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Chapter 23 : Antibiotic Resistance Plasmids

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Abstract:

This chapter provides an overview of plasmid classification systems and then describes the various mechanisms of plasmid-mediated resistance to antibacterial agents. The major pathways for the evolution of bacterial resistance plasmids are discussed. In general, plasmid-mediated resistance to antibacterials is a result of three major mechanisms: (i) destruction or modification of the antibacterial agents, (ii) prevention of the antibacterial agent from reaching its target in the bacterial cell, and (iii) production of an altered bacterial target. Resistance to tetracyclines, macrolides, glycopeptides, and quinolones are examples of this type of resistance. The majority of the approximately 60 known gene cassettes code for antibiotic resistance determinants. Genes in integrons have been found to encode resistance to a wide variety of antibiotics, including aminoglycosides, chloramphenicol, erythromycin, and the β-lactams. The aadA1 gene cassette (encoding spectinomycin resistance), carried by Tn21, is one of the most widespread resistance genes. Although the epidemiology of integrons has only recently been investigated, several reports have emphasized the importance of integrons in the dissemination of antibiotic resistance. IncHI1 plasmids are representative of antibiotic resistance plasmids that play a central role in the emergence and reemergence of bacterial pathogens. The chapter highlights the dynamic processes involved in plasmid evolution to acquire resistance markers. Transposons, integrons, conjugation, and other mechanisms of resistance spread are all employed by pathogens to respond to continued antibiotic usage in the clinic and in the environment.

Citation: Taylor D, Gibreel A, Tracz D, Lawley T. 2004. Antibiotic Resistance Plasmids, p 473-492. In Funnell B, Phillips G (ed), Plasmid Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817732.ch23

