Chapter 9 : The Genera Klebsiella and Raoultella

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The first, , was proposed for strains isolated from plants (banana, rice, sugar cane, and maize) and human clinical samples based on DNA-DNA hybridization, sequencing of six genes, and phenotypic properties. The inherent difficulties in identification and separation of (and ) species, both in the past and the present, have made interpretation of clinical and environmental epidemiologic data of the genera difficult. Most and species can be isolated from diverse mammals, birds, reptiles, insects, and environmental sources. In nosocomial infections, catheterization is believed to be an important factor in the incidence and spread of strains. This chapter talks about laboratory identification that includes isolation, biochemical methods, biotyping and immunodiagnostics. As with other pathogenic bacteria, virulence in is both multifactorial and complex, and the virulence factors produced may vary depending upon the site of the infection. If agglutination is inhibited by D-mannose, the adhesins are classified as mannose-sensitive hemagglutinins (MSHA) or mannose resistant. In six antimicrobial resistance prevalence studies published between 2001 and 2004 from Europe and North America, ranges of susceptibility were as follows: ceftazidime, 92 to 95%; ceftriaxone, 96 to 98%; cefotaxime, 96%; cefepime, 97 to 98%; ciprofloxacin, 93 to 95%; piperacillin-tazobactam, 90 to 97%; imipenem, 98 to 100%; gentamicin, 95 to 96%; amikacin, 98 to 99%; and trimethoprimsulfamethoxazole (SXT), 88 to 90%.

Citation: Janda J, Abbott S. 2006. The Genera Klebsiella and Raoultella, p 115-136. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch9

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1. Alberti, S.,, S. Hernandez-Alles,, J. Gil,, J. Reina,, J. Martinez-Beltran,, S. Camprubi,, J. M. Tomas,, and V. J. Benedi. 1993. Development of an enzyme-linked immunosorbent assay method for typing and quantitation of Klebsiella pneumoniae lipopolysaccharide: application to serotype O1. J. Clin. Microbiol. 31:13791381.
2. Altmann, G.,, E. Ostfield,, S. Zohar,, and E. Theodor. 1977. Rhinoscleroma. Isr. J. Med. Sci. 13:6264.
3. Anderson, M. J.,, and E. N. Janoff. 1998. Klebsiella endocarditis: report of two cases and review. Clin. Infect. Dis. 26:468474.
4. Andraca, R.,, R. S. Edson,, and E. B. Kern. 1993. Rhinoscleroma: a growing concern in the United States? Mayo Clinic experience. Mayo Clin. Proc. 68:11511157.
5. Avery, R. K.,, S. D. Salman,, and A. S. Baker. 1995. Rhinoscleroma treated with ciprofloxacin: a case report. Laryngoscope 105:854856.
6. Bagley, S. T.,, R. L. Seidler,, and D. J. Brenner. 1981. Klebsiella planticola sp. nov.: a new species of Enterobacteriaceae found primarily in nonclinical environments. Curr. Microbiol. 6: 105109.
7. Bangert, R. L.,, A. C. S. Ward,, E. H. Stauber,, B. R. Cho,, and P. R. Widders. 1988. A survey of the aerobic bacteria in the feces of captive raptors. Avian Dis. 32:5362.
8. Bascomb, S.,, S. L. Abbott,, J. D. Bobolis,, D. A. Bruckner,, S. J. Connell,, S. K. Cullen,, M. Daugherty,, D. Glenn,, J. M. Janda,, S. J. Lentsch,, D. Lindquist,, P. B. Mayhew,, D. M. Nothaft,, J. R. Skinner,, G. B. Williams,, J. Wong,, and B. L. Zimmer. 1997. Multicenter evaluation of the MicroScan Rapid Gram- Negative Identification Type Panel. J. Clin. Microbiol. 35:25312536.
9. Bascomb, S.,, S. P. Lapage,, W. R. Wilcox,, and M. A. Curtis. 1971. Numerical classification of the tribe Klebsiellae. J. Gen. Microbiol. 66:279295.
10. Basu, S.,, K. K. Mukherjee,, B. Poddar,, J. S. Goraya,, K. Chawla,, and V. R. Parmar. 2001. An unusual case of neonatal brain abscess following Klebsiella pneumoniae septicemia. Infection 29:283285.
11. Bauernfeind, A. C. Petermuller, and R. Schneider. 1981. Bacteriocins as tools in analysis of nosocomial Klebsiella pneumoniae infections. J. Clin. Microbiol. 14:1519.
12. Berman, S. J.,, E. W. Johnson,, C. Nakatsu,, M. Alkan,, R. Chen,, and J. LeDuc. 2004. Burden of infection in patients with end-stage renal disease requiring long-term dialysis. Clin. Infect. Dis. 39:17471753.
13. Blaylock, R. S. M. 2001. Normal oral bacterial flora from some southern African snakes. Onderstepoort J. Vet. Res. 68:175182.
14. Bottone, E. J.,, A. A. Perez II,, and J. L. Oeser. 1994. Loofah sponges as reservoirs and vehicles in the transmission of potentially pathogenic bacterial species to the human skin. J. Clin. Microbiol. 32:469472.
15. Bourbeau, P. P.,, and B. J. Heiter. 1998. Comparison of Vitek GNI and GNI+ cards for identification of gram-negative bacteria. J. Clin. Microbiol. 36:27752777.
16. Boye, K.,, and D. S. Hansen. 2003. Sequencing of 16S rDNA of Klebsiella: taxonomic relation within the genus and to other Enterobacteriaceae. Int. J. Med. Microbiol. 292:495503.
17. Brenner, D. J.,, J. J. Farmer III,, F. W. Hickman,, M. A. Asbury,, and A. G. Steigerwalt. 1977. Taxonomic and nomenclature changes in Enterobacteriaceae. HEW publication (CDC) 79-8356. Centers for Disease Control, Atlanta, Ga.
18. Brenner, D. J.,, A. G. Steigerwalt,, and G. R. Fanning. 1972. Differentiation of Enterobacter aerogenes from Klebsiellae by deoxyribonucleic acid reassociation. Int. J. Syst. Bacteriol. 22:193200.
19. Brisse, S.,, S. Issenhuth-Jeanjean,, and P. A. D. Grimont. 2004. Molecular serotyping of Klebsiella species isolates by restriction of the amplified capsular antigen gene cluster. J. Clin. Microbiol. 42:33883398.
20. Broug-Holub, E.,, G. B. Toews,, J. F. Van Iwaarden,, R, M. Strieter,, S. L. Kunkel,, R. Paine III,, and T. J. Standford. 1997. Alveolar macrophages are required for protective pulmonary defense in murine Klebsiella pneumonia: elimination of alveoloar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect. Immun. 65:11391146.
21. Bruce, S. K.,, D. G. Schick,, L. Tanaka,, E. M. Jimenez,, and J. Z. Montgomerie. 1981. Selective medium for isolation of Klebsiella pneumoniae. J. Clin. Microbiol. 13:11141116.
