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Chapter 5 : Activity In Vitro of the Quinolones

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Abstract:

This chapter reviews the in vitro activities of the currently available and several investigational fluoroquinolones on the basis of data from published literature. The primary purpose of the chapter is to explore the potential antimicrobial spectrum of the class rather than to highlight specific agents. Antimicrobial activity was performed for gram-negative bacteria, gastrointestinal pathogens, respiratory tract pathogens, gram-positive bacteria, anaerobic bacteria, genital pathogens, mycoplasmas and ureaplasmas. The influence of serum on activities of fluoroquinolones in vitro is usually of minimal consequence. Minimal bactericidal concentrations (MBCs) of the various fluoroquinolone antimicrobials were almost always within two dilutions of the MIC. The newer agents seem to behave similarly. Clinafloxacin and gatifloxacin MBCs are generally within two dilutions of MICs. The bactericidal activities of fluoroquinolones have also been studied in vitro, in pharmacodynamic models that simulate serum antimicrobial concentrations following standard dosing in humans. Resistance in was detected after fewer passages in ciprofloxacin than in levofloxacin or trovafloxacin. In the treatment of infections due to gram-negative bacteria, it is not uncommon to witness the use of fluoroquinolones in combination with other antibiotics that display a similar antibacterial spectrum. The fluoroquinolones continue to provide excellent in vitro activity against most commonly encountered gram-negative bacteria. However, in certain areas of the world or in specific institutional settings, significant numbers of or spp. are now resistant to available agents of this class. Rates of resistance among clinical isolates of are higher still.

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
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1. Allemandi, D. A.,, L. Fabiana,, A. Manzo,, and R. H. Manzo. 1994. In-vitro activity of new sulphanilil fluoroquinolones against Staphylococcus aureus . J. Antimicrob. Chemother. 3 4: 261 265.
2. Alonso, R.,, T. Pelaez,, M. J. Gonzalez-Abad,, L. Alcala,, P. Munoz,, M. Rodriguez-Creixems,, and E. Bouza. 2001. In vitro activity of new quinolones against Clostridium difficile . J. Antimicrob. Chemother. 47: 195 197.
3. Alovero, F. L.,, X . S. Pan,, J. E. Morris,, R. H. Manzo,, and L. M. Fisher. 2000. Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase. Antimicrob. Agents Chemother. 44: 320 325.
4. Amyes, S. G. B.,, D. R. Baird,, D. W. Crook,, S. H. Gillespie,, A. J. Howard,, B. A. Oppenhiem,, S. J. Pedler,, A. Paull,, D. S. Tompkins,, and S. A. Lawrie. 1994. A multicentre study of the in-vitro activity of cefotaxime, cefuroxime, ceftazidime, ofloxacin and ciprofloxacin against blood and urinary pathogens. J. Antimicrob. Chemother. 34: 639 648.
5. Balcabao, I. P.,, L. Alou,, L. Aguilar,, M. L. Gomez-Lus,, and J. Prieto. 2001. Influence of the decrease in ciprofloxacin susceptibility and the presence of human serum on the in vitro susceptibility of Streptococcus pneumoniae to five new quinolones. J. Antimicrob. Chemother. 48: 907 909.
6. Ballow, C. H.,, R. N. Jones,, D. M. Johnson,, J. A. Deinhart,, J. J. Schentag, and SPAR Study Group. 1997. Comparative in vitro assessment of sparfloxacin activity and spectrum using results from over 14,000 pathogens isolated at 190 medical centers in the USA. Diagn. Microbiol. Infect. Dis. 29: 173 186.
7. Barry, A. L.,, P. C. Fuchs,, and S. D. Brown. 2001. In vitro activities of three nonfluorinated quinolones against representative bacterial isolates. Antimicrob. Agents Chemother 45: 1923 1927.
8. Bartlett, J. G.,, R. F. Breiman,, L. A. Mandell,, and T. M. File, Jr. 1998. Community-acquired pneumonia in adults: guidelines for management. Clin. Infect. Dis. 26: 811 838.
9. Bassetti, M.,, L. M. Dembry,, P. A. Farrel,, D. A. Callan,, and V. T. Andriole. 2002. Antimicrobial activities of BMS- 284756 compared with those of fluoroquinolones and {3- lactams against gram-positive clinical isolates. Antimicrob. Agents Chemother. 46: 234 238.
10. Bauernfeind, A. 1997. Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin. J. Antimicrob. Chemother. 40: 639 651.
11. Bebear, C. M.,, H. Renaudin,, A. Boudjadja,, and C. Bebear. 1998. In vitro activity of BAY 12-8039, a new fluoroquinolone, against mycoplasmas. Antimicrob. Agents Chemother. 42: 703 704.
12. Bebear, C. M.,, H. Renaudin,, A. Charron,, D. Gruson,, M. Lefrancois,, and C. Bebear. 2000. In vitro activity of trovafloxacin compared to those of five antimicrobials against mycoplasmas including mycoplasma hominis and Urealplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized. Antimicrob. Agents Chemother. 44: 2557 2560.
