1887

Chapter 10 : Collectins and the Acute-Phase Response

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Ebook: Choose a downloadable PDF or ePub file. Chapter is a downloadable PDF file. File must be downloaded within 48 hours of purchase

Buy this Chapter
Digital (?) $15.00

Preview this chapter:
Zoom in
Zoomout

Collectins and the Acute-Phase Response, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555817671/9781555812911_Chap10-1.gif /docserver/preview/fulltext/10.1128/9781555817671/9781555812911_Chap10-2.gif

Abstract:

This chapter focuses on one essential component of the innate immune system, that is, non-antibody-mediated pathogen recognition and opsonization. In particular, the focus is on the collectin subgroup of the superfamily of lectins, known as the C-type lectins. The collectins appear to play an important role as pattern recognition molecules in the protection of mammals from viral, fungal, and bacterial infection. In humans and rodents, mannose-binding lectin (MBL) is the only major serum collectin, although low levels of both surfactant protein A (SP-A) and surfactant protein D (SP-D) are also found in serum. Three additional serum collectins, con-glutinin, CL-43, and CL-46, have been identified in the cow but not yet in other species. The chapter describes the structure of the collectin. For MBL as a serum protein, its role appears to be as an ante-antibody as it acts like a broad-spectrum antibody and is able to activate complement via a novel mechanism. The chapter explores the experimental evidence that supports these contentions. The findings that SP-A and SP-D play a pivotal role in the regulation of macrophagemediated inflammation in the lung, in the defense against invasion by pathogens, and in modulating inflammatory responses to infection and allergenic stimuli have intriguing clinical implications for a range of lung diseases. A great deal of progress has been made in defining the role for collectins as first-line host defense molecules. The exciting possibility exists that this knowledge may be harnessed and translated into novel adjuvant therapies.

Citation: Clark H, Reid K, Stehle T, Ezekowitz A. 2004. Collectins and the Acute-Phase Response, p 199-218. In Kaufmann S, Medzhitov R, Gordon S (ed), The Innate Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555817671.ch10

Key Concept Ranking

Innate Immune System
0.627805
Adaptive Immune System
0.55033624
Respiratory syncytial virus
0.5404763
Major Histocompatibility Complex
0.47064674
Viruses
0.43766558
0.627805
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of FIGURE 1
FIGURE 1

Mammalian lectins. The collectins form a subgroup of the C-type lectin superfamily. The lung collectins SP-A and SP-D, with the serum collectin MBL, are the only secreted collectins so far described in humans.

Citation: Clark H, Reid K, Stehle T, Ezekowitz A. 2004. Collectins and the Acute-Phase Response, p 199-218. In Kaufmann S, Medzhitov R, Gordon S (ed), The Innate Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555817671.ch10
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 2
FIGURE 2

MBL, SP-A, and SP-D are collectins with collagenous and carbohydrate-binding domains. Oligomerization of the trimeric building blocks greatly enhances the avidity of binding to carbohydrate targets via the CRDs.

Citation: Clark H, Reid K, Stehle T, Ezekowitz A. 2004. Collectins and the Acute-Phase Response, p 199-218. In Kaufmann S, Medzhitov R, Gordon S (ed), The Innate Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555817671.ch10
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 3
FIGURE 3

Comparison of the structural features of the CRDs from MBL and SP-D. Both MBL and SP-D trimers are very similar in structure. A striking feature of the SP-D trimer structure is the central area containing positively charged residues (indicated in dark gray) that may facilitate its interaction with negatively charged residues on pathogen targets such as LPS.

Citation: Clark H, Reid K, Stehle T, Ezekowitz A. 2004. Collectins and the Acute-Phase Response, p 199-218. In Kaufmann S, Medzhitov R, Gordon S (ed), The Innate Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555817671.ch10
Permissions and Reprints Request Permissions
Download as Powerpoint

