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Chapter 27 : Some Memories of Jacques Monod

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Some Memories of Jacques Monod, Page 1 of 2

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Abstract:

The author's first encounter with Jacques Monod was over forty years ago when he gave the Dunham lectures at the Harvard Medical School. In 1965 that Monod and the author published their joint paper with J.- P. Changeux on what has come to be known as the M–W–C allosteric model. This paper, which appeared in the Journal of Molecular Biology, grew out of a seminar the author gave in Paris in 1964; and in turn was the result of a talk given the preceding summer at Cold Spring Harbor. The underlying linkage principles, in accordance with which ligand-linked conformational changes can give rise to both homotropic and heterotropic control, had already been laid down, and it was this subject that formed the basis of the talk the author gave in Paris. The introductory part dealing with the possible role of symmetry in the assembly of oligomeric proteins was largely due to Jacques. Although the author had introduced the concept of symmetry, pointing out that insofar as site interactions were the reflection of the spacing of the sites, symmetry of function as represented by symmetry of the binding curve implied a certain geometric symmetry in a macromolecule. The rest of the paper was based largely on the sure principles of classical thermodynamics. In the talks by Jacques and the author, Jacques stressed the geometric symmetry concept; the author stressed more on abstract thermodynamic ideas, taking the occasion also to introduce the closely related concept of the binding potential.

Citation: Koshland, Jr. D. 2003. Some Memories of Jacques Monod, p 249-254. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch27

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Gene Expression
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Daniel E. Koshland, Jr.

Citation: Koshland, Jr. D. 2003. Some Memories of Jacques Monod, p 249-254. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch27
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