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Chapter 25 : Progress in Development of a Vaccine to Aid Malaria Control

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Abstract:

The resurgence of malaria morbidity and mortality underlines the failure of hopes for the eradication of malaria of the middle part of the 20th century. By the 1950s, control measures based on chemotherapy with chloroquine and use of dichlorodiphenyltrichloroethane (DDT) had reduced the disease burden of malaria so substantially that many policymakers believed the task of malaria control was close to being completed. DNA sequences from parasites can be delivered as DNA molecules (DNA vaccines) or various recombinant attenuated DNA viruses to generate candidate DNA-based vaccines. There is an unimaginably large number of possible malaria constructs for inclusion in a malaria vaccine. In general, recombinant protein-based platforms are chosen where antibody induction is thought to be the most important effector mechanism. Adjuvants are chemicals which, when administered in combination with an antigen, augment the immune response to the antigen. All vaccines, including malaria vaccines, are evaluated in animal models to assess their safety and immunogenicity. For a vaccine to have any public health impact it must be licensed, manufactured, promoted, and distributed. Once a vaccine that prevents clinical disease is licensed by a regulatory authority, it may yet be many years before the vaccine is added to local immunization programs in countries where malaria is endemic. Inclusion of sexual-stage vaccine components in multistage vaccines is theoretically attractive.

Citation: Moorthy V, Dubovsky F. 2005. Progress in Development of a Vaccine to Aid Malaria Control, p 480-498. In Sherman I (ed), Molecular Approaches to Malaria. ASM Press, Washington, DC. doi: 10.1128/9781555817558.ch25
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1. Acosta, C. J.,, C.M. Galindo,, D. Schellenberg,, J. J. Aponte,, E. Kahigwa,, H. Urassa,, J. R. Schellenberg,, H. Masanja,, R. Hayes,, A. Y. Kitua,, F. Lwilla,, H. Mshinda,, C. Menendez,, M. Tanner,, and P. L. Alonso. 1999. Evaluation of the SPf66 vaccine for malaria control when delivered through the EPI scheme in Tanzania. Trop. Med. Int. Health 4: 368 376.
2. Aikawa, M.,, C. T. Atkinson,, L. M. Beaudoin,, M. Sedegah,, Y. Charoenvit,, and R. Beaudoin. 1990. Localization of CS and non-CS antigens in the sporogonic stages of Plasmodium yoelii. Bull.W. H. O. 68(Suppl.): 165 171.
3. Alloueche, A.,, P. Milligan,, D. J. Conway,, M. Pinder,, K. Bojang,, T. Doherty,, N. Tornieporth,, J. Cohen,, and B. M. Greenwood. 2003. Protective efficacy of the RTS,S/AS02 Plasmodium falciparum malaria vaccine is not strain specific. Am.J. Trop. Med. Hyg. 68: 97 101.
4. Alonso, P. L.,, T. Smith,, J. R. Schellenberg,, H. Masanja,, S. Mwankusye,, H. Urassa,, I. Bastos de Azevedo,, J. Chongela,, S. Kobero,, C. Menendez, et al. 1994. Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern Tanzania. Lancet 344: 1175 1181.
5. Amara, R. R.,, F. Villinger,, J.D. Altman,, S. L. Lydy,, S. P. O'Neil,, S. I. Staprans,, D. C. Montefiori,, Y. Xu,, J. G. Herndon,, L. S. Wyatt,, M. A. Candido,, N. L. Kozyr,, P. L. Earl,, J. M. Smith,, H. L. Ma,, B.D. Grimm,, M. L. Hulsey,, J. Miller,, H.M. McClure,, J. M. McNicholl,, B. Moss,, and H. L. Robinson. 2001. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/ MVA vaccine. Science 292: 69 74.
6. Anderson, R. J.,, C.M. Hannan,, S.C. Gilbert,, S. M. Laidlaw,, E. G. Sheu,, S. Korten,, R. Sinden,, G. A. Butcher,, M. A. Skinner,, and A.V. Hill. 2004. Enhanced CD8+T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus. J. Immunol. 172: 3094 3100.
7. Badell, E.,, C. Oeuvray,, A. Moreno,, S. Soe,, N. van Rooijen,, A. Bouzidi,, and P. Druilhe. 2000. Human malaria in immunocompromised mice: an in vivo model to study defense mechanisms against Plasmodium falciparum. J. Exp. Med. 192: 1653 1660.