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1. Allard, J. D.,, and K. P. Bertrand. 1993. Sequence of a class E tetracycline resistance gene from Escherichia coli and comparison of related tetracycline efflux proteins. J Bacteriol. 175:45544560.
2. Allard, J. D.,, M. L. Gibson,, L. H. Vu,, T. T. Nguyen,, and K. P. Bertrand. 1993. Nucleotide sequence of class D tetracycline resistance genes from Salmonella ordonez. Mol. Gen. Genet. 237:301305.
3. Allignet, J.,, N. Liassine,, and N. el Solh. 1998. Characterization of a staphylococcal plasmid related to pUBl 10 and c u rving two novel genes, vatC and vgbBy encoding resistance to streptogramins A and B and similar antibiotics. Antimicrob. Agents Chemother. 42:17941798.
4. Allignet, J.,, V. Loncle,, P. Mazodier,, and N. el Solh. 1988. Nucleotide sequence of a staphylococcal plasmid gene, vgby encoding a hydrolase inactivating the B components of virginiamycin- like antibiotics. Plasmid 20:271275.
5. Alton, N. K.,, and D. Vapnek. 1979. Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9. Nature 282:864869.
6. Ambler, R. P. 1980. The structure of beta-lactamases. Philos. Trans. R. Soc. London Biol. Sci. 289:321331.
7. Amyes, S. G.,, and J. T. Smith. 1974. R-factor trimethoprim resistance mechanism: an insusceptible target site. Biochem. Biophys. Res. Commun. 58:412418.
8. Andremont, A.,, G. Gcrbaud,, and P. Courvalin. 1986. Plasmid-mediated high-level resistance to erythromycin in Escherichia coli. Antimicrob. Agents Chemother. 29:515518.
9. Arakawa, Y.,, M. Murakami,, K. Suzuki,, H. Ito,, R. Wacharotayankun,, S. Ohsuka,, N. Kato,, and M. Ohta. 1995. A novel integron-like element carrying the metallo-beta-lactamase gene blaLMP. Antimicrob. Agents Cbemother. 39: 16121615.
10. Archer, G. L.,, D. R. Dietrick,, and J . L. Johnston. 1985. Molecular epidemiology of transmissible gentamicin resistance among coagulase-negative Staphylococci in a cardiac surgery unit. J. Infect. Dis. 151:243251.
11. Arlet, G.,, M. Rouveau,, D. Bengoufa,, M. H. Nicolas,, and A. Philippon. 1991. Novel transferable extended-spectrum beta-lactamase (SHV-6) from Klebsiella pneumoniae conferring selective resistance to ceftazidime. FEMS Microbiol. Lett. 65:5762.
12. Arthur, M.,, D. Autissier,, and P. Courvalin. 1986. Analysis of the nucleotide sequence of the ereB gene encoding the erythromycin esterase type II. Nucleic Acids Res. 14:49874999.
13. Arthur, M.,, and P. Courvalin. 1993. Genetics and mechanisms of glycopeptide resistance in Enterococci. Antimicrob. Agents Chemother. 37:15631571.
14. Arthur, M.,, P. Reynolds,, and P. Courvalin. 1996. Glycopeptide resistance in Enterococci. Trends Microbiol. 4:401407.
15. Austin, S.,, and K. Nordstrom. 1990. Partition-mediated incompatibility of bacterial plasmids. Cell 60:351354.
16. Barthelemy, M.,, J. Peduzzi,, H. Ben Yaghlane,, and R. Labia. 1988. Single amino acid substitution between SHV-1 beta-lactamase and cefotaxime-hydrolyzing SHV-2 enzyme. FEBS Lett. 231:217220.
17. Barthelemy, P.,, D. Autissier,, G. Gerbaud,, and P. Courvalin. 1984. Enzymic hydrolysis of erythromycin by a strain of Escherichia coli. A new mechanism of resistance. J. Antibiot. (Tokyo) 37:16921696.
18. Bass, L.,, C. A. Liebert,, M. D. Lee,, A. O. Summers,, D. G. White,, S. G. Thayer,, and J. J. Maurer. 1999. Incidence and characterization of integrons, genetic elements mediating multiple-drug resistance, in avian Escherichia coli. Antimicrob. Agents Chemother. 43:29252929.
19. Bauernfeind, A.,, J. M. Casellas,, M. Goldberg,, M. Holley,, R. Jungwirth,, P. Mangold,, T. Rohnisch,, S. Schweighart,, and R. Wilhelm. 1992. A new plasmidic cefotaximase from patients infected with Salmonella typhimurium. Infection 20:158163.
20. Bauernfeind, A.,, H. Grimm,, and S. Schweighart. 1990. A new plasmidic cefotaximase in a clinical isolate of Escherichia coli. Infection 18:294298.
21. Bauernfeind, A.,, I. Schneider,, R. Jungwirth,, H. Sahly,, and U. Ullmann. 1999. A novel type of AmpC beta-lactamase, ACC-1, produced by a Klebsiella pneumoniae strain causing nosocomial pneumonia. Antimicrob. Agents Chemother. 43:19241931.
22. Bauernfeind, A.,, L. Stemplinger,, R. Jungwirth,, P. Mangold,, S. Amann,, E. Akalin,, O. Ang,, C. Hal,, and J. M. Casellas. 1996. Characterization of beta-lactamase gene blaPER 2, which encodes an extended-spectrum class A beta-lactamase. Antimicrob. Agents Chemother. 40:616620.
23. Bauernfeind, A.,, I. Stemplinger,, R. Jungwirth,, R. Wilhclm,, and Y. Chong. 1996. Comparative characterization of the cephamycinase blaCMY 1 gene and its relationship with other beta-lactamase genes. Antimicrob. Agents Chemother. 40: 19261930.
24. Bauernfeind, A.,, S. Wagner,, R. Jungwirth,, I. Schneider,, and D. Meyer. 1997. A novel class C beta-lactamase (FOX-2) in Escherichia coli conferring resistance to ccphamycins. Antimicrob. Agents Chemother. 41:20412046.
25. Bennett, A. D.,, and W. V. Shaw. 1983. Resistance to fusidic acid in Escherichia coli mediated by the type I variant of chloramphenicol acetyltransferase. A plasmid-encoded mechanism involving antibiotic binding. Biochem. J. 215: 2938.
26. Bergquist, P. L.,, S. Saadi,, and W. K. Maas. 1986. Distribution of basic replicons having homology with RepFIA, RepFIB, and RepFIC among IncF group plasmids. Plasmid 15:1934.
27. Bernard, H.,, C. Tancrcdc,, V. Livrelli,, A. Morand,, M. Barthelemy,, and R. Labia. 1992. A novel plasmid-mediated extended-spectrum beta-lactamase not derived from TEMor SHV-type enzymes, J. Antimicrob. Chemother. 29:590592.
28. Berryman, D. I.,, and J . I. Rood. 1995. The closely related ermB-ermAM genes from Clostridium perfringens. Enterococcus faecalis (pAM beta 1), and Streptococcus agalactiae (pIP50l) are flanked by variants of a directly repeated sequence. Antimicrob. Agents Chemother. 39:18301834.
29. Bissonnette, L.,, S. Champetier,, J . P. Buisson,, and P. H. Roy. 1991. Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn7696: similarity of the product to transmembrane transport proteins. J. Bacteriol. 173:44934502.
30. Bonnet, R.,, J. L. Sampaio,, R. Labia,, C. De Champs,, D. Sirot,, C. Chanal,, and J. Sirot. 2000. A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil. Antimicrob. Agents Chemotber. 44:19361942.
31. Boronin, A. M. 1992. Diversity of Pseudomonas plasmids: to what extent? FEMS Microbiol Lett. 79:461467.
32. Bozdogan, B.,, L. Berrezouga,, M. S. Kuo,, D. A. Yurck,, K. A. Farley,, B. J . Stockman,, and R. Leclercq. 1999. A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025. Antimicrob. Agents Chemother. 43:925929.
33. Bradford, P. A.,, C. Urban,, N. Mariano,, S. J. Projan,, J. J. Rahal,, and K. Bush. 1997. Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamasc, and the foss of an outer membrane protein. Antimicrob. Agents Chemother. 41:563569.
34. Brehm, J .,, G. Salmond,, and N. Minton. 1987. Sequence of the adenine methylase gene of the Streptococcus faecalis plasmid pAM beta 1. Nucleic Acids Res. 15:3177.
35. Brisson-Noel, A.,, M. Arthur,, and P. Courvalin. 1988. Evidence for natural gene transfer from gram-positive cocci to Escherichia coli. J. Bacteriol. 170:17391745.
36. Brisson-Noel, A.,, and P. Courvalin. 1986. Nucleotide sequence of gene linA encoding resistance to lincosamides in Staphylococcus haemolyticus. Gene 43:247253.
