein associated with neonatal meningitis. J. Clin. Microbiol. 28: 1760 1763.
91. Lin, F.-Y. C.,, W. F. Devoe,, C. Morrison,, J. Libonati,, P. Powers,, R. J. Gross,, B. Rowe,, E. Israel,, and J. G. Morris. 1987. Outbreak of neonatal Citrobacter diversus meningitis in a suburban hospital. Pediatr. Infect. Dis. J. 6: 50 55.
92. Lipsky, B. A.,, E. W. Hook III,, A. A. Smith,, and J. J. Plorde. 1980. Citrobacter infections in humans experience at the Seattle Veterans Administration Medical Center and a review of the literature. Rev. Infect. Dis. 2: 746 760.
93. Luperchio, S. A.,, and D. B. Schauer. 2001. Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia. Microbes Infect. 3: 333 340.
94. Luperchio, S. A.,, J. V. Newman,, C. A. Dangler,, M. D. Schrenzel,, D. J. Brenner,, A. G. Steigerwalt,, and D. B. Schauer. 2000. Citrobacter rodentium, the causative agent of transmissable murine colonic hyperplasia, exhibits clonality: synonymy of C. rodentium and mouse-pathogenic Escherichia coli. J. Clin. Microbiol. 38: 4343 4350.
95. Mainardi, J.-L.,, P. Mugnier,, A. Coutrot,, A. Buu-Hoï,, E. Collatz,, and L. Gutmann. 1997. Carbapenem resistance in a clinical isolate of Citrobacter freundii. Antimicrob. Agents Chemother. 41: 2352 2354.
96. Martinez, J. L.,, E. Cercenado,, F. Baquero,, J. C. Perez-Díaz,, and A. Delgado-Iribarren. 1987. Incidence of aerobactin production in gram-negative hospital isolates. FEMS Microbiol. Lett. 43: 351 353.
97. McDaniel, T. K.,, K. G. Jarvis,, M. S. Donnenberg,, and J. B. Kaper. 1995. A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens . Proc. Natl. Acad. Sci. USA 92: 1664 1668.
98. Miki, K.,, K. Tamura,, R. Sakazaki,, and Y. Kosako. 1996. Respeciation of the original reference strains of serovars in the Citrobacter freundii (Bethesda-Ballerup Group) antigenic scheme of West and Edwards. Microbiol. Immunol. 40: 915 921.
99. Miller, J. M.,, and P. Alachi. 1996. Evaluation of a new computer-enhanced identification program for microorganisms: adaptation of BioBASE for identification of members of the family Enterobacteriaceae. J. Clin. Microbiol. 34: 179 181.
100. Miller, J. M.,, and D. L. Rhoden. 1991. Preliminary evaluation of Biolog, a carbon source utilization method for bacterial identification. J. Clin. Microbiol. 29: 1143 1147.
101. Morgan, M. G.,, C. Stuart,, A. T. Leanord,, M. Enright,, and G. F. Cole. 1992. Citrobacter diversus brain abscess: case report and molecular epidemiology . J. Med. Microbiol. 36: 273 278.
102. Morris, J. G., Jr.,, F.-Y. C. Lin,, C. B. Morrison,, R. J. Gross,, R. Khabbaz,, K. O. Maher,, B. Rowe,, E. Israel,, and J. P. Libonati. 1986. Molecular epidemiology of neonatal meningitis due to Citrobacter diversus: a study of isolates from hospitals in Maryland. J. Infect. Dis. 154: 409 414.
103. Müller, H. E. 1986. Occurrence and clinical significance of tyrosine clearing positive Citrobacter freundii in human faecal specimens. Zentbl. Bakteriol. Hyg. A 262: 412 416.
104. Müller, G. F.,, and H. Keller. 1992. Spondylitis durch Citrobacter diversus. 1992. Schweiz. Med. Wochenschr. 122: 1173 1177.
105. Mundy, R.,, D. Pickard,, R. K. Wilson,, C. P. Simmons,, G. Dougan,, and G. Frankel. 2003. Identification of a novel type IV pilus gene cluster required for gastrointestinal colonization of Citrobacter rodentium. Mol. Microbiol. 48: 795 809.
106. Murphey, D. K.,, E. J. Septimus,, and D. C. Waagner. 1992. Catfish-related injury and infection: report of two cases and review of the literature. Clin. Infect. Dis. 14: 689 693.