22. Bruno-Murtha, L. A.,, M. A. Sedghivaziri,, and R. D. Arbeit. 1990. Crepitant myonecrosis caused by Klebsiella pneumoniae in an immunocompromised diabetic patient. J. Infect. Dis. 162:14151416.
23. Buenviaje, G. N.,, P. W. Ladds,, L. Melville,, and S. C. Manolis. 1994. Disease-husbandry associations in farmed crocodiles in Queensland and the Northern Territory. Aust. Vet. J. 71:165173.
24. Buffenmeyer, C. L.,, R. R. Rycheck,, and R. B. Yee. 1976. Bacteriocin (Klebocin) sensitivity typing of Klebsiella. J. Clin. Microbiol. 4:239244.
25. Carpenter, J. L. 1990. Klebsiella pulmonary infections: occurrence at one medical center and review. Rev. Infect. Dis. 12:672682.
26. Carter, J.,, F. J. Bowden,, K. S. Sriprakash,, I. Bastian,, and D. J. Kemp. 1999. Diagnostic polymerase chain reaction for donovanosis. Clin. Infect. Dis. 28:11681169.
27. Carter, J.,, S. Hutton,, K. S. Sriprakash,, D. J. Kemp,, G. Lum,, J. Savage,, and F. J. Bowden. 1997. Culture of the causative organism of donovanosis (Calymmatobacterium granulomatis) in HEp-2 cells. J. Clin. Microbiol. 35:29152917.
28. Chang, C. M.,, F. H. Lu,, H. R. Guo,, and W. C. Ko. 2005. Klebsiella pneumoniae fascial space infections of the head and neck in Taiwan: emphasis on diabetic patients and repetitive infections. J. Infect. 50:3440.
29. Chang, S.-C.,, C.-T. Fang,, P.-R. Hsueh,, Y.-C. Chen,, and K.-T. Luh. 2000. Klebsiella pneumoniae isolates causing liver abscess in Taiwan. Diagn. Microbiol. Infect. Dis. 37:279284.
30. Chang, W. N.,, C. H. Lu,, J. J. Wu,, C. B. Lei,, and C. R. Huang. 2003. Community-acquired spontaneous Klebsiella pneumoniae meningitis in adult cirrhotic patients with and without diabetes. Eur. J. Clin. Microbiol. Infect. Dis. 22:271273.
31. Cheng, H.-P.,, F.-Y. Chang,, C.-P. Fung,, and L.-K. Siu. 2002. Klebsiella pneumoniae liver abscess in Taiwan is not caused by a clonal spread strain. J. Microbiol. Immunol. Infect. 35:8588.
32. Chetoui, H.,, E. Delhalle,, P. Melin,, A. Sabri,, P. Thonart,, and P. De Mol. 1999. Epidemiological typing of extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolates by pulsed-field gel electrophoresis and antibiotic susceptibility patterns. Res. Microbiol. 150:265272.
33. Chung, B. H. Y.,, S. Y. Ha,, G. C. F. Chan,, A. Chiang,, T. L. Lee,, H. K. Ko,, C. Y. Lee,, C. W. Luk,, and Y. L. Lau. 2003. Klebsiella infection in patients with thalassemia. Clin. Infect. Dis.36:575579.
34. Cowan, S. T.,, K. J. Steel,, and C. A. Shaw. 1960. A classification of the Klebsiella group. J. Gen. Microbiol. 23:601612.
35. Darfeuille-Michaud, A.,, C. Jallat,, D. Aubel,, D. Sirot,, C. Rich,, J. Sirot,, and B. Joly. 1992. R-plasmid-encoded adhesive factor in Klebsiella pneumoniae strains responsible for human nosocomial finections. Infect. Immunol. 60:4445.
36. Di Martino, P.,, D. Sirot,, B. Joly,, C. Rich,, and A. Darfeuille- Michaud. 1997. A relationship between adhesion to intestinal Caco-2 cells and multidrug resistance in Klebsiella pneumoniae clinical isolates. J. Clin. Microbiol. 35:14991503.
37. Donay, J. L.,, D. Mathieu,, P. Fernandes,, C. Pregermain,, P. Breul,, A. Wargnier,, I. Casin,, F. X. Weill,, P. H. Lagrange,, and J. L. Herrmann. 2004. Evaluation of the automated Phoenix system for potential routine use in the clinical microbiology laboratory. J. Clin. Microbiol. 42:15421546.
38. Drancourt, M.,, C. Bollet,, A. Carta,, and P. Rousselier. 2001. Phylogenetic analyses of Klebsiella species delineate Klebsiella and Raoultella gen. nov., with description of Raoultella ornithinolytica comb. nov., Raoultella terrigena comb. nov. and Raoultella planticola comb. nov. 2001. Int. J. Syst. Evol. Microbiol. 51:925932.
39. Draper, C. S.,, R. D. Walker,, and H. E. Lawler. 1981. Patterns of oral bacterial infection in captive snakes. J. Am. Vet. Med. Assoc. 179:12231226.
40. Dutour, C.,, R. Bonnet,, H. Marchandin,, M. Boyer,, C. Chanal,, D. Sirot,, and J. Sirot. 2002. CTX-M-1, CTX-M-3, and CTXM-14 β-lactamases from Enterobacteriaceae isolated in France. Antimicrob. Agents Chemother. 46:534537.
41. Dylewski, J. S.,, and I. Dylewski. 1998. Necrotizing fasciitis with Klebsiella liver abscess. Clin. Infect. Dis. 27:15611562.
42. Endimiani, A.,, F. Luzzaro,, M. Perilli,, G. Lombardi,, A. Coli,, A. Tamborini,, G. Amicosante,, and A. Toniolo. 2004. Bacteremia due to Klebsiella pneumoniae isolates producing the TEM-52 extended-spectrum β-lactamase: treatment outcome of patients receiving imipenem or ciprofloxacin. Clin. Infect. Dis. 38:243251.
43. Ewing, E. H. 1972. Edwards and Ewing’s Identification of Enterobacteriaceae, 3rd ed. Burgess Publishing Co., Minneapolis, Minn.
44. Farmer, J. J., III,, B. R. Davis,, F. W. Hickman-Brenner,, A. McWhorter,, G. P. Huntley-Carter,, M. A. Asbury,, C. Riddle,, H. G. Wathen-Grady,, C. Elias,, G. R. Fanning,, A. G. Steigerwalt,, C. M. O’Hara,, G. K. Morris,, P. B. Smith,, and D. J. Brenner. 1985. Biochemical identification of new species and biotypes of Enterobacteriaceae isolated from clinical specimens. J. Clin. Microbiol. 21:4676.
45. Farrell, D. J.,, I. Morrissey,, D. De Rubeis,, M. Robbins,, and D. Felmingham. 2003. A UK multicentre study of the antimicrobial susceptibility of bacterial pathogens causing urinary tract infection. J. Infect. 46:94100.
