1887

Chapter 30 : CD1 and Tuberculosis

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Ebook: Choose a downloadable PDF or ePub file. Chapter is a downloadable PDF file. File must be downloaded within 48 hours of purchase

Buy this Chapter
Digital (?) $15.00

Preview this chapter:
Zoom in
Zoomout

CD1 and Tuberculosis, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555817657/9781555812959_Chap30-1.gif /docserver/preview/fulltext/10.1128/9781555817657/9781555812959_Chap30-2.gif

Abstract:

This chapter reviews the immunobiology of CD1 and its potentially important role in the immune response to infection. Importantly, CD1 is expressed on dendritic cell (DC) within granulomas from patients with both and infections, although the role of DC in granuloma formation and maintenance is unclear. One of the hallmarks of bacteria is the capacity to survive within the intracellular environment. A significant increase in CD1c-restricted Tcell proliferation was observed in the tuberculosis group compared to the purified protein derivative (PPD)-negative control group. Interestingly, patients with clinically active pulmonary tuberculosis showed no significant response to lipid antigens or whole bacterial sonicates. Lipid-immunized guinea pigs challenged with virulent via aerosol administration exhibit reduced pulmonary pathology compared to negative control animals. bacilli possess one of the more unusual cell walls in the bacterial kingdom, with many of the lipid molecules being unique to this genus. A more thorough understanding of how CD1 antigen presentation fits into the overall host immune response to infection may lead to novel interventional therapies and improved vaccine formulations for tuberculosis and other infectious diseases.

Citation: Dascher C, Brenner M. 2005. CD1 and Tuberculosis, p 475-488. In Cole S, Eisenach K, McMurray D, Jacobs, Jr. W (ed), Tuberculosis and the Tubercle Bacillus. ASM Press, Washington, DC. doi: 10.1128/9781555817657.ch30

Key Concept Ranking

Major Histocompatibility Complex
0.5037389
Tumor Necrosis Factor alpha
0.445515
Transforming Growth Factor beta
0.421633
0.5037389
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of Figure 1
Figure 1

Hypothetical evolution of CD1 and the MHC. There are five distinct CD1 genes in humans that are unlinked to the MHC locus. These are divided into two groups based on sequence homology. Analysis of protein sequence data shows that CD1 diverged from the MHC family early in vertebrate evolution. The divergence of MHC I and MHC II is estimated at approximately 250 million to 300 million years ago. CD1 and MHC I share many structural features and thus probably have a common ancestor. However, the exact time of the divergence of CD1 and MHC I is difficult to estimate since both gene families are under strong selective pressure. So far, CD1 genes have been found only in placental mammals.

Citation: Dascher C, Brenner M. 2005. CD1 and Tuberculosis, p 475-488. In Cole S, Eisenach K, McMurray D, Jacobs, Jr. W (ed), Tuberculosis and the Tubercle Bacillus. ASM Press, Washington, DC. doi: 10.1128/9781555817657.ch30
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 2
Figure 2

Structure of the human CD1b protein-lipid complex. (a and b) Two orthogonal views of the human CD1b structure from the side (a) and from the top (b) of the structure with bound phosphatidylinositol in the antigen binding pocket. The internal cavity that forms the antigen binding pocket is shown as a transparent surface, and the various channels are indicated as A′, C′, F′, and T′. (c) Structure of human HLA-A2, with the human T-cell leukemia virus type 1 Tax peptide (space filling) in the antigen binding groove shown for comparison to CD1b ( ). (d) Structure of mycolic acid with the meromycolate chain (dark) and the shorter alpha chain (light) and carboxylate groups. (e) Hypothetical model of mycolic acid as it would appear folded into the CD1b protein. The left-hand orthogonal view corresponds to the orientation of the CD1b protein in panel a, and the right hand view corresponds to the orientation in b. In this model, the C long meromycolate chain (dark) is fully contained within channels A′, T′ and F′, a superchannel of ca. 70 Å. The shorter C alkyl chain (light) is lodged in the C? channel. The crystal structure provides no guidance to how to model the end of the C chain in the mycolic acid, and this part of the model is therefore indicated by an extended gray chain. Panels a, b, and e reprinted from reference with permission from the authors and publisher. © 2002 Nature Publishing Group.