13. Bebear, C. M.,, H. Renaudin,, T. Schaeverbeke,, F. Leblanc,, and C. Bebear. 1999. In-vitro activity of grepafloxacin, a new fluoroquinolone, against mycoplasmas. J. Antimicrob. Chemother. 43: 711 714.
14. Bermudez, L. E.,, C. B. Inderlied,, P. Kolonoski,, M. Wu,, L. Barbara-Burnham,, and L. S. Young. 1996. Activities of Bay Y 3118, levofloxacin, and ofloxacin alone or in combination with ethambutol against Mycobacterium avium complex in vitro, in human macrophages, and in beige mice. Antimicrob. Agents Chemother. 40: 546 551.
15. Biedenbach, D. J.,, M. A. T. Croco,, T. J. Barrett,, and R. N. Jones. 1999. Comparative in vitro activity of gatifloxacin against Stenotrophomonas maltophilia and Burkholderia species isolates including evaluation of disk diffusion and E test methods. Eur. J. Clin. Microbiol. Infect. Dis. 18: 428 431.
16. Biedenbach, D. J.,, and R. N. Jones. 1995. In vitro evaluation of DV-7751a, a new fluoroquinolone with an enhanced spectrum of activity against gram-positive aerobic organisms and anaerobes. Antimicrob. Agents Chemother. 39: 1636 1643.
17. Boisivon, A.,, N. Dhoyen,, and C. Carbon. 1995. Activity of CI-960 alone and in combination with amoxycillin against Listeria monocytogenes, and comparison with other quinolones. J. Antimicrob. Chemother. 36: 527 530.
18. Bonacorsi, S.,, F. Fitoussi,, S. Lhopital,, and E. Bingen. 1999. Comparative in vitro activities of meropenem, imipenem, temocillin, piperacillin, and ceftazidime in combination with tobramycin, rifampin, or ciprofloxacin against Burkholderia cepacia isolates from patients with cystic fibrosis. Antimicrob. Agents Chemother. 43: 213 217.
19. Boos, M.,, S. Mayer,, A. Fischer,, K. Kohrer,, S. Scheuring,, P. Heisig,, J. Verhoef, Ad. C. Fluit, and F.-J. Schmitz. 2001. In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus . Antimicrob. Agents Chemother. 45: 938 942.
20. Brisse, S.,, D. Milatovic,, A. C. Fluit,, J. Verhoef,, N. Martin,, S. Scheuring,, K. Kohrer,, and F.-J. Schmitz. 1999. Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae , and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins. Antimicrob. Agents Chemother. 43: 2051 2055.
21. Brueggemann, A. B.,, K. C. Kugler,, and G. V. Doern. 1997. In vitro activity of BAY 12-8039, a novel 8- methoxyquinolone, compared to activities of six fluoroquinolones against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis . Antimicrob. Agents Chemother. 41: 1594 1597.
22. Burgess, D. S.,, and R. W. Hastings. 2000. Activity of piperacillin/tazobactam in combination with amikacin, ciprofloxacin, and trovafloxacin against Pseudomonas aeruginosa by time-kill. Diagn. Microbiol. Infect. Dis. 38: 37 41.
23. Bustamante, C. I.,, G. L. Drusano,, R. C. Wharton,, and J. C. Wade. 1987. Synergism of the combinations of imipenem plus ciprofloxacin and imipenem plus amikacin against Pseudomonas aeruginosa and other bacterial pathogens. Antimicrob. Agents Chemother. 31: 632 634.
24. Carmeli, Y.,, N. Troillet,, G. M. Eliopoulos,, and M. N. Samore. 1999. Emergence of antibiotic-resistant Pseudomonas aeruginosa: comparison of risks associated with different antipseudomonal agents. Antimicrob. Agents Chemother. 43: 1379 1382.
25. Chin, N.-X.,, and H. C. Neu. 1987. Synergy of imipenem—a novel carbapenem, and rifampin and ciprofloxacin against Pseudomonas aeruginosa, Serratia marcescens, and Enterobacter species. Chemotherapy 33: 183 188.
26. Cohen, M. A.,, M. D. Huband,, J. W. Gage,, S. L. Yoder,, G. E. Roland,, and S. J. Gracheck. 1997. In-vitro activity of clinafloxacin, trovafloxacin, and ciprofloxacin. J. Antimicrob. Chemother. 40: 205 211.
27. Cohen, M. A.,, S. L. Yoder,, M. D. Huband,, G. E. Roland,, and C. L. Courtney. 1995. In vitro and in vivo activities of clinafloxacin, CI-990 (PD 131112), and PD 138312 versus enterococci. Antimicrob. Agents Chemother. 39: 2123 2127.
28. Cohn, M. L.,, and K. B. Waites. 2001. Antimicrobial activities of gatifloxacin against nosocomial isolates of Stenotrophomonas maltophilia measured by MIC and timekill studies. Antimicrob. Agents Chemother. 45: 2126 2128.