References

/content/book/10.1128/9781555817671.chap10
1. Arai, T.,, P. Tabona,, and J. A. Summerfield. 1993. Human mannose-binding protein gene is regulated by interleukins, dexamethasone and heat shock. Q. J. Med. 86:575582.
2. Bachurski, C. J.,, G. F. Ross,, M. Ikegami,, B.W. Kramer,, and A. H. Jobe. 2001. Intra-amniotic endotoxin increases pulmonary surfactant proteins and induces SP-B processing in fetal sheep. Am. J. Physiol. Lung Cell. Mol. Physiol. 280:L279L285.
3. Ballard, P. L.,, S. Hawgood,, H. Liley,, G. Wellenstein,, L.W. Gonzales,, B. Benson,, B. Cordell,, and R. T. White. 1986. Regulation of pulmonary surfactant apoprotein SP 28-36 gene in fetal human lung. Proc. Natl. Acad. Sci. USA 83:95279531.
4. Bax, W. A.,, O. J. Cluysenaer,, A. K. Bartelink,, P. C. Aerts,, R. A. Ezekowitz,, and H. van Dijk. 1999. Association of familial deficiency of mannose-binding lectin and meningococcal disease. Lancet 354: 10941095.
5. Bickerstaff, M. C.,, M. Botto,, W. L. Hutchinson,, J. Herbert,, G. A. Tennent,, A. Bybee,, D. A. Mitchell,, H.T. Cook,, P. J. Butler,, M. J. Walport,, and M. B. Pepys. 1999. Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity. Nat. Med. 5:694697.
6. Borron, P. J.,, E. C. Crouch,, J. F. Lewis,, J. R. Wright,, F. Possmayer,, and L. J. Fraher. 1998a. Recombinant rat surfactant-associated protein D inhibits human T lymphocyte proliferation and IL-2 production. J. Immunol. 161:45994603.
7. Borron, P.,, F. X. McCormack,, B. M. Elhalwagi,, Z. C. Chroneos,, J. F. Lewis,, S. Zhu,, J. R. Wright,, V. L. Shepherd,, F. Possmayer,, K. Inchley,, and L. J. Fraher. 1998b. Surfactant protein A inhibits T cell proliferation via its collagen-like tail and a 210- kDa receptor. Am. J. Physiol. 275:L679L686.
8. Botas, C.,, F. Poulain,, J. Akiyama,, C. Brown,, L. Allen,, J. Goerke,, J. Clements,, E. Carlson,, A. M. Gillespie,, C. Epstein,, and S. Hawgood. 1998. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc. Natl. Acad. Sci. USA 95:1186911874.
9. Bourbon, J. R.,, and B. Chailley-Heu. 2001. Surfactant proteins in the digestive tract, mesentery, and other organs: evolutionary significance. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 129:151161.
10. Bowness, P.,, K. A. Davies,, P. J. Norsworthy,, P. Athanassiou,, J. Taylor-Wiedeman,, L. K. Borysiewicz,, P. A. Meyer,, and M. J. Walport. 1994. Hereditary C1q deficiency and systemic lupus erythematosus. Q. J. Med. 87:455464.
11. Brinker, K. G.,, E. Martin,, P. Borron,, E. Mostaghel,, C. Doyle,, C. V. Harding,, and J. R. Wright. 2001. Surfactant protein D enhances bacterial antigen presentation by bone marrow-derived dendritic cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 281:L1453L1463.
12. Cai, G. Z.,, G. L. Griffin,, R. M. Senior,, W. J. Longmore,, and M. A. Moxley. 1999. Recombinant SP-D carbohydrate recognition domain is a chemoattractant for human neutrophils. Am. J. Physiol. 276:L131L136.
13. Chida, S.,, D. S. Phelps,, C. Cordle,, R. Soll,, J. Floros,, and H.W. Taeusch. 1988. Surfactant-associated proteins in tracheal aspirates of infants with respiratory distress syndrome after surfactant therapy. Am. Rev. Respir. Dis. 137:943947.
14. Clark, H.,, and K. B. Reid. 2002. Structural requirements for surfactant protein D function in vitro and in vivo: therapeutic potential of recombinant SP-D. Immunobiology 205:619631.
15. Clark, H.W.,, K. B. Reid,, and R. B. Sim. 2000. Collectins and innate immunity in the lung. Microbes Infect. 2:273278.
16. Clark, H.,, N. Palaniyar,, P. Strong,, J. Edmondson,, S. Hawgood,, and K. B. Reid. 2002. Surfactant protein d reduces alveolar macrophage apoptosis in vivo. J. Immunol. 169:28922899.
17. Crosdale, D. J.,, K. V. Poulton,, W. E. Ollier,, W. Thomson,, and D. W. Denning. 2001. Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis. J. Infect. Dis. 184:653656.
18. Crouch, E.C.,, A. Persson,, G. L. Griffin,, D. Chang,, and R. M. Senior. 1995. Interactions of pulmonary surfactant protein D (SP-D) with human blood leukocytes. Am. J. Respir. Cell Mol. Biol. 12:410415.