46. Favre-Bonte, S.,, A. Darfeuille-Michaud,, and C. Forestier. 1995. Aggregative adherence of Klebsiella pneumoniae to human intestinal-407 cells. Infect. Immun. 63:13181328.
47. Feldman, C.,, S. Ross,, A. G. Mahomed,, J. Omar,, and C. Smith. 1995. The aetiology of severe community-acquired pneumonia and its impact on initial, empiric, antimicrobial chemotherapy. Respir. Med. 89:187192.
48. Feldman, C.,, C. Smith,, H. Levy,, P. Ginsberg,, S. D. Miller,, and J. J. Koornhof. 1990. Klebsiella pneumoniae bacteraemia at an urban general hospital. J. Infect. 20:2131.
49. Ferguson, J. L.,, T. V. McCaffrey,, E. B. Kern,, and W. J. Martin III. 1990. Effect of Klebsiella ozaenae on ciliary activity in vitro: implications in the pathogenesis of atrophic rhinitis. Otolaryngol. Head Neck Surg.102:207211.
50. Flournoy, D. J. 1993. Incidence of bacteria from clean-catch and catheterized urine of nursing home residents. J. Okla. State Med. Assoc. 86:550552.
51. Freney, J.,, R. Gavini,, H. Alexandre,, S. Madier,, D. Izard,, H. Leclerc,, and J. Fleurette. 1986. Nosocomial infection and colonization by Klebsiella trevisanii. J. Clin. Microbiol. 23:948950.
52. Freney, J.,, M. O. Husson,, F. Gavini,, S. Madier,, A. Martra,, D. Izard,, H. Leclerc,, and H. Fleurette. 1988. Susceptibilities to antibiotics and antiseptics of new species of the family Enterobacteriaceae. Antimicrob. Agents Chemother. 32:873876.
53. Fryklund, B.,, K. Tullus,, and L. G. Burnam. 1995. Epidemiology and attack index of gram-negative bacteria causing invasive infection in three special-care neonatal units and risk factors for infection. Infection 23:7680.
54. Funke, G.,, D. Monnet,, C. DeBernardis,, A. Von Graevenitz,, and J. Freney. 1998. Evaluation of the VITEK 2 System for rapid identification of medically relevant gram-negative rods. J. Clin. Microbiol. 36:19481952.
55. Garcia de la Torre, M.,, J. Romero-Vivas,, J. Martinez-Beltran,, A. Guerrero,, M. Meseguer,, and E. Bouza. 1985. Klebsiella bacteremia: an analysis of 100 episodes. Rev. Infect. Dis. 7:143150.
56. Gaston, M. A.,, B. A. Ayling-Smith,, and T. L. Pitt. 1987. New bacteriophage typing scheme for subdivision of the frequent capsular serotypes of Klebsiella spp. J. Clin. Microbiol. 25:12281232.
57. Gavini, F.,, D. Izard,, P. A. D. Grimont,, A. Beji,, E. Algernon,, and H. Leclerc. 1986. Priority of Klebsiella planticola Bagley, Seidler, and Brenner 1982 over Klebsiella trevasanii Ferragut, Izard, Gavini, Kersters, De Ley, and Leclerc 1983. Int. J. Syst. Bacteriol. 36:486488.
58. Gera, N.,, A. Bhatia,, and S. K. Tickoo. 1995. Cytomorphic features of scleromatous lymphadenitis on fine-needle aspiration cytology: a case report. Diagn. Cytopathol. 13:320321.
59. Goldstein, E. J. C.,, R. P. Lewis,, W. J. Martin,, and P. H. Edelstein. 1978. Infections caused by Klebsiella ozaenae: a changing disease spectrum. J. Clin. Microbiol. 8:413418.
60. Gordon, D. M.,, and F. FitzGibbon. 1999. The distribution of enteric bacteria from Australian mammals: host and geographical effects. Microbiology 145:26632671.
61. Gordon, K. A.,, R. N. Jones, and SENTRY Participant Groups (Europe, Latin America, North America). 2003. Susceptibility patterns of orally administered antimicrobials among urinary tract infection pathogens from hospitalized patients in North America: comparison report to Europe and Latin America. Results from the SENTRY Antimicrobial Surveillance Program (2000). Diagn. Microbiol. Infect. Dis. 45:295301.
62. Gori, A.,, F. Espinasse,, A. Deplano,, C. Nonhoff,, M. H. Nicolas,, and M. J. Struelens. 1996. Comparison of pulsed-field gel electrophoresis and randomly amplified DNA polymorphism analysis for typing extended-spectrum- β-lactamase-producing Klebsiella pneumoniae. J. Clin. Microbiol. 34: 24482453.
63. Granier, S. A.,, V. Leflon-Guibout,, F. W. Goldstein,, and M.-H. Nicolas-Chanoine. 2003. Enterobacterial repetitive intergenic consensus 1R PCR assay for detection of Raoultella sp. isolates among strains identified as Klebsiella oxytoca in the clinical laboratory. J. Clin. Microbiol. 41:17401742.
64. Granier, S. A.,, L. Plaisance,, V. Lefon-Guibout,, E. Lagier,, S. Morand,, F. W. Goldstein,, and M.-H. Nicolas-Chanoine. 2003. Recognition of two genetic groups in the Klebsiella oxytoca taxon on the basis of chromosomal β-lactamase and housekeeping gene sequences as well as ERIC-1R PCR typing. Int. J. Syst. Evol. Microbiol. 53:661668.
65. Gregersen, N.,, W. Van Nierop,, A. Von Gottberg,, A. Duse,, V. Davies,, and P. Cooper. 1999. Klebsiella pneumoniae with extended spectrum beta-lactamase activity associated with a necrotizing enterocolitis outbreak. Pediatr. Infect. Dis. J. 18:963967.
66. Grimont, F.,, P. A. D. Grimont,, and C. Richard,. 1991. The genus Klebsiella, p. 27752796. In M. P. Starr,, H. Stolp,, H. G. Trouper,, A. Balows,, and H. G. Schlegel (ed.), The Prokaryotes: a Handbook on Habitats, Isolation, and Identification of Bacteria, 2nd ed. Springer-Verlag, Berlin, Germany.
67. Guarino, A.,, S. Guandalini,, M. Alessio,, F. Gentile,, L. Tarallo,, G. Capano,, M. Migliavacca,, and A. Rubino. 1989. Characteristics and mechanism of action of a heat-stable enterotoxin produced by Klebsiella pneumoniae from infants with secretory diarrhea. Pediatr. Res. 25:514518.
68. Guerin, F.,, C. Le Bouguenec,, J. Gilquin,, F. Haddad,, and F. W. Goldstein. 1998. Bloody diarrhea caused by Klebsiella pneumoniae: a new mechanism of bacterial virulence? Clin. Infect. Dis. 27:648649.
69. Habib, A. G.,, and P. A. Tambyah. 2003. Community-acquired Klebsiella pneumoniae central nervous system infections in adults in Singapore. Eur. J. Clin. Microbiol. Infect. Dis. 22:486488.