29. Coll, R.,, D. Gargallo-Viola,, E. Tudela,, M. A. Xicota,, S. Llovera,, and J. Guinea. 1996. Antibacterial activity and pharmacokinetics of four new 7-azetidinyl fluoroquinolones. Antimicrob. Agents Chemother. 40: 274 277.
30. Cormican, M. G.,, and R. N. Jones. 1997. Antimicrobial activity and spectrum of LB20304, a novel naphthyridone. Antimicrob. Agents Chemother. 41: 204 211.
31. Coyle, E. A.,, G. W. Kaatz,, and M. J. Rybak. 2001. Activities of newer fluoroquinolones against ciprofloxacin-resistant Streptococcus pneumoniae . Antimicrob. Agents Chemother 45: 1654 1659.
32. Davies, T. A.,, A. Evangelista,, S. Pfleger,, K. Bush,, D. F. Sahm,, and R. Goldschmidt. 2002. Prevalence of single mutations in topoisomerase type II genes among levofloxacin- susceptible clinical strains of Streptococcus pneumoniae isolated in the United States in 1992 to 1996 and 1999 to 2000. Antimicrob. Agents Chemother. 46: 119 124.
33. Deguchi, T.,, M. Yasuda,, M. Nakano,, E. Kanematsu,, S. Ozeki,, S. Ishihara,, I. Saito,, and Y. Kawada. 1997. Antimicrobial activity of a new fluoroquinolone, DU-6859a, against quinolone-resistant clinical isolates of Neisseria gonorrhoeae with genetic alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV. J. Antimicrob. Chemother. 39: 247 249.
34. Deshpande, L. M.,, D. J. Diekema,, and R. N. Jones. 1999. Comparative activity of clinafloxacin and nine other compounds tested against 2000 contemporary clinical isolates from patients in United States hospitals. Diagn. Microbiol. Infect. Dis. 35: 81 88.
35. Deshpande, L. M.,, and R. N. Jones. 2000. Antimicrobial activity of advanced-spectrum fluoroquinolones tested against more than 2000 contemporary bacterial isolates of species causing community-acquired respiratory tract infections in the United States ( 1999 ). Diagn. Microbiol. Infect. Dis. 37: 139 142.
36. Dhople, A. M.,, and M. A. Ibanez. 1993. In-vitro activity of three new fluoroquinolones and synergy with ansamycins against Mycobacterium leprae . J. Antimicrob. Chemother 32: 445 451.
37. Diekema, D. J.,, R. N. Jones,, and K. V. I. Rolston. 1999. Antimicrobial activity of gatifloxacin compared to seven other compounds tested against gram-positive organisms isolated at 10 cancer-treatment centers. Diagn. Microbiol. Infect. Dis. 34: 37 43.
38. Doern, G. V.,, K. P. Heilmann,, H. K. Huynh,, P. R. Rhomberg,, S. L. Coffman,, and A. B. Brueggemann. 2001. Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000, including a comparison of resistance rates since 1994-1995. Antimicrob. Agents Chemother. 45: 1721 1729.
39. Dreses-Werringloer, U.,, I. Padubrin,, B. Jiirgens-Saathoff,, A. P. Hudson,, H. Zeidler,, and L. Kohler. 2000. Persistence of Chlamydia trachomatis is induced by ciprofloxacin and ofloxacin in vitro. Antimicrob. Agents Chemother 44: 3288 3297.
40. Dubois, J.,, and C. St.-Pierre. 1999. In vitro activity of gatifloxacin compared with ciprofloxacin, clarithromycin, erythromycin, and rifampin, against Legionella species. Diagn. Microbiol. Infect. Dis. 33: 261 265.
41. Dudley, M. N.,, J. Blaser,, D. Gilbert,, K. H. Mayer,, and S. H. Zinner. 1991. Combination therapy with ciprofloxacin plus azlocillin against Pseudomonas aeruginosa: effect of simultaneous versus staggered administration in an in vitro model of infection. J. Infect. Dis. 164: 499 506.
42. Edelstein, P. H.,, T. Shinzato,, E. Doyle,, and M. A. C. Edelstein. 2001. In vitro activity of gemifloxacin (SB- 265805, LB20304a) against Legionella pneumophila and its pharmacokinetics in guinea pigs with L. pneumophila pneumonia. Antimicrob. Agents Chemother. 45: 2204 2209.
43. Eliopoulos, G. 1999. Activity of newer fluoroquinolones in vitro against gram-positive bacteria. Drugs 58( Suppl. 2): 23 28.
44. Eliopoulos, G. M.,, and C. T. Eliopoulos. 1989. Ciprofloxacin in combination with other antimicrobials. Am. J. Med. 87( Suppl. 5A): 17S 22S.
45. Eliopoulos, G. M.,, and C. T. Eliopoulos,. 1993. Activity in vitro of the quinolones, p. 161 193. In D. C. Hooper, and J. S. Wolfson (ed.), Quinolone Antimicrobial Agents, 2nd ed. American Society for Microbiology, Washington, D.C.