Citation: Dascher C, Brenner M. 2005. CD1 and Tuberculosis, p 475-488. In Cole S, Eisenach K, McMurray D, Jacobs, Jr. W (ed), Tuberculosis and the Tubercle Bacillus. ASM Press, Washington, DC. doi: 10.1128/9781555817657.ch30
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 3
Figure 3

Structures of known CD1 lipid antigens. The first six lipid molecules are derived from species and are presented by either CD1a, CD1b, or CD1c. The αGC (far right) is derived from the marine sponge . All of the molecules have a common structural motif, which is a hydrophobic acyl chain linked to a hydrophilic head group such as a simple sugar or carboxylate group. Both structural and functional data support a model in which the hydrophobic acyl chain is anchored into the CD1 binding groove and the hydrophilic head group is exposed to the aqueous environment and interacts with the TCR. While the αGC is not known to exist in bacteria or mammalian tissues, it is a ligand for CD1d and a potent stimulator of CD1d-restricted NK T cells. Lipid structures courtesy of Branch Moody, Brigham and Women's Hospital.

Citation: Dascher C, Brenner M. 2005. CD1 and Tuberculosis, p 475-488. In Cole S, Eisenach K, McMurray D, Jacobs, Jr. W (ed), Tuberculosis and the Tubercle Bacillus. ASM Press, Washington, DC. doi: 10.1128/9781555817657.ch30
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 4
Figure 4

T-cell adaptive immunity. Multiple antigen presentation pathways are available to the host immune system for stimulation of T cells. A model antigen-presenting cell, such as a DC, is able to take up pathogens or pathogen-derived molecules from the surrounding extracellular environment. Live organisms are able to prevent maturation of the phagosome and hence prevent interaction with lysosomes and subsequent killing. The bacilli may survive and grow within the phagosome environment and thus evade immune surveillance. Some evidence exists for secretion of proteins into the cytosol, where they could be processed for presentation by MHC I. Lipid antigens with different structures may partition into different intracellular compartments. For example, short-chain lipids may traffic to recycling endosomes, where they would be accessible to CD1a, while long-chain lipids may traffic to lysosomes for loading and presentation by CD1b. Dashed lines represent the main-line sequence of endosomal maturation. Lipids may be transported out of the phagosome containing live organisms to then enter the antigen presentation pathway for CD1 and MHC II. Likewise, secreted antigens or lipids shed from extracellular bacteria are taken up by endocytosis and enter the endosomal network. Each of the CD1 molecules traffics through the endocytic system in a unique pattern. The CD1a isoform samples recycling endosomes, while CD1b samples late endosomes and lysosomes. The CD1c isoform samples both of these compartments. Together, the CD1 antigen presentation system is able to survey most of the intracellular environment for potential antigenic lipid molecules and to transport these to the cell surface for T-cell recognition.

Citation: Dascher C, Brenner M. 2005. CD1 and Tuberculosis, p 475-488. In Cole S, Eisenach K, McMurray D, Jacobs, Jr. W (ed), Tuberculosis and the Tubercle Bacillus. ASM Press, Washington, DC. doi: 10.1128/9781555817657.ch30
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 5
Figure 5

Effector functions of CD1-restricted T cells. T cells reactive to lipids presented by CD1 on the cell surface secrete high levels of proinflammatory cytokines including IFN-γ and tumor necrosis factor alpha (TNF-α), both critical for containment of infections and granuloma formation. Furthermore, activation of macrophages increases the killing of ingested bacilli. The CD1-restricted T cells release perforin and granulysin, which have direct bactericidal effects on . The CD1-restricted T cells are also cytolytic and have the capacity to kill infected host cells in a CD1-dependent manner.

Citation: Dascher C, Brenner M. 2005. CD1 and Tuberculosis, p 475-488. In Cole S, Eisenach K, McMurray D, Jacobs, Jr. W (ed), Tuberculosis and the Tubercle Bacillus. ASM Press, Washington, DC. doi: 10.1128/9781555817657.ch30
Permissions and Reprints Request Permissions
Download as Powerpoint