8. Ballou, W. R.,, S. L. Hoffman,, J. A. Sherwood,, M. R. Hollingdale,, F. A. Neva,, W. T. Hockmeyer,, D. M. Gordon,, I. Schneider,, R.A. Wirtz,, and J. F. Young. 1987. Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Lancet i: 1277 1281.
9. Birkett, A.,, K. Lyons,, A. Schmidt,, D. Boyd,, G. A. Oliveira,, A. Siddique,, R. Nussenzweig,, J. M. Calvo-Calle,, and E. Nardin. 2002. A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts. Infect. Immun. 70: 6860 6870.
10. Boisgerault, F.,, G. Moron,, and C. Leclerc. 2002. Virus-like particles: a new family of delivery systems. Expert Rev.Vaccines 1: 101 109.
11. Bojang, K. A.,, P. J. Milligan,, M. Pinder,, L. Vigneron,, A. Alloueche,, K. E. Kester,, W. R. Ballou,, D. J. Conway,, W. H. Reece,, P. Gothard,, L. Yamuah,, M. Delchambre,, G. Voss,, B. M. Greenwood,, A. Hill,, K. P. McAdam,, N. Tornieporth,, J. D. Cohen,, T. Doherty,, H. Silveira,, K. Bojang,, and J. Cohen. 2001. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial. Lancet 358: 1927 1934.
12. Bouharoun-Tayoun, H.,, P. Attanath,, A. Sabchareon,, T. Chongsuphajaisiddhi,, and P. Druilhe. 1990. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J. Exp. Med. 172: 1633 1641.
13. Breman, J. G. 2001. The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. Am. J.Trop. Med. Hyg. 64: 1 11.
14. Brown, A. E.,, P. Singharaj,, H. K. Webster,, J. Pipithkul,, D. M. Gordon,, J.W. Boslego,, K. Krinchai,, P. Su-archawaratana,, C. Wongsrichanalai,, and W. R. Ballou. 1994. Safety, immunogenicity and limited efficacy study of a recombinant Plasmodium falciparum circumsporozoite vaccine in Thai soldiers. Vaccine 12: 102 108.
15. Church, L.W.,, T. P. Le,, J. P. Bryan,, D. M. Gordon,, R. Edelman,, L. Fries,, J. R. Davis,, D. A. Herrington,, D. F. Clyde,, M. J. Shmuklarsky,, I. Schneider,, T. W. McGovern,, J. D. Chulay,, W. R. Ballou,, and S. L. Hoffman. 1997. Clinical manifestations of Plasmodium falciparum malaria experimentally induced by mosquito challenge. J.Infect. Dis. 175: 915 920.
16. Cochrane, A. H.,, R. S. Nussenzweig,, and E. H. Nardin,. 1980. Immunization against sporozoites. In J. P. Kreier (ed.), Malaria, vol. 3. Academic Press, New York,N.Y.
17. Cohen, S.,, I. A. McGregor,, and S. Carrington. 1961. Gamma globulin and acquired immunity to malaria. Nature 192: 733 737.
18. Corr, M.,, D. J. Lee,, D. A. Carson,, and H. Tighe. 1996. Gene vaccination with naked plasmid DNA: mechanism of CTL priming. J.Exp. Med. 184: 1555 1560.
19. Crosnier, J.,, P. Jungers,, A. M. Courouce,, A. Laplanche,, E. Benhamou,, F. Degos,, B. Lacour,, P. Prunet,, Y. Cerisier,, and P. Guesry. 1981. Randomised placebo-controlled trial of hepatitis B surface antigen vaccine in French haemodialysis units: I, medical staff. Lancet i: 455 459.
20. D'Alessandro, U.,, A. Leach,, C. J. Drakeley,, S. Bennett,, B. O. Olaleye,, G.W. Fegan,, M. Jawara,, P. Langerock,, M.O. George,, and G.A. Targett. 1995. Efficacy trial of malaria vaccine SPf66 in Gambian infants. Lancet 346: 462 467.
21. Doolan, D. L.,, J. C. Aguiar,, W. R. Weiss,, A. Sette,, P. L. Felgner,, D. P. Regis,, P. Quinones-Casas,, J. R. Yates III,, P. L. Blair,, T. L. Richie,, S. L. Hoffman,, and D. J. Carucci. 2003. Utilization of genomic sequence information to develop malaria vaccines. J. Exp. Biol. 206: 3789 3802.