46. Fass, R. J.,, J. Barnishan,, M. C. Solomon,, and L. W. Ayers. 1996. In vitro activities of quinolones, (3-lactams, tobramycin, and trimethoprim-sulfamethoxazole against nonfermentative gram-negative bacilli. Antimicrob. Agents Chemother. 40: 1412 1418.
47. Fernandez-Roblas, R.,, F. Cabria,, J. Esteban,, J. C. Lopez,, I. Gadea,, and F. Soriano. 2000. In vitro activity of gemifloxacin (SB-265805) compared with 14 other antimicrobials against intestinal pathogens. J. Antimicrob. Chemother. 46: 1023 1027.
48. Fremaux, A.,, G. Sissia,, and P. Geslin. 1999. In-vitro bacteriostatic activity of levofloxacin and three other fluoroquinolones against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae . J. Antimicrob. Chemother. 43( Suppl. C): 9 14.
49. Fukuda, H.,, R. Kishii,, M. Takei,, and M. Hosaka. 2001. Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniae . Antimicrob. Agents Chemother. 45: 1649 1653.
50. Fung-Tome, J. C.,, B. Minassian,, B. Kolek,, E. Huczko,, L. Aleskunes,, T. Stickle,, T. Washo,, E. Gradeiski,, L. Valera,, and D. P. Bonner. 2000. Antibacterial spectrum of a novel desfluoro^) quinolone, BMS-284756. Antimicrob. Agents Chemother. 44: 3351 3356.
51. Garcia, M. T.,, C. Pelaz,, M. J. Gimenez,, and L. Aguilar. 2000. In vitro activities of gemifloxacin versus five quinolones and two macrolides against 271 Spanish isolates of Legionella pneumophila: influence of charcoal on susceptibility test results. Antimicrob. Agents Chemother. 44: 2176 2178.
52. Garcia-Garrote, F.,, E. Cercenado,, J. Martin-Pedroviejo,, O. Cuevas,, and E. Bouza. 2001. Comparative in vitro activity of the new quinolone gemifloxacin (SB-265805) with other fluoroquinolones against respiratory tract pathogens. J. Antimicrob. Chemother. 47: 681 684.
53. Garcia-Rodriguez, J. A.,, J. E. Garcia Sanchez,, M. I. Garcia Garcia,, M. J. Fresnadillo,, I. Trujillano,, and E. Garcia Sanchez. 1994. In-vitro activity of four new fluoroquinolones. J. Antimicrob. Chemother. 34: 53 64.
54. Gargallo-Viola, D.,, S. Ferrer,, E. Tudela,, M. Robert,, R. Coll,, R. Roser,, and J. Guinea. 2001. Antibacterial activities and pharmacokinetics of E-4767 and E-5065, two new 8-chlorofluoroquinolones with a 7-azetidin ring substituent. Antimicrob. Agents Chemother. 45: 3113 3121.
55. Gilbert, D. N.,, S.J. Kohlhepp,, K. A. Slama,, G. Grunkemeier,, G. Lewis,, R. J. Dworkin,, S. E. Slaughter,, and J. E. Leggett. 2001. Phenotypic resistance of Staphylococcus aureus, selected Enterobacteriaceae, and Pseudomonas aeruginosa after single and multiple in vitro exposures to ciprofloxacin, levofloxacin, and trovafloxacin. Antimicrob. Agents Chemother. 45: 883 892.
56. Gohara, Y.,, S. Arai,, A. Akashi,, K. Kuwano,, C-C. Tseng,, S. Matsubara,, M. Matumoto,, and T. Furudera. 1993. In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae . Antimicrob. Agents Chemother. 37: 1826 1830.
57. Goldstein, E. J.,, and D. M. Citron. 1992. Comparative activity of ciprofloxacin, ofloxacin, sparfloxacin, temafloxacin, CI-960, CI-990, and WIN 57273 against anaerobic bacteria. Antimicrob. Agents Chemother. 36: 1158 1162.
58. Goldstein E. J.,, D. M. Citron,, S. Hunt Gerardo,, M. Hudspeth,, and C. V. Merriam. 1997. Comparative in vitro activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against 387 aerobic and anaerobic bite wound isolates. Antimicrob. Agents Chemother. 41: 1193 1195.
59. Goldstein, E. J.,, D. M. Citron,, C. V. Merriam,, K. Tyrrell,, and Y. Warren. 1999. Activity of gatifloxacin compared to those of five other quinolones versus aerobic and anaerobic isolates from skin and soft tissue samples of human and animal bite wound infections. Antimicrob. Agents Chemother 43: 1475 1479.
60. Goldstein, E. J.,, D. M. Citron,, C. V. Merriam,, Y. Warren,, and K. Tyrrell. 2000. Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens. Antimicrob. Agents Chemother 44: 2747 2751.