37. Brisson-Noel, A.,, P. Delrieu,, D. Samain,, and P. Courvalin. 1988. Inactivation of lincosaminide antibiotics in Staphylococcus. Identification of lincosaminide O-nucleotidyltransferases and comparison of the corresponding resistance genes. J. Biol. Chem. 263:1588015887.
38. Brown, A. W.,, S. C Rankin,, and D. J. Platt. 2000. Detection and characterisation of integrons in Salmonella enterica serotype cnteritidis. FEMS Microbiol Lett. 191:145149.
39. Brown, G. M. 1962. The biosynthesis of folic acid. II. Inhibition by sulfonamides.J. Biol. Chem. 237:536540.
40. Bugg, T. D.,, G. D. Wright,, S. Dutka-Malen,, M. Arthur,, P. Courvalin,, and C. T. Walsh. 1991. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 30:1040810415.
41. Burdett, V. 1996. Tet(M)-promoted release of tetracycline from ribosomes is GTP dependent. J. Bacteriol 178:32463251.
42. Bure, A.,, P. Legrand,, G. Arlet,, V. Jarlicr,, G. Paul,, and A. Philippon. 1988. Dissemination in five French hospitals of Klebsiella pneumoniae serotype K25 harbouring a new transferable enzymatic resistance to third generation cephalosporins and aztreonam. Eur.J. Clin. Microbiol. Infect. Dis. 7:780782.
43. Bush, K.,, G. A. Jacoby,, and A. A. Medeiros. 1995. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39:12111233.
44. Cao, V.,, T. Lambert,, and P. Courvalin. 2002. ColE1-like plasmid pIP843 of Klebsiella pneumoniae encoding extendedspectrum beta-lactamase CTX-M-17, Antimicrob. Agents Chemother. 46:12121217.
45. Capage, M. A.,, J. K. Goodspeed,, and J. R. Scott. 1982. Incompatibility group Y member relationships: pIP231 and plasmid prophages P1 and P7. Plasmid 8:307311.
46. Carattoli, A. 2001. Importance of integrons in the diffusion of resistance. Vet. Res. 32:243259.
47. Catchpole, I.,, C. Thomas,, A. Davies,, and K. G. Dyke. 1988. The nucleotide sequence of Staphylococcus aureus plasmid pT48 conferring inducible macrolide-lincosamide-streptogramin B resistance and comparison with similar plasmids expressing constitutive resistance. J. Gen. Microbiol 134: 697709.
48. Ceglowski, P.,, A. Boitsov,, S. Chai,, and J . C. Alonso. 1993. Analysis of the stabilization system of pSM19035-derived plasmid pBT233 in Bacillus subtilis. Gene 136:112.
49. Chalkley, L. J.,, S. van Vuuren,, R. C. Ballard,, and P. L. Botha. 1995. Characterisation of penA and tetM resistance genes of Neisseria gonorrhoeae isolated in southern Africa— epidemiological monitoring and resistance development. S. Afr. Med. J. 85:775780.
50. Chang, S.,, and S. N. Cohen. 1979. High frequency transformation of Bacillus subtilis protoplasts by plasmid DNA. Mol. Gen. Genet. 168:111115.
51. Charles, I. G.,, J . W. Keyte,, and W. V. Shaw. 1985. Nucleotide sequence analysis of the cat gene of Proteus Mirabilis: comparison with the type I (Tn9) cat gene. J. Bacteriol 164:123129.
52. Charpentier, E.,, G. Gerbaud,, and P. Courvalin. 1993. Characterization of a new class of tetracycline-resistance gene tet (S) in Listeria monocytogenes BM4210. Gene 131: 2734.
53. Cloeckaert, A.,, S. Baucheron,, G. Flaujac,, S. Schwarz,, C. Kchrenberg,, J . L. Martel,, and E. Chaslus-Dancla. 2000. Plasmid-mediated florfenicol resistance encoded by the floR gene in Escherichia coli isolated from cattle. Antimicrob. Agents Chemother. 44:28582860.
54. Collis, C. M.,, and R. M. Hall. 1992. Gene cassettes from the insert region of integrons are excised as covalently closed circles. Mol. Microbial. 6:28752885.
55. Connell, S. R.,, C. A. Trieber,, U. Stelzl,, E. Einfeldt,, D. E. Taylor,, and K. H. Nierhaus. 2002. The tetracycline resistance protein Tet(o) perturbs the conformation of the ribosomal decoding centre. Mol. Microbiol. 45:14631472.
56. Cooksey, R.,, J . Swenson,, N. Clark,, E. Gay,, and C. Thornsberry, 1990. Patterns and mechanisms of beta-lactam resistance among isolates of Escherichia coli from hospitals in the United States. Antimicrob. Agents Chemother. 34: 739745.
57. Couturier, M.,, F. Bex,, P. L, Bergquist, and W. K. Maas. 1988. Identification and classification of bacterial plasmids. Microbiol Rev. 52:375395.
58. Datta, N., 1975. Epidemiology and classification of plasmids, p. 915. In D. Schlessinger (ed.), Microbiology—1974. American Society for Microbiology, Washington, D.C..
59. Datta, N., 1979. Plasmid classification: incompatibility grouping, p. 312 . In K. N. Timmis, and A. Pühlers (ed.), Plasmids of Medical Environmental and Commercial Importance. Elseviers/North Holland Publishing Co., Amsterdam, The Netherlands.
60. Datta, N., 1984. Plasmids in enteric bacteria, p. 487496. In L. E. Bryan (ed.). Antimicrobial Drug Resistance. Academic Press, Orlando, Fla..
61. Datta, N.,, and R. W. Hedges. 1972. R factors identified in Paris, some conferring gentamicin resistance, constitute a new compatibility group. Ann. Inst. Pasteur (Paris) 123:849852.
62. Davey, R., B. P. I. Bird,, S. M. Nikoletti,, J. Praszkier,, and J. Pittard. 1984. The use of mini-Gal plasmids for rapid incompatibility grouping of conjugative R plasmids. Plasmid 11:234242.
63. Davies, J . 1994. Inactivation of antibiotics and the dissemination of resistance genes. Science 264:375382.
64. Davies, J.,, and G. D. Wright. 1997. Bacterial resistance to aminoglycoside antibiotics. Trends Microbiol 5:234240.
65. De La Cruz, F.,, J. C. Zabala,, and J. M. Ortiz. 1979. Incompatibility among alpha hemolyic plasmids studied after inactivation of the alpha hemolysin gene by transposition of Tn802. Plasmid 2:507519.
66. De Rossi, E.,, M. C. Blokpoel,, R. Cantoni,, M. Branzoni,, G. Riccardi,, D. B. Young,, K. A. De Smet,, and O. Ciferri. 1998. Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet(V), from Mycobacterium smegmatis. Antimicrob. Agents Chemother. 42:19311937.
67. Dombusch, K.,, G. H. Miller,, R. S. Hare,, and K. J . Shaw. 1990. Resistance to aminoglycoside antibiotics in gram-negative bacilli and staphylococci isolated from blood. Report from a European collaborative study. The ESGAR Study Group (European Study Group on Antibiotic Resistance). J. Antimicrob. Chemother. 26:131144.
68. Dutka-Malen, S.,, R. Leclercq,, V. Coutant,. J. Duval,, and P. Courvalin. 1990. Phenotypic and genotypic heterogeneity of glycopeptidc resistance determinants in gram-positive bacteria. Antimicrob. Agents Chemother. 34:18751879.
69. Dutta, G. N.,, and L. A. Devriese. 1981. Degradation of macrolide-lincosamide-streptogramin antibiotics by Lactobacillus strains from animals. Ann. Microbiol. (Paris) 132A: 5157.
70. Evers, S.,, and P. Courvalin. 1996. Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. Bacteriol 178:13021309.
71. Evers, S.,, D. F. Sahm,, and P. Courvalin. 1993. The vanB gene of vancomycin-resistant Enterococcus faecalis V583 is structurally related to genes encoding D-Ala:D-Ala ligascs and glycopeptide-resistance proteins VanA and VanC. Gene 124:143144.
72. Ferretti, J. J.,, K. S. Gilmore,, and P. Courvalin. 1986. Nucleotide sequence analysis of the gene specifying the Afunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities. J. Bacteriol 167:631638.
73. Pica, A.,, M. E. Fernandez-Beros,, L. Aron-Hott,, A. Rivas,, K. D'Ottone,, J . Chumpitaz,, J . M. Guevara,, M. Rodriguez,, and F. Cabello. 1997. Antibiotic-resistant Salmonella typhi from two outbreaks: few ribotypes and IS2O0 types harbor Inc HI1 plasmids. Microb. Drug Resist. 3:339343.
74. Finlay, B., B. W. Paranchych,, and S. Falkow. 1983. Characterization of conjugative plasmid EDP208.J. Bacteriol. 156:230235.
