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Chapter 27 : The Transcriptome of Human Malaria Vectors

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Abstract:

This chapter traces the development of gene expression studies in mosquitoes from a historical perspective. In addition, it reviews the relevant technologies that made the advances possible. While the principal focus is on the anopheline vectors of malaria, in particular, the authors intend to cite relevant advances in other insects, most notably the yellow fever mosquito, . The rapid development of molecular techniques and their applications in model organisms such as the vinegar fly, , fostered the reemergence of interest in whether genetics bolstered by molecular biology could provide useful tools in combating malaria transmission. Extensive expressed sequence tag (EST) studies designed to dissect the molecular components of innate immunity in mosquitoes have generated large amounts of information on the mosquito transcriptome. Extensive cDNA sequencing also has been used to identify genes differentially expressed in insecticide-resistant and -susceptible mosquitoes. Serial analysis of gene expression (SAGE) is based on the sequential analysis in large quantities of short cDNA sequence tags. Genes activated by both bacterial and malaria infection include those encoding a peptidoglycan recognition protein LB receptor, the gram-negative bacteria-binding protein opsonin, an fibrinogen- like lectin, a thioester-containing putative opsonin, the 14-D serine protease, the CED-6-like phagocytic adaptor,and the leucinerich repeat putative receptor. Monitoring genome-wide changes in gene expression patterns in whole specimens is now feasible, and it is expected that this will be possible with other vectors in the near future.

Citation: Marinotti O, James A. 2005. The Transcriptome of Human Malaria Vectors, p 516-530. In Sherman I (ed), Molecular Approaches to Malaria. ASM Press, Washington, DC. doi: 10.1128/9781555817558.ch27

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Tables

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TABLE 1

Number of NCBI entries for RNAs indexed by the keyword

Citation: Marinotti O, James A. 2005. The Transcriptome of Human Malaria Vectors, p 516-530. In Sherman I (ed), Molecular Approaches to Malaria. ASM Press, Washington, DC. doi: 10.1128/9781555817558.ch27

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