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Color Plates

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COLOR PLATE P

(Preface)

Citation: Kaufmann S, Medzhitov R, Gordon S. 2004. Color Plates, In The Innate Immune Response to Infection. ASM Press, Washington, DC.
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COLOR PLATE 1

(chapter 4) Expression of a c- EGFP transgene in mice.A 7.2-kb c- promoter plus enhancer directs the expression of the EGFP reporter gene into cells of the MPS of the mice. These examples illustrate the abundance of macrophages in all of the tissues of the mouse, as well as their characteristic stellate morphology and association with epithelia. Panels A and B illustrate the abundance of macrophages in the intestine; the EGFP+ marker is expressed specifically in lamina propria macrophages, as shown in the longitudinal section of colon's crypts (A) and in the cross section of small intestine villi (B). (C) The remarkably ramified morphology of microglia, the macrophages of the brain-expressing EGFP. (D) Transgenic EGFP expression in the macrophages that occupy the kidney interstitium aligned along basement membranes of kidney tubules. (E) Note the uneven distribution of Kupffer cells, the liver macrophages, within liver lobules.Within the skin, dermal macrophages express EGFP, as do Langerhans cells, the immature antigen-presenting DCs within the epidermis, as shown in (F), which is a cross section of the skin (arrow). Macrophage numbers change substantially in many organs of the female reproductive system during estrous cycle and pregnancy. (G) EGFP expression in macrophages lining the epithelial cells of alveoli of lactating mammary gland. (H) Numerous EGFP+ macrophages within the uterine endometrium.

Citation: Kaufmann S, Medzhitov R, Gordon S. 2004. Color Plates, In The Innate Immune Response to Infection. ASM Press, Washington, DC.
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COLOR PLATE 2

(chapter 8) Renal scarring and tissue damage in mIL-8Rh KO mice. (A) The infected mice develop acute pyelonephritis, with bacteremia and enlarged edematous kidneys. After several weeks, there is renal scarring with abscesses and small pale kidneys. (B) Tissue neutrophil aggregates visualized by the antineutrophil antibody RB6-8C5. (C) Renal scarring with fibrosis, as shown by trichrome staining.

Citation: Kaufmann S, Medzhitov R, Gordon S. 2004. Color Plates, In The Innate Immune Response to Infection. ASM Press, Washington, DC.
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COLOR PLATE 3

In situ hybridization showing expression of NOD2 in human Paneth cells. Digoxigenin-labeled NOD2 antisense riboprobe was hybridized to a section of normal human terminal ileum and detected immunohistochemically using an antibody to digoxigenin and a peroxidase-labeled secondary antibody. The brown peroxidase reaction product is seen in the basolateral portion of the cells, while the apically located secretory vesicles are unstained. A control section hybridized to a sense-strand NOD2 riboprobe is shown on the right. The sections were counterstained with hematoxylin and viewed under a 40× phase-contrast objective to demonstrate the granules.

Citation: Kaufmann S, Medzhitov R, Gordon S. 2004. Color Plates, In The Innate Immune Response to Infection. ASM Press, Washington, DC.
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COLOR PLATE 4

(chapter 17) Amphipathic distribution of cationic hydrophilic and hydrophobic amino acids in antimicrobial peptides of different structural classes. Red, basic (positively charged) amino acids; green, hydrophobic amino acids. Other amino acids are not shown. Magainin is depicted in its α-helical configuration.

Citation: Kaufmann S, Medzhitov R, Gordon S. 2004. Color Plates, In The Innate Immune Response to Infection. ASM Press, Washington, DC.
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COLOR PLATE 5

(chapter 17) The membrane target of antimicrobial peptides of multicellular organisms and the basis of specificity. Protegrin is depicted as a prototype; colors as in Fig. 1 (from Zasloff, 2002).

Citation: Kaufmann S, Medzhitov R, Gordon S. 2004. Color Plates, In The Innate Immune Response to Infection. ASM Press, Washington, DC.
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COLOR PLATE 6

(chapter 17) The SMH mechanism of action of an antimicrobial peptide. An α-helical peptide is depicted. (A) Carpeting of the outer leaflet with peptides. (B) Integration of the peptide into the membrane and thinning of the outer leaflet. (C) Phase transition and “wormhole” formation. Transient “pores” form at this stage. (D) Transport of lipids and peptides into the inner leaflet. (E) Diffusion of peptides onto intracellular targets (in some cases). (F) Collapse of the membrane into fragments and physical disruption of the target cell's membrane. Lipids with yellow head groups are acidic, or negatively charged. Lipids with black head groups have no net charge.

Citation: Kaufmann S, Medzhitov R, Gordon S. 2004. Color Plates, In The Innate Immune Response to Infection. ASM Press, Washington, DC.
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