70. Hansen, D. S.,, H. M. Aucken,, T. Abiola,, and R. Podschun. 2004. Recommended test panel for differentiation of Klebsiella species on the basis of a trilateral interlaboratory evaluation of 18 biochemical tests. J. Clin. Microbiol. 42: 36653669.
71. Hansen, D. S.,, F. Mestre,, S. Alberti,, S. Hernandez-Alles,, D. Alvarez,, A. Domenech-Sanchez,, J. Gil,, S. Merino,, J. M. Tomas,, and V. J. Benedi. 1999. Klebsiella pneumoniae lipopolysaccharide O typing: revision of prototype strains of O-group distribution among clinical isolates from different sources and countries. J. Clin. Microbiol. 37:5662.
72. Harada, H.,, and H. Ishikawa. 1997. Phylogenetical relationship based on groE genes among phenotypically related Enterobacter, Pantoea, Klebsiella, Serratia and Erwinia species. J. Gen. Appl. Microbiol. 43:355361.
73. Hart, C. A.,, and S. K. Rao. 1999. Donovanosis. J. Med. Microbiol. 48:707709.
74. Hartstein, A. I.,, V. M. Morthland,, J. W. Rouke,, R. Sykes,, and A. L. Rashad. 1993. Plasmid DNA analysis, biotyping, and antimicrobic susceptibility as subtyping tests for Klebsiella pneumoniae and Klebsiella oxytoca. Diagn. Microbiol. Infect. Dis. 16:3541.
75. Hengstler, K. A.,, R. Hammann,, and A.-M. Fahr. 1997. Evaluation of BBL CHROMagar Orientation Medium for detection and presumptive identification of urinary tract pathogens. J. Clin. Microbiol. 35:27732777.
76. Higaki, M.,, T. Chida,, H. Takano,, and R. Nakaya. 1990. Cytotoxic component(s) of Klebsiella oxytoca on HEp-2 cells. Microbiol. Immunol. 34:147151.
77. Ho, P. L.,, W. M. Tang,, and K. Y. Yuen. 2000. Klebsiella pneumoniae necrotizing fasciitis associated with diabetes and liver cirrhosis. Clin. Infect. Dis. 30:989990.
78. Hohl, P.,, J. Luthy-Hottenstein,, J. Zollinger-Iten,, and M. Altwegg. 1990. In vitro activities of fleroxacin, cefetamet, ciproloxacin, ceftriaxone, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against rare members of the family Enterobacteriaceae primarily of human (clinical) origin. Antimicrob. Agents Chemother. 34:16051608.
79. Holmes, B.,, M. Costas,, M. Ganner,, S. L. W. On,, and M. Stevens. 1994. Evaluation of Biolog System for identification of some gram-negative bacteria of clinical importance. J. Clin. Microbiol. 32:19701975.
80. Ichpujani, R. L.,, R. Bhatia,, P. Aggarwal,, B. R. Anand,, and A. N. R. Chowdhury. 1983. Klebiocin type and diarrhoeagenicity of Klebsiella pneumoniae. Indian J. Med. Res. 77:605607.
81. Izard, D.,, C. Ferragut,, F. Gavini,, K. Kersters,, J. DeLey,, and H. Leclerc. 1981. Klebsiella terrigena, a new species from soil and water. Int. J. Syst. Bacteriol. 31:116127.
82. Javaloyas, M.,, D. Garcia-Somoza,, and F. Gudiol. 2002. Epidemiology and prognosis of bacteremia: a 10-y study in a community hospital. Scand. J. Infect. Dis. 34:436441.
83. Jonas, D.,, B. Spitzmuller,, F. D. Daschner,, J. Verhoef,, and S. Brisse. 2004. Discrimination of Klebsiella pneumoniae and Klebsiella oxytoca phylogenetic groups and other Klebsiella species by use of amplified fragment length polymorphism. Res. Microbiol. 155:1723.
84. Jones, R. N.,, D. J. Biedenbach,, and A. C. Gales. 2003. Sustained activity and spectrum of selected extended-spectrum β-lactams (carbapenems and cefepime) against Enterobacter spp. and ESBL-producing Klebsiella spp.: report from the SENTRY antimicrobial surveillance program (USA, 1997-2000). Int. J. Antimicrob. Agents 21:17.
85. Jones, R. N.,, K. C. Kugler,, M. A. Pfaller,, P. L. Winokur, and the SENTRY Surveillance Group, North America. 1999. Characteristics of pathogens causing urinary tract infections in hospitals in North America: results from the SENTRY antimicrobial surveillance program, 1997. Diagn. Microbiol. Infect. Dis. 35:5563.
86. Jones, R. N.,, M. A. Pfaller,, S. D. Allen,, E. H. Gerlack,, P. C. Fuchs,, and K. E. Alderidge. 1991. Antimicrobial activity of cefpirome: an update compared to five third-generation cepahlosporins against nearly 6000 recent clinical isolates from five medical centers. Diagn. Microbiol. Infect. Dis. 14:361364.
87. Jossart, M.-F.,, and R. J. Courcol. 1999. Evaluation of an automated system for identification of Enterobacteriaceae and nonfermenting bacilli. Eur. J. Clin. Microbiol. Infect. Dis. 18:902907.
88. Karlowsky, J. A.,, M. E. Jones,, D. C. Mayfield,, C. Thornsberry,, and D. F. Sahm. 2002. Cetriaxone activity against gram-positive and gram-negative pathogens isolated in US clinical microbiology laboratories from 1996 to 2000: results from the Surveillance Network (TSN). Int. J. Antimicrob. Agents 19:413426.
89. Karlowsky, J. A.,, M. E. Jones,, C. Thornsberry,, I. R. Friedland,, and D. F. Sahm. 2003. Trends in antimicrobial susceptibilities among Enterobacteriaceae isolated from hospitalized patients in the United States from 1998 to 2001. Antimicrob. Agents Chemother. 47:16721680.
90. Karpas, C. M.,, and I. Boman. 1966. The significance of Klebsiella enteritis. Am. J. Clin. Pathol. 46:632640.
91. Kim, B. N.,, J. Ryu,, Y. S. Kim,, and J. H. Woo. 2002. Retrospective analysis of clinical and microbiological aspects of Klebsiella oxytoca bacteremia over a 10-year period. Eur. J. Clin. Microbiol. Infect. Dis. 21:419426.
92. Kitch, T. T.,, M. R. Jacobs,, and P. C. Appelbaum. 1994. Evaluation of RapID onE System for identification of 379 strains in the family Enterobacteriaceae and oxidase-negative gram-egative nonfermenters. J. Clin. Microbiol. 32:931934.
93. Klipstein, F. A.,, and R. F. Engert. 1976. Purification and properties of Klebsiella pneumoniae heat-stable toxin. Infect. Immun. 13:373381.
94. Ko, W.-C.,, D. L. Paterson,, A. J. Sagnimeni,, D. S. Hansen,, A. Von Gottberg,, S. Mohapatra,, J. M. Casella,, H. Goossens,, L. Mulazimoglu,, G. Trenholme,, K. P. Klugman,, J. G. McCormack,, and V. L. Yu. 2002. Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg. Infect. Dis. 8:160166.
