Chapter 8 : Replication Hits 50

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In eukaryotes, DNA replication appears to occur in stationary factories that can be visualized as foci in the nucleus via either immunofluorescence microscopy of replication proteins or fluorescence microscopy of live cells carrying green fluorescent protein-tagged replication proteins. In bacteria, the division plane at midcell is a crucial locus where most of the events leading to cytokinesis take place. Using green fluorescent proteintagged subunits of the Pol III HE, researches have shown that the DNA polymerases assemble and replicate DNA at midcell in . Studies on the effect of moving on chromosomal dimer resolution and on the tolerance of deletions and inversions in the terminus region have led to the suggestion that the chromosome is polarized, meaning that the directionality of the path taken along the chromosome away from has some physical manifestation. The proteins required for restart primosome assembly—PriA, PriB, PriC, DnaT, DnaB, DnaC, and DnaG—were discovered originally because they acted to assemble a primosome on φX174 viral DNA during its conversion to the replicative form. In , estimates of the probability that a replication fork formed at will be arrested before completing replication of one arm of the chromosome vary from 0.15 to almost certainty.

Citation: Marians K. 2005. Replication Hits 50, p 169-176. In Higgins N (ed), The Bacterial Chromosome. ASM Press, Washington, DC. doi: 10.1128/9781555817640.ch8

Key Concept Ranking

Replication Fork
Lagging Strand
Leading Strand
DNA Replication
DNA Polymerase I
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