References

/content/book/10.1128/9781555817657.chap30
1. Angenieux, C.,, J. Salamero,, D. Fricker,, J. P. Cazenave,, B. Goud,, D. Hanau,, and H. de La Salle. 2000. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J. Biol. Chem. 275:3775737764.
2. Beatty, W. L.,, E. R. Rhoades,, H. J. Ullrich,, D. Chatterjee,, J. E. Heuser,, and D. G. Russell. 2000. Trafficking and release of mycobacterial lipids from infected macrophages. Traffic 1:235247.
3. Beckman, E. M.,, A. Melian,, S. M. Behar,, P. A. Sieling,, D. Chatterjee,, S. T. Furlong,, R. Matsumoto,, J. P. Rosat,, R. L. Modlin,, and S. A. Porcelli. 1996. CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family. J. Immunol. 157:27952803.
4. Beckman, E. M.,, S. A. Porcelli,, C. T. Morita,, S. M. Behar,, S. T. Furlong,, and M. B. Brenner. 1994. Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature 372:691694.
5. Behar, S. M.,, C. C. Dascher,, M. J. Grusby,, C. R. Wang,, and M. B. Brenner. 1999. Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J. Exp. Med. 189:19731980.
6. Bendelac, A.,, R. D. Hunziker,, and O. Lantz. 1996. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J. Exp. Med. 184:12851293.
7. Brigl, M.,, and M. B. Brenner. 2003. CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22:817890.
8. Brigl, M.,, L. Bry,, S. C. Kent,, J. E. Gumperz,, and M. B. Brenner. 2003. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat. Immunol. 4:12301237.
9. Briken, V.,, R. M. Jackman,, S. Dasgupta,, S. Hoening,, and S. A. Porcelli. 2002. Intracellular trafficking pathway of newly synthesized CD1b molecules. EMBO. J. 21:825834.
10. Briken, V.,, R. M. Jackman,, G. F. Watts,, R. A. Rogers,, and S. A. Porcelli. 2000. Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. J. Exp. Med. 192:281288.
11. Calabi, F.,, and A. Bradbury. 1991. The CD1 system. Tissue Antigens 37:19.
12. Calabi, F.,, J. M. Jarvis,, L. Martin,, and C. Milstein. 1989. Two classes of CD1 genes. Eur. J. Immunol. 19:285292.
13. Calabi, F.,, and C. Milstein. 1986. A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. Nature 323:540543.
14. Cao, X.,, M. Sugita,, N. Van Der Wel,, J. Lai,, R. A. Rogers,, P. J. Peters,, and M. B. Brenner. 2002. CD1 molecules efficiently present antigen in immature dendritic cells and traffic independently of MHC class II during dendritic cell maturation. J. Immunol. 169:47704777.
15. Carnaud, C.,, D. Lee,, O. Donnars,, S. H. Park,, A. Beavis,, Y. Koezuka,, and A. Bendelac. 1999. Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163:46474650.
16. Cernadas, M.,, M. Sugita,, N. Van Der Wel,, X. Cao,, J. E. Gumperz,, S. Maltsev,, G. S. Besra,, S. M. Behar,, P. J. Peters,, and M. B. Brenner. 2003. Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development. J. Immunol. 171:41494155.
17. Chackerian, A.,, J. Alt,, V. Perera,, and S. M. Behar. 2002. Activation of NKT cells protects mice from tuberculosis. Infect. Immun. 70:63026309.
18. Dascher, C. C.,, and M. B. Brenner,. 2003. CD1 antigen presentation and infectious disease, p. 164182. In H. Herwald (ed.), Host Response Mechanisms in Infectious Disease, vol. 10. S. Karger, Basel, Switzerland.
19. Dascher, C. C.,, and M. B. Brenner. 2003. Evolutionary constraints on CD1 structure: insights from comaprative genomic analysis. Trends Immunol. 24:412418.
20. Dascher, C. C.,, K. Hiromatsu,, J. W. Naylor,, P. P. Brauer,, K. A. Brown,, J. R. Storey,, S. M. Behar,, E. S. Kawasaki,, S. A. Porcelli,, M. B. Brenner,, and K. P. LeClair. 1999. Conservation of a CD1 multigene family in the guinea pig. J. Immunol. 163:54785488.
