Chapter 25 : Receptor-Mediated Recognition of Mycobacterium tuberculosis by Host Cells

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is an intracellular pathogen of mononuclear phagocytes and is highly adapted to the human host. This chapter reviews advances in the understanding of the molecular determinants that mediate the interaction of with host cells such as monocytes/ macrophages, epithelial cells, and dendritic cell (DC). In this context, it also reviews a family of important regulators of innate immune cell activation, the toll-like receptor (TLR) family. The mannose caps of cell wall LAM (ManLAM) have also recently been shown to be recognized by DC-SIGN on DC, a lectin that functions as a bacterial adhesion and pattern recognition receptor. In addition to the lipoarabinomannan (LAM)-mannose receptor (MR) interaction, strains possess their own lectins, some of which are specific for mannans and may be involved in bacterial binding to host cells. Toll is a member of a family of related proteins in the fly that are important for host defense against pathogens, most probably because they direct the production of antimicrobial peptides. The cytoplasmic domain of Toll was found to be homologous to the cytoplasmic domain of the mammalian interleukin-1 (IL-1) and IL-18 receptors, suggesting that similar receptors might be encoded in the mammalian genome. Some TLR proteins utilize coreceptors that augment TLR-dependent responses and, in some cases, are required for TLR function. Recently, several laboratories have investigated the roles of TLR2 and TLR4 in host responses to mycobacterial infection.

Citation: Fenton M, Riley L, Schlesinger L. 2005. Receptor-Mediated Recognition of Mycobacterium tuberculosis by Host Cells, p 405-426. In Cole S, Eisenach K, McMurray D, Jacobs, Jr. W (ed), Tuberculosis and the Tubercle Bacillus. ASM Press, Washington, DC. doi: 10.1128/9781555817657.ch25
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