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Chapter 22 : Another Route

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Another Route, Page 1 of 2

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Abstract:

At the meeting of the author and Jacques Monod, Monod explained to him how he intended to organize his biological training. By deciding that his essay should bear on "prediction of the conformation of a protein from its amino acid sequence," Monod put the author right into the field of protein folding, a theme which has since remained the subject of his research. When, after a decade, the author tries to understand why he got so deeply involved in that subject, he can find two main reasons, both related to the fact that Monsieur Monod himself had become particularly interested in protein folding. To account for the large size of proteins, Monod tried to analyze the constraints which the functional features of a protein exert on its structure: the existence of a catalytic site, requiring the exact relative positioning of half a dozen amino acids; the stability of the protein conformation, requiring, according to the “oil drop model,” a hydrophobic core; the solubility of the molecule, requiring the presence on its surface of polar residues that are able to interact with the solvent. Monod's interest in protein conformation survived his involvement in the direction of the Pasteur Institute.

Citation: Schwartz M. 2003. Another Route, p 207-216. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch22
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Figures

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Figure 1

In the hall of the Director's office, with his young Airedale Vicky, ca. 1973. (Photograph by Madeleine Brunerie.)

Citation: Schwartz M. 2003. Another Route, p 207-216. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch22
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Figure 2

Ca. 1970.

Citation: Schwartz M. 2003. Another Route, p 207-216. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch22
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Figure 3

Citation: Schwartz M. 2003. Another Route, p 207-216. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch22
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