21. Dascher, C. C.,, K. Hiromatsu,, X. Xiong,, C. M. Morehouse,, G. F. Watts,, G. Liu,, D. N. McMurray,, K. P. LeClair,, S. Porcelli,, and M. B. Brenner. 2003. Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis. Int. Immunol. 15:915925.
22. Ding, Y. H.,, K. J. Smith,, D. N. Garboczi,, U. Utz,, W. E. Biddison,, and D. C. Wiley. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8:403411.
23. D’Souza, C. D.,, A. M. Cooper,, A. A. Frank,, S. Ehlers,, J. Turner,, A. Bendelac,, and I. M. Orme. 2000. A novel nonclassic β2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung. Am. J. Respir. Cell Mol. Biol. 23:188193.
24. Elewaut, D.,, A. P. Lawton,, N. A. Nagarajan,, E. Maverakis,, A. Khurana,, S. Honing,, C. A. Benedict,, E. Sercarz,, O. Bakke,, M. Kronenberg,, and T. I. Prigozy. 2003. The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Vα14i NKT cells. J. Exp. Med. 198:11331146.
25. Exley, M.,, J. Garcia,, S. B. Wilson,, F. Spada,, D. Gerdes,, S. M. Tahir,, K. T. Patton,, R. S. Blumberg,, S. Porcelli,, A. Chott,, and S. P. Balk. 2000. CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes. Immunology 100:3747.
26. Faure, F.,, S. Jitsukawa,, C. Miossec,, and T. Hercend. 1990. CD1c as a target recognition structure for human T lymphocytes: analysis with peripheral blood gamma/delta cells. Eur. J. Immunol. 20:703706.
27. Gadola, S. D.,, N. R. Zaccai,, K. Harlos,, D. Shepherd,, J. C. Castro-Palomino,, G. Ritter,, R. R. Schmidt,, E. Y. Jones,, and V. Cerundolo. 2002. Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains. Nat. Immunol. 3: 721726.
28. Gansert, J. L.,, V. Kiessler,, M. Engele,, F. Wittke,, M. Rollinghoff,, A. M. Krensky,, S. A. Porcelli,, R. L. Modlin,, and S. Stenger. 2003. Human NKT cells express granulysin and exhibit antimycobacterial activity. J. Immunol. 170:31543161.
29. Gilleron, M.,, S. Stenger,, Z. Mazorra,, F. Wittke,, S. Mariotti,, G. Bohmer,, J. Prandi,, L. Mori,, G. Puzo,, and G. De Libero. 2004. Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis. J. Exp. Med. 199:649659.
30. Grant, E. P.,, E. M. Beckman,, S. M. Behar,, M. Degano,, D. Frederique,, G. S. Besra,, I. A. Wilson,, S. A. Porcelli,, S. T. Furlong,, and M. B. Brenner. 2002. Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex. J. Immunol. 168:39333940.
31. Grant, E. P.,, M. Degano,, J. P. Rosat,, S. Stenger,, R. L. Modlin,, I. A. Wilson,, S. A. Porcelli,, and M. B. Brenner. 1999. Molecular recognition of lipid antigens by T cell receptors. J. Exp. Med. 189:195205.
32. Gumperz, J. E.,, and M. B. Brenner. 2001. CD-specific T cells in microbial immunity. Curr. Opin. Immunol. 13:471478.
33. Gumperz, J. E.,, C. Roy,, A. Makowska,, D. Lum,, M. Sugita,, T. Podrebarac,, Y. Koezuka,, S. A. Porcelli,, S. Cardell,, M. B. Brenner,, and S. M. Behar. 2000. Murine CD1d-restricted T cell recognition of cellular lipids. Immunity 12:211221.
34. Han, M.,, L. I. Hannick,, M. DiBrino,, and M. A. Robinson. 1999. Polymorphism of human CD1 genes. Tissue Antigens 54:122127.
35. Hansen, D. S.,, M. A. Siomos,, L. Buckingham,, A. A. Scalzo,, and L. Schofield. 2003. Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Immunity 18:391402.
36. Hiromatsu, K.,, C. C. Dascher,, K. P. LeClair,, M. Sugita,, S. T. Furlong,, M. B. Brenner,, and S. A. Porcelli. 2002. Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens. J. Immunol. 169:330339.