19. Crouch, E.,, K. Hartshorn,, and I. Ofek. 2000. Collectins and pulmonary innate immunity. Immunol. Rev. 173:5265.
20. Dahl, M. R.,, S. Thiel,, M. Matsushita,, T. Fujita,, A. C. Willis,, T. Christensen,, T. Vorup-Jensen,, and J. C. Jensenius. 2001. MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 15:127135.
21. Downing, J. F.,, R. Pasula,, J. R. Wright,, H. L. D. Twigg,, and W. J. D. Martin. 1995. Surfactant protein a promotes attachment of Mycobacterium tuberculosis to alveolar macrophages during infection with human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 92:48484852.
22. Drickamer, K. 1989. Demonstration of carbohydrate- recognition activity in diverse proteins which share a common primary structure motif. 627th meeting , Nottingham 17:1315.
23. Drogari-Apiranthitou, M.,, C. A. Fijen,, S. Thiel,, A. Platonov,, L. Jensen,, J. Dankert,, and E. J. Kuijper. 1997. The effect of mannan-binding lectin on opsonophagocytosis of Neisseria meningitidis. Immunopharmacology 38:9399.
24. Eda, S.,, Y. Suzuki,, T. Kawai,, K. Ohtani,, T. Kase,, Y. Fujinaga,, T. Sakamoto,, T. Kurimura,, and N. Wakamiya. 1997. Structure of a truncated human surfactant protein D is less effective in agglutinating bacteria than the native structure and fails to inhibit haemagglutination by influenza A virus. Biochem. J. 323:393399.
25. Epstein, J.,, Q. Eichbaum,, S. Sheriff,, and R. A. Ezekowitz. 1996.The collectins in innate immunity. Curr. Opin. Immunol. 8:2935.
26. Ezekowitz, A. B. 1991. Ante-antibody immunity. Curr. Biol. 1:6062.
27. Ezekowitz, R. A.,, L. E. Day,, and G. A. Herman. 1988. A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins. J. Exp. Med. 167:10341046. (Erratum 174:753, 1991.)
28. Ezekowitz, R. A.,, M. Kuhlman,, J. E. Groopman,, and R. A. Byrn. 1989. A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus. J. Exp. Med. 169: 185196.
29. Ezekowitz, R. A.,, D. J. Williams,, H. Koziel,, M.Y. Armstrong,, A. Warner,, F. F. Richards,, and R. M. Rose. 1991. Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor. Nature 351: 155158.
30. Fadok, V. A.,, and G. Chimini. 2001.The phagocytosis of apoptotic cells. Semin. Immunol. 13:365372.
31. Ferguson, J. S.,, D. R. Voelker,, F. X. McCormack,, and L. S. Schlesinger. 1999. Surfactant protein D binds to Mycobacterium tuberculosis bacilli and lipoarabinomannan via carbohydrate-lectin interactions resulting in reduced phagocytosis of the bacteria by macrophages. J. Immunol. 163:312321.
32. Ferguson, J. S.,, D. R. Voelker,, J. A. Ufnar,, A. J. Dawson,, and L. S. Schlesinger. 2002. Surfactant protein D inhibition of human macrophage uptake of Mycobacterium tuberculosis is independent of bacterial agglutination. J. Immunol. 168:13091314.
33. Garred, P.,, T. Pressler,, H. O. Madsen,, B. Frederiksen,, A. Svejgaard,, N. Hoiby,, M. Schwartz,, and C. Koch. 1999. Association of mannose- binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. J. Clin. Invest. 104:431437.
34. Garred, P.,, T. Pressler,, S. Lanng,, H. O. Madsen,, C. Moser,, I. Laursen,, F. Balstrup,, and C. Koch. 2002. Mannose-binding lectin (MBL) therapy in an MBL-deficient patient with severe cystic fibrosis lung disease. Pediatr. Pulmonol. 33:201207.
35. Geertsma, M. F.,, P. H. Nibbering,, H. P. Haagsman,, M. R. Daha,, and R. van Furth. 1994. Binding of surfactant protein A to C1q receptors mediates phagocytosis of Staphylococcus aureus by monocytes. Am. J. Physiol. 267:L578L584.
36. Gulati, S.,, K. Sastry,, J. C. Jensenius,, P. A. Rice,, and S. Ram. 2002. Regulation of the mannan-binding lectin pathway of complement on Neisseria gonorrhoeae by C1-inhibitor and alpha 2-macroglobulin. J. Immunol. 168:40784086.
37. Guo, X.,, H. M. Lin,, Z. Lin,, M. Montano,, R. Sansores,, G. Wang,, S. DiAngelo,, A. Pardo,, M. Selman,, and J. Floros. 2001. Surfactant protein gene A, B, and D marker alleles in chronic obstructive pulmonary disease of a Mexican population. Eur. Respir. J. 18:482490.
38. Haataja, R.,, R. Marttila,, P. Uimari,, J. Lofgren,, M. Ramet,, and M. Hallman. 2001. Respiratory distress syndrome: evaluation of genetic susceptibility and protection by transmission disequilibrium test. Hum. Genet. 109:351355.
