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The Bacterial Chromosome

Editor: N. Patrick Higgins1
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Affiliations: 1: Department of Biochemistry and Molecular Genetics and Howell Heflin Center for Human Genetics University of Alabama at Birmingham, Birmingham, Alabama
Content Type: Monograph
Format: Electronic, Hardcover
Publication Year: 2005

Category: Microbial Genetics and Molecular Biology; Bacterial Pathogenesis

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is a state-of-the art examination of the mechanisms governing genetic inheritance, a timely update to the 1990 publication of the same name. Advances in evolutionary theory have been stimulated by the availability of complete bacterial sequences, while recent biochemical research has revealed how protein machines control chromosome function.

Incorporating section overviews provided by eminent geneticists and biochemists, the book provides a link between classical experiments in chromosome physiology and new developments in genetic research. From the first section, “Genetic and Physical Structure,” to the last, “Nonhomologous Recombination,” comprehensively covers the fundamental systems required for all bacterial cells to replicate chromosomes and organize genetic information. Complex biochemical reactions, including DNA replication, genetic recombination, and RNA transcription, are presented from both genetic and physical perspectives. The implications of the DNA sequence database are incorporated with information on horizontal gene transfer and the impact of phage genes on bacterial genomes.

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