22. Edelman, R.,, S. S. Wasserman,, J. G. Kublin,, S. A. Bodison,, E. H. Nardin,, G.A. Oliveira,, S. Ansari,, C. L. Diggs,, O. L. Kashala,, B. J. Schmeckpeper,, and R. G. Hamilton. 2002. Immediate-type hypersensitivity and other clinical reactions in volunteers immunized with a synthetic multi-antigen peptide vaccine (PfCS-MAP1NYU) against Plasmodium falciparum sporozoites. Vaccine 21: 269 280.
23. Evans, J.T.,, C.W. Cluff,, D.A. Johnson,, M. J. Lacy,, D. H. Persing,, and J. R. Baldridge. 2003. Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529. Expert Rev.Vaccines 2: 219 229.
24. Fine, E.,, M. Aikawa,, A. H. Cochrane,, and R. S. Nussenzweig. 1984. Immuno-electron microscopic observations on Plasmodium knowlesi sporozoites: localization of protective antigen and its precursors. Am. J.Trop. Med. Hyg. 33: 220 226.
25. Gardner, M. J.,, N. Hall,, E. Fung,, O. White,, M. Berriman,, R.W. Hyman,, J. M. Carlton,, A. Pain,, K. E. Nelson,, S. Bowman,, I. T. Paulsen,, K. James,, J. A. Eisen,, K. Rutherford,, S. L. Salzberg,, A. Craig,, S. Kyes,, M. S. Chan,, V. Nene,, S. J. Shallom,, B. Suh,, J. Peterson,, S. Angiuoli,, M. Pertea,, J. Allen,, J. Selengut,, D. Haft,, M.W. Mather,, A. B. Vaidya,, D. M. Martin,, A. H. Fairlamb,, M. J. Fraunholz,, D. S. Roos,, S.A. Ralph,, G. I. McFadden,, L. M. Cummings,, G. M. Subramanian,, C. Mungall,, J. C. Venter,, D. J. Carucci,, S. L. Hoffman,, C. Newbold,, R.W. Davis,, C. M. Fraser,, and B. Barrell. 2002. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419: 498 511.
26. Genton, B.,, I. Betuela,, I. Felger,, F. Al-Yaman,, R. F. Anders,, A. Saul,, L. Rare,, M. Baisor,, K. Lorry,, G.V. Brown,, D. Pye,, D. O. Irving,, T. A. Smith,, H. P. Beck,, and M. P. Alpers. 2002. A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea. J. Infect. Dis. 185: 820 827.
27. Gonzalez, C.,, D. Hone,, F. R. Noriega,, C. O. Tacket,, J. R. Davis,, G. Losonsky,, J. P. Nataro,, S. Hoffman,, A. Malik,, E. Nardin, et al. 1994. Salmonella typhi vaccine strain CVD 908 expressing the circumsporozoite protein of Plasmodium falciparum: strain construction and safety and immunogenicity in humans. J. Infect. Dis. 169: 927 931.
28. Good, M. F.,, D. Pombo,, I. A. Quakyi,, E. M. Riley,, R. A. Houghten,, A. Menon,, D.W. Alling,, J. A. Berzofsky,, and L. H. Miller. 1988. Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum:immunodominant T-cell domains map to the polymorphic regions of the molecule. Proc. Natl.Acad. Sci. USA 85: 1199 1203.
29. Greenwood, B.,, and T. Mutabingwa. 2002. Malaria in 2002. Nature 415: 670 672.
30. Guerin, P. J.,, P. Olliaro,, F. Nosten,, P. Druilhe,, R. Laxminarayan,, F. Binka,, W. L. Kilama,, N. Ford,, and N. J. White. 2002. Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development. Lancet Infect. Dis. 2: 564 573.
31. Gurunathan, S.,, D.M. Klinman,, and R.A. Seder. 2000. DNA vaccines:immunology, application, and optimization. Annu. Rev. Immunol. 18: 927 974.
32. Haddad, D.,, E. Bilcikova,, A.A. Witney,, J. M. Carlton,, C. E. White,, P. L. Blair,, R. Chattopadhyay,, J. Russell,, E. Abot,, Y. Charoenvit,, J. C. Aguiar,, D. J. Carucci,, and W. R. Weiss. 2004. Novel antigen identification method for discovery of protective malaria antigens by rapid testing of DNA vaccines encoding exons from the parasite genome. Infect. Immun. 72: 1594 1602.
