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Chapter 14 : Treatment of Infections of the Ears, Nose, and Throat and Nasal Carriage

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Abstract:

Despite the widespread use of quinolones to treat infections of the ears, nose, and throat, well-controlled studies are uncommon. Malignant (necrotizing) external otitis is an invasive infection of the external auditory canal and skull base, whose typical host is the elderly patient with diabetes mellitus. With the advent and widespread use of quinolones for all ear infections, patients with malignant external otitis are being diagnosed and treated earlier in the course of the disease, thus changing the clinical spectrum of this infection. Oral ciprofloxacin has been used successfully for individuals with auricular perichondritis. Potential limitations of oral quinolones for the treatment of soft-tissue infections of the auricle are suggested by reports of phototoxic lesions induced by quinolones in the auricular skin of mouse models. Cumulative evidence supports the utility of quinolones for treatment of chronic ear infections with multiresistant bacterial. Infections of the ear, nose, and throat are among the most common outpatient maladies in the world. Oral quinolones are the drugs of choice for the treatment of disease caused by , including malignant external otitis and auricular perichondritis. Similarly, there appears to be little rationale for the use of quinolones as initial therapy for otitis media, sinusitis, or pharyngotonsillitis. In fact, pneumococcal bacteremia following ciprofloxacin therapy for acute otitis media has been reported.

Citation: Grandis J, Yu V. 2003. Treatment of Infections of the Ears, Nose, and Throat and Nasal Carriage, p 245-250. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.ch14
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References

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1. Amorosa, L.,, G. C. Modugno,, and A. Pirodda. 1996. Malignant external otitis: review and personal experience. Acta Otolaryngol. Suppl. 521:316.
2. Asian, A. 1998. A new dosage regimen for topical application of ciprofloxacin in the management of chronic suppurative otitis media. Otolaryngol. Head Neck Surg. 118:883885.
3. Barrow, H. N.,, and M. J . Levenson. 1992. Necrotizing 'malignant' external otitis caused by Staphylococcus epidermidis. Arch. Otolaryngol. Head Neck Surg. 118:9496.
4. Barza, M. 1988. Pharmacokinetics andefficacy of the new quinolones in infections of the eye, ear, nose, and throat. Rev. Infect. Dis. 10(Suppl1):S241S247.
5. Blondeau, J . M.,, and Y. Yaschuk. 1995. In vitro activities of ciprofloxacin, cefotaxime, ceftriaxone, chloramphenicol, and rifampin against fully susceptible and moderately penicillinresistant Neisseria meningitidis. Antimicrob. Agents Chemother. 39:25772579.
6.Centers for Disease Controland Prevention. 1997. Control and prevention of meningococcaldisease: recommendations of the Advisory Committee on Immunization Practices (ACIP). Morb. Mortal. Wkly. Rep. 46(RR-5):110.
7. Chandler, J. R. 1968. Malignant external otitis. Laryngoscope 78:12571294.
8. Chow, J . W.,, and V. L. Yu. 1992. Failure of oral ciprofloxacin in suppressing Staphylococcus aureus carriage in hemodialysis patients. J. Antimicrob. Chemother. 29:8889.
9. Darouiche, R.,, B. Perkins,, B. D. Musher,, R. Hamill,, and S. Tsai. 1990. Levels of rifampin and ciprofloxacin in nasal secretions; correlation with MIC 90 and eradication of nasopharyngeal carriage of bacteria. J. Infect. Dis. 162:11241127.
10. Davis, J .,, G. A. Gates,, C. Lerner,, M. G. Davis, Jr.,, J. T. Mader,, and A. Dinesman. 1992. Adjuvant hyperbaric oxygen in malignant external otitis. Arch. Otolaryngol. Head Neck Surg. 118:8993.
11. Dworzack, D. L.,, C. C. Sanders,, E. A. Horowitz,, J . Allais,, M. Sookpranee,, W. E. Sanders,, and F. M. Ferraro. 1988. Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers. Antimicrob. Agents Chemother. 32:17401741.
12. Esposito, S.,, G. D'Errico,, and C. Montanaro. 1990. Topical and oral treatment of chronic otitis media with ciprofloxacin. A preliminary study. Arch. Otolaryngol. Head Neck Surg. 116:557559.
