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Chapter 7 : Evolutionary History and Population Genetics of Human Malaria Parasites

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Evolutionary History and Population Genetics of Human Malaria Parasites, Page 1 of 2

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Abstract:

The central theme of this chapter is the molecular evolution of species of the genus —the experimental methods, conclusions, and confounding elements peculiar to . While one section of the chapter is a brief summary of studies on the evolutionary history of and related organisms, another is a summary of the molecular population genetics of contemporary world populations of the two most virulent human malaria parasites. In addition to humans, parasites infect a range of vertebrate hosts, including birds, lizards, rodents, and nonhuman primates. Malaria has also been found in African rodents, and many of the species have been adapted to laboratory mice and rats and used as models for human malarias. ovale and cause the rarest and least virulent forms of malaria. Population studies of and , however, have already yielded unexpected results, paradoxical conclusions, and questions calling for additional research. Genome-level research has made it possible to explore malaria evolution in greater depth and rigor to help complete the picture. These changes have come through malaria parasite genome projects (for , , , and ) and their associated databases, access to automated DNA sequencers in most modern laboratories, an increasingly sophisticated understanding of the unusual molecular biology and evolution of the parasites, and improvements in methods of statistical inference from DNA sequence differences within and among populations.

Citation: Zilversmit M, Hartl D. 2005. Evolutionary History and Population Genetics of Human Malaria Parasites, p 95-109. In Sherman I (ed), Molecular Approaches to Malaria. ASM Press, Washington, DC. doi: 10.1128/9781555817558.ch7
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FIGURE 1

Summary phylogenetic tree showing the relationship between malaria parasites of mammals. Note that primate species are monophyletic, with the exception of the - pairing, which is outside both rodent and primate clades. Rodent and primate parasites form monophyletic groups. Branch lengths are not proportional; only nodes with statistical support of ≥85% are shown ( ).

Citation: Zilversmit M, Hartl D. 2005. Evolutionary History and Population Genetics of Human Malaria Parasites, p 95-109. In Sherman I (ed), Molecular Approaches to Malaria. ASM Press, Washington, DC. doi: 10.1128/9781555817558.ch7
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Image of FIGURE 2
FIGURE 2

Unrooted tree showing the relationship of infrakingdom Alveolata () to other infrakingdoms (including parasites and genomic models) within the domain Eukarya ( ).The dotted line indicates the possible sister relationship of Plantae to some protist groups ( ). Branch lengths are not proportional; only nodes showing statistical support of ≥85% are included.

Citation: Zilversmit M, Hartl D. 2005. Evolutionary History and Population Genetics of Human Malaria Parasites, p 95-109. In Sherman I (ed), Molecular Approaches to Malaria. ASM Press, Washington, DC. doi: 10.1128/9781555817558.ch7
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Image of FIGURE 3
FIGURE 3

Placement of the order Haemosporidia with the phylum Apicomplexa and relation of Apicomplexa within Alveolata. The infrakingdom Discicristata is the sister group to Alveolata and includes several well-studied parasites. Branch lengths are not proportional; only nodes showing statistical support of ≥85% are included ( ).

Citation: Zilversmit M, Hartl D. 2005. Evolutionary History and Population Genetics of Human Malaria Parasites, p 95-109. In Sherman I (ed), Molecular Approaches to Malaria. ASM Press, Washington, DC. doi: 10.1128/9781555817558.ch7
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Image of FIGURE 4
FIGURE 4

An unrooted neighbor-joining tree showing the relationships between nine populations. Only nodes with a bootstrap value of >75% are shown. Note that the African isolates (Zimbabwe, Congo, Uganda) from an area of high transmission show a large overall difference from the other isolates, but the relationship of the individual isolates cannot be distinguished with any statistical certainty. However, in South America, the Colombian and Bolivian-Brazilian isolates show a greater distance from each other than even overall distances from isolates from elsewhere in the world. (Figure adapted from .)

Citation: Zilversmit M, Hartl D. 2005. Evolutionary History and Population Genetics of Human Malaria Parasites, p 95-109. In Sherman I (ed), Molecular Approaches to Malaria. ASM Press, Washington, DC. doi: 10.1128/9781555817558.ch7
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