39. Hakansson, K.,, N. K. Lim,, H. J. Hoppe,, and K. B. Reid. 1999. Crystal structure of the trimeric alphahelical coiled-coil and the three lectin domains of human lung surfactant protein D. Struct. Fold. Des. 7:255264.
40. Hartshorn, K. L.,, E. C. Crouch,, M. R. White,, P. Eggleton,, A. I. Tauber,, D. Chang,, and K. Sastry. 1994. Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses. J. Clin. Invest. 94:311319.
41. Hartshorn, K. L.,, M. R. White,, V. Shepherd,, K. Reid,, J. C. Jensenius,, and E. C. Crouch. 1997. Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins. Am. J. Physiol. 273:L1156L1166.
42. Hartshorn, K. L.,, E. Crouch,, M. R. White,, M. L. Colamussi,, A. Kakkanatt,, B. Tauber,, V. Shepherd,, and K. N. Sastry. 1998. Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria. Am. J. Physiol. 274:L958L969.
43. Hartshorn, K. L.,, M. R. White,, D. R. Voelker,, J. Coburn,, K. Zaner,, and E. C. Crouch. 2000. Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutinin to antiviral activity. Biochem. J. 351:449458.
44. Hickling, T. P.,, H. Bright,, K. Wing,, D. Gower,, S. L. Martin,, R. B. Sim,, and R. Malhotra. 1999. A recombinant trimeric surfactant protein D carbohydrate recognition domain inhibits respiratory syncytial virus infection in vitro and in vivo. Eur. J. Immunol. 29:34783484.
45. Hickman-Davis, J.,, J. Gibbs-Erwin,, J. R. Lindsey,, and S. Matalon. 1999. Surfactant protein A mediates mycoplasmacidal activity of alveolar macrophages by production of peroxynitrite. Proc. Natl. Acad. Sci. USA 96:49534958.
46. Hirose, S.,, Y. Jiang,, Y. Hamano,, and T. Shirai. 2000. Genetic aspects of inherent B-cell abnormalities associated with SLE and B-cell malignancy: lessons from New Zealand mouse models. Int. Rev. Immunol. 19:389421.
47. Hoffmann, J. A.,, F. C. Kafatos,, C.A. Janeway,, and R. A. Ezekowitz. 1999. Phylogenetic perspectives in innate immunity. Science 284:13131318.
48. Holmskov, U. L. 2000. Collectins and collectin receptors in innate immunity.APMIS 100 (Suppl.):159.
49. Hoppe, H. J.,, and K. B. Reid. 1994. Collectins— soluble proteins containing collagenous regions and lectin domains—and their roles in innate immunity. Protein Sci. 3:11431158.
50. Hoppe, H. J.,, P. N. Barlow,, and K. B. Reid. 1994. A parallel three stranded alpha-helical bundle at the nucleation site of collagen triple-helix formation. FEBS Lett. 344:191195.
51. Ikeda, K.,, T. Sannoh,, N. Kawasaki,, T. Kawasaki,, and I. Yamashina. 1987. Serum lectin with known structure activates complement through the classical pathway. J. Biol. Chem. 262:74517454.
52. Ikegami, M.,, B. M. Elhalwagi,, N. Palaniyar,, K. Dienger,, T. Korfhagen,, J. A. Whitsett,, and F. X. McCormack. 2001.The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SPA null mouse. J. Biol. Chem. 276:3854238548.
53. Ip, W. K.,, S.Y. Chan,, C. S. Lau,, and Y. L. Lau. 1998. Association of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene. Arthritis Rheum. 41:16631668.
54. Kabha, K.,, J. Schmegner,, Y. Keisari,, H. Parolis,, J. Schlepper-Schaeffer,, and I. Ofek. 1997. SP-A enhances phagocytosis of Klebsiella by interaction with capsular polysaccharides and alveolar macrophages. Am. J. Physiol. 272:L344L352.
55. Kala, P.,, T. Ten Have,, H. Nielsen,, M. Dunn,, and J. Floros. 1998. Association of pulmonary surfactant protein A (SP-A) gene and respiratory distress syndrome: interaction with SP-B. Pediatr. Res. 43:169 177.
56. Kase, T.,, Y. Suzuki,, T. Kawai,, T. Sakamoto,, K. Ohtani,, S. Eda,, A. Maeda,, Y. Okuno,, T. Kurimura,, and N. Wakamiya. 1999. Human mannan- binding lectin inhibits the infection of influenza A virus without complement. Immunology 97:385392.
57. Klabunde, J.,, A. C. Uhlemann,, A. E. Tebo,, J. Kimmel,, R.T. Schwarz,, P. G. Kremsner,, and J. F. Kun. 2002. Recognition of Plasmodium falciparum proteins by mannan-binding lectin, a component of the human innate immune system. Parasitol. Res. 88:113117.