33. Hay, S. I.,, C. A. Guerra,, A. J. Tatem,, A. M. Noor,, and R.W. Snow. 2004. The global distribution and population at risk of malaria: past, present, and future. Lancet Infect. Dis. 4: 327 336.
34. Herrington, D. A.,, D. F. Clyde,, G. Losonsky,, M. Cortesia,, J. R. Murphy,, J. Davis,, S. Baqar,, A. M. Felix,, E. P. Heimer,, and D. Gillessen. 1987. Safety and immunogenicity in man of a syn-thetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature 328: 257 259.
35. Herrington, D. A.,, G. A. Losonsky,, G. Smith,, F. Volvovitz,, M. Cochran,, K. Jackson,, S. L. Hoffman,, D. M. Gordon,, M. M. Levine,, and R. Edelman. 1992. Safety and immunogenicity in volunteers of a recombinant Plasmodium falciparum circumsporozoite protein malaria vaccine produced in Lepidopteran cells. Vaccine 10: 841 846.
36. Hirunpetcharat, C.,, J. Wipasa,, S. Sakkhachornphop,, T. Nitkumhan,, Y. Z. Zheng,, S. Pichyangkul,, A. M. Krieg,, D. S. Walsh,, D. G. Heppner,, and M. F. Good. 2003. CpG oligodeoxynucleotide enhances immunity against blood-stage malaria infection in mice parenterally immunized with a yeastexpressed 19 kDa carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1. Vaccine 21: 2923 2932.
37. Hoffman, S. L.,, R. Edelman,, J. P. Bryan,, I. Schneider,, J. Davis,, M. Sedegah,, D. Gordon,, P. Church,, M. Gross,, C. Silverman, et al. 1994. Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant. Am. J.Trop. Med. Hyg. 51: 603 612.
38. Hoffman, S. L.,, C. N. Oster,, C.V. Plowe,, G. R. Woollett,, J. C. Beier,, J. D. Chulay,, R. A. Wirtz,, M. R. Hollingdale,, and M. Mugambi. 1987. Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications. Science 237: 639 642.
39. Holder, A.A.,, J.A. Guevara Patino,, C. Uthaipibull,, S. E. Syed,, I. T. Ling,, T. Scott-Finnigan,, and M. J. Blackman. 1999. Merozoite surface protein 1, immune evasion, and vaccines against asexual blood stage malaria. Parassitologia 41: 409 414.
40. John, C. C.,, R.A. O'Donnell,, P.O. Sumba,, A. M. Moormann,, T. F. de Koning-Ward,, C. L. King,, J.W. Kazura,, and B. S. Crabb. 2004. Evidence that invasion-inhibitory antibodies specific for the 19- kDa fragment of merozoite surface protein-1 (MSP- 119) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa. J.Immunol. 173: 666 672.
41. Kaslow, D. C. 2002. Transmission-blocking vaccines. Chem. Immunol. 80: 287 307.
42. Kenney, R.T.,, and R. Edelman. 2003. Survey of human- use adjuvants. Expert Rev.Vaccines 2: 167 188.
43. Kester, K. E.,, D. A. McKinney,, N. Tornieporth,, C. F. Ockenhouse,, D. G. Heppner,, T. Hall,, U. Krzych,, M. Delchambre,, G. Voss,, M. G. Dowler,, J. Palensky,, J. Wittes,, J. Cohen,, and W. R. Ballou. 2001. Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria. J. Infect. Dis. 183: 640 647.
44. Klinman, D. M.,, K. M. Barnhart,, and J. Conover. 1999. CpG motifs as immune adjuvants. Vaccine 17: 19 25.
45. Kocken, C. H.,, H. Ozwara,, A. van der Wel,, A. L. Beetsma,, J. M. Mwenda,, and A.W. Thomas. 2002. Plasmodium knowlesi provides a rapid in vitro and in vivo transfection system that enables doublecrossover gene knockout studies. Infect. Immun. 70: 655 660.
46. Lengeler, C. 2000. Insecticide-treated bednets and curtains for preventing malaria. Cochrane Database Syst. Rev. 2000: CD000363.
47. Li, S.,, M. Rodrigues,, D. Rodriguez,, J. R. Rodriguez,, M. Esteban,, P. Palese,, R. S. Nussenzweig,, and F. Zavala. 1993. Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ Tcell- mediated protective immunity against malaria. Proc. Natl.Acad. Sci. USA 90: 5214 5218.
