1887

Colonization of Mucosal Surfaces

Editors: James P. Nataro1, Paul S. Cohen2, Harry L. T. Mobley3, Jeffrey N. Weiser4
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Affiliations: 1: University of Maryland School of Medicine, Baltimore, Maryland; 2: University of Rhode Island, Kingston, Rhode Island; 3: University of Michigan Medical School, Ann Arbor, Michigan; 4: University of Pennsylvania, Philadelphia, Pennsylvania
Content Type: Monograph
Format: Electronic
Publication Year: 2005

Category: Clinical Microbiology; Bacterial Pathogenesis

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is a state-of-the-art presentation of the opposing evolutionary forces that ultimately determine the health of host organisms and survival of pathogenic microorganisms. As mammalian defenses evolve to protect against infection, pathogens are simultaneously evolving to circumvent new barriers and gain access to valuable host nutrients and energy. Written by experts in the field, this new volume is an in-depth examination of the complex ecosystems of the mammalian mucosa and the successful adaptations of microorganisms that enable them to effectively colonize these surfaces.

First addressing general consideration, then comprehensively covers colonization of the respiratory tract, the gastrointestinal tract, and the genitourinary tract and considers the various organisms present at these surfaces. Aspects of bacterial colonization revealed by the most recent research are also contemplated, including penetration of the mucous layer, innate immune effectors and their subversion, signaling of the host cells by adherence factors, modulation of adherence, phase variation of colonization factors, and regulation of colonization effectors.

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Doody Enterprises

18 August 2013

Univ. of Maryland School of Medicine, Baltimore. Covers the complex ecosystems which are the mammalian mucosa and examines mechanisms adapted by microorganisms to colonize these surfaces effectively. Offers broad overview and introduction to the field of microbiology, numerous references, and halftone illustrations. DNLM: Mucous Membrane-microbiology.

Description

This book reviews the current information on how infectious agents interact with the mucosal surface of its host. It is divided into separate sections dealing with the respiratory tract, gastrointestinal tract and the urogenital tract.

Purpose

The purpose is to provide an overview of the mammalian mucosa. It reviews mechanisms used to protect the host as well as the mechanisms used by pathogens to overcome this protection. This makes the book unique in that it specifically focuses on host-pathogen interactions with the mucosal surface.

Audience

This is a book that will assist individuals conducting research in the area of mucosal immunity, host defenses at the mucosal surface and those studying microbial pathogenesis. In my opinion, this could be used in part to teach a graduate level microbial pathogenesis course.

Features

The book is divided into four sections. First the book addresses general issues that are common among the different mucosal surfaces. The other three sections deal specifically with the respiratory mucosa, gastrointestinal mucosa, and urogenital mucosa. I liked the organization since the general issues section correlated and led into the specific systems. Unfortunately, there was very little discussion regarding viral pathogens and atypical bacterial pathogens such as mycobacteria, chlamydia and mycoplasma. There is much research regarding the interaction of these pathogens with the mucosal surface and it would have enhanced the book. Additionally, a short section at the end of the book that brings this all back together and a review of where there is a gap in understanding certain problems would be helpful. This could include a summary of pertinent research in this area that is still needed.

Assessment

Overall, I will refer to this book with both medical students, residents, and graduate students. It describes the interaction of the mucosal surface and pathogens very clearly.

Doody Enterprises

Reviewer: Rebecca Horvat, PhD, D(ABMM) (University of Kansas Medical Center)

Review Date: Unknown

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