58. Kuan, S. F.,, K. Rust,, and E. Crouch. 1992. Interactions of surfactant protein D with bacterial lipopolysaccharides. Surfactant protein D is an Escherichia coli-binding protein in bronchoalveolar lavage. J. Clin. Invest. 90:97106.
59. Kuhlman, M.,, K. Joiner,, and R. A. Ezekowitz. 1989.The human mannose-binding protein functions as an opsonin. J. Exp. Med. 169:17331745.
60. Lee, R. T.,, Y. Ichikawa,, M. Fay,, K. Drickamer,, M. C. Shao,, and Y. C. Lee. 1991. Ligand-binding characteristics of rat serum-type mannose-binding protein (MBP-A). Homology of binding site architecture with mammalian and chicken hepatic lectins. J. Biol. Chem. 266:48104815.
61. LeVine, A. M.,, and J.A. Whitsett. 2001. Pulmonary collectins and innate host defense of the lung. Microbes Infect. 3:161166.
62. LeVine, A. M.,, M. D. Bruno,, K. M. Huelsman,, G. F. Ross,, J. A. Whitsett,, and T. R. Korfhagen. 1997. Surfactant protein A-deficient mice are susceptible to group B streptococcal infection. J. Immunol. 158:43364340.
63. LeVine, A. M.,, K. E. Kurak,, M. D. Bruno,, J. M. Stark,, J. A. Whitsett,, and T. R. Korfhagen. 1998. Surfactant protein-A-deficient mice are susceptible to Pseudomonas aeruginosa infection. Am. J. Respir. Cell Mol. Biol. 19:700708.
64. LeVine, A. M.,, K. E. Kurak,, J. R. Wright,, W. T. Watford,, M. D. Bruno,, G. F. Ross,, J. A. Whitsett,, and T. R. Korfhagen. 1999a. Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice. Am. J. Respir. Cell Mol. Biol. 20:279286.
65. LeVine, A. M.,, J. Gwozdz,, J. Stark,, M. Bruno,, J. Whitsett,, and T. Korfhagen. 1999b. Surfactant protein- A enhances respiratory syncytial virus clearance in vivo. J. Clin. Invest. 103:10151021.
66. LeVine, A. M.,, J. A. Whitsett,, J. A. Gwozdz,, T. R. Richardson,, J. H. Fisher,, M. S. Burhans,, and T. R. Korfhagen. 2000. Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung. J. Immunol. 165:39343940.
67. LeVine, A. M.,, J. A. Whitsett,, K. L. Hartshorn,, E. C. Crouch,, and T. R. Korfhagen. 2001. Surfactant protein D enhances clearance of influenza A virus from the lung in vivo. J. Immunol. 167:58685873.
68. Lim, B. L.,, J.Y. Wang,, U. Holmskov,, H. J. Hoppe,, and K. B. Reid. 1994. Expression of the carbohydrate recognition domain of lung surfactant protein D and demonstration of its binding to lipopolysaccharides of gram-negative bacteria. Biochem. Biophys. Res. Commun. 202:16741680.
69. Lipscombe, R. J.,, Y. L. Lau,, R. J. Levinsky,, S. M., J. A. Summerfield, and M. W. Turner. 1992. Identical point mutation leading to low levels of mannose binding protein and poor C3b mediated opsonisation in Chinese and Causasian populations. Immunol. Lett. 32:253258.
70. Lofgren, J.,, M. Ramet,, M. Renko,, R. Marttila,, and M. Hallman. 2002. Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants. J. Infect. Dis. 185:283289.
71. Lu, J. H.,, S. Thiel,, H. Wiedemann,, R. Timpl,, and K. B. Reid. 1990. Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2C1s2 complex, of the classical pathway of complement, without involvement of C1q. J. Immunol. 144:22872294.
72. Lu, J.,, C. Teh,, U. Kishore,, and K. B. Reid. 2002. Collectins and ficolins: sugar pattern recognition molecules of the mammalian innate immune system. Biochim. Biophys. Acta 1572:387400.
73. Madan, T.,, P. Eggleton,, U. Kishore,, P. Strong,, S. S. Aggrawal,, P. U. Sarma,, and K. B. Reid. 1997. Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infect. Immun. 65:31713179.
74. Madan, T.,, U. Kishore,, M. Singh,, P. Strong,, E. M. Hussain,, K. B. Reid,, and P. U. Sarma. 2001. Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis. Infect. Immun. 69:27282731.
75. Madsen, J.,, A. Kliem,, I. Tornoe,, K. Skjodt,, C. Koch,, and U. Holmskov. 2000. Localization of lung surfactant protein D on mucosal surfaces in human tissues. J. Immunol. 164:58665870.
76. Malhotra, R.,, S. Thiel,, K. B. Reid,, and R. B. Sim. 1990. Human leukocyte C1q receptor binds other soluble proteins with collagen domains. J. Exp. Med. 172:955959.
77. Malhotra, R.,, J. Haurum,, S. Thiel,, and R. B. Sim. 1992. Interaction of C1q receptor with lung surfactant protein A. Eur. J. Immunol. 22:14371445.