13. Fombeur, J .P.,, S. Barrault,, G. Koubbi,, J . N. Laurier,, D. Ebbo,, F. Lecomte,, N. Sorrel,, and S. Dobler. 1994. Study of the efficacy and safety of ciprofloxacin in the treatment of chronic otitis. Chemotherapy 40(Suppl. l):2934.
14. Force, R. W.,, M. C. Hart,, S. A. Plummer,, D. A. Powell,, and M. C. Nahata. 1995. Topical ciprofloxacin for otorrhea after tympanostomy tube placement. Arch. Otolaryngol. Head Neck Surg. 121:880884.
15. Ford, G. R.,, and R. G. Courteney-Harris. 1990. Another hazard of ear syringing: malignant external otitis. J. Laryngol. Otol. 104:709710.
16. Fradis, M.,, A. Brodsky,, J . Ben-David,, I. Srugo,, J . Larboni,, and L. Podoshin. 1997. Chronic otitis media treated topically with ciprofloxacin or tobramycin. Arch. Otolaryngol. Head Neck Surg. 123:10571060.
17. Frieden, T. R.,, and R. J . Mangi. 1990. Inappropriate use of oral ciprofloxacin. JAMA 264:14381440.
18. Garty, I.,, G. Rosen,, and Y. Holdstein. 1985. The radionuclide diagnosis, evaluation and follow-up of malignant external otitis (MEO). The value of immediate blood pool scanning.J. Laryngol. Otol. 99:109115.
19. Gehanno, P. 1997. Multicenter study of the efficacy and safety of oral ciprofloxacin in the treatment of chronic suppurative otitis media in adults. The French Study Group. Otolaryngol. Head Neck Surg. 117:8390.
20. Gherini, S. G.,, D. E. Brackmann,, and W. G. Bradley. 1986. Magnetic resonance imaging and computerized tomography in malignant external otitis. Laryngoscope 96:542548.
21. Giamarellou, H.,, N. Galanakis,, E. Daphnis,, H. Stephanou,, and P. Sfikakis. 1988. Treating acute and choronic otitis with ciprofloxacin: a step forward a better prognosis? Rev. Infect. Dis. 10(Suppl. 1):S248.
22. Gilbert, D.N.,, A. D. Tice,, P. K. Marsh,, P. C. Craven,, and L. C. Preheim. 1987. Oral ciprofloxacintherapy for chronic contiguous osteomyelitis caused by aerobic gram-negative bacilli. Am. J. Med. 82(Suppl. 4A):254258.
23. Grandis, J . R.,, H. D. Curtin,, and V. L. Yu. 1995. Necrotizing (malignant) external otitis: prospective comparison of CT and MR imaging in diagnosis and follow-up. Radiology 196:499504.
24. Hardoff, R.,, S. Gips,, N. Uri,, A. Front,, and A. Tamir. 1994. Semiquantitative skull planar and SPECT bone scintigraphy in diabetic patients: differentiation of necrotizing (malignant) external otitis from severe external otitis.J. Nucl. Med. 35:411415.
25. Hessen, M.T.,, M. J . Ingerman,, D. H. Kaufman,, P. Weiner,, J . Santoro,, O. M. Korzeniowski,, J . Boscia,, M. Topiel,, L. M. Bush,, D. Kaye,, and M. Levison. 1987. Clinical efficacy of ciprofloxacin therapy for gram-negative bacillary osteomyelitis. Am. J. Med. 82(Suppl. 4A):262265.
26. Hickey, S. A.,, G. R. Ford,, A. F. O'Connor,, S. J . Eykyn,, and P. H. Sonksen. 1989. Treating malignant otitis with oral ciprofloxacin. Br. Med. J. 299:550551.
27. Hirata, C.A.,, D. R. Guay,, W. M. Awni,, D. J . Stein,, and P. K. Peterson. 1989. Steady-statepharmacokinetics of intravenous and oral ciprofloxacin in elderly patients. Antimicrob. Agents Chemother. 33:19271931.
28. Iwasawa, T. 1984. Fundamental andclinical studies of DL- 8280 in the otorhinolaryngologic field. Chemotherapy(Tokyo) 32(Suppl. 1):10011012.