37. Hiromatsu, K.,, C. C. Dascher,, M. Sugita,, C. Gingrich-Baker,, S. M. Behar,, K. P. LeClair,, M. B. Brenner,, and S. A. Porcelli. 2002. Characterization of guinea-pig group 1 CD1 proteins. Immunology 106:159172.
38. Hirsch, C. S.,, R. Hussain,, Z. Toossi,, G. Dawood,, F. Shahid,, and J. J. Ellner. 1996. Cross-modulation by transforming growth factor beta in human tuberculosis: suppression of antigen- driven blastogenesis and interferon gamma production. Proc. Natl. Acad. Sci. USA 93:31933198.
39. Hmama, Z.,, R. Gabathuler,, W. A. Jefferies,, G. de Jong,, and N. E. Reiner. 1998. Attenuation of HLA-DR expression by mononuclear phagocytes infected with Mycobacterium tuberculosis is related to intracellular sequestration of immature class II heterodimers. J. Immunol. 161:48824893.
40. Hughes, A. L. 1991. Evolutionary origin and diversification of the mammalian CD1 antigen genes. Mol. Biol. Evol. 8:185201.
41. Jackman, R. M.,, S. Stenger,, A. Lee,, D. B. Moody,, R. A. Rogers,, K. R. Niazi,, M. Sugita,, R. L. Modlin,, P. J. Peters,, and S. A. Porcelli. 1998. The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens. Immunity 8:341351.
42. Jones, D. C.,, C. M. Gelder,, T. Ahmad,, I. A. Campbell,, M. C. Barnardo,, K. I. Welsh,, S. E. Marshall,, and M. Bunce. 2001. CD1 genotyping of patients with Mycobacterium malmoense pulmonary disease. Tissue Antigens 58:1923.
43. Kang, S. J.,, and P. Cresswell. 2002. Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. J. Biol. Chem. 277:4483844844.
44. Kawano, T.,, J. Cui,, Y. Koezuka,, I. Toura,, Y. Kaneko,, K. Motoki,, H. Ueno,, R. Nakagawa,, H. Sato,, E. Kondo,, H. Koseki,, and M. Taniguchi. 1997. CD1d-restricted and TCR-mediated activation of vα14 NKT cells by glycosylceramides. Science 278:16261629.
45. Kawashima, T.,, Y. Norose,, Y. Watanabe,, Y. Enomoto,, H. Narazaki,, E. Watari,, S. Tanaka,, H. Takahashi,, I. Yano,, M. B. Brenner,, and M. Sugita. 2003. Cutting edge: Major CD8 T cell response to live bacillus Calmette-Guérin is mediated by CD1 molecules. J. Immunol. 170:53455348.
46. Kronenberg, M.,, and L. Gapin. 2002. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2:557568.
47. Moody, D. B.,, V. Briken,, T. Y. Cheng,, C. Roura-Mir,, M. R. Guy,, D. H. Geho,, M. L. Tykocinski,, G. S. Besra,, and S. A. Porcelli. 2002. Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation. Nat. Immunol. 3:435442.
48. Moody, D. B.,, and S. A. Porcelli. 2003. Intracellular pathways of CD1 antigen presentation. Nat. Rev. Immunol. 3: 1122.
49. Moody, D. B.,, B. B. Reinhold,, M. R. Guy,, E. M. Beckman,, D. E. Frederique,, S. T. Furlong,, S. Ye,, V. N. Reinhold,, P. A. Sieling,, R. L. Modlin,, G. S. Besra,, and S. A. Porcelli. 1997. Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 278:283286.
50. Moody, D. B.,, T. Ulrichs,, W. Muhlecker,, D. C. Young,, S. S. Gurcha,, E. Grant,, J. P. Rosat,, M. B. Brenner,, C. E. Costello,, G. S. Besra,, and S. A. Porcelli. 2000. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 404:884888.
51. Moody, D. B.,, D. C. Young,, T. Y. Cheng,, J. P. Rosat,, C. Roura-Mir,, P. B. O’Connor,, D. M. Zajonc,, A. Walz,, M. J. Miller,, S. B. Levery,, I. A. Wilson,, C. E. Costelo,, M. B. Brenner. 2004. T-cell activation by lipopeptide antigens. Science 303:527531.
52. Mukherjee, S.,, T. T. Soe,, and F. R. Maxfield. 1999. Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails. J. Cell Biol. 144:12711284.
53. Nieuwenhuis, E. E.,, T. Matsumoto,, M. Exley,, R. A. Schleipman,, J. Glickman,, D. T. Bailey,, N. Corazza,, S. P. Colgan,, A. B. Onderdonk,, and R. S. Blumberg. 2002. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat. Med. 8:588593.