95. Koo, F. C. W.,, and M. D. Stein. 1986. Detection of an extracellular toxin produced by burn isolates of Klebsiella pneumoniae Curr. Microbiol. 13:2327.
96. Korvick, J. A.,, C. S. Bryan,, B. Farber,, T. R. Beam, Jr.,, L. Schenfeld,, R. R. Muder,, D. Weinbaum,, R. Lumish,, and D. N. Gerding. 1992. Prospective observational study of Klebsiella bacteremia in 230 patients: outcome for antibiotic combinations versus monotherapy. Antimicrob. Agents Chemother. 36:26392644.
97. Kovtunovych, G.,, T. Lytvynenko,, V. Negrutska,, O. Lar,, S. Brisse,, and N. Kozyrovska. 2003. Identification of Klebsiella oxytoca using a specific PCR assay targeting the polygalaturonase pehX gene. Res. Microbiol. 154:587592.
98. Krasilnikov, A. P.,, N. A. Izraitel,, and I. A. Krylov. 1971. Focal incidence of scleroma. J. Hyg. Epidemiol. Microbiol. Immunol. 15:243257.
99. Krontal, S.,, E. Leibovitz,, M. Greenwald-Maimon,, D. Fraser,, and R. Dagan. 2002. Klebsiella bacteremia in children in southern Israel (1988-1997). Infection 30:125131.
100. Kuo, C.-H.,, C.-S. Changchien,, J.-J. Chen,, D.-I. Tai,, S.-S. Chiou,, and C.-M. Lee. 1995. Septic acute cholecystitis. Scand. J. Gastroenterol. 30:272275.
101. Kuzina, L. V.,, J. L. Peloquin,, D. C. Vacek,, and T. A. Miller. 2001. Isolation and identification of bacteria associated with adult laboratory Mexican fruit flies, Anastrepha ludens (Diptera: Tephritidae). Curr. Microbiol. 42:290294.
102. Lau, Y.-J.,, B.-S. Hu,, W.-L. Wu,, Y.-H. Lin,, H.-Y. Chang,, and Z.-Y. Shi. 2000. Identification of a major cluster of Klebsiella pneumoniae isolates from patients with liver abscess in Taiwan. J. Clin. Microbiol. 38:412414.
103. Lee, P.-Y.,, W.-N. Chang,, C.-H. Lu,, M.-W. Lin,, B.-C. Cheng,, C.-C. Chien,, C.-J. Chang,, and H.-W. Chang. 2003. Clinical feature and in vitro antimicrobial susceptibilities of community-acquired Klebsiella pneumoniae meningitis in Taiwan. J. Antimicrob. Chemother. 51:957962.
104. Lee, T. Y.,, S. F. Ko,, Y. F. Cheng,, Y. L. Wang,, and W. Y. Chen. 1995. Primary gas-containing mediastinal abscess in a diabetic patient. Am. J. Emerg. Med. 13:427429.
105. Leverstein-Hall, M. A.,, A. C. Fluit,, A. Paauw,, A. T. A. Box,, S. Brisse,, and J. Verhoef. 2002. Evaluation of the Etest ESBL and the BD Phoenix, VITEK 1, and VITEK 2 automated instruments for detection of extended-spectrum beta-lactamases in multiresistant Escherichia coli and Klebsiella spp. J. Clin. Microbiol. 40:37033711.
106. Li, X.,, D. Zhang,, F. Chen,, J. Ma,, Y. Dong,, and L. Zhang. 2004. Klebsiella singaporensis sp. nov., a novel isomaltuloseproducing bacterium. Int. J. Syst. Evol. Microbiol. 54: 21312136.
107. Liliang, P.-C.,, Y.-C. Lin,, T.-M. Su,, C.-S. Rau,, C.-H. Lu,, W.-N. Chang,, T.-C. Lee,, and H.-J. Chen. 2001. Klebsiella brain abscess in adults. Infection 29:8186.
108. Ling, T. K. W.,, P. C. Tam,, Z. K. Liu,, and A. F. B. Cheng. 2001. Evaluation of VITEK 2 rapid identification and susceptibility testing system against gram-negative clinical isolates. J. Clin. Microbiol. 39:29642966.
109. Livrelli, V.,, C. De Champs,, P. Di Martino,, A. Darfeuille- Michaud,, C. Forestier,, and B. Joly. 1996. Adhesive properties and antibiotic resistance of Klebsiella, Enterobacter, and Serratia clinical isolates involved in nosocomial infections. J. Clin. Microbiol. 34:19631969.
110. Lucet, J. C.,, S. Chevret,, D. Decre,, D. Vanjak,, A. Macrez,, J. P. Bedos,, M. Wolff,, and B. Regnier. 1996. Outbreak of multiply resistant Enterobacteriaceae in an intensive care unit: epidemiology and risk factors for acquistion. Clin. Infect. Dis. 22:430436.
111. Maloway, M. S.,, B. Chester,, and L. Allerhand. 1972. Isolation and microbiologic differentiation of Klebsiella rhinoscleromatis and Klebsiella ozaenae in cases of chronic rhinitis. Am. J. Clin. Pathol. 58:550553.
112. Mayhall, C. G. 2003. The epidemiology of burn wound infections: then and now. Clin. Infect. Dis. 37:543550.
113. McIver, C. J.,, and J. W. Tapsall. 1990. Assessment of conventional and commercial methods for identification of clinical isolates of cysteine-requiring strains of Escherichia coli and Klebsiella species. J. Clin. Microbiol. 28:19471951.
114. McIver, C. J.,, and J. W. Tapsall. 1993. Further studies of clinical isolates of cysteine-requiring Escherichia coli and Klebsiella and possible mechanisms for their selection in vivo. J. Med. Microbiol. 39:382387.
115. Merino, S.,, S. Camprubi,, V. Benedi,, and J. M. Tomas. 1992. Mechanisms of Klebsiella pneumoniae resistance to complement-mediated killing. Infect. Immun. 60:25292535.
116. Minami, J.,, S. Katayama,, O. Matsushita,, H. Sakamoto,, and A. Okabe. 1994. Enterotoxic activity of Klebsiella oxytoca cytotoxin in rabbit intestinal loops. Infect. Immun. 62:172177.
117. Minami, J.,, A. Okabe,, J. Shiode,, and H. Hayashi. 1989. Production of a unique cytotoxin by Klebsiella pneumoniae. Microb. Pathog. 7:203211.
118. Minami, J.,, S. Saito,, T. Yoshida,, T. Uemara,, and A. Okabe. 1992. Biological activities and chemical composition of a cytotoxin of Klebsiella oxytoca. J. Gen. Microbiol. 138:19211927.
119. Monnet, D.,, and J. Freney. 1994. Method for differentiating Klebsiella planticola and Klebsiella terrigena from other Klebsiella species. J. Clin. Microbiol. 32:11211122.