75. Flensburg, J .,, and R. Steen. 1986. Nucleotide sequence analysis of the trimethoprim resistant dihydrofolate reductase encoded by R plasmid R751. Nucleic Acids Res. 14:5933.
76. Fluit, A. C.,, and F. J. Schmitz. 1999. Class 1 integrons, gene cassettes, mobility, and epidemiology. Eur.J. Clin. Microbiol. Infect. Dis. 18:761770.
77. Fons, M.,, T. Hege,, M. Ladire,, P. Raibaud,, R. Ducluzeau,, and E. Maguin. 1997. Isolation and characterization of a plasmid from Lactobacillus fermentum conferring erythromycin resistance. Plasmid 37:199203.
78. Forbes, B. A.,, and D. R. Schaberg. 1983. Transfer of resistance plasmids from Staphylococcus epidermis to Staphylococcus aureus: evidence for conjugative exchange of resistance.J. Bacteriol 153:627634.
79. Fortineau, N.,, L. Poirel,, and P. Nordmann. 2001. Plasmid-mediated and inducible cephalosporinase DHA-2 from Klebsiella pneumoniae. J. Antimicrob. Chemother. 47:207210.
80. Francia, M. V.,, P. Avila,, F. de la Cruz,, and J . M. Garcia Lobo. 1997. A hot spot in plasmid F for site-specific recombination mediated by Tn21 integron integrase. J. Bacteriol 179:44194425.
81. French, G.,, Y. Abdulla,, R. Heathcock,, S. Poston,, and J . Cameron. 1992. Vancomycin resistance in south London. Lancet 339:818819.
82. Frere, J . M. 1995. Beta-lactamases and bacterial resistance to antibiotics. Mol. Microbiol. 16:385395.
83. Gabant, P.,, A. O. Chahdi,, and M. Couturier. 1994. Nucleotide sequence and replication characteristics of RepHIIB: a replicon specific to the IncHIl plasmids. Plasmid 31:111120.
84. Gabant, P.,, P. Newnham,, D. Taylor,, and M. Couturier. 1993. Isolation and location on the R27 map of two replicons and an incompatibility determinant specific for IncHI 1 plasmids. J. Bacteriol 175:76977701.
85. Gaffney, D. F.,, E. Cundliffe,, and T. J . Foster. 1981. Chloramphenicol resistance that does not involve chloramphenicol acetyltransferase encoded by plasmids from gramnegative bacteria. J. Gen. Microbiol 125:113121.
86. Gazouli, M.,, L. S. Tzouvelekis,, E. Prinarakis,, V. Miriagou,, and E. Tzelepi. 1996. Transferable cefoxitin resistance in enterobacteria from Greek hospitals and characterization of a plasmid-mediated group 1 beta-lactamase (LAT-2). Antimicrob. Agents Chemother. 40:17361740.
87. Gonzalez Leiza, M.,, J . C. Perez-Diaz,, J . Ayala,, J. M. Casellas,, J. Martinez-Beltran,, K. Bush,, and F. Baquero. 1994. Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid- mediated beta-lactamase with two molecular variants. Antimicrob. Agents Chemother. 38:21502157.
88. Guerra, B.,, S. M. Soto,, J . M. Arguelles,, and M. C. Mendoza. 2001. Multidrug resistance is mediated by large plasmids carrying a class 1 integron in the emergent Salmonella enterica serotype (4,5,12:i:-). Antimicrob. Agents Chemother. 45:13051308.
89. Gutmann, L.,, B. Ferre,, F. W. Goldstein,, N. Rizk,, E. Pinto- Schuster,, J . F. Acar,, and E. Collatz. 1989. SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams. Antimicrob. Agents Chemother. 33:951956.
90. Hall, R. M.,, D. E. Brookes,, and H. W. Stokes. 1991. Sitespecific insertion of genes into integrons: role of the 59-base element and determination of the recombination cross-over point. Mol. Microbiol. 5:19411959.
91. Hall, R. M.,, and C. M. Collis. 1995. Mobile gene cassettes and integrons: capture and spread of genes by site-specific recombination. Mol. Microbiol. 15:593600.
92. Hall, R. M.,, and H. W. Stokes. 1993. Integrons: novel DNA elements which capture genes by site-specific recombination. Genetica 90:115132.
93. Hansen, L., M. L. M. McMurry,, S. B. Levy,, and D. C. Hirsh. 1993. A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline. Antimicrob. Agents Chemother. 37:26992705.
94. Harnett, N.,, S. McLeod,, Y. AuYong,, J . Wan,, S. Alexander, R, Khakhria, and C. Krishnan. 1998, Molecular characterization of muttiresistant strains of Salmonella typhi from South Asia isolated in Ontario, Canada. Can. J . Microbial. 44:356363.
95. Hedges, R. W.,, and N. Datta. 1971. fi- R factors giving chloramphenicol resistance. Nature 234:220221.
96. Hedges, R. W.,, V. Rodrigucz-Lcmoine,, and N. Datta. 1975. R factors from Serratia marcescens. J. Gen. Microbiol 86:8892.
97. Heikkila, E.,, L. Sundstrom,, M. Skurnik,, and P. Huovinen, 1991. Analysis of genetic localization of the type I trimetho prim resistance gene from Escherichia coli isolated in Finland. Antimicrob. Agents Chemother. 35:15621569.
98. Hillen, W.,, and K. Schollmeier. 1983. Nucleotide sequence of the Tn 10 encoded tetracycline resistance gene. Nucleic Acids Res. 11:525539.
99. Hodel-Christian, S. L.,, and B. E. Murray. 1990. Mobilization of the gentamicin resistance gene in Enterococcus faecalis. Antimicrob. Agents Chemother. 34:12781280.
100. Horii, T.,, Y. Arakawa,, M. Ohta,, S. Ichiyama, R, Wacharotayankun, and N. Kato. 1993. Plasmid-mediated AmpC-type beta-lactamase isolated from Klebsiella pneumoniae confers resistance to broad-spectrum beta-lactams, including moxalactam. Antimicrob. Agents Chemother. 37:984990.
101. Horinouchi, S.,, W. H. Byeon,, and B. Weisblum. 1983. A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis.J. Bacteriol. 154:12521262.
102. Horinouchi, S.,, and B. Weisblum. 1982. Nucleotide sequence and functional map of pE194, a plasmid that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibodies. J. Bacteriol. 150:804814.
103. Hoshino, T.,, T. Ikeda,, N. Tomizuka,, and K. Furukawa. 1985. Nucleotide sequence of the tetracycline resistance gene of pTHT15, a thermophilic Bacillus plasmid: comparison with staphylococcal TcR controls. Gene 37:131138.
104. lordanescu, S.,, and M. Surdeanu. 1980. New incompatibility groups of Staphylococcus aureus plasmids. Plasmid 4:256260.
105. lordanescu, S.,, M. Surdeanu,, P. Della Latta,, and R. Novick. 1978. Incompatibility and molecular relationships between small staphylococcal plasmids carrying the same resistance marker. Plasmid 1:468479.
106. Ito, H.,, Y. Arakawa,, S. Ohsuka,, R. Wacharotayankun,, N. Kato,, and M. Ohta. 1995. Plasmid-mediated dissemination of the metallo-beta-lactamase geneLMP among clinically isolated strains of Serratia marcescens. Antimicrob. Agents Chemother. 39:824829.
107. Ivanoff, B.,, and M. M. Levine. 1997. Typhoid fever: continuing challenges from a resilient bacterial foe. Bull. Inst. Pasteur 95:129142.
108. Jacoby, G. A.,, and G. L. Archer. 1991. New mechanisms of bacterial resistance to antimicrobial agents. N. Engl. J. Med. 324:601612.
109. Kim, E.,, and T. Aoki. 1996. Sequence analysis of the florfenicol resistance gene encoded in the transferable R-plasmid of a fish pathogen, Pasteurella piscicida. Microbiol. Immunol. 40:665669.
110. Koeck, J . L.,, G. Arlet,, A. Philippon,, S. Basmaciogullari,, H. V. Thien,, Y. Buisson,, and J. D. Cavallo. 1997. A plasmidmediated CMY-2 beta-lactamase from an Algerian clinical isolate of Salmonella senftenberg. FEMS Microbiol. Lett. 152:255260.
111. Kono, M.,, K. O'Hara,, and T. Ebisu. 1992. Purification and characterization of macrolide 2'-phosphotransferase type ll from a strain of Escherichia coli highly resistant to macrolide antibiotics. FEMS Microbiol. Lett. 76:8994.
112. L'Abee-Lund, T. M.,, and H. Sorum. 2001. Class 1 integrons mediate antibiotic resistance in the fish pathogen Aeromonas salmonicida worldwide. Microb. Drug Resist. 7:263272.