48. Lopez, J.A.,, C. Weilenman,, R. Audran,, M.A. Roggero,, A. Bonelo,, J. M. Tiercy,, F. Spertini,, and G. Corradin. 2001. A synthetic malaria vaccine elicits a potent CD8(+) and CD4(+)T lymphocyte immune response in humans. Implications for vaccination strategies. Eur. J. Immunol. 31: 1989 1998.
49. Lopez, M. C.,, Y. Silva,, M. C. Thomas,, A. Garcia,, M. J. Faus,, P. Alonso,, F. Martinez,, G. Del Real,, and C. Alonso. 1994. Characterization of SPf(66)n: a chimeric molecule used as a malaria vaccine. Vaccine 12: 585 591.
50. Luke, T.C.,, and S. L. Hoffman. 2003. Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine. J. Exp. Biol. 206: 3803 3808.
51. Mahoney, R.T.,, and J. E. Maynard. 1999. The introduction of new vaccines into developing countries. Vaccine 17: 646 652.
52. Makobongo, M. O.,, G. Riding,, H. Xu,, C. Hirunpetcharat,, D. Keough,, J. de Jersey,, P. Willadsen,, and M. F. Good. 2003. The purine salvage enzyme hypoxanthine guanine xanthine phosphoribosyl transferase is a major target antigen for cell-mediated immunity to malaria. Proc. Natl. Acad. Sci. USA 100: 2628 2633.
53. Marsh, K.,, and R. J. Howard. 1986. Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants. Science 231: 150 153.
54. Massaga, J. J.,, A.Y. Kitua,, M. M. Lemnge,, J. A. Akida,, L. N. Malle,, A. M. Ronn,, T. G. Theander,, and I. C. Bygbjerg. 2003. Effect of intermittent treatment with amodiaquine on anaemia and malarial fevers in infants in Tanzania: a randomised placebo-controlled trial. Lancet 361: 1853 1860.
55. McConkey, S. J.,, W. H. Reece,, V. S. Moorthy,, D. Webster,, S. Dunachie,, G. Butcher,, J. M. 494 Vuola,, T. J. Blanchard,, P. Gothard,, K. Watkins,, C. M. Hannan,, S. Everaere,, K. Brown,, K. E. Kester,, J. Cummings,, J. Williams,, D. G. Heppner,, A. Pathan,, K. Flanagan,, N. Arulanantham,, M.T. Roberts,, M. Roy,, G. L. Smith,, J. Schneider,, T. Peto,, R. E. Sinden,, S. C. Gilbert,, and A.V. Hill. 2003. Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat. Med. 9: 729 735.
56. Menard, R.,, A.A. Sultan,, C. Cortes,, R. Altszuler,, M. R. van Dijk,, C. J. Janse,, A. P. Waters,, R. S. Nussenzweig,, and V. Nussenzweig. 1997. Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes. Nature 385: 336 340.
57. Mitchell, G. H.,, A.W. Thomas,, G. Margos,, A. R. Dluzewski,, and L. H. Bannister. 2004. Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells. Infect. Immun. 72: 154 158.
58. Miyahira, Y.,, A. Garcia-Sastre,, D. Rodriguez,, J. R. Rodriguez,, K. Murata,, M. Tsuji,, P. Palese,, M. Esteban,, F. Zavala,, and R. S. Nussenzweig. 1998. Recombinant viruses expressing a human malaria antigen can elicit potentially protective immune CD8(+) responses in mice. Proc. Natl.Acad. Sci. USA 95: 3954 3959.
59. Moorthy, V. S.,, M. F. Good,, and A.V. Hill. 2004a. Malaria vaccine developments. Lancet 363: 150 156.
60. Moorthy, V. S.,, E. B. Imoukhuede,, S. Keating,, M. Pinder,, D. Webster,, M. A. Skinner,, S. C. Gilbert,, G. Walraven,, and A.V. Hill. 2004b. Phase 1 evaluation of 3 highly immunogenic prime-boost regimens, including a 12-month reboosting vaccination, for malaria vaccination in Gambian men. J. Infect. Dis. 189: 2213 2219.
