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Chapter 24 : To Fold or Not to Fold: The Way Toward Research

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Abstract:

The author's plan was to learn phage genetics for use in later physicochemical studies of genetic problems. Two surprises were awaiting him. One was a student (Alex Fritsch) who wanted to work with him; he was particularly interested in the uses of the analytical ultracentrifuge. The second surprise was a manuscript by Jacques Monod on a model for allosteric enzymes. It proposed a general model for allosteric enzymes. The particular protein which was discussed in detail was hemoglobin, which was not then known to be an allosteric protein. He looked down at the set of four dice, glued together, which he used as a model in thinking about the symmetry properties of oligomeric proteins. But the logic of the allosteric model seemed to require that proteins be flexible. Jacques admitted then that the answers to allosteric mechanisms would probably come from physicochemical studies of purified proteins, together with their crystal structures. Hemoglobin, in particular, became one of the most intensively studied molecules known to chemists.

Citation: Goldberg M. 2003. To Fold or Not to Fold: The Way Toward Research, p 221-228. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch24

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Protein Folding
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Test Tubes
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Michel Goldberg

Citation: Goldberg M. 2003. To Fold or Not to Fold: The Way Toward Research, p 221-228. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch24
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