54. Ochoa, M. T.,, S. Stenger,, P. A. Sieling,, S. Thoma-Uszynski,, S. Sabet,, S. Cho,, A. M. Krensky,, M. Rollinghoff,, E. Nunes Sarno,, A. E. Burdick,, T. H. Rea,, and R. L. Modlin. 2001. T-cell release of granulysin contributes to host defense in leprosy. Nat. Med. 7:174179.
55. Porcelli, S.,, M. B. Brenner,, J. L. Greenstein,, S. P. Balk,, C. Terhorst,, and P. A. Bleicher. 1989. Recognition of cluster of differentiation 1 antigens by human CD4-CD8- cytolytic T lymphocytes. Nature 341:447450.
56. Porcelli, S.,, C. T. Morita,, and M. B. Brenner. 1992. CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen. Nature 360:593597.
57. Porcelli, S. A. 1995. The CD1 family: a third lineage of antigen- presenting molecules. Adv. Immunol. 59:198.
58. Porcelli, S. A.,, and M. B. Brenner. 1997. Antigen presentation: mixing oil and water. Curr. Biol. 7:R508R511.
59. Prigozy, T. I.,, P. A. Sieling,, D. Clemens,, P. L. Stewart,, S. M. Behar,, S. A. Porcelli,, M. B. Brenner,, R. L. Modlin,, and M. Kronenberg. 1997. The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules. Immunity 6:187197.
60. Rhoades, E.,, F. Hsu,, J. B. Torrelles,, J. Turk,, D. Chatterjee,, and D. G. Russell. 2003. Identification and macrophage-activating activity of glycolipids released from intracellular Mycobacterium bovis BCG. Mol. Microbiol. 48:875888.
61. Rosat, J. P.,, E. P. Grant,, E. M. Beckman,, C. C. Dascher,, P. A. Sieling,, D. Frederique,, R. L. Modlin,, S. A. Porcelli,, S. T. Furlong,, and M. B. Brenner. 1999. CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ αβ T cell pool. J. Immunol. 162:366371.
62. Roura-Mir, C.,, and D. B. Moody. 2003. Sorting out self and microbial lipid antigens for CD1. Microbes Infect. 5:11371148.
63. Shamshiev, A.,, A. Donda,, I. Carena,, L. Mori,, L. Kappos,, and G. De Libero. 1999. Self glycolipids as T-cell autoantigens. Eur. J. Immunol. 29:16671675.
64. Sieling, P. A.,, D. Chatterjee,, S. A. Porcelli,, T. I. Prigozy,, R. J. Mazzaccaro,, T. Soriano,, B. R. Bloom,, M. B. Brenner,, M. Kronenberg,, P. J. Brennan,, and R. L. Modlin. 1995. CD1- restricted T cell recognition of microbial lipoglycan antigens. Science 269:227230.
65. Sieling, P. A.,, D. Jullien,, M. Dahlem,, T. F. Tedder,, T. H. Rea,, R. L. Modlin,, and S. A. Porcelli. 1999. CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. J. Immunol. 162:18511588.
66. Skold, M.,, and S. M. Behar. 2003. Role of CD1d-restricted NKT cells in microbial immunity. Infect. Immun. 71:54475455.
67. Sousa, A. O.,, R. J. Mazzaccaro,, R. G. Russell,, F. K. Lee,, O. C. Turner,, S. Hong,, L. Van Kaer,, and B. R. Bloom. 2000. Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc. Natl. Acad. Sci. USA 97:42044208.
68. Spada, F. M.,, E. P. Grant,, P. J. Peters,, M. Sugita,, A. Melian,, D. S. Leslie,, H. K. Lee,, E. van Donselaar,, D. A. Hanson,, A. M. Krensky,, O. Majdic,, S. A. Porcelli,, C. T. Morita,, and M. B. Brenner. 2000. Self-recognition of CD1 by γ/δ T cells: implications for innate immunity. J. Exp. Med. 191:937948.
69. Stenger, S.,, D. A. Hanson,, R. Teitelbaum,, P. Dewan,, K. R. Niazi,, C. J. Froelich,, T. Ganz,, S. Thoma-Uszynski,, A. Melian,, C. Bogdan,, S. A. Porcelli,, B. R. Bloom,, A. M. Krensky,, and R. L. Modlin. 1998. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 282:121125.