61. Gomi, H.,, Z.-D. Jiang,, J. A. Adachi,, D. Ashley,, B. Lowe,, M. P. Verenkar,, R. Steffen,, and H. L. Dupont. 2001. In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions. Antimicrob. Agents Chemother. 45: 212 216.
62. Gordon, K. A.,, J. Fusco,, D. J. Biedenback,, M. A. Pfaller,, and R. N. Jones. 2001. Antimicrobial susceptibility testing of clinical isolates of Bordetella pertussis from Northern California: report from the SENTRY antimicrobial surveillance program. Antimicrob. Agents Chemother. 45: 3599 3600.
63. Gradelski, E.,, L. Valera,, D. Bonner,, and J. Fung-Tome. 2001. Synergistic activities of gatifloxacin in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species. Antimicrob. Agents Chemother. 45: 3220 3222.
64. Guinea, J.,, M. Robert,, D. Gargallo-Viola,, M. A. Xicota,, J. Garcia,, E. Tudela,, M. Esteve,, R. Coll,, M. Pares,, and R. Roser. 1993. In vitro and in vivo antibacterial activities of E-4868, a new fluroquinolone with a 7-azetidin ring substituent. Antimicrob. Agents Chemother. 37: 868 874.
65. Haller, I. 1985. Comprehensive evaluation of ciprofloxacinaminoglycoside combinations against Enterobacteriaceae and Pseudomonas aeruginosa strains. Antimicrob. Agents Chemother. 28: 663 666.
66. Hamamoto, K.,, T. Shimizu,, N. Fujimoto,, Y. Zhang,, and S. Arai. 2001. In vitro activities of moxifloxacin and other fluoroquinolones against Mycoplasma pneumoniae . Antimicrob. Agents Chemother. 45: 1908 1910.
66a. Hardy, D.,, D. Amsterdam,, L. A. Mandell,, and C. Rotstein. 2000. Comparative in vitro activities of ciprofloxacin, gemifloxacin, grepafloxacin, moxifloxacin, ofloxacin, sparfloxacin, trovafloxacin, and other antimicrobial agents against bloodstream isolates of gram-positive cocci. Antimicrob. Agents Chemother. 44: 802 805.
67. Hayward, C. L.,, M. E. Erwin,, M. S. Barrett,, and R. N. Jones. 1999. Comparative antimicrobial activity of gatifloxacin tested against Campylobacter jejuni including fluoroquinolone- resistant clinical isolates. Diagn. Microbiol. Infect. Dis. 34: 99 102.
68. Hecht, D. W.,, and J. R. Osmolski. 1996. Comparison of activities of trovafloxacin (CP-99,219) and five other agents against 585 anaerobes with use of three media. Clin. Infect. Dis. 23( Suppl. 1): S44 S50.
69. Hecht, D. W.,, and H. M. Wexler. 1996. In vitro susceptibility of anaerobes to quinolones in the United States. Clin. Infect. Dis. 23( Suppl. 1): S2 S8.
69a. Heine, H. S.,, R. Dicks,, and G. Andrews. 2001. In vitro activity of oritavancin (LY 333328), levofloxacin, meropenem, GAR936 and linezolid against strains of Bacillus anthracis. abstr. E-524. In Program and Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy . American Society for Microbiology, Washington, D.C.
70. Heine, H. S.,, M. J. England,, D. M. Waag,, and W. R. Byrne. 2001. In vitro antibiotic susceptibilities of Burkholderia mallei (causative agent of glanders) determined by broth microdilution and E-test. Antimicrob. Agents Chemother 45: 2119 2121.
71. Heinemann, B.,, H. Wisplinghoff,, M. Edmond,, and H. Seifert. 2000. Comparative activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against epidemiologically defined Acinetobacter baumannii strains. Antimicrob. Agents Chemother. 44: 2211 2213.
72. Hershberger, E.,, and M. J. Rybak. 2000. Activities of trovafloxacin, gatifloxacin, clinafloxacin, sparfloxacin, levofloxacin, and ciprofloxacin against penicillin-resistant Streptococcus pneumoniae in an in vitro infection model. Antimicrob. Agents Chemother. 44: 598 601.
73. Hirose, K.,, K. Tamura,, H. Sagara,, and H. Watanabe. 2001. Antibiotic susceptibilities of Salmonella enterica Serovar Typhi and S. enterica Serovar Paratyphi A isolated from patients in Japan. Antimicrob. Agents Chemother. 45: 956 958.
74. Hoogkamp-Korstanje, J. A. A.,, and J. Roelofs-Willemse. 2000. Comparative in vitro activity of moxifloxacin against gram-positive clinical isolates. J. Antimicrob. Chemother 45: 31 39.
75. Horiuchi, S.,, Y. Inagaki,, N. Yamamoto,, N. Okamura,, Y. Imagawa,, and R. Nakaya. 1993. Reduced susceptibilities of Shigella sonnei strains isolated from patients with dysentery to fluoroquinolones. Antimicrob. Agents Chemother 37: 2486 2489.