113. Lampson, B. C.,, and J. T. Parisi. 1986. Naturally occurring Staphylococcus epidermidis plasmid expressing constitutive macrolide-lincosamide-streptogramin B resistance contains a deleted attenuator. J. Bacteriol. 166:479483.
114. Lampson, B. .,, W. von David,, and J. T. Parisi. 1986. Novel mechanism for plasmid-mediated erythromycin resistance by pNE24 from Staphylococcus epidermidis. Antimicrob. Agents Chemother. 30:653658.
115. Lane, D.,, and R. C. Gardner. 1979. Second EcoRI fragment of F capable of self-replication. J. Bacteriol. 139:141151.
116. Lawley, T., D. V. Burland,, and D. E. Taylor. 2000. Analysis of the complete nucleotide sequence of the tetracycline-resistance transposon Tn10. Plasmid 43:235239.
117. Lawley, T., D. M. W. Gilmour,, J. E. Gunton,, L. J. Standeven,, and D. E. Taylor, 2002. Functional and mutational analysis of conjugative transfer region 1 (Tral) from the IncHII plasmid R27.J. Bacteriol. 184:21732180.
118. Le Goffie, F.,, M. L. Capmau,, J. Abbe,, C. Cerceau,, A. Dublanchet,, and J . Duval. 1977. Plasmid mediated pristinamycin resistance: PH IA, a pristinamycin 1A hydrolase. Ann. Microbiol. (Paris) 128B:471474.
119. LeBlanc, D. J.,, L. N. Lee,, B. M. Titmas,, C. J. Smith,, and F. C. Tenover. 1988. Nucleotide sequence analysis of tetracycline resistance gene tetO from Streptococcus mutans DL5. J . Bacteriol. 170:36183626.
120. Liebert, C. A.,, R. M. Hall,, and A. O. Summers. 1999. Transposon Tn21, flagship of the floating genome. Microbiol. Mol Biol Rev. 63:507522.
121. Lopez, J.,, J. C. Rodriguez,, I. Andres,, and J. M. Ortiz. 1989. Characterization of the RepFVIl replicon of the hemolyic plasmid pSU233: nucleotide sequence of an incFVII determinant.J. Gen. Microbiol. 135:17631768.
122. Maher, D.,, and D. E. Taylor. 1993. Host range and transfer efficiency of incompatibility group HI plasmids. Can. J. Microbiol. 39:581587.
123. Manavathu, E. K., C L. Fernandez, B. S. Cooperman, and D. E. Taylor. 1990. Molecular studies on the mechanism of tetracycline resistance mediated by Tet(O). Antimicrob. Agents Chemother. 34:7177.
124. Marchese, A.,, G. Arlet,, G. C. Schito,, P. H. Lagrange,, and A. Philippon. 1998. Characterization of FOX-3, an AmpC-type plasmid-mediated beta-lactamase from an Italian isolate of Klebsiella oxytoca. Antimicrob. Agents Cbemother. 42:464467.
125. Martinez-Martinez, L.,, A. Pascual,, and G. A. Jacoby. 1998. Quinolone resistance from a transferable plasmid. Lancet 351:797799.
126. Matsuoka, M.,, M. Inoue,, Y. Nakajima,, and Y. Endo. 2002. New erm gene in Staphylococcus aureus clinical isolates. Antimicrob. Agents Chemother. 46:211215.
127. Matsuoka, M.,, L. Janosi,, K. Endou,, and Y. Nakajima. 1999. Cloning and sequences of inducible and constitutive macrolide resistance genes in Staphylococcus aureus that correspond to an ABC transporter. FEMS Microbiol. Lett. 181:91100.
128. Mazel, D.,, and J . Davies. 1999. Antibiotic resistance in microbes. Cell. Mol. Life Sci. 56:742754.
129. Meynell, E.,, G. G. Meynell,, and N. Datta. 1968. Phylogenetic relationships of drug-resistance factors and other transmissible bacterial plasmids. Bacteriol. Rev. 32: 5583.
130. Milton, I. D.,, C. L. Hewitt,, and C. R. Harwood. 1992. Cloning and sequencing of a plasmid-mediated erythromycin resistance determinant from Staphylococcus xylosus. FEMS Microbiol. Lett. 76:141147.
131. Minami, S.,, M. Akama,, H. Araki,, Y. Watanabe,, H. Narita,, S. Iyobe,, and S. Mitsuhashi. 1996. Imipenem and cephem resistant Pseudomonas aeruginosa carrying plasmids coding for class B beta-lactamase. J . Antimicrob. Chemother. 37:433444.
132. Mitsuhashi, S., 1971, Epidemiology of bacterial drug resistance, p. 123. In S. Mitsuhashi (ed.), Transferable Drug Resistance Factor R. University Park Press, Baltimore, Md.
133. Monod, M.,, C. Denoya,, and D. Dubnau. 1986. Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis.J. Bacteriol. 167:138147.
134. Neu, H. C. 1992. The crisis in antibiotic resistance. Science 257:10641073.
135. Nicolas, M. H.,, V. Jarlier,, N. Honore,, A. Philippon,, and S. T. Cole. 1989. Molecular characterization of the gene encoding SHV-3 beta-lactamase responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae. Antimicrob. Agents Cbemother. 33:20962100.
136. Noguchi, N.,, T. Aoki,, M. Sasatsu,, M. Kono,, K. Shishido,, and T. Ando. 1986. Determination of the complete nucleotide sequence of pNSl, a staphylococcal tetracyclineresistance plasmid propagated in Bacillus subtilis. FEMS Microbiol. Lett. 37:283288.
137. Noguchi, N.,, A. Emura,, H. Matsuyama,, K. O'Hara,, M. Sasatsu,, and M. Kono. 1995. Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coli. Antimicrob. Agents Chemother. 39:23592363.
138. Novick, R. 1967. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology 33:155166.
139. Novick, R. 1976. Plasmid-protein relaxation complexes in Staphylococcus aureus.J. Bacteriol. 127:11771187.
140. Novick, R. P. 1987. Plasmid incompatibility. Microbiol. Rev. 51:381395.
141. Novick, R. P. 1989. Staphylococcal plasmids and their replication. Annu. Rev. Microbiol. 43:537565.
142. Oh, T. G.,, A. R. Kwon,, and E. C. Choi. 1998. Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics. J. Bacteriol. 180: 57885791.
143. Olsen, R. H.,, and P. Shipley. 1973. Host range and properties of the Pseudomonas aeruginosa R factor R1822. J. Bacteriol. 113:772780.
144. Ounissi, H.,, and P. Courvalin. 1985. Nucleotide sequence of the gene ereA encoding the erythromycin esterase in Escherichia coli. Gene 35:271278.
145. Papanicolaou, G. A.,, A. A. Medeiros,, and G. A. Jacoby. 1990. Novel plasmid-mediated beta-lactamase (MIR-1) conferring resistance to oxyimino- and alpha-methoxy beta-lactams in clinical isolates of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 34:22002209.
146. Parkhill, J .,, G. Dougan,, K. D. James,, N. R. Thomson,, D. Pickard,, J. Wain,, C. Churcher,, K. L. Mungall,, S. D. Bentley,, M. T. Holden,, M. Sebaihia,, S. Baker,, D. Basham,, K. Brooks,, T. Chillingworth,, P. Connerton,, A. Cronin,, P. Davis,, R. M. Davies,, L. Dowd,, N. White,, J. Farrar,, T. Feltwell,, N. Hamlin,, A. Haque,, T. T. Hien,, S. Holroyd,, K. Jagels,, A. Krogh,, T. S. Larsen,, S. Leather,, S. Moule,, P. O'Gaora,, C. Parry,, M. Quail,, K. Rutherford,, M. Simmonds,, J. Skelton,, K. Stevens,, S. Whitehead,, and B. G. Barrell. 2001. Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature 413:848852.
147. Parsons, Y.,, R. M. Hall,, and H. W. Stokes. 1991. A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGOIOO. Antimicrob. Agents Chemother. 35: 24362439.
148. Partridge, S. R.,, G. D. Recchia,, H. W. Stokes,, and R. M. Hall. 2001. Family of class I integrons related to ln4 from Tn1696. Antimicrob. Agents Chemother. 45:30143020.
149. Patterson, J. E.,, and M. J. Zervos. 1990. High-level gentamicin resistance in Enterococcus: microbiology, genetic basis, and epidemiology. Rev. Infect. Dis. 12:644652.
150. Payne, D., J. N. Woodford,, and S. G. Amyes. 1992. Characterization of the plasmid mediated beta-lactamase BIL-I. J. Antimicrob. Chemother. 30:119127.
151. Philippon, A.,, G. Arlet,, and G. A. Jacoby. 2002. Plasmid-determined AmpC-type beta-lactamases. Antimicrob. Agents Chemother. 46:111.
152. Ploy, M. C.,, P. Courvalin,, and T. Lambert. 1998. Characterization of In40 of Enterobacter aerogenes BM2688, a class 1 integron with two new gene cassettes, cmlAl and qacF. Antimicrob. Agents Chemother. 42:25572563.