29. Joachims, H. Z.,, J . Danino,, and R. Raz. 1988. Malignant external otitis: treatment with fluoroquinolones. Am. J. Otolaryngol. 9:102105.
30. Kasemsuwan, L.,, and P. Clongsuesuek. 1997. A double blind, prospective trial of topical ciprofloxacin versus normal saline solution in the treatment of otorrhoea. Clin. Otolaryngol. Allied Sci. 22:4446.
31. Kielhofner, M.,, R. L. Atmar,, R. J . Hamill,, and D. M. Musher. 1992. Life-threatening Pseudomonas aeruginosa infections in patients with human immunodeficiency virus infection. Clin. Infect. Dis. 14:403411.
32. Kiris, M.,, M. Berktas,, E. Egeli,, and A. Kutluhan. 1998. The efficacy of topical ciprofloxacin in the treatment of chronic suppurative otitis media. Entechnology 77:904905.
33. Klein, J . O. 2001. In vitro and in vivo antimicrobial activity of topical ofloxacin and other ototopical agents. Pediatr. Infect. Dis. J. 20:102103.
34. Legent, F.,, P. Bordure,, C. Beauvillain,, and P. Berche. 1994. Controlled prospective study of oral ciprofloxacin versus amoxycillin/clavulanic acid in chronic suppurative otitis media in adults. Chemotherapy 40(Suppl. l):1623.
35. Leggett, J . M.,, and K. Prendergast. 1988. Malignant external otitis: the use of oral ciprofloxacin. J. Laryngol. Otol. 102:5354.
36. Lesse, A.J.,, C. Freer,, R. A. Salata,, J . B. Francis,, and W. M. Scheld. 1987. Oral ciprofloxacintherapy for gram-negative bacillary osteomyelitis. Am. J. Med. 82(Suppl. 4A):247253.
37. Levenson, M. J .,, S. C. Pansier,, J. Dolitsky,, and G. Bindra. 1991. Ciprofloxacin: drug of choice in the treatment of malignant external otitis (MEO). Laryngoscope 101:821824.
38. Levin, W. J.,, J. H. Shary III,, L. T. Nichols,, and F. E. Lucente. 1986. Bone scanning in severe external otitis. Laryngoscope 96:11931195.
39. Lucente, F. E.,, S. C. Parisier,, and P. M. Som. 1983. Complications of the treatment of malignant external otitis. Laryngoscope 93:279281.
40. Lucente, F. E.,, S. C. Parisier,, P. M. Som,, and L. M. Arnold. 1982. Malignant external otitis: a dangerous misnomer? Otolaryngol. Head Neck Surg. 90:266269.
41. Mader, J . T.,, and J . T. Love. 1982. Malignant external otitis. Cure with adjunctive hyperbaric oxygen therapy. Arch. Otolaryngol. 108:3840.
42. Massias, L.,, P. Buffe,, B. Cohen,, Y. Cudennec,, P. Gehanno,, O. Sterkers,, and R. Farinotti. 1994. Study of the distribution of oral ciprofloxacin into the mucosa of the middle ear and the cortical bone of the mastoid process. Chemotherapy 40(Suppl. l):37.
43. McElroy, E. A., Jr.,, and G. L. Marks. 1991. Fatal necrotizing otitis externa in a patient with AIDS. Rev. Infect. Dis. 13:12461247.
44. Miro, N. 2000. Controlled multicenter study on chronic suppurative otitis media treated with topical applications of ciprofloxacin 0.2% solution in single-dose containers or combination of polymyxin B, neomycin, and hydrocortisone suspension. Otolaryngol. Head Neck Surg. 123:617623.
45. Morrison, G. A.,, and C. M. Bailey. 1988. Relapsing malignant otitis externa successfully treated with ciprofloxacin. J. Laryngol. Otol. 102:872876.
46. Munoz, A.,, and E. Martinez-Chamorro. 1998. Necrotizing external otitis caused by Aspergillus fumigatus: computed tomography and high resolution magnetic resonance imaging in an AIDS patient.J. Laryngol. Otol. 112:98102.
