Chapter 14 : The Genus

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By 1919, two species were recognized: and . By omission of the principal protein bands, all biogroup 2 strains clustered together, while biogroup 3 strains formed two distinct groups of 4 and 12 strains. This study was followed by an international collaborative effort where biogroup 2 and 3 strains were subjected to DNA-DNA hybridization. In hospital-acquired disease, protei are most frequently recovered from infected wounds resulting from surgical procedures, decubitus ulcers, or infections involving the skin or subcutaneous tissues. The clinical significance of many of these isolates is questionable, since infections are often of a polymicrobic etiology. Molecular techniques have been employed to estimate genetic diversity and to study relatedness but have not been explored to any great extent regarding epidemiology, due to a lack of reported outbreaks associated with these bacteria. A number of molecular techniques have been used to fingerprint , , and strains. These techniques include ribotyping, random amplified polymorphic DNA (RAPD) analysis, and repetitive element-PCR. This chapter contains cumulative data on the in vitro susceptibility of protei to various chemotherapeutic agents obtained from a number of broad-based surveys concerning drug resistance among members of the family .

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14

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Random Amplified Polymorphic DNA
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Figure 1

Swarming of on MacConkey agar as evident by concentric rings of growth. Courtesy of E. J. Bottone.

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14
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Figure 2

A positive Dienes test on Trypticase soy agar. The line of demarcation (center) indicates that the two strains are not related. Courtesy of E. J. Bottone.

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14
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Figure 3

Current model of virulence factors and possible sites of action during infection of the urinary tract. Reprinted from reference 26 (copyright 2000) with permission of Elsevier.

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14
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Table 1

Current composition of the genus

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14
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Table 2

Recent cases of meningitis

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14
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Table 3

Identification of species with commercial systems

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14
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Table 4

Separation of DNA groups within the complex

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14
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Table 5

Virulence factors of species

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14
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Table 6

Virulence factors of associated with ascending UTI in the CBA mouse model

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14
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Table 7

In vitro susceptibility of species to select antimicrobial agents

Citation: Janda J, Abbott S. 2006. The Genus , p 233-259. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch14

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