120. Montgomerie, J. Z. 1979. Epidemiology of Klebsiella and hospital-associated infections. Rev. Infect. Dis. 1:736753.
121. Montgomerie, J. Z.,, and J. K. Ota. 1980. Klebsiella bacteremia. Arch. Intern. Med. 140:525527.
122. Murray, K. A.,, B. H. Clements,, and S. E. Keas. 1981. Klebsiella ozaenae septicemia associated with Hansen’s disease. J. Clin. Microbiol. 14:703705.
123. Naemura, L. G.,, S. T. Bagley,, R. J. Seidler,, and J. B. Kaper. 1979. Numerical taxonomy of Klebsiella pneumoniae strain isolated from clinical and nonclinical sources. Curr. Microbiol. 2:175180.
124. Nassif, X.,, J. Fournier,, J. Arondel,, and P. J. Sansonetti. 1989. Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor. Infect. Immun. 57:546552.
125. Nassif, X.,, and P. J. Sansonetti. 1986. Correlation of the virulence of Klebsiella pneumoniae K1 and K2 with the presence of plasmid encoding aerobactin. Infect. Immun. 54:603608.
126.National Committee for Clinical Laboratory Standards. 2002. Performance Standards for Antimicrobial Susceptibility Testing; Twelfth Informational Supplement. NCCLS document M100-S12. National Committee for Clinical Laboratory Standards, Wayne, Pa.
127. Nicolle, L. E. 2001. Urinary tract pathogens in complicated infection and in elderly individuals. J. Infect. Dis. 183(Suppl. 1):S5S8.
128. Nordmann, P. 1998. Trends in β-lactam resistance among Enterobacteriaceae. Clin. Infect. Dis. 27(Suppl. 1):S100S106.
129. Novak, S. S.,, and R. A. Seigel. 1986. Gram-negative septicemia in American alligators (Alligator mississippiensis). J. Wildl. Dis. 22:484487.
130. O’Hara, C. M.,, and J. M. Miller. 2000. Evaluation of the MicroScan Rapid Neg ID3 Panel for identification of Enterobacteriaceae and some common gram-negative nonfermenters. J. Clin. Microbiol. 38:35773580.
131. O’Hara, C. M.,, and J. M. Miller. 2003. Evaluation of the Vitek 2 ID-GNB Assay for identification of members of the family Enterobacteriaceae and other nonenteric gram-negative bacilli and comparison with the Vitek GNI+ Card. J. Clin. Microbiol. 41:20962101.
132. O’Hara, C. M.,, G. L. Westbrook,, and J. M. Miller. 1997. Evaluation of Vitek GNI+ and Becton Dickinson Microbiology Systems Crystal E/NF Identification Systems for identification of members of the family Enterobacteriaceae and other gram-negative, glucose-fermenting and non-glucose-fermenting bacilli. J. Clin. Microbiol. 35:32693273.
133. Olarte, J.,, W. W. Ferguson,, N. D. Henderson,, and L. Torregrosa. 1961. Klebsiella strains isolated from diarrheal infants. Am. J. Dis. Child. 101:763770.
134. Oliver, J. M.,, E. D. Dorval,, J. Loulergue,, Y. Bacq,, G. Duval,, and E. H. Metman. 1991. Klebsiella oxytoca and antibiotic-associated non-pseudomembranous colitis. Gastroenterology 100:A605.
135. Ørskov, I., 1984. Genus V. Klebsiella Trevisan 1885, 105AL, p. 461465. In N. R. Krieg, and J. G. Holt (ed.), Bergey’s Manual of Systematic Bacteriology, vol. 1. Williams & Wilkins, Baltimore, Md.
136. Ørskov, I.,, and M. A. Fife-Asbury. 1977. New Klebsiella capsular antigen, K82, and the deletion of five of those previously assigned. Int. J. Syst. Bacteriol. 27:386387.
137. Österblad, M.,, O. Pensala,, M. Peterzéns,, H. Helenius,, and P. Huovinen. 1999. Antimicrobial susceptibility of Enterobacteriaceae isolated from vegetables. J. Antimicrob. Chemother. 43:503509.
138. Paterson, D. L.,, W.-C. Ko,, A. Von Gottberg,, S. Mohapatra,, J. M. Casellas,, H. Goossens,, L. Mulazimoglu,, G. Trenholme,, K. P. Klugman,, R. A. Bonomo,, L. B. Rice,, M. M. Wagener,, J. G. McCormack,, and V. L. Yu. 2004. International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum β -lactamase production in nosocomial infections. Ann. Intern. Med. 140:2632.
139. Paul, C.,, G. Pialoux,, B. Dupont. J. Fleury, G. Gonzalez-Canali, M. Eliaszewicz, P. Sansonetti, and T. Genereau. 1993. Infection due to Klebsiella rhinoscleromatis in two patients infected with immunodeficiency virus. Clin. Infect. Dis. 16:441442.
140. Peele, D.,, J. Bradfield,, W. Pryor,, and S. Vore. 1997. Comparison of identifications of human and animal source gramnegative bacteria by API 20E and Crystal E/NF systems. J. Clin. Microbiol. 35:213216.
141. Penner, C.,, B. Maycher,, and R. Long. 1994. Pulmonary gangrene a complication of bacterial pneumonia. Chest 105:567573.
142. Pfaller, M. A.,, R. N. Jones,, D. J. Biedenbach, and the MYSTIC Program Study Group (USA). 2001. Antimicrobial resistance trends in medical centers using carbapenems: report of 1999 and 2000 results from the MYSTIC Program (USA). Diagn. Microbiol. Infect. Dis. 41:177182.
143. Picard, E.,, D. Gillis,, L. Klapholz,, L. Schreiber,, and D. Engelhard. 1994. Toxic epidermal necrolysis associated with Klebsiella pneumoniae. Pedriatr. Dermatol. 11:331334.
144. Podschun, R. 1991. Isolation of K. terrigena from human feces: biochemical reactions, capsule types, and antibiotic sensitivity. Zentralbl. Bakteriol. 275:7378.
145. Podschun, R.,, H. Acktun,, J. Okpara,, O. Linderkamp,, U. Ullmann,, and M. Borneff-Lipp. 1998. Isolation of Klebsiella planticola from newborns in a neonatal ward. J. Clin. Microbiol. 36:23312332.
146. Podschun, R.,, and U. Ullmann. 1992. Isolation of Klebsiella terrigena from clinical specimens. Eur. J. Clin. Microbiol. Infect. Dis. 11:349352.
147. Podschun, R.,, and U. Ullmann. 1994. Incidence of Klebsiella planticola among clinical Klebsiella isolates. Med. Microbiol. Lett. 3:9095.
148. Podschun, R.,, and U. Ullmann. 1998. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin. Microbiol. Rev. 11:589603.
149. Podschun, R.,, D. Sievers,, A. Fischer,, and U. Ullmann. 1993. Serotypes, hemagglutinins, siderophore synthesis, and serum resistance of Klebsiella isolates causing urinary tract infections. J. Infect. Dis. 168:14151421.