61. Moorthy, V. S.,, M. Pinder,, W.H. Reece,, K. Watkins,, S. Atabani,, C. Hannan,, K. Bojang,, K. P. McAdam,, J. Schneider,, S. Gilbert,, and A. V. Hill. 2003. Safety and immunogenicity of DNA/ modified vaccinia virus ankara malaria vaccination in African adults. J. Infect. Dis. 188: 1239 1244.
62. Moser, C.,, I. C. Metcalfe,, and J. F. Viret. 2003. Virosomal adjuvanted antigen delivery systems. Expert Rev.Vaccines 2: 189 196.
63. Nardin, E. H.,, J. M. Calvo-Calle,, G. A. Oliveira,, R. S. Nussenzweig,, M. Schneider,, J.M. Tiercy,, L. Loutan,, D. Hochstrasser,, and K. Rose. 2001. A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types. J. Immunol. 166: 481 489.
64. Nardin, E. H.,, G. A. Oliveira,, J. M. Calvo-Calle,, Z. R. Castro,, R. S. Nussenzweig,, B. Schmeckpeper,, B. F. Hall,, C. Diggs,, S. Bodison,, and R. Edelman. 2000. Synthetic malaria peptide vaccine elicits high levels of antibodies in vaccinees of defined HLA genotypes. J. Infect. Dis. 182: 1486 1496.
65. Nosten, F.,, C. Luxemburger,, D. E. Kyle,, W. R. Ballou,, J. Wittes,, E. Wah,, T. Chongsuphajaisiddhi,, D. M. Gordon,, N. J. White,, J. C. Sadoff,, D. G. Heppner, et al. 1996. Randomised doubleblind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand. Lancet 348: 701 707.
66. Ockenhouse, C. F.,, P. F. Sun,, D. E. Lanar,, B. T. Wellde,, B. T. Hall,, K. Kester,, J. A. Stoute,, A. Magill,, U. Krzych,, L. Farley,, R. A. Wirtz,, J. C. Sadoff,, D. C. Kaslow,, S. Kumar,, L.W. Church,, J. M. Crutcher,, B. Wizel,, S. Hoffman,, A. Lalvani,, A.V. Hill,, J. A. Tine,, K. P. Guito,, C. deTaisne,, R. Anders,, W. R. Ballou, et al. 1998. Phase I/IIa safety,immunogenicity, and efficacy trial of NYVAC-Pf 7, a pox-vectored,multiantigen,multistage vaccine candidate for Plasmodium falciparum malaria. J. Infect. Dis. 177: 1664 1673.
67. Oeuvray, C.,, H. Bouharoun-Tayoun,, H. Gras- Masse,, E. Bottius,, T. Kaidoh,, M. Aikawa,, M.C. Filgueira,, A. Tartar,, and P. Druilhe. 1994. Merozoite surface protein-3: a malaria protein inducing antibodies that promote Plasmodium falciparum killing by cooperation with blood monocytes. Blood 84: 1594 1602.
68. Paoletti, E. 1996. Applications of pox virus vectors to vaccination: an update. Proc. Natl. Acad. Sci. USA 93: 11349 11353.
69. Perri, S.,, C. E. Greer,, K. Thudium,, B. Doe,, H. Legg,, H. Liu,, R. E. Romero,, Z. Tang,, Q. Bin,, T.W. Dubensky, Jr.,, M. Vajdy,, G.R. Otten,, and J. M. Polo. 2003. An alphavirus replicon particle chimera derived from Venezuelan equine encephalitis and Sindbis viruses is a potent gene-based vaccine delivery vector. J.Virol. 77: 10394 10403.
70. Phillips-Howard, P. A.,, B. L. Nahlen,, M. S. Kolczak,, A.W. Hightower,, F. O. ter Kuile,, J. A. Alaii,, J. E. Gimnig,, J. Arudo,, J. M. Vulule,, A. Odhacha,, S. P. Kachur,, E. Schoute,, D. H. Rosen,, J.D. Sexton,, A. J. Oloo,, and W.A. Hawley. 2003. Efficacy of permethrin-treated bed nets in the prevention of mortality in young children in an area of high perennial malaria transmission in western Kenya. Am. J.Trop. Med. Hyg. 68: 23 29.
71. Pombo, D. J.,, G. Lawrence,, C. Hirunpetcharat,, C. Rzepczyk,, M. Bryden,, N. Cloonan,, K. Anderson,, Y. Mahakunkijcharoen,, L. B. Martin,, D. Wilson,, S. Elliott,, D. P. Eisen,, J. B. Weinberg,, A. Saul,, and M. F. Good. 2002. Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum. Lancet 360: 610 617.