47. Noel, S. B.,, P. Scallan,, M. C. Meadors,, T. J . Meek, Jr.,, and G. A. Pankey. 1989. Treatment of Pseudomonas aeruginosa auricular perichondritis with oral ciprofloxacin. J. Dermatol. Surg. Oncol. 15:633637.
48. Ostfeld, E.,, M. Segal,, and B. Czeraobilsky. 1981. Malignant external otitis: early histopathologic changes and pathogenic mechanism. Laryngoscope 91:965970.
49. Parisier, S. C.,, F. E. Lucente,, P. M. Som,, S. Z. Hirschman,, L. M. Arnold,, and J. D. Roffman. 1982. Nuclear scanning in necrotizing progressive "malignant" external otitis. Laryngoscope 92:10161019.
50. Peterson, L.,, J . Quick,, B. Jensen,, S. Homann,, and S. Johnson. 1990. Emergence of ciprofloxacin resistance in nosocomial methicillin-resistant staphylococcus aureus isolation; resistance during ciprofloxacin plus rifampin therapy for methicillin- resistant S. aureus colonization. Arch. Intern. Med. 150:21512155.
51. Piccirillo, J . F.,, and S. M. Parnes. 1989. Ciprofloxacin for the treatment of chronic ear disease. Laryngoscope 99:510513.
52. Piercy, E. A.,, R. Bawdon,, and M. P. A. Mac-Kowiak. 1989. Penetration of ciprofloxacin into saliva and nasal secretion and effect of the drug on the oropharyngeal flora of all subjects. Antimicrob. Agents Chemother. 33:16451646.
53. Pugsley, M. P.,, D. L. Dworzack,, J . Roccaforte,, C. C. Sanders,, J. Bakken,, and W. E. Sanders. 1988. An open study of the efficacy of a single dose of ciprofloxacin in eliminating the chronic nasopharyngeal carriage of Neisseria meningitidis. J. Infect. Dis. 157:852853.
54. Reiss, P.,, R. Hadderingh,, L. J . Schot,, and S. A. Danner. 1991. Invasive external otitis caused by Aspergillus fumigatus in two patients with AIDS. AIDS 5:605606.
55. Renkonen, O. V.,, A. Sivonen,, and R. Visakorpi. 1987. Effect of ciprofloxacin on carrier rate of Neisseria meningitidis in army recruits in Finland. Antimicrob. Agents Chemother. 31:962963.
56. Ress, B. D.,, M. Luntz,, F. F. Telischi,, T. J . Balkany,, and M. L. Whiteman. 1997. Necrotizing external otitis in patients with AIDS. Laryngoscope 107:456460.
57. Rivas Lacarte, M. P.,, and F. Pumarola Segura. 1990. [Malignant otitis externa and HIV antibodies. A case report]. An. Otorrinolaringol. Ibero Am. 17:505512.
58. Rubin, J.,, H. D. Curtin,, V. L. Yu,, and D. B. Kamerer. 1990. Malignant external otitis: utility of CT in diagnosis and follow- up. Radiology 174:3914.
59. Rubin, J .,, G. Stoehr,, V. L. Yu,, R. R. Muder,, A. Matador,, and D. B. Kamerer. 1989. Efficacy of oral ciprofloxacin plus rifampin for treatment of malignant external otitis. Arch. Otolaryngol. Head Neck Surg. 115:10631069.
60. Rubin, J ., , and V. L. Yu. 1988. Malignant external otitis: insights into pathogenesis, clinical manifestations, diagnosis, and therapy. Am. J. Med. 85:391398.
61. Rubin, J .,, V. L. Yu,, D. B. Kamerer,, and M. Wagener. 1990. Aural irrigation with water: a potential pathogenic mechanism for inducing malignant external otitis? Ann. Otol. Rhinol. Laryngol. 99:117119.
62. Rubin, J .,, V. L. Yu,, and S. E. Stool. 1988. Malignant external otitis in children.J. Pediatr. 113:965970.
63. Sade, J.,, R. Lang,, S. Goshen,, and R. Kitzes-Cohen. 1989. Ciprofloxacintreatment of malignant external otitis. Am. J. Med. 87(Suppl. 5A):138S141S.