76. Horowitz, H. W.,, T.-C. Hsieh,, M. E. Aguero-Rosenfeld,, F. Kalantarpour,, I. Chowdhury,, G. P. Wormser,, and J. M. Wu. 2001. Antimicrobial susceptibility of Ehrlichia phagocytophila. Antimicrob. Agents Chemother. 45: 786 788.
77. Ince, D.,, and D. C. Hooper. 2001. Mechanisms and frequency of resistance to gatifloxacin in comparison to AM- 1121 and ciprofloxacin in Staphylococcus aureus . Antimicrob. Agents Chemother. 45: 2755 2764.
78. Isenberg, H. D.,, P. Alperstein,, and K. France. 1999. In vitro activity of ciprofloxacin, levofloxacin, and trovafloxacin, alone and in combination with p-lactams, against clinical isolates of Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Burkholderia cepacia . Diagn. Microbiol. Infect. Dis. 33: 81 86.
79. Johnson, D. M.,, R. N. Jones,, M. E. Erwin, and the Quality Control Study Group. 1999. Antistreptococcal activity of SB-265805 (LB20304), a novel fluoronaphthyridone, compared with five other compounds, including quality control guidelines. Diagn. Microbiol. Infect. Dis. 33: 87 91.
80. Join-Lambert, O. F.,, M. Michea-Hamzehpour,, T. Kohler,, F. Chau,, F. Faurisson,, S. Dautrey,, C. Vissuzaine,, C. Carbon,, and J. Pechere. 2001. Differential selection of multidrug efflux mutants by trovafloxacin and ciprofloxacin in and experimental model of Pseudomonas aeruginosa acute pneumonia in rats. Antimicrob. Agents Chemother. 45: 571 576.
81. Jonas, D.,, I. Engels,, C. Friedhoff,, B. Spitznuiller,, F. D. Daschner,, and U. Frank. 2001. Efficacy of moxifloxacin, trovafloxacin, clinafloxacin and levofloxacin against intracellular Legionella pneumophila . J. Antimicrob. Chemother 47: 147 152.
82. Jones, M. E.,, A. M. Staples,, I. Critchley,, C. Thornsberry,, P. Heinze,, H. D. Engler,, and D. F. Sahm. 2000. Benchmarking the in vitro activities of moxifloxacin and comparator agents against recent respiratory isolates from 377 medical centers throughout the United States. Antimicrob. Agents Chemother. 44: 2645 2652.
83. Jones, R. N.,, C. H. Ballow,, J. J. Schentag,, D. M. Johnson,, J. A. Deinhart, and the SPAR Study Group. 1998. In vitro evaluation of sparfloxacin activity and spectrum against 24,940 pathogens isolated in the United States and Canada, the final analysis. Diagn. Microbiol. Infect. Dis. 31: 313 325.
84. Jones, R. N.,, M. L. Beach,, M. A. Pfaller,, and G. V. Doern. 1998. Antimicrobial activity of gatifloxacin tested against 1676 strains of ciprofloxacin-resistant gram-positive cocci isolated from patient infections in North and South America. Diagn. Microbiol. Infect. Dis. 32: 247 252.
85. Jones, R. N.,, D. J. Biedenbach,, M. E. Erwin,, M. L. Beach,, M. A. Pfaller, and the Quality Control Study Group. 1999. Activity of gatifloxacin against Haemophilus influenzae and Moraxella catarrhalis, including susceptibility test development, E-test comparisons, and quality control guidelines for H. influenzae . J. Clin. Microbiol 37: 1999 2002.
86. Jones, R. N.,, M. A. T. Croco,, K. C. Kugler,, M. A. Pfaller,, M. L. Beach and the SENTRY Participants Group (North America). 2000. Respiratory tract pathogens isolated from patients hospitalized with suspected pneumonia: frequency of occurrence and antimicrobial susceptibility patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997). Diagn. Microbiol. Infect. Dis. 37: 115 125.
87. Jones, R. N.,, D. M. Johnson,, M. E. Erwin,, M. L. Beach,, D. J. Biedenbach,, M. A. Pfaller, and the Quality Control Study Group 1999. Comparative antimicrobial activity of gatifloxacin tested against Streptococcus spp., including quality control guidelines and Etest method validation. Diagn. Microbiol. Infect. Dis. 34: 91 98.
88. Kato, N.,, H. Kato,, K. Tanaka-Bando,, K. Watanabe,, and K. Ueno. 1996. Comparison of in vitro activities of DU-6859a and other fluoroquinolones against Japanese isolates of anaerobic bacteria. Clin. Infect. Dis. 23( Suppl. 1): S31 S5.
89. Kaye, K. S.,, S. Cosgrove,, A. Harris,, G. M. Eliopoulos,, and Y. Carmeli. 2001. Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp. Antimicrob. Agents Chemother. 45: 2628 2630.
90. Kenny, G. E.,, and F. D. Cartwright. 2001. Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristindalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones. Antimicrob. Agents Chemother. 45: 2604 2608.