72. Richie, T. L.,, R. Wang,, Y. Charoenvit,, D. Freilich,, J. E. Epstein,, S. Kumar,, J. Aguiar,, G. Gray,, S. E. Parker,, P. Hobart,, S. Kradjian,, J. A. Norman,, J. Sacci,, T. C. Luke,, S. L. Hoffman, et al. 2001 Safety, immunogenicity and efficacy of MuStDO5, a five gene sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with human GMCSF DNA. Am. J.Trop. Med. Hyg. 65(Suppl.): 230.
73. Rosen, J. B.,, and J. G. Breman. 2004. Malaria intermittent preventive treatment in infants, chemoprophylaxis, and childhood vaccinations. Lancet 363: 1386 1388.
74. Roy, M. J.,, M. S. Wu,, L. J. Barr,, J.T. Fuller,, L. G. Tussey,, S. Speller,, J. Culp,, J. K. Burkholder,, W. F. Swain,, R. M. Dixon,, G. Widera,, R. Vessey,, A. King,, G. Ogg,, A. Gallimore,, J. R. Haynes,, and D. Heydenburg Fuller. 2000. Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particlemediated administration of a hepatitis B virus DNA vaccine. Vaccine 19: 764 778.
75. Sachs, J.,, and P. Malaney. 2002. The economic and social burden of malaria. Nature 415: 680 685.
76. Saul, A.,, G. Lawrence,, A. Smillie,, C.M. Rzepczyk,, C. Reed,, D. Taylor,, K. Anderson,, A. Stowers,, R. Kemp,, A. Allworth,, R. F. Anders,, G. V. Brown,, D. Pye,, P. Schoofs,, D. O. Irving,, S. L. Dyer,, G. C. Woodrow,, W. R. Briggs,, R. Reber,, and D. Sturchler. 1999. Human phase I vaccine trials of 3 recombinant asexual stage malaria antigens with Montanide ISA720 adjuvant. Vaccine 17: 3145 3159.
77. Schellenberg, D.,, C. Menendez,, E. Kahigwa,, J. Aponte,, J. Vidal,, M. Tanner,, H. Mshinda,, and P. Alonso. 2001. Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised, placebo-controlled trial. Lancet 357: 1471 1477.
78. Schneider, J.,, S. C. Gilbert,, T. J. Blanchard,, T. Hanke,, K. J. Robson,, C. M. Hannan,, M. Becker,, R. Sinden,, G. L. Smith,, and A.V. Hill. 1998. Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat. Med. 4: 397 402.
79. Schneider, J.,, S. C. Gilbert,, C. M. Hannan,, P. Degano,, E. Prieur,, E.G. Sheu,, M. Plebanski,, and A.V. Hill. 1999. Induction of CD8+T cells using heterologous prime-boost immunisation strategies. Immunol. Rev. 170: 29 38.
80. Sherwood, J. A.,, C. N. Oster,, M. Adoyo-Adoyo,, J. C. Beier,, G. S. Gachihi,, P. M. Nyakundi,, W. R. Ballou,, A. D. Brandling-Bennett,, I. K. Schwartz,, J. B. Were, et al. 1991. Safety and immunogenicity of a Plasmodium falciparum sporozoite vaccine: boosting of antibody response in a population with prior natural exposure to malaria. Trans. R. Soc.Trop. Med. Hyg. 85: 336 340.
81. Shiver, J.W.,, and E.A. Emini. 2004. Recent advances in the development of HIV-1 vaccines using replication- incompetent adenovirus vectors. Annu. Rev. Med. 55: 355 372.
82. Singh, S.,, M. C. Kennedy,, C.A. Long,, A. J. Saul,, L. H. Miller,, and A. W. Stowers. 2003. Biochemical and immunological characterization of bacterially expressed and refolded Plasmodium falciparum 42-kilodalton C-terminal merozoite surface protein 1. Infect. Immun. 71: 6766 6774.
83. Sinnis, P.,, and E. Nardin. 2002. Sporozoite antigens: biology and immunology of the circumsporozoite protein and thrombospondin-related anonymous protein. Chem. Immunol. 80: 70 96.
84. Snow, R. W.,, M. Craig,, U. Deichmann,, and K. Marsh. 1999. Estimating mortality, morbidity and disability due to malaria among Africa's nonpregnant population. Bull.W. H.O. 77: 624 640.
