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Chapter 32 : Jacques Monod: Scientist, Humanist, and Friend

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Jacques Monod: Scientist, Humanist, and Friend, Page 1 of 2

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Abstract:

In the course of research work, the author's group observed a fact that seemed very significant. A certain compound, phenyl-β-D-thiogalactoside, devoid of inductive capacity, proved capable of counteracting the action of an effective inducer such as methyl-β-D-thiogalactoside. The study of galactoside permease was to reveal another fact of great significance. Several years earlier, following Lederberg’s work, the group had isolated some “constitutive” mutants of β-galactosidase, that is, strains in which the enzyme was synthesized in the absence of any galactoside. The author then had to admit that a constitutive mutation, although very strongly linked to the loci governing galactosidase, galactoside permease, and transacetylase, had taken place in a gene (i) distinct from the other three (z, y, and Ac), and that the relationship of this gene to the three proteins violated the postulate of Beadle and Tatum. The model that the group had studied is interesting primarily because it proposes a functional correlation between certain elements of the molecular structure of proteins and certain of their physiologic properties, specifically those that are significant at the level of integration, of dynamic organization, of metabolism. If the proposed correlation is experimentally verified, then it is an additional reason for having confidence in the development of our discipline which, transcending its original domain, the chemistry of heredity, today is oriented toward the analysis of the more complex biological phenomena: the development of higher organisms and the operation of their networks of functional coordinations.

Citation: Luria S. 2003. Jacques Monod: Scientist, Humanist, and Friend, p 285-288. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch32

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Citation: Luria S. 2003. Jacques Monod: Scientist, Humanist, and Friend, p 285-288. In Ullmann A (ed), Origins of Molecular Biology. ASM Press, Washington, DC. doi: 10.1128/9781555817763.ch32
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