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Chapter 11 : Permeability as an Excuse to Write What I Feel

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Permeability as an Excuse to Write What I Feel, Page 1 of 2

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Abstract:

This chapter states that initial rates of β-galactosidase production were very similar with and without inducer. The author thinks it is safe to say that this PaJaMa experiment provided the basis and frame of reference for further studies on the mechanism of enzyme regulation. The PaJaMa experiment is the basis of a historical-philosophical study of the nature of discovery by Kenneth Schaffner, who interviewed the individuals involved and reconstructed a composite of what happened. From the PaJaMa studies on the molecular nature of induction—proposed to be the effects of interaction of a lactose-related inducer with the repressor protein, which initiates a quite different process of gene expression—Jacques Monod became interested in how a small molecule can modify a protein’s function. The author says that the time spent by him in Monod’s laboratory was certainly one of the most remarkable of his career, as he learned there of the great power of genetics in combination with biochemistry.

Citation: Cohen G. 2003. Permeability as an Excuse to Write What I Feel, p 109-116. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch11

Key Concept Ranking

Amino Acids
0.77317446
Messenger RNA
0.5307412
Multifunctional Enzyme
0.52888244
0.77317446
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J. Monod and G. Cohen, 1954.

Citation: Cohen G. 2003. Permeability as an Excuse to Write What I Feel, p 109-116. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch11
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Citation: Cohen G. 2003. Permeability as an Excuse to Write What I Feel, p 109-116. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch11
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