85. Snow, R.W.,, J. F. Trape,, and K. Marsh. 2001. The past, present and future of childhood malaria mortality in Africa. Trends Parasitol. 17: 593 597.
86. Stewart, M. J.,, and J. P. Vanderberg. 1988. Malaria sporozoites leave behind trails of circumsporozoite protein during gliding motility. J. Protozool. 35: 389 393.
87. Stoute, J.A.,, M. Slaoui,, D.G. Heppner,, P. Momin,, K. E. Kester,, P. Desmons,, B.T. Wellde,, N. Garcon,, U. Krzych,, M. Marchand, et al. 1997. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N. Engl. J. Med. 336: 86 91.
88. Stowers, A. W.,, M. C. Kennedy,, B. P. Keegan,, A. Saul,, C.A. Long,, and L. H. Miller. 2002. Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malaria. Infect. Immun. 70: 6961 6967.
89. Ulmer, J. B.,, J. J. Donnelly,, S. E. Parker,, G. H. Rhodes,, P. L. Felgner,, V. J. Dwarki,, S. H. Gromkowski,, R. R. Deck,, C. M. DeWitt,, A. Friedman, et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259: 1745 1749.
90. Valero, M. V.,, L. R. Amador,, C. Galindo,, J. Figueroa,, M. S. Bello,, L.A. Murillo,, A. L. Mora,, G. Patarroyo,, C. L. Rocha,, M. Rojas, et al. 1993. Vaccination with SPf66, a chemically synthesised vaccine, against Plasmodium falciparum malaria in Colombia. Lancet 341: 705 710.
91. Vreden, S. G.,, J. P. Verhave,, T. Oettinger,, R.W. Sauerwein,, and J. H. Meuwissen. 1991. Phase I clinical trial of a recombinant malaria vaccine consisting of the circumsporozoite repeat region of Plasmodium falciparum coupled to hepatitis B surface antigen. Am. J.Trop. Med. Hyg. 45: 533 538.
92. Wang, R.,, D. L. Doolan,, T. P. Le,, R.C. Hedstrom,, K. M. Coonan,, Y. Charoenvit,, T. R. Jones,, P. Hobart,, M. Margalith,, J. Ng,, W. R. Weiss,, M. Sedegah,, C. de Taisne,, J.A. Norman,, and S. L. Hoffman. 1998. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282: 476 480.
93. Wang, R.,, J. Epstein,, F. M. Baraceros,, E. J. Gorak,, Y. Charoenvit,, D. J. Carucci,, R. C. Hedstrom,, N. Rahardjo,, T. Gay,, P. Hobart,, R. Stout,, T. R. Jones,, T. L. Richie,, S. E. Parker,, D. L. Doolan,, J. Norman,, and S. L. Hoffman. 2001. Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine. Proc. Natl.Acad. Sci. USA 98: 10817 10822.
94. Wang, R.,, J. Epstein,, Y. Charoenvit,, F. M. Baraceros,, N. Rahardjo,, T. Gay,, J. G. Banania,, R. Chattopadhyay,, P. de la Vega,, T. L. Richie,, N. Tornieporth,, D. L. Doolan,, K. E. Kester,, D. G. Heppner,, J. Norman,, D. J. Carucci,, J.D. Cohen,, and S. L. Hoffman. 2004. Induction in humans of CD8+ and CD4+T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein. J. Immunol. 172: 5561 5569.
95. Weiss, W. R.,, S. Mellouk,, R. A. Houghten,, M. Sedegah,, S. Kumar,, M. F. Good,, J. A. Berzofsky,, L. H. Miller,, and S. L. Hoffman. 1990. Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes. J. Exp. Med. 171: 763 773.
96. World Health Organization. 2003. Africa Malaria Report.
97. Yoshida, N.,, R. S. Nussenzweig,, P. Potocnjak,, V. Nussenzweig,, and M. Aikawa. 1980. Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite. Science 207: 71 73.

Tables

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TABLE 1

Some models and assays used for preclinical assessment of malaria vaccine candidates

Citation: Moorthy V, Dubovsky F. 2005. Progress in Development of a Vaccine to Aid Malaria Control, p 480-498. In Sherman I (ed), Molecular Approaches to Malaria. ASM Press, Washington, DC. doi: 10.1128/9781555817558.ch25

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