91. Kerawala, M.,, J. E. Ambler,, P. Y. C. Lee,, and Y. J. Drabu. 2001. In vitro activity of gemifloxacin (SB-265805) compared to eleven other antimicrobial agents against streptococcal isolates, excluding Streptococcus pneumoniae . Eur. ]. Clin. Microbiol. Infect. Dis. 20: 271 275.
92. Kiehlbauch, J. A.,, C. N. Baker,, and I. K. Wachsmuth. 1992. In vitro susceptibilities of aerotolerant Campylobacter isolates to 22 antimicrobial agents. Antimicrob. Agents Chemother. 36: 717 722.
93. Kim, J. H.,, J. A. Kang,, Y. G. Kim,, J. W. Kim,, J. H. Lee,, E. C. Choi,, and B. K. Kim. 1997. In vitro and in vivo antibacterial efficacies of CFC-222, a new fluoroquinolone. Antimicrob. Agents Chemother. 41: 2209 2213.
94. Kim, J. H.,, J. A. Kang,, Y. Lee,, K. H. Lee,, J. H. Lee,, E. C. Choi,, and B. K. Kim. 1998. Susceptibility of penicillinsusceptible and -resistant pneumococci to CFC-222, a new fluoroquinolone. J. Antimicrob. Chemother. 42: 527 530.
95. Kitzis, M.-D.,, F. W. Goldstein,, M. Miegi,, and J.-F. Acar. 1999. In-vitro activity of levofloxacin, a new fluoroquinolone: evaluation against Haemophilus influenzae and Moraxella catarrhalis . J. Antimicrob. Chemother 43( Suppl. C) 21 26.
96. Klein, M. B.,, C. M. Nelson,, and J. L. Goodman. 1997. Antibiotic susceptibility of the newly cultivated agent of human granulocytic ehrlichiosis: promising activity of quinolones and rifamycins. Antimicrob. Agents Chemother 41: 76 79.
97. Kleinkauf, N.,, G. Ackermann,, R. Schaumann,, and A. C. Rodloff. 2001. Comparative in vitro activities of gemifloxacin, other quinolones, and nonquinolone antimicrobials against obligately anaerobic bacteria. Antimicrob. Agents Chemother. 45: 1896 1899.
98. Kohler, T.,, M. Michea-Hamzehpour,, P. Plesiat,, A.-L. Kahr,, and J.-C. Pechere. 1997. Differential selection of multidrug efflux systems by quinolones by Pseudomonas aeruginosa . Antimicrob. Agents Chemother. 41: 2540 2543.
99. Kraiczy, P.,, J. Weigand,, T. A. Wichelhaus,, P. Heisig,, H. Backes,, V. Schafer,, G. Acker,, V. Brade,, and K.-P. Hunfeld. 2001. In vitro activities of fluoroquinolones against the spirochete Borrelia burgdorferi . Antimicrob. Agents Chemother. 45: 2486 2494.
100. Kutlin, A.,, P. M. Roblin,, and M. R. Hammerschlag. 2002. Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection model. Antimicrob. Agents Chemother 46: 409 412.
101. Lee, A.,, W. Mao,, M. S. Warren,, A. Mistry,, K. Hoshino,, R. Okumura,, H. Ishida,, and O. Lomovskaya. 2000. Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance. J. Bacteriol. 182: 3142 3150.
102. McDonald, L. C.,, F.-J. Chen,, H.-J. Lo,, H.-C. Yin,, P.-L. Lu,, C.-H. Huang,, P. Chen,, T.-L. Lauderdale,, and M. Ho. 2001. Emergence of reduced susceptibility and resistance to fluoroquinolones in Escherichia coli in Taiwan and contributions of distinct selective pressures. Antimicrob. Agents Chemother. 45: 3084 3091.
103. Malay, S.,, P. M. Roblin,, T. Reznik,, A. Kutlin,, and M. R. Hammerschlag. 2002. In vitro activities of BMS-284756 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae . Antimicrob. Agents Chemother.
104. Marco, F.,, M. Almela,, J. Nolla-Salas,, P. Coll,, I. Gasser,, M. D. Ferrer,, M. de Simon. 2000. In vitro activities of 22 antimicrobial agents against Listeria monocytogenes strains isolated in Barcelona, Spain. Diagn. Microbiol. Infect. Dis. 38: 259 261.
105. Martinez-Martinez, L.,, P. Joyanes,, A. I. Suarez,, and E. J. Perea. 2001. Activities of gemifloxacin and five other antimicrobial agents against Listeria monocytogenes and coryneform bacteria isolated from clinical samples. Antimicrob. Agents Chemother. 45: 2390 2392.
106. Martinez-Martinez, L.,, A. Pascual,, A. I. Suarez,, and E. J. Perea. 1999. In-vitro activity of levofloxacin, ofloxacin and D-ofloxacin against coryneform bacteria and Listeria monocytogenes . J. Antimicrob. Chemother. 43( Suppl. C): 27 32.