70. Stenger, S.,, R. J. Mazzaccaro,, K. Uyemura,, S. Cho,, P. F. Barnes,, J. P. Rosat,, A. Sette,, M. B. Brenner,, S. A. Porcelli,, B. R. Bloom,, and R. L. Modlin. 1997. Differential effects of cytolytic T cell subsets on intracellular infection. Science 276: 16841687.
71. Stetson, D. B.,, M. Morhrs,, R. L. Reinhardt,, J. L. Baron,, Z. Wang,, L. Gapin,, M. Kronenberg,, and R. M. Locksley. 2003. Costitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector functrion. J. Exp. Med. 198:10691076.
72. Sugita, M.,, X. Cao,, G. F. Watts,, R. A. Rogers,, J. S. Bonifacino,, and M. B. Brenner. 2002. Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells. Immunity 16:697706.
73. Sugita, M.,, E. P. Grant,, E. van Donselaar,, V. W. Hsu,, R. A. Rogers,, P. J. Peters,, and M. B. Brenner. 1999. Separate pathways for antigen presentation by CD1 molecules. Immunity 11:743752.
74. Sugita, M.,, R. M. Jackman,, E. van Donselaar,, S. M. Behar,, R. A. Rogers,, P. J. Peters,, M. B. Brenner,, and S. A. Porcelli. 1996. Cytoplasmic tail-dependent localization of CD1b antigen- presenting molecules to MIICs. Science 273:349352.
75. Sugita, M.,, P. J. Peters,, and M. B. Brenner. 2000. Pathways for lipid antigen presentation by CD1 molecules: nowhere for intracellular pathogens to hide. Traffic 1:295300.
76. Sugita, M.,, S. A. Porcelli,, and M. B. Brenner. 1997. Assembly and retention of CD1b heavy chains in the endoplasmic reticulum. J. Immunol. 159:23582365.
77. Sugita, M.,, N. vanDerWel,, R. A. Rogers,, P. J. Peters,, and M. B. Brenner. 2000. CD1c molecules broadly survey the endocytic system. Proc. Natl. Acad. Sci. USA 97:84458450.
78. Uehira, K.,, R. Amakawa,, T. Ito,, K. Tajima,, S. Naitoh,, Y. Ozaki,, T. Shimizu,, K. Yamaguchi,, Y. Uemura,, H. Kitajima,, S. Yonezu,, and S. Fukuhara. 2002. Dendritic cells are decreased in blood and accumulated in granuloma in tuberculosis. Clin. Immunol. 105:296303.
79. Ulrichs, T.,, D. B. Moody,, E. Grant,, S. H. Kaufmann,, and S. Porcelli. 2003. T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection. Infect. Immun. 71:30763087.
80. Vincent, M. S.,, J. E. Gumperz,, and M. B. Brenner. 2003. Understanding the function of CD1-restricted T cells. Nat. Immunol. 4:517523.
81. Vincent, M. S.,, D. S. Leslie,, J. E. Gumperz,, X. Xiong,, E. P. Grant,, and M. B. Brenner. 2002. CD1-dependent dendritic cell instruction. Nat. Immunol. 3:11631168.
82. Winau, F.,, V. Schwierzeck,, R. Hurwitz,, N. Remmel,, P. A. Sieling,, R. L. Modlin,, S. A. Porcelli,, V. Brinkmann,, M. Sugita,, K. Sandhoff,, S. H. Kaufmann,, and U. E. Schaible. 2004. Saposin C is required for lipid presentation by human CD1b. Nat. Immunol. 5:169174.
83. Zajonc, D. M.,, M. A. Elsliger,, L. Teyton,, and I. A. Wilson. 2003. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 Å. Nat. Immunol. 4:808815.
84. Zeng, Z.,, A. R. Castano,, B. W. Segelke,, E. A. Stura,, P. A. Peterson,, and I. A. Wilson. 1997. Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science 277:339345.
85. Zhou, D.,, C. Cantu III,, Y. Sagiv,, N. Schrantz,, A. B. Kulkarni,, X. Qi,, D. J. Mahuran,, C. R. Morales,, G. A. Grabowski,, K. Benlagha,, P. Savage,, A. Bendelac,, and L. Teyton. 2004. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science 303:523527.

Tables

Generic image for table
Table 1

Antigen-presenting pathways for T cells

Citation: Dascher C, Brenner M. 2005. CD1 and Tuberculosis, p 475-488. In Cole S, Eisenach K, McMurray D, Jacobs, Jr. W (ed), Tuberculosis and the Tubercle Bacillus. ASM Press, Washington, DC. doi: 10.1128/9781555817657.ch30

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error