153. Poirel, L.,, T. Naas,, D. Nicolas,, L. Collet,, S. Bellais,, J . D. Cavallo,, and P. Nordmann. 2000. Characterization of VIM- 2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France. Antimicrob. Agents Chemother. 44:891897.
154. Poirel, L.,, I. Le Thomas,, T. Naas,, A. Karim,, and P. Nordmann. 2000. Biochemical sequence analyses of GES-I, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae. Antimicrob. Agents Chemother. 44:622632.
155. Power, E. G.,, Y. H. Abdulla,, H. G. Talsania,, W. Spice,, S. Aathithan,, and G. L. French. 1995. van A genes in vancomycin- resistant clinical isolates of Oerskovia turbata and Arcanobacterium (Coryttebacterium) haemolyticum.J. Antimicrob. Chemother. 36:595606.
156. Proctor, G. N.,, J . McKell,, and R. H. Rownd. 1983. Chloramphenicol acetyltransferase may confer resistance to fusidic acid by sequestering the drug. J. Bacteriol. 155:937939.
157. Radstrom, P.,, O. Skold,, G. Swedberg,, J . Flensburg,, P. H. Roy,, and L. Sundstrom. 1994. Transposon Tn5090 of plasmid R751, which carries an integron, is related to Tn7, Mu, and the retroelements. J. Bacteriol. 176:32573268.
158. Radstrom, P.,, and G. Swedberg. 1988. RSF1010 and a conjugative plasmid contain sulII one of two known genes for plasmid-borne sulfonamide resistance dihydroptcroate synthase. Antimicrob. Agents Cbemother. 32:16841692.
159. Rasmussen, J . L.,, D. A. Odelson,, and F. L. Macrina. 1986. Complete nucleotide sequence and transcription of ermF, a inacrolidc-lincosamide-strcptogramin B resistance determinant from Bacteroides fragilis. J. Bacteriol. 168:523533.
160. Rasmussen, J . L.,, D. A. Odelson,, and F. L. Macrina. 1987. Complete nucleotide sequence of insertion clement IS4351 from Bacteroides fragilis. J. Bacteriol. 169:35733580.
161. Recchia, G. D.,, and R. M. Hall. 1995. Gene cassettes: a new class of mobile element. Microbiology 141:30153027.
162. Rende-Fournier, R.,, R. Leclereq,, M. Galimand,, J . Duval,, and P. Courvalin. 1993. Identification of the sat A gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145. Antimicrob. Agents Chemother. 37:21192125.
163. Reynolds, P. E. 1989. Structure, biochemistry and mechanism of action of glycopeptide antibiotics. Eur. J. Clin. Microbiol. Infect. Dis. 8:943950.
164. Richards, H.,, and N. Datta. 1979. Reclassification of incompatibility group L. (IncL) plasmids. Plasmid 2:293295.
165. Roberts, M. C.,, J. Sutcliffe,, P. Courvalin,, L. B. Jensen,, J. Rood,, and H. Seppala. 1999. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. Antimicrob. Agents Cbemother. 43:28232830.
166. Rosen, B. P. 1999. The role of efflux in bacterial resistance to soft metals and metalloids. Essays Biocbem. 34:115.
167. Ross, J. L.,, E. A. Eady,, J. H. Cove,. W. J. Cunliffc,, S. Baumberg,, and J. C. Wootton. 1990. Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family. Mol Microbiol. 4:12071214.
168. Rowe-Magnus, D. A.,, and D. Mazel. 2001, Integrons: natural tools for bacterial genome evolution. Curr. Opin. Microbiol 4:565569.
169. Roy, C.,, C. Segura,, M. Tirado,, R. Reig,, M. Hermida,, D. Teruel,, and A. Foz. 1985. Frequency of plasmid-determined beta-lactamases in 680 consecutively isolated strains of Enterobacteriaceae. Eur. J. Clin. Microbiol. 4:146147.
170. Rubens, C. E.,, W. F. McNeill,, and W. E. Farrar, Jr. 1979. Transposable plasmid deoxyribonucleic acid sequence in Pseudomonas aeruginosa which mediates resistance to gentamicin and four other antimicrobial agents. J. Bacteriol 139:877882.
171. Saadi, S.,, W. K. Maas,, and P. L. Bergquist. 1984. RepFIC, a basic replicon of IncFI plasmids that has homology with a basic replicon of IncFII plasmids. Plasmid 12:6164.
172. Salyers, A. A.,, B. S. Speer,, and N. B. Shoemaker. 1990. New perspectives in tetracycline resistance. Mol Microbiol 4:151156.
173. Schmidt, A. S.,, M. S. Bruun,, J . L. Larsen, and I Dalsgaard. 2001. Characterization of class 1 integrons associated with R-plasmids in clinical Aeromonas salmonicida isolates from various geographical areas. J. Antimicrob. Chemother. 47:735743.
174. Serwold-Davis, T. M.,, and N. B. Groman. 1988. Identification of a methylase gene for erythromycin resistance within the sequence of a spontaneously deleting fragment of Corynbacterium diphtheriae plasmid pNG2. FEMS Microbiol Lett. 46:714.
175. Shaw, K., J. P. N. Rather,, R. S. Hare,, and G. H. Miller. 1993. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol Rev. 57:138163.
176. Shaw, W.V. 1983. Chloramphenicol acetyltransferase: enzymology and molecular biology. CRC Crit. Rev. Biochem. 14:147.
177. Sherburne, C. K.,, T. D. Lawley,, M. W. Gilmour,, F. R. Blattner,, V. Burland,, E. Grotbeck,, D. J. Rose,, and D. E. Taylor. 2000. The complete DNA sequence and analysis of R27, a large IncHI plasmid from Salmonella typhi that is temperature sensitive for transfer. Nucleic Acids Res. 28:21772186.
178. Simonsen, C. C.,, E. Y. Chen,, and A. D. Levinson. 1983. Identification of the type I trimethoprim-resistant dihydrofolate reductase specified by the Escherichia coli R-plasmid R483: comparison with procaryotic and eucaryotic dihydrofolate reductases.J. Bacteriol 155:10011008.
179. Singh, K. V.,, R. R. Reves,, L. K. Pickering,, and B. E. Murray. 1992. Identification by DNA sequence analysis of a new plasmid-encoded trimethoprim resistance gene in fecal Escherichia coli isolates from children in day-care centers. Antimicrob. Agents Chemother. 36:17201726.
180. Sloan, J .,, L. M. McMurry,, D. Lyras,, S. B. Levy,, and J. I. Rood. 1994. The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P)y which mediates active tetracycline efflux, and tetB(P)t which is related to the ribosomal protection family of tetracycline-resistance determinants. Mol. Microbiol 11:403415.
181. Somkuti, G. A.,, D. K. Solaiman,, and D. H. Steinberg, 1997. Molecular properties of the erythromycin resistance plasmid pPV141 from Staphylococcus chromogenes. Plasmid 37: 119127.
182. Somkuti, G. A.,, D. K. Solaiman,, and D. H. Steinberg. 1998. Molecular characterization of the erythromycin resistance plasmid pPV142 from Staphylococcus simulans. FEMS Microbiol Lett. 165:281288.
183. Sougakoff, W.,, B. Papadopoulou, P, Nordmann, and P. Courvalin. 1987. Nucleotide sequence and distribution of gene tetO encoding tetracycline resistance in Campylobacter coli. FEMS Microbiol Lett. 44:153159.
184. Spahn, C. M.,, G. Blaha,, R. K. Agrawal,, P. Penezek,, R. A. Grassucci,, C. A. Trieber,, S. R. Connell,, D. E. Taylor,, K. H. Nierhaus,, and J. Frank. 2001. Localization of the ribosomal protection protein Tet(O) on the ribosome and the mechanism of tetracycline resistance. Mol Cell 7:10371045.
185. Speer, B. S.,, and A. A. Salyers. 1988, Characterization of a novel tetracycline resistance that functions only in aerobically grown Escherichia coli.J. Bacteriol 170:14231429.
186. Speer, B. S.,, and A. A. Salyers. 1989. Novel aerobic tetracycline resistance gene that chemically modifies tetracycline. J. Bacteriol 171:148153.
187. Speer, B., S. N. B. Shoemaker,, and A. A. Salyers. 1992. Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance. Clin. Microbiol Rev. 5:387399.
188. Stapleton, P. D.,, K. P. Shannon,, and G. L. French. 1999. Carbapenem resistance in Escherichia coli associated with plasmid-determined CMY-4 beta-lactamase production and loss of an outer membrane protein. Antimicrob. Agents Chemother. 43:12061210.