150. Prodinger, W. M.,, M. Fille,, A. Bauernfeind,, S. Stemplinger,, S. Amann,, B. Pfausler,, C. Las-Florl,, and M. P. Dierich. 1996. Molecular epidemiology of Klebsiella pneumoniae producing SHV-5 β -lactamase: parallel outbreaks due to multiple plasmid transfer. J. Clin. Microbiol. 34:564568.
151. Pruzzo, C.,, and G. Satta. 1988. Capsular antigenic variations by lysogenic conversion in Klebsiella pneumoniae: relationship with virulence. Curr. Microbiol. 16:259263.
152.Public Health Laboratory Service. 2002. Klebsiella spp, Enterobacter spp, Serratia spp, and Citrobacter spp from bacteraemias, England and Wales 2001. Commun. Dis. Rep. CDR Wkly. [Online.] http://www.hpa.org.uk/cdr/PDFfiles/2002/cdr2002.pdf.
153. Quentin, C.,, C. Arpin,, V. Dubois,, C. Andre,, I. Lagrange,, I. Fischer,, J.-P. Brochet,, F. Grobost,, J. Jullin,, B. Dutilh,, G. Larribet,, and P. Noury. 2004. Antibiotic resistance rates and phenotypes among isolates of Enterobacteriaceae in French extra-hospital practice. Eur. J. Clin. Microbiol. Infect. Dis. 23:185193.
154. Rahimian, J.,, T. Wilson,, V. Oram,, and R. S. Holzman. 2004. Pyogenic liver abscess: recent trends in etiology and mortality. Clin. Infect. Dis. 39:16541659.
155. Rau, C.-S.,, W.-N. Chang,, Y.-C. Lin,, C.-H. Lu,, P.-C. Liliang,, T.-M. Su,, Y.-D. Tsai,, C.-J. Chang,, P.-Y. Lee,, M.-W. Lin,, and B.-C. Cheng. 2002. Brain abscess caused by aerobic gramnegative bacilli: clinical features and therapeutic outcomes. Clin. Neurol. Neurosurg. 105:6065.
156. Ritter, M. S.,, H. Mroch,, and M. J. Burns. 1993. Soaring suppurative sea shells from the sea shore: Pseudomonas aeruginosa and Klebsiella pneumoniae septic arthritis after a marine sea shell injury. Pediatr. Emerg. Care 9:289291.
157. Ronald, A. 2002. The etiology of urinary tract infection: traditional and emerging pathogens. Am. J. Med. 113(Suppl. 1A):14S19S.
158. Rosenblueth, M.,, L. Martinez,, J. Silva,, and E. Martinez- Romero. 2004. Klebsiella variicola, a novel species with clinical and plant-associated isolates. System. Appl. Microbiol. 27:2735.
159. Saccente, M. 1999. Klebsiella pneumoniae liver abscess, endophthalmitis, and meningitis in a man with newly recognized diabetes mellitus. Clin. Infect. Dis. 29:15701571.
160. Sahly, H.,, R. Podschun,, T. A. Oelschlaeger,, M. Greiwe,, H. Parolis,, D. Hasty,, J. Kekow,, U. Ullmann,, I. Ofek,, and S. Sela. 2000. Capsule impedes adhesion to and invasion of epithelial cells by Klebsiella pneumoniae. Infect. Immun. 68:67446749.
161. Sakazaki, R.,, K. Tamura,, Y. Kosako,, and E. Yoshizaki. 1989. Klebsiella ornithinolytica sp. nov., formerly known as ornithine-positive Klebsiella oxytoca. Curr. Microbiol. 18:201206.
162. Sanders, C. C.,, A. F. Ehrhardt,, E. S. Moland,, K. S. Thomson,, B. Zimmer,, and D. E. Roe. 2002. β lasEN: microdilution panel for identifying β -lactamases present in isolates of Enterobacteriaceae. J. Clin. Microbiol. 40:123127.
163. Sanguinetti, M.,, B. Posteraro,, T. Spanu,, D. Ciccaglione,, L. Romano,, B. Fiori,, G. Nicoletti,, S. Zanetti,, and G. Fadda. 2003. Characterization of clinical isolates of Enterobacteriaceae from Italy by the BD Phoenix extended-spectrum β -lactamase detection method. J. Clin. Microbiol. 41:14631468.
164. Saurina, G.,, J. M. Quale,, V. M. Manikal,, E. Oydna,, and D. Landman. 2000. Antimicrobial resistance in Enterobacteriaceae in Brooklyn, NY: epidemiology and relation to antibiotic usage patterns. J. Antimicrob. Chemother. 45:895898.
165. Schaberg, D. R.,, D. H. Culver,, and R. P. Gaynes. 1991. Major trends in the microbial etiology of nosocomial infection. Am. J. Med. 91(Suppl. 3B):72S74S.
166. Silvanose, C. D.,, T. A. Bailey,, J. L. Naldo,, and J. C. Howlett. 2001. Bacterial flora of the conjunctiva and nasal cavity in normal and diseased captive bustards. Avian Dis. 45:447451.
167. Simoons-Smit, A. M.,, A. M. J. J. Verweij-Van Vaught,, and D. M. Maclaren. 1986. The role of K antigens as virulence factors in Klebsiella. J. Med. Microbiol. 21:133137.
168. Smith, S. M.,, J. T. Digori,, and R. H. K. Eng. 1982. Epidemiology of Klebsiella antibiotic resistance and serotypes. J. Clin. Microbiol. 16:868873.
169. Spanu, T.,, F. Luzzaro,, M. Perilli,, G. Amicosante,, A. Toniolo,, G. Fadda, and the Italian ESBL Study Group. 2002. Occurrence of extended-spectrum β -lactamases in members of the family Enterobacteriaceae in Italy: implications for resistance to β -lactams and other antimicrobial drugs. Antimicrob. Agents Chemother. 46:196202.
170. Stamm, W. E.,, and T. M. Hooton. 1993. Management of urinary tract infections in adults. N. Engl. J. Med. 329:13281334.
171. Steward, C. D.,, J. M. Mohammed,, J. A. Swenson,, S. A. Stocker,, P. P. Williams,, R. P. Gaynes,, J. E. McGowan, Jr.,, and F. Tenover. 2003. Antimicrobial susceptibility testing of carbapenems: multicenter validity testing and accuracy levels of five antimicrobial test methods detecting resistance in Enterobacteriaceae and Pseudomonas aeruginosa isolates. J. Clin. Microbiol. 41:351358.
172. Strampfer, M. J.,, P. E. Schoch,, and B. A. Cunha. 1987. Cerebral abscess by Klebsiella ozaenae. J. Clin. Microbiol. 25:15531554.
173. Stratton, C. W. 1984. Klebsiella. Infect. Control 5:343347.
174. Struve, C.,, and K. A. Krogfelt. 2004. Pathogenic potential of environmental Klebsiella pneumonie isolates. Environ. Microbiol. 6:584590.