107. Naas, T.,, D. Aubert,, N. Fortineau,, and P. Nordmann. 2002. Cloning and sequencing of the β-lactamase gene and surrounding DNA sequences of Citrobacter braakii, Citrobacter murliniae, Citrobacter werkmanii, Escherichia fergusonii and Enterobacer cancerogenus. FEMS Microbiol. Lett. 215: 81 87.
108. Nicolle, L. E. 2001. Urinary tract pathogens in complicated infection and in elderly individuals. J. Infect. Dis. 183( Suppl. 1): S5 S8.
109. Novak, S. S.,, and R. A. Seigel. 1986. Gram-negative septicemia in American alligators ( Alligator mississippiensis). J. Wildl. Dis. 22: 484 487.
110. Oelschlaeger, T. A.,, P. Guerry,, and D. J. Kopecko. 1993. Unusual microtubule-dependent endocytosis mechanisms triggered by Campylobacter jejuni and Citrobacter freundii. Proc. Natl. Acad. Sci. USA 90: 6884 6888.
111. O’Hara, C. M.,, and J. M. Miller. 2003. Evaluation of the Vitek 2 ID-GNB assay for identification of members of the family Enterobacteriaceae and other nonenteric gramnegative bacilli and comparison with the Vitek GNI+ card. J. Clin. Microbiol. 41: 2096 2101.
112. O’Hara, C. M.,, D. L. Rhoden,, and J. M. Miller. 1992. Reevaluation of the API 20E identification system versus conventional biochemicals for identification of members of the family Enterobacteriaceae: a new look at an old product. J. Clin. Microbiol. 30: 123 125.
113. O’Hara, C. M.,, S. B. Roman,, and J. M. Miller. 1995. Ability of commercial identification systems to identify newly recognized species of Citrobacter. J. Clin. Microbiol. 33: 242 245.
114. O’Hara, C. M.,, F. C. Tenover,, and J. M. Miller. 1993. Parallel comparison of accuracy of API 20E, Vitek GNI, MicroScan Walk/Away Rapid ID, and Becton Dickinson Cobas Micro ID-E/NF for identification of members of the family Enterobacteriaceae and common gram-negative, nonglucose-fermenting bacilli. J. Clin. Microbiol. 31: 3165 3169.
115. O’Hara, C. M.,, G. L. Westbrook,, and J. M. Miller. 1997. Evaluation of Vitek GNI+ and Becton Dickinson Microbiology Systems Crystal E/NF identification systems for identification of members of the family Enterobacteriaceae and other gram-negative, glucose-fermenting and non-glucosefermenting bacilli. J. Clin. Microbiol. 35: 3269 3273.
116. Papasian, C. J.,, J. Kinney,, S. Coffman,, R. J. Hollis,, and M. A. Pfaller. 1996. Transmission of Citrobacter koseri from mother to infant documented by ribotyping and pulsed-field gel electrophoresis. Diagn. Microbiol. Infect. Dis. 26: 63 67.
117. Parry, M. F.,, J. H. Hutchinson,, N. A. Brown,, C.-H. Wu,, and L. Estreller. 1980. Gram-negative sepsis in neonates: a nursery outbreak due to hand carriage of Citrobacter diversus. Pediatrics 65: 1105 1109.
118. Pepperell, C.,, J. V. Kus,, M. A. Gardam,, A. Humar,, and L. L. Burrows. 2002. Low-virulence Citrobacter species encode resistance to multiple antimicrobials. Antimicrob. Agents Chemother. 46: 3555 3560.
119. Pfaller, M. A.,, D. Sahm,, C. O’Hara,, C. Ciaglia,, M. Yu,, N. Yamane,, G. Scharnweber,, and D. Rhoden. 1991. Comparison of the AutoSCAN-W/A rapid bacterial identification system and the Vitek AutoMicrobic system for identification of gram-negative bacilli. J. Clin. Microbiol. 29: 1422 1428.
120. Philippon, A.,, J. Dusart,, B. Joris,, and J.-M. Frère. 1998. The diversity, structure, and regulation of β-lactamases. Cell. Mol. Life Sci. 54: 341 346.
121. Prais, D.,, M. Nussinovitch,, L. Harel,, and J. Amir. 2003. Citrobacter koseri (diversus) meningitis in an otherwise healthy adolescent. Scand. J. Infect. Dis. 35: 202 204.
122. Raidal, S. R.,, M. Ohara,, R. P. Hobbs,, and R. I. Prince. 1998. Gram-negative bacterial infections and cardiovascular parasitism in green sea turtles ( Chelonia mydas). Aust. Vet. J. 76: 415 417.