189. Stokes, H. W.,, and R. M. Hall. 1989. A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: integrons. Mol. Microbiol 3: 16691683.
190. Stone, D.,, and S. L. Smith. 1979. The amino acid sequence of the trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67 J. Biol Chem. 254:1085710861.
191. Summers, A. O.,, and G. A. Jacoby. 1977. Plasmid-determined resistance to tellurium compounds. J. Bacteriol 129: 276281.
192. Sundstrom, L.,, P. Radstrom,, G. Swedberg,, and O. Skold. 1988. Site-specific recombination promotes linkage between trimethoprim and sulfonamide resistance genes. Sequence characterization of dhfrV and sull and a recombination active locus of Tn21. Mol Gen. Genet. 213:191201.
193. Sundstrom, L.,, G. Swedberg,, and O. Skold. 1993. Characterization of transposon Tn5086, carrying the site-specifically inserted gene dhfrVH mediating trimethoprim resistance. J. Bacteriol 175:17961805.
194. Swedberg, G. 1987. Organization of two sulfonamide resistance genes on plasmids of gram-negative bacteria. Antimicrob. Agents Chemother. 31:306311.
195. Tauch, A.,, S. Krieft,, A. Puhler,, and J . Kalinowski. 1999. The tetAB genes of the Corynebacterium striatum R-plasmid pTPIO encode an ABC transporter and confer tetracycline, oxytetracycline and oxacillin resistance in Corynebacterium glutamicum. FEMS Microbiol Lett. 173:203209.
196. Tauch, A.,, A. Puhler,, J. Kalinowski,, and G. Thierbach. 2000. TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology to gram-negative regulated efflux systems. Plasmid 44:285291.
197. Tauch, A.,, Z. Zheng,, A. Puhler, and J , Kalinowski. 1998. Corynebacterium striatum chloramphenicol resistance transposon Tn5564: genetic organization and transposition in Corynebacterium glutamicum. Plasmid 40:126139.
198. Taylor, D. E., 1989>. General properties of resistance plasmids, p. 325357. In L. E. Bryan (ed.), Handbook of Experimental Pharmacology. Springer-Verlag, New York, N.Y..
199. Taylor, D. E.,, and D. E. Bradley. 1987. Location on RP4 of a tellurite-resistance determinant not normally expressed in IncP alpha plasmids. Antimicrob. Agents Chemother. 31:823825.
200. Taylor, D. E.,, and R. B. Grant. 1977. R plasmids of the S incompatibility group belong to the H2 incompatibility group. Antimicrob. Agents Chemother. 12:431434.
201. Taylor, D. E.,, K. Hiratsuka,, H. Ray,, and E. K. Manavathu. 1987. Characterization and expression of a cloned tetracycline resistance determinant from Campylobacter jejuni plasmid pUA466.J. Bacteriol 169:29842989.
202. Taylor, D. E.,, and J . G. Levine. 1980. Studies of temperature- sensitive transfer and maintenance of H incompatibility group plasmids. J. Gen. Microbiol. 116:475484.
203. Tolun, A.,, and D. R. Helinski. 1981. Direct repeats of the F plasmid incC region express F incompatibility. Cell 24:687694.
204. Tran, J . H.,, and G. A. Jacoby. 2002. Mechanism of plasmid-mediated quinolone resistance. Proc. Natl Acad. Sci. USA 99:56385642.
205. Trieber, C. A.,, N. Burkhardt,, K. H. Nierhaus,, and D. E. Taylor. 1998. Ribosomal protection from tetracycline mediated by Tet(O): Tet(O) interaction with ribosomes is GTP-dependent. Biol. Chem. 379:847855.
206. Tzouvelekis, L. S.,, E. Tzelepi,, A. F. Mentis,, and A. Tsakris. 1993. Identification of a novel plasmid-mediated beta-lactamase with chromosomal cephalosporinase characteristics from Klebsiella pneumoniae. J. Antimicrob. Chemother. 31:645654.
207. Udo, E. E.,, D. E. Townsend,, and W. B. Grubb. 1987. A conjugative staphylococcal plasmid with no resistance phenotype. FEMS Microbiol. Lett. 40:279283.
208. van Treeck, U.,, F. Schmidt,, and B. Wiedemann. 1981. Molecular nature of a streptomycin and sulfonamide resistance plasmid (pBPl) prevalent in clinical Escherichia coli strains and integration of an ampicillin resistance transposon (TnA). Antimicrob. Agents Chemother. 19:371380.
209. Verbist, L., 1990. The antimicrobial activity of fusidic acid. J. Antimicrob. Chemother. 25(Suppl B):15.
210. Vcrdet, C.,, G. Arlet,, S. Ben Rcdjcb,, A. Ben Hassen,, P. H. Lagrange,, and A. Philippon. 1998. Characterisation of CMY-4, an AmpC-type plasmid-mediated beta-lactamase in a Tunisian clinical isolate of Proteus mirabilis. FEMS Microbiol Lett. 169:235240.
211. Wang, Y.,, and D. E. Taylor. 1990. Chloramphenicol resistance in Campylobacter coli: nucleotide sequence, expression, and cloning vector construction. Gene 94:2328.
212. Watanabe, T. 1963. Infective heredity of multiple drug resistance in bacteria. Bacteriol Rev. 27:87115.
213. Watanabe, T. 1969. Bacterial episomes and plasmids. CIBA Found. Symp. 1969:8197.
214. Waters, S. H.,, P. Rogowsky,, J . Grinsted,, J . Altenbuchner,, and R. Schmitt. 1983. The tetracycline resistance determinants of RP1 and Tn 1721 : nucleotide sequence analysis. Nucleic Acids Res. 11:60896105.
215. Weisblum, B. 1995. Erythromycin resistance by ribosome modification. Antimicrob. Agents Chemother. 39:577585.
216. Wondrack, L.,, M. Massa,, B. V. Yang,, and J . Suteliffe. 1996. Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides. Antimicrob. Agents Chemother. 40:992998.
217. Woodford, N.,, A. P. Johnson,, D. Morrison,, and D. C. Speller. 1995. Current perspectives on glycopeptide resistance. Clin. Microbiol. Rev. 8:585615.
218. Woodford, N.,, B. L. Jones,, Z. Baccus,, H. A. Ludlam,, and D. F. Brown. 1995. Linkage of vancomycin and high-level gentamicin resistance genes on the same plasmid in a clinical isolate of Enterococcus faecalis. J. Antimicrob. Chemother. 35:179184.
219. Woodford, N.,, D. J . Payne,, A. P. Johnson,, M. J . Weinbren,, R. M. Perinpanayagam,, R. C George,, B. D. Cookson,, and S. G. Amyes. 1990. Transferable cephalosporin resistance not inhibited by clavulanatc in Escherichia coli. Lancet 336:253.
220. Wu, S. W.,, K. Dornbusch,, M. Norgren,, and G. Kronvall. 1992. Extended spectrum beta-lactamase from Klebsiella oxytoca, not belonging to the TEM or SHV family.J. Antimicrob. Chemother. 30:316.
221. Wylie, B. A.,, and H. J . Koornhof. 1991. Nucleotide sequence of dihydrofolate reductase type VI. J. Med. Microbiol 35:214218.
222. Yan, J. -J.,, S.-M. Wu,, S.-H. Tsai,, J.-J. Wu,, and I.-J. Su. 2000. Prevalence of SHV-12 among clinical isolates of Klebsiella pneumoniae producing extended-spectrum beta-lactamases and identification of a novel AmpC enzyme (CMY-8) in southern Taiwan. Antimicrob. Agents Chemother. 44:14381442.
223. Young, H. K.,, M. J . Qumsich,, and M. L. Mcintosh. 1994. Nucleotide sequence and genetic analysis of the type lb trimethoprim-resistant, Tn4132-encoded dihydrofolate reductase. J. Antimicrob. Chemother. 34:715725.
224. Zhao, J .,, and T. Aoki. 1992. Nucleotide sequence analysis of the class G tetracycline resistance determinant from Vibrio anguillarum. Microbiol Immunol. 36:10511060.
225. Zhao, S.,, D. G. White,, B. Ge,, S. Ayers,, S. Friedman,, L. English,, D. Wagner,, S. Gaines,, and J. Meng. 2001. Identification and characterization of integron-mediated antibiotic resistance among Shiga toxin-producing Escherichia coli isolates. Appl Environ. Microbiol 67:15581564.
226. Zolg, J. W.,, and U . J . Hanggi. 1981. Characterization of a R plasmid-associated trimethoprim-resistant dihydrofolate reductase and determination of the nucleotide sequence of the reductase gene. Nucleic Acids Res. 9:697710.