175. Sugawara, Y.,, O. Sato,, T. Miyata,, H. Kimura,, M. Yamaoka,, H. Uozaki,, T. Oka,, and M. Makuuchi. 1997. Ruptured abdominal aorta secondary to psoas muscle abscess due to Klebsiella pneumoniae in an alcoholic. J. Infect. 35:185188.
176. Szabo, D.,, Z. Filetoth,, J. Szentandrassy,, M. Nemedi,, E. Toth,, C. Jeney,, G. Kispal,, and F. Rozgony. 1999. Molecular epidemiology of a cluster of cases due to Klebsiella pneumoniae producing SHV-5 extended-spectrum β -lactamase in the premature intensive care unit of a Hungarian hospital. J. Clin. Microbiol. 37:41674169.
177. Talan, D. A.,, F. M. Abrahamian,, G. J. Moran,, D. M. Citron,, J. O. Tan,, and E. J. C. Goldstein, for the Emergency Medicine Human Bite Infection Study Group. 2003. Clinical presentation and bacteriologic analysis of infected human bites in patients presenting to emergency departments. Clin. Infect. Dis. 37:14811489.
178. Tang, L.,, and S. Chen. 1994. Klebsiella pneumoniae meningitis: prognostic factors. Scand. J. Infect. Dis. 26:95102.
179. Tang, L.,, and S. Chen. 1994. Klebsiella ozaenae meningitis: report of two cases and review of the literature. Infection 22:5861.
180. Tarkkanen, A.,, B. L. Allen,, P. H. Williams,, M. Kauppi,, K. Haahtela,, A. Siitonen,, I. Orskov,, F. Orskov,, and S. Clegg. 1992. Fimbriation, capsulation, and iron-scavenging systems of Klebsiella strains associated with human urinary tract infection. Infect. Immun. 60:11871192.
181. Tenover, F. C.,, M. J. Mohammed,, T. S. Gorton,, and Z. F. Dembek. 1999. Detection and reporting of organisms producing extended-spectrum β -lactamases: survey of laboratories in Connecticut. J. Clin. Microbiol. 37:40654070.
182. Thi, P. L. N.,, S. Yassibanda,, A. Aidara,, C. Le Bouguenec,, and Y. Germani. 2003. Enteropathogenic Klebsiella pneumoniae HIV-infected adults, Africa. Emerg. Infect. Dis. 9:135137.
183. Thom, B. T. 1970. Klebsiella in feces. Lancet ii:1033.
184. Thomson, K. S.,, C. C. Sanders,, and E. S. Moland. 1999. Use of microdilution with and without β -lactamase inhibitors as a phenotypic test for β -lactamase production among Escherichia coli, Klebsiella spp., Enterobacter spp., Citrobacter freundii, and Serratia marcescens. Antimicrob. Agents Chemother. 43:13931400.
185. Thornsberry, C. 1994. Susceptibility of clinical bacterial isolates to ciprofloxacin in the United States.Infection 22(Suppl.):S80S89.
186. Thornton, S. M.,, S. Nolan,, and F. M. D. Gulland. 1998. Bacterial isolates from California sea lions (Zalophus californianus), harbor seals (Phoca vitulina), and northern elephant seals (Mirounga angustirostris) admitted to a rehabilitation center along the central California coast, 1994-1995. J. Zoo Wildl. Med. 29:171179.
187. Trautman, M.,, A. S. Cross,, G. Reich,, H. Held,, R. Podschun,, and R. Marre. 1996. Evaluation of a competitive ELISA method for the determination of Klebsiella O antigens. J. Med. Microbiol. 44:4451.
188. Trotter, J. F.,, and W. L. Peterson. 1992. Injection sclerotherapy as a cause of Klebsiella pneumoniae peritonitis. J. Clin. Gastroenterol. 15:329331.
189. Vernet, V.,, A. Philippon,, C. Madoulet,, R. Vistelle,, R. Jaussaud,, and C. Chippaux. 1995. Virulence factors (aerobactin and mucoid phenotype) in Klebsiella pneumoniae and Escherichia coli blood culture isolates. FEMS Microbiol. Lett. 130:5157.
190. Wang, H.,, S. Kelkar,, W. Wu,, M. Chen,, and J. P. Quinn. 2003. Clinical isolates of Enterobacteriaceae producing extended-spectrum β -lactamases: prevalence of CTX-M-3 at a hospital in China. Antimicrob. Agents Chemother. 47:790793.
191. Wang, J.-H.,, Y.-C. Liu,, S. S.-J. Lee,, M.-Y. Yen,, Y.-S. Chen,, J.-H. Wang,, S.-R. Wann,, and H.-H. Lin. 1998. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin. Infect. Dis. 26:14341438.
192. Wang, T. K. F.,, S. S. Y. Wong,, and P. C. Y. Woo. 2001. Two cases of pyomyositis caused by Klebsiella pneumoniae and review of the literature. Eur. J. Clin. Microbiol. Infect. Dis. 20:576580.
193. Wauters, G.,, A. Boel,, G. P. Voorn,, J. Verhaegen,, F. Meunier,, M. Janssens,, and L. Verbist. 1995. Evaluation of a new identification system, Crystal Enteric/Non-fermenter, for gramnegative bacilli. J. Clin. Microbiol. 33:845849.
194. Westbrook, G. L.,, C. M. O’Hara,, S. B. Roman,, and J. M. Miller. 2000. Incidence and identification of Klebsiella planticola in clinical isolates with emphasis on newborns. J. Clin. Microbiol. 38:14951497.
195. Williams, P.,, P. A. Lambert,, and M. R. W. Brown. 1988. Penetration of immunoglobulins through the Klebsiella capsule and their effect on cell-surface hydrophobicity. J. Med. Microbiol. 26:2935.
196. Wisplinghoff, H.,, T. Bischoff,, S. M. Tallent,, H. Seifert,, R. P. Wenzel,, and M. B. Edmond. 2004. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis. 39:309317.
197. Woodward, B. W.,, M. Carter,, and R. J. Seidler. 1979. Most nonclinical Klebsiella strains are not K. pneumoniae sensu stricto. Curr. Microbiol. 2:181185.
198. Yang, C.-C.,, C.-H. Yen,, M.-W. Ho,, and J.-H. Wang. 2004. Comparison of pyogenic liver abscess caused by non-Klebsiella pneumoniae and Klebsiella pneumoniae. J. Microbiol. Immunol. Infect. 37:176184.


Generic image for table
Table 1

Members of the genera and

Citation: Janda J, Abbott S. 2006. The Genera Klebsiella and Raoultella, p 115-136. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch9
Generic image for table
Table 2

Identification of and species by commercial systems

Citation: Janda J, Abbott S. 2006. The Genera Klebsiella and Raoultella, p 115-136. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch9
Generic image for table
Table 3

Potential virulence factors of species

Citation: Janda J, Abbott S. 2006. The Genera Klebsiella and Raoultella, p 115-136. In The Enterobacteria, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817541.ch9

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