78. Malhotra, R.,, J. Lu,, U. Holmskov,, and R. B. Sim. 1994. Collectins, collectin receptors and the lectin pathway of complement activation. Clin. Exp. Immunol. 97(Suppl. 2):49.
79. Mamula, M. J.,, S. Fatenejad,, and J. Craft. 1994. B cells process and present lupus autoantigens that initiate autoimmune T cell responses. J. Immunol. 152: 14531461.
80. McCormack, F. X.,, T. E. King, Jr.,, D. R. Voelker,, P. C. Robinson,, and R. J. Mason. 1991. Idiopathic pulmonary fibrosis. Abnormalities in the bronchoalveolar lavage content of surfactant protein A. Am. Rev. Respir. Dis. 144:160166.
81. McIntosh, J. C.,, A. H. Swyers,, J. H. Fisher,, and J. R. Wright. 1996. Surfactant proteins A and D increase in response to intratracheal lipopolysaccharide. Am. J. Respir. Cell Mol. Biol. 15:509519.
82. McNeely, T. B.,, and J. D. Coonrod. 1993. Comparison of the opsonic activity of human surfactant protein A for Staphylococcus aureus and Streptococcus pneumoniae with rabbit and human macrophages. J. Infect. Dis. 167:9197.
83. McNeely, T. B.,, and J. D. Coonrod. 1994. Aggregation and opsonization of type A but not type B Haemophilus influenzae by surfactant protein A. Am. J. Respir. Cell Mol. Biol. 11:114122.
84. Mills, J. A. 1994. Systemic lupus erythematosus. N. Engl. J. Med. 330:18711879.
85. Miyamura, K.,, R. Malhotra,, H. J. Hoppe,, K. B. Reid,, P. J. Phizackerley,, P. Macpherson,, and A. Lopez Bernal. 1994. Surfactant proteins A (SP-A) and D (SP-D): levels in human amniotic fluid and localization in the fetal membranes. Biochim. Biophys. Acta 1210:303307.
86. Morel, L.,, B. P. Croker,, K. R. Blenman,, C. Mohan,, G. Huang,, G. Gilkeson,, and E. K. Wakeland. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc. Natl. Acad. Sci. USA 97:66706675.
87. Morel, L.,, K. R. Blenman,, B. P. Croker,, and E. K. Wakeland. 2001. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc. Natl. Acad. Sci. USA 98:17871792.
88. Mullighan, C. G.,, S. E. Marshall,, and K. I. Welsh. 2000. Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency. Scand. J. Immunol. 51:111122.
89. Mullighan, C. G.,, S. Heatley,, K. Doherty,, F. Szabo,, A. Grigg,, T. P. Hughes,, A. P. Schwarer,, J. Szer,, B. D. Tait,, L. Bik To,, and P. G. Bardy. 2002. Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation. Blood 99:35243529.
90. Naves, M.,, A. H. Hajeer,, L. S. Teh,, E. J. Davies,, J. Ordi-Ros,, P. Perez-Pemen,, M. Vilardel-Tarres,, W. Thomson,, J. Worthington,, and W. E. Ollier. 1998. Complement C4B null allele status confers risk for systemic lupus erythematosus in a Spanish population. Eur. J. Immunogenet. 25:317320.
91. Neth, O.,, I. Hann,, M.W. Turner,, and N. J. Klein. 2001. Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study. Lancet 358:614618.
92. Ng, K. K.,, K. Drickamer,, and W. I. Weis. 1996. Structural analysis of monosaccharide recognition by rat liver mannose-binding protein. J. Biol. Chem. 271: 663674.
93. Ng, K. K.,, A. R. Kolatkar,, S. Park-Snyder,, H. Feinberg,, D. A. Clark,, K. Drickamer,, and W. I. Weis. 2002. Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J. Biol. Chem. 277:1608816095.
94. Odendahl, M.,, A. Jacobi,, A. Hansen,, E. Feist,, F. Hiepe,, G. R. Burmester,, P. E. Lipsky,, A. Radbruch,, and T. Dorner. 2000. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J. Immunol. 165:59705979.
95. Ogden, C.A.,, A. deCathelineau,, P. R. Hoffmann,, D. Bratton,, B. Ghebrehiwet,, V. A. Fadok,, and P. M. Henson. 2001. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 194:781795.
96. O'Riordan, D. M.,, J. E. Standing,, K.Y. Kwon,, D. Chang,, E. C. Crouch,, and A. H. Limper. 1995. Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages. J. Clin. Invest. 95:26992710.
97. Paananen, R.,, V. Glumoff,, R. Sormunen,, W. Voorhout,, and M. Hallman. 2001. Expression and localization of lung surfactant protein B in Eustachian tube epithelium. Am. J. Physiol. Lung Cell. Mol. Physiol. 280:L214L220.