Tables

Generic image for table
Table 1

Plasmid incompatibility groups in

Citation: Taylor D, Gibreel A, Tracz D, Lawley T. 2004. Antibiotic Resistance Plasmids, p 473-492. In Funnell B, Phillips G (ed), Plasmid Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817732.ch23
Generic image for table
Table 2

Plasmid incompatibility groups in

Citation: Taylor D, Gibreel A, Tracz D, Lawley T. 2004. Antibiotic Resistance Plasmids, p 473-492. In Funnell B, Phillips G (ed), Plasmid Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817732.ch23
Generic image for table
Table 3

Plasmid incompatibility groups in S.

Citation: Taylor D, Gibreel A, Tracz D, Lawley T. 2004. Antibiotic Resistance Plasmids, p 473-492. In Funnell B, Phillips G (ed), Plasmid Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817732.ch23
Generic image for table
Table 4

Completely sequenced resistance plasmids from gram-positive and gram-negative bacteria

Citation: Taylor D, Gibreel A, Tracz D, Lawley T. 2004. Antibiotic Resistance Plasmids, p 473-492. In Funnell B, Phillips G (ed), Plasmid Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817732.ch23
Generic image for table
Table 5

Completely sequenced broad-host-range resistance plasmids

Citation: Taylor D, Gibreel A, Tracz D, Lawley T. 2004. Antibiotic Resistance Plasmids, p 473-492. In Funnell B, Phillips G (ed), Plasmid Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817732.ch23

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