123. Rais-Bahrami, K.,, and B. L. Short. 2000. Citrobacter sepsis and severe newborn respiratory failure supported with extracorporeal membrane oxygenation. J. Perinatol. 4: 265 266.
124. Ratner, A. J.,, R. S. Mosca,, and H. A. Zucker. 2002. Citrobacter mediastinitis following surgery in a neonate. J. Infect. 44: 52 58.
125. Richard, C.,, B. Brisou,, and J. Lioult. 1972. Étude taxonomique de Levinea, nouveau genre de la famille des Entérobacteréries. Ann. Inst. Pasteur 122: 1137 1146.
126. Richards, M. J.,, J. R. Edwards,, D. H. Culver,, R. P. Gaynes, and the National Nosocomial Infectious Surveillance System. 1999. Nosocomial infections in pediatric intensive care units in the United States. Pediatrics 103: e39.
127. Richards, M. J.,, J. R. Edwards,, D. H. Culver,, R. P. Gaynes, and the National Nosocomial Infections Surveillance System. 2000. Nosocomial infections in combined medical-surgical intensive care units in the United States. Infect. Control Hosp. Epidemiol. 21: 510 515.
128. Robinson, A.,, Y. S. McCarter,, J. Tetreault. 1995. Comparison of Crystal Enteric/Nonfermenter system, API 20E system, and Vitek Automicrobic system for identification of gram-negative bacilli. J. Clin. Microbiol. 33: 364 370.
129. Roberts, F. J. 1980. A review of positive blood cultures: identification and source of microorganisms and patterns of sensitivity to antibiotics. Rev. Infect. Dis. 2: 329 339.
130. Sakazaki, R., 1984. Genus IV. Citrobacter Werkman and Gillen 1932, 173 AL, p. 458 461. In N. R. Krieg, and J. G. Holt (ed.), Bergey’s Manual of Systematic Bacteriology, vol. 1. Williams & Wilkins, Baltimore, Md.
131. Samonis, G.,, E. Anaissie,, L. Elting,, and G. P. Bodey. 1991. Review of Citrobacter bacteremia in cancer patients over a sixteen-year period. Eur. J. Clin. Microbiol. Infect. Dis. 10: 479 485.
132. Sanguinetti, M.,, B. Posteraro,, T. Spanu,, D. Ciccaglione,, L. Romano,, B. Fiori,, G. Nicoletti,, S. Zanetti,, and G. Fadda. 2003. Characterization of clinical isolates of Enterobacteriaceae from Italy by the BD Phoenix extended-spectrum β-lactamase detection method. J. Clin. Microbiol. 41: 1463 1468.
133. Schaberg, D. R.,, D. H. Culver,, and R. P. Gaynes. 1991. Major trends in the microbial etiology of nosocomial infection. Am. J. Med. 91: 3B72S 3B75S.
134. Schauer, D. B.,, and S. Falkow. 1993. Attaching and effacing locus of a Citrobacter freundii biotype that causes transmissible murine colonic hyperplasia. Infect. Immun. 61: 2486 2492.
135. Schauer, D. B.,, and S. Falkow. 1993. The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissable murine colonic hyperplasia. Infect. Immun. 61: 4654 4661.
136. Schauer, D. B.,, B. A. Zabel,, I. F. Pedraza,, C. M. O’Hara,, A. G. Steigerwalt,, and D. J. Brenner. 1995. Genetic and biochemical characterization of Citrobacter rodentium sp. nov. J. Clin. Microbiol. 33: 2064 2068.
137. Schmidt, H.,, M. Montag,, J. Bockemühl,, J. Heesemann,, and H. Karch. 1993. Shiga-like toxin II-related cytotoxins in Citrobacter freundii strains from humans and beef samples. Infect. Immun. 61: 534 543.
138. Schubert, S.,, S. Cuenca,, D. Fischer,, and J. Heesemann. 2000. High-pathogenicity island of Yersinia pestis in Enterobacteriaceae isolated from blood cultures and urine samples: prevalence and functional expression. J. Infect. Dis. 182: 1268 1271.
139. Sechter, I.,, G. Altmann,, D. Cahan,, I. Braunstein,, and C. B. Gerichter. 1981. Antigenic scheme of Citrobacter koseri. J. Clin. Microbiol. 14: 620 622.
140. Sedlák, J. 1973. Present knowledge and aspects of Citrobacter. Curr. Top. Microbiol. Immunol. 62: 41 59.
141. Sherley, M.,, D. M. Gordon,, and P. J. Collignon. 2003. Species differences in plasmid carriage in the Enterobacteriaceae. Plasmid 49: 79 85.
