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Chapter 16 : The Wonderful Year

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The Wonderful Year, Page 1 of 2

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Abstract:

During the course of an analysis of the ability of compounds related to lactose to act as inducers of β-galactosidase, Howard Rickenberg, working with Georges Cohen and Gérard Buttin in Monod’s laboratory, discovered the inducible transport system (“permease”) for β-galactosidases. Monod's earlier studies had shown that the genetic regulation of the galactoside permease was coordinated with that of the β-galactosidase, and indeed that the gene for β-galactosidase (the gene) and that for the permease (the gene) were part of the same genetic unit, or operon. Monod proposed that the permease would have the property of binding its substrate and suggested that the author's group try to identify it by this property. The active galactoside permease has not yet been isolated, but Fox and Kennedy have isolated and characterized the gene product, which they called the M-protein, after modifying it with the -ethylmaleimide, using a clever modification of the binding idea based on Adam Kepes' observation that the β-galactosidase permease contains essential sulfhydryl groups that are protected by the substrate. The exit of galactose was also found to be inhibited by substances, such as α-methyglucoside and succinate that were not substrates for the galactose permease. Monod was intimately involved in everything that was going on in the laboratory, from sporulation to permeation, and in those days he was always in the laboratory, available for discussion of the work.

Citation: Perrin D. 2003. The Wonderful Year, p 163-167. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch16

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Agnes Ullmann and David Perrin, 1970.

Citation: Perrin D. 2003. The Wonderful Year, p 163-167. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch16
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Citation: Perrin D. 2003. The Wonderful Year, p 163-167. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch16
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