98. Peterslund, N. A.,, C. Koch,, J. C. Jensenius,, and S. Thiel. 2001. Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet 358:637638.
99. Phelps, D. S.,, and R. M. Rose. 1991. Increased recovery of surfactant protein A in AIDS-related pneumonia. Am. Rev. Respir. Dis. 143:10721075.
100. Pikaar, J. C.,, W. F. Voorhout,, L. M. van Golde,, J. Verhoef,, J. A. Van Strijp,, and J. F. van Iwaarden. 1995. Opsonic activities of surfactant proteins A and D in phagocytosis of gram-negative bacteria by alveolar macrophages. J. Infect. Dis. 172:481489.
101. Restrepo, C. I.,, Q. Dong,, J. Savov,, W. I. Mariencheck,, and J. R. Wright. 1999. Surfactant protein D stimulates phagocytosis of Pseudomonas aeruginosa by alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 21:576585.
102. Sastry, K.,, G. A. Herman,, L. Day,, E. Deignan,, G. Bruns,, C. C. Morton,, and R.A. Ezekowitz. 1989. The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10. J. Exp. Med. 170:11751189.
103. Schagat, T. L.,, J. A. Wofford,, and J. R. Wright. 2001. Surfactant protein A enhances alveolar macrophage phagocytosis of apoptotic neutrophils. J. Immunol. 166:27272733.
104. Schelenz, S.,, R. Malhotra,, R. B. Sim,, U. Holmskov,, and G. J. Bancroft. 1995. Binding of host collectins to the pathogenic yeast Cryptococcus neoformans: human surfactant protein D acts as an agglutinin for acapsular yeast cells. Infect. Immun. 63:3360 3366.
105. Sheriff, S.,, C. Y. Chang,, and R. A. Ezekowitz. 1994. Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alphahelical coiled-coil. Nat. Struct. Biol. 1:789794.
106. Strong, P.,, K. B. Reid,, and H. Clark. 2002. Intranasal delivery of a truncated recombinant human SP-D is effective at down regulating allergic hypersensitivity in mice sensitised to allergens of Aspergillus fumigatus. Clin. Exp. Immunol. 130:1924.
107. Super, M.,, S. Thiel,, J. Lu,, R. J. Levinsky,, and M. W. Turner. 1989. Association of low levels of mannan- binding protein with a common defect of opsonisation. Lancet 2:12361239.
108. Tabona, P.,, A. Mellor,, and J. A. Summerfield. 1995. Mannose binding protein is involved in first-line host defence: evidence from transgenic mice. Immunology 85:153159.
109. Taylor, P. R.,, A. Carugati,, V. A. Fadok,, H. T. Cook,, M. Andrews,, M. C. Carroll,, J. S. Savill,, P. M. Henson,, M. Botto,, and M. J. Walport. 2000. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J. Exp. Med. 192:359366.
110. Terai, I.,, and K. Kobayashi. 1993. Perinatal changes in serum mannose-binding protein (MBP) levels. Immunol. Lett. 38:185187.
111. Terai, I.,, K. Kobayashi,, T. Fujita,, and K. Hagiwara. 1993. Human serum mannose binding protein (MBP): development of an enzyme-linked immunosorbent assay (ELISA) and determination of levels in serum from 1085 normal Japanese and in some body fluids. Biochem. Med. Metab. Biol. 50:111119.
112. Tino, M. J.,, and J. R. Wright. 1996. Surfactant protein A stimulates phagocytosis of specific pulmonary pathogens by alveolar macrophages. Am. J. Physiol. 270:L677L688.
113. Tino, M. J.,, and J. R. Wright. 1999. Surfactant proteins A and D specifically stimulate directed actin-based responses in alveolar macrophages. Am. J. Physiol. 276:L164L174.
114. Tsutsumi, A.,, K. Sasaki,, N. Wakamiya,, K. Ichikawa,, T. Atsumi,, K. Ohtani,, Y. Suzuki,, T. Koike,, and T. Sumida. 2001. Mannose-binding lectin gene: polymorphisms in Japanese patients with systemic lupus erythematosus, rheumatoid arthritis and Sjogren's syndrome. Genes Immun. 2:99104.
115. Turner, M. W.,, and R. M. Hamvas. 2000. Mannose-binding lectin: structure, function, genetics and disease associations. Rev. Immunogenet. 2:305322.
116. Vandivier, R.W.,, C. A. Ogden,, V. A. Fadok,, P. R. Hoffmann,, K. K. Brown,, M. Botto,, M. J. Walport,, J. H. Fisher,, P. M. Henson,, and K. E. Greene. 2002. Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J. Immunol. 169:39783986.
117. van Iwaarden, J. F.,, J. A. van Strijp,, M. J. Ebskamp,, A. C. Welmers,, J. Verhoef,, and L. M. van Golde. 1991. Surfactant protein A is opsonin in phagocytosis of herpes simplex virus type 1 by rat alveolar macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 261:L204L209.