142. Shih, C.-C.,, Y.-C. Chen,, S.-C. Chang,, K.-T. Luh,, and W.-C. Hsieh. 1996. Bacteremia due to Citrobacter species: significance of primary intraabdominal infection. Clin. Infect. Dis. 23: 543 549.
143. Soriano, A. L.,, R. G. Russell,, D. Johnson,, R. Lagos,, I. Sechter,, and J. G. Morris, Jr. 1991. Pathophysiology of Citrobacter diversus neonatal meningitis: comparative studies in an infant mouse model. Infect. Immun. 59: 1352 1358.
144. Sotto, A.,, J. C. Bernard,, C. Brunschwig,, D. Blin,, F. M. Lopez,, and B. Combe. 1994. Bifocal cervical spondylodiscitis due to Citrobacter diversus. Infection 22: 423 424.
145. Šourek, J.,, and E. Aldová. 1988. Importance of serological tests in the diagnosis of Citrobacter diversus and Citrobacter amalonaticus. Syst. Appl. Microbiol. 11: 60 66.
146. Spröer, C.,, U. Mendrock,, J. Swiderski,, E. Lang,, and E. Stackebrandt. 1999. The phylogenetic position of Serratia, Buttiauxella and some other genera of the family Enterobacteriaceae. Int. J. Syst. Bacteriol. 49: 1433 1438.
147. Straussberg, R.,, L. Harel,, and J. Amir. 2001. Long-term outcome of neonatal Citrobacter koseri (diversus) meningitis treated with imipenem/meropenem and surgical drainage. Infection 29: 280 282.
148. Sugandhi, R. P.,, V. K. Beena,, P. G. Shivananda,, and M. Baliga. 1992. Citrobacter sepsis in infants. Ind. J. Pediatr. 59: 309 312.
149. Tang, L.-M.,, S.-T. Chen,, and T.-N. Lui. 1994. Citrobacter meningitis in adults. Clin. Neurol. Neurosurg. 96: 52 57.
150. Tellez, I.,, G. S. Chrysant,, I. Omer,, and W. E. Dismukes. 2000. Citrobacter diversus endocarditis. Am. J. Med. Sci. 320: 408 410.
151. Thornsberry, C. 1994. Susceptibility of clinical bacterial isolates to ciprofloxacin in the United States. Infection 22( Suppl. 2): S80 S89.
152. Thornton, S. M.,, S. Nolan,, and F. M. D. Gulland. 1998. Bacterial isolates from California sea lions ( Zalophus californianus), harbor seals ( Phoca vitulina), and northern elephant seals ( Mirounga angustirostris) admitted to a rehabilitation center along the central California coast, 1994-1995. J. Zoo Wildl. Med. 29: 171 176.
153. Thurm, V.,, and B. Gericke. 1994. Identification of infant food as a vehicle in a nosocomial outbreak of Citrobacter freundii: epidemiological subtyping by alloenzyme, wholecell protein and antibiotic resistance. J. Appl. Bacteriol. 76: 553 558.
154. Toranzo, A. E.,, J. M. Cutrín,, B. S. Roberson,, S. Núñez,, J. M. Abell,, F. M. Hetrick,, and A. M. Baya. 1994. Comparison of the taxonomy, serology, drug resistance transfer, and virulence of Citrobacter freundii strains from mammals and poikilothermic hosts. Appl. Environ. Microbiol. 60: 1789 1797.
155. Tschäpe, H.,, R. Prager,, W. Streckel,, A. Fruth,, E. Tietze,, and G. Böhme. 1995. Verotoxinogenic Citrobacter freundii associated with severe gastroenteritis and cases of haemolytic uraemic syndrome in a nursery school: green butter as the infection source. Epidemiol. Infect. 114: 441 450.
156. Visser, M. R.,, L. Bogaards,, M. Rozenberg-Arska,, and J. Verhoef. 1992. Comparison of the autoSCAN-W/A and Vitek Automicrobic systems for identification and susceptibility testing of bacteria. Eur. J. Clin. Microbiol. Infect. Dis. 11: 979 984.
157. Wang, H.,, S. Kelkar,, W. Wu,, M. Chen,, and J. P. Quinn. 2003. Clinical isolates of Enterobacteriaceae producing extendedspectrum βlactamases: prevalence of CTX-M-3 at a hospital in China. Antimicrob. Agents Chemother. 47: 790 793.