64. Sasaki, T.,, T. Unno,, T. Tomiyamo,, O. Yamai,, and T. Iwasawa. 1984. Evaluation of clinical effectiveness and safety of dl-8280 in acute lacunar tonsillitis. Otol. Fukuoka 30:484513.
65. Scott, G. B.,, B. E. Buck,, J . G. Leterman,, F. L. Bloom,, and W. P. Parks. 1984. Acquired immunodeficiency syndrome in infants. N. Engl. J. Med. 310:7681.
66. Shimoda, K.,, M. Yoshida,, N. Wagai,, S. Takayama,, and M. Kato. 1993. Phototoxic lesions induced by quinolone antibacterial agents in auricular skin and retina of albino mice, [see comments]. Toxicol. Pathol. 21:554561.
67. Shultz, T. R.,, J . W. Tapsall,, P. A. White,, and P. J . Newton. 2000. An invasive isolate of Neisseria meningitidis showing decreased susceptibility to quinolones. Antimicrob. Agents Chemother. 44:1116.
68. Shupak, A.,, E. Greenberg,, R. Hardoff,, C. Gordon,, Y. Melamed,, and W. S. Meyer. 1989. Hyperbaric oxygenation for necrotizing (malignant) otitis externa. Arch. Otolaryngol. Head Neck Surg. 115:14701475.
69. Slama, T.G.,, J . Misinski,, and S. Sklar. 1987. Oral ciprofloxacin therapyfor osteomyelitis caused by aerobic gran-negative bacilli. Am. J.Med. 82:S259S261.
70. Smith, S. M.,, R. H. K. Eng,, and F. Tomang-Tecson. 1990. Epidemiology of ciprofloxacin resistance among patients with methicillin-resistant Staphyloccus aureus. J. Antimicrob. Chemother. 26:567572.
71. Soliman, A. E. 1978. A rare case of malignant otitis externa in a non-diabetic patient.J. Laryngol. Otol. 92:811812.
72. Stokkel, M. P.,, R. P. Takes,, B. L. van Eck-Smit,, and R. J . Baatenburg de Jong. 1997. The value of quantitative gallium- 67 single-photon emission tomography in the clinical management of malignant external otitis. Eur. J. Nucl. Med. 24:14291432.
73. Sundberg, L.,, and T. Eden. 1990. Penetration of enoxacin into middle ear effusion. Acta Otolaryngol. 109:438443.
74. Tapsall, J .W.,, T. Shultz,, E. Limnios,, R. Munro,, J . Mercer,, R. Porritt,, J . Griffith,, G. Hogg,, G. Lum,, A. Lawrence,, D. Hansman,, P. Collignon,, P. Southwell,, K. Ott,, M. Gardam,, C. J . Richardson,, J . Bates,, D. Murphy,, and H. Smith. 2001. Surveillance of antibiotic resistance in invasive isolates of Neisseria meningitidis in Australia 1994-1999. Pathology 33:359361.
75. Tong, M.,, J . Woo,, and C. v. Hasselt. 1996. A double-blind comparative study of ofloxacin otic drops versus neomycinpolymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media. J. Laryngol. Otol. 110:309314.
76. Tutkun, A.,, A. Ozagar,, A. Koc,, C. Batman,, C. Uneri,, and M. A. Sehitoglu. 1995. Treatment of chronic ear disease. Topical ciprofloxacin vs topical gentamicin. Arch. Otolaryngol. Head Neck Surg. 121:14141416.
77. Van de Heyning, P. H.,, S. R. Pattyn,, and H. D. Valcke. 1986. Ciprofloxacin in oral treatment of ear infections. Pharm. Weekbl. Sci. 8:6366.
78. Weinroth, S. E.,, D. Schessel,, and C. U. Tuazon. 1994. Malignant otitis externa in AIDS patients: case report and review of the literature. Ear Nose Throat J. 73:772778.
79. Wise, R.,, and I. A. Donovan. 1987. Tissue penetration and metabolism of ciprofloxacin. Am. J. Med. 82(Suppl. 4A): 103107.
80. Wiseman, L. R.,, and J. A. Balfour. 1994. Ciprofloxacin. A review of its pharmacological profile and therapeutic use in the elderly. Drugs Aging 4:145173.

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