118. Van Iwaarden, J. F.,, J. C. Pikaar,, J. Storm,, E. Brouwer,, J. Verhoef,, R. S. Oosting,, L. M. van Golde,, and J. A. van Strijp. 1994. Binding of surfactant protein A to the lipid A moiety of bacterial lipopolysaccharides. Biochem. J. 303:407411.
119. van Rozendaal, B. A.,, C. H. van de Lest,, M. van Eijk,, L. M. van Golde,, W. F. Voorhout,, H. P. van Helden,, and H. P. Haagsman. 1999. Aerosolized endotoxin is immediately bound by pulmonary surfactant protein D in vivo. Biochim. Biophys. Acta 1454: 261269.
120. Villarreal, J.,, D. Crosdale,, W. Ollier,, A. Hajeer,, W. Thomson,, J. Ordi,, E. Balada,, M. Villardell,, L. S. Teh,, and K. Poulton. 2001. Mannose binding lectin and FcgammaRIIa (CD32) polymorphism in Spanish systemic lupus erythematosus patients. Rheumatology (Oxford) 40:10091012.
121. Wallis, R.,, and J.Y. Cheng. 1999. Molecular defects in variant forms of mannose-binding protein associated with immunodeficiency. J. Immunol. 163:49534959.
122. Wallis, R.,, and R. B. Dodd. 2000. Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations. J. Biol. Chem. 275:3096230969.
123. Wallis, R.,, and K. Drickamer. 1999. Molecular determinants of oligomer formation and complement fixation in mannose-binding proteins. J. Biol. Chem. 274:35803589.
124. Walport, M. J.,, K.A. Davies,, and M. Botto. 1998. C1q and systemic lupus erythematosus. Immunobiology 199:265285.
125. Wang, J.Y.,, C. C. Shieh,, P. F. You,, H.Y. Lei,, and K. B. Reid. 1998. Inhibitory effect of pulmonary surfactant proteins A and D on allergen-induced lymphocyte proliferation and histamine release in children with asthma. Am. J. Respir. Crit. Care Med. 158:510 518.
126. Watford, W. T.,, J. R. Wright,, C. G. Hester,, H. Jiang,, and M. M. Frank. 2001. Surfactant protein A regulates complement activation. J. Immunol. 167: 65936600.
127. Weber, B.,, A. Borkhardt,, S. Stoll-Becker,, I. Reiss,, and L. Gortner. 2000. Polymorphisms of surfactant protein A genes and the risk of bronchopulmonary dysplasia in preterm infants. Turk. J. Pediatr. 42:181185.
128. Weis, W. I.,, and K. Drickamer. 1994. Trimeric structure of a C-type mannose-binding protein. Structure 2:12271240.
129. Wert, S. E.,, M. Yoshida,, A. M. LeVine,, M. Ikegami,, T. Jones,, G. F. Ross,, J. H. Fisher,, T. R. Korfhagen,, and J. A. Whitsett. 2000. Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc. Natl. Acad. Sci. USA 97:59725977.
130. Wright, J. R.,, and D. C. Youmans. 1993. Pulmonary surfactant protein A stimulates chemotaxis of alveolar macrophage. Am. J. Physiol. 264:L338L344.
131. Wright, J. R.,, P. Borron,, K. G. Brinker,, and R. J. Folz. 2001. Surfactant Protein A. Regulation of innate and adaptive immune responses in lung inflammation. Am. J. Respir. Cell Mol. Biol. 24:513517.
132. Zhang, P.,, A. McAlinden,, S. Li,, T. Schumacher,, H. Wang,, S. Hu,, L. Sandell,, and E. Crouch. 2001. The amino-terminal heptad repeats of the coiled-coil neck domain of pulmonary surfactant protein d are necessary for the assembly of trimeric subunits and dodecamers. J. Biol. Chem. 276:1986219870.

Tables

Generic image for table
TABLE 1

Microbial targets of SP-A

Citation: Clark H, Reid K, Stehle T, Ezekowitz A. 2004. Collectins and the Acute-Phase Response, p 199-218. In Kaufmann S, Medzhitov R, Gordon S (ed), The Innate Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555817671.ch10
Generic image for table
TABLE 2

Microbial targets of SP-D

Citation: Clark H, Reid K, Stehle T, Ezekowitz A. 2004. Collectins and the Acute-Phase Response, p 199-218. In Kaufmann S, Medzhitov R, Gordon S (ed), The Innate Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555817671.ch10
Generic image for table
TABLE 3

Microbial targets of MBL

Citation: Clark H, Reid K, Stehle T, Ezekowitz A. 2004. Collectins and the Acute-Phase Response, p 199-218. In Kaufmann S, Medzhitov R, Gordon S (ed), The Innate Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555817671.ch10

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error