158. Warren, J. R.,, J. J. Farmer III,, F. E. Dewhirst,, K. Birkhead,, T. Zembower,, L. R. Peterson,, L. Sims,, and M. Bhattacharya. 2000. Outbreak of nosocomial infections due to extendedspectrum β-lactamase-producing strains of Enteric Group 137, a new member of the family Enterobacteriaceae closely related to Citrobacter farmeri and Citrobacter amalonaticus. J. Clin. Microbiol. 38: 3946 3952.
159. Wayne, L. G. 1994. Actions of the Judicial Commission of the International Committee on Systematic Bacteriology on requests for opinions published between January 1985 and July 1993. Int. J. Syst. Bacteriol. 44: 177 178.
160. Werkman, C. H.,, and G. F. Gillen. 1932. Bacteria producing trimethylene glycol. J. Bacteriol. 23: 167 182.
161. Widrow, C. A.,, S. M. Kellie,, B. R. Saltzman,, and U. Mathur-Wagh. 1991. Pyomyositis in patients with the human immunodeficiency virus: an unusual form of disseminated bacterial infection. Am. J. Med. 91: 129 136.
162. Williams, W. W.,, J. Mariano,, M. Spurrier,, H. D. Donnell, Jr.,, R. I. Beckenridge, Jr.,, R. L. Anderson,, I. K. Wachsmuth,, C. Thornsberry,, D. R. Graham,, D. W. Thibeault,, and J. R. Allen. 1984. Nosocomial meningitis due to Citrobacter diversus in neonates: new aspects of the epidemiology. J. Infect. Dis. 150: 229 235.
163. Woods, C. R., Jr.,, E. O. Mason, Jr.,, and S. L. Kaplan. 1992. Interaction of Citrobacter diversus strains with HEp-2 epithelial and human umbilical vein endothelial cells. J. Infect. Dis. 166: 1035 1044.
164. Woods, C. R., Jr.,, J. Versalovic,, T. Koeuth,, and J. R. Lupski. 1992. Analysis of relationships among isolates of Citrobacter diversus by using DNA fingerprints generated by repetitive sequence-based primers in the polymerase chain reaction. J. Clin. Microbiol. 30: 2921 2929.
165. Yan, J.-J.,, W.-C. Ko,, C.-L. Chuang,, and J.-J. Wu. 2002. Metallo-β-lactamase-producing Enterobaceriaceae isolates in a university hospital in Taiwan: prevalence of IMP-8 in Enterobacter cloacae and first identification of VIM-2 in Citrobacter freundii. J. Antimicrob. Chemother. 50: 503 511.
166. York, M. K.,, G. F. Brooks,, and E. H. Fiss. 1992. Evaluation of the autoSCAN-W/A rapid system for identification and susceptibility testing of gram-negative fermentative bacilli. J. Clin. Microbiol. 30: 2903 2910.
167. Young, V. M.,, D. M. Kenton,, B. J. Hobbs,, and M. R. Moody. 1971. Levinea, a new genus of the family Enterobacteriaceae. Int. J. Syst. Bacteriol. 21: 58 63.

Tables

Generic image for table
Table 1

Current taxonomic composition of the genus

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 2

Distribution of recently described species

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 3

Clinical presentations associated with infection

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 4

Presentations of meningitis

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 5

. Identification of species by selected commercial systemsa

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 6

Distinguishing biochemical characteristics of major groups within the genus

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 8

Biotypes of

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 7

Relative distribution of former members within the complex

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 9

Distinguishing features of enteric group 137 from and

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 10

Potential virulence factors operative in the genus sensu lato

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12
Generic image for table
Table 11

Antimicrobial susceptibility of species

Citation: Janda J, Abbott S. 2006. The Genus Citrobacter, p 181-204. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch12

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