107. Maurin, M.,, C. Abergel,, and D. Raoult. 2001. DNA gyrasemediated natural resistance to fluoroquinolones in Ehrlichia spp. Antimicrob. Agents Chemother. 45: 2098 2105.
108. Maurin, M.,, and D. Raoult. 1993. Antimicrobial susceptibility of Rochalimaea quintana, Rochalimaea vinsonii, and the newly recognized Rochalimaea henselae . J. Antimicrob. Chemother. 32: 587 594.
109. Maurin, M.,, and D. Raoult. 1997. Bacteriostatic and bactericidal activity of levofloxacin against Rickettsia rickettsii, Rickettsia conoril, 'Israeli spotted fever group rickettsia' and Coxiella burnetii . J. Antimicrob. Chemother. 39: 725 730.
110. Mayer, L.,, and E. Nagy. 1999. Investigation of the synergic effects of aminoglycoside-fluoroquinolone and third-generation cephalosporin combinations against clinical isolates of Pseudomonas spp. J. Antimicrob. Chemother. 43: 651 657.
110a. McClosky, L. M.,, T. Moore,, N. Niconovich,, B. Donald,, J. Broskey,, C. Jakielaszek,, S. Rittenhouse,, and K. Colman. 2000. In vitro activity of gemifloxacin against a broad range of recent clinical isolates from the USA. J. Antimicrob. Chemother. 45( Suppl. 1): 13 21.
111. Michea-Hamzehpour, M.,, J. C. Pechere,, B. Marchou,, and R. Auckenthaler. 1986. Combination therapy: a way to limit emergence of resistance? Am. J. Med. 80( Suppl. 6B): 138 142.
112. Milatovic, D.,, F.-J. Schmitz,, S. Brisse,, J. Verhoef,, and A. C. Fluit. 2000. In vitro activities of sitafloxacin (DU-6859a) and six other fluoroquinolones against 8,796 clinical bacterial isolates. Antimicrob. Agents Chemother. 44: 1102 1107.
113. Miyashita, N.,, Y. Niki,, and T. Matsushima. 2001. In vitro and in vivo activities of sitafloxacin against Chlamydia spp. Antimicrob. Agents Chemother. 45: 3270 3272.
113a. Mohammed, J.,, C. K. Marston,, T. Popovic,, R. S. Weyant,, and F. C. Tenover. 2001. Antimicrobial susceptibility testing of Bacillus anthracis. abstr. UL-9. In Program and Abstracts of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
114. Molbak, K.,, D. L. Baggesen,, F. M. Aarestrup,, J. M. Ebbesen,, J. Engberg,, K. Frydendahl,, P. Gerner-Smidt,, A. M. Petersen,, and H. C. Wegener. 1999. An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype Typhimurium DT104. N. Engl. J. Med. 341: 1420 1425.
115. Montanari, M. P.,, M. Mingoia,, and P. E. Varaldo. 2001. In vitro antibacterial activities of AF 3013, the active metabolite of prulifloxacin, against nosocomial and community Italian Isolates. Antimicrob. Agents Chemother 45: 3616 3622.
116. Murios Bellido, J. L.,, F. J. Sanchez Hernandez,, M. N. Gutierrez Zufiaurre,, and J. A. Garcia-Rodriguez. 2000. In vitro activity of newer fluoroquinolones against Stenotrophomonas maltophilia . J. Antimicrob. Chemother. 46: 334 335.
117. Murdoch, D. R.,, and L. B. Reller. 2001. Antimicrobial susceptibilities of Group B streptococci isolated from patients with invasive disease: 10-year perspective. Antimicrob. Agents Chemother. 45: 3623 3624.
118. Nagai, K.,, T. A. Davies,, G. A. Pankuch,, B. E. Dewasse,, M. R. Jacobs,, and P. C. Appelbaum. 2000. In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae . Antimicrob. Agents Chemother. 44: 2740 2746.
119. Nord, C. E. 1996. In vitro activity of quinolones and other antimicrobial agents against anaerobic bacteria. Clin. Infect Dis. 23( Suppl. 1): S15 S18.
120. Oh, J.-L.,, K.-S. Paek,, M.-J. Ahn,, M.-Y. Kim,, C. Y. Hong,, I.-C. Kim,, and J.-H. Kwak. 1996. In vitro and in vivo evaluations of LB20304, a new fluoronaphthyridone. Antimicrob. Agents Chemother. 40: 1564 1568.
121. Pankuch, G. A.,, K. Nagai,, T. A. Davies,, M. R. Jacobs,, and P. C. Appelbaum. 2002. Antipneumococcal activity of BMS-284756 compared with those of six other agents. Antimicrob. Agents Chemother. 46: 252 354.
122. Pfaller, M. A.,, and R. N. Jones. 1997. Comparative antistreptococcal activity of two newer fluoroquinolones, levofloxacin and sparfloxacin. Diagn. Microbiol. Infect. Dis. 29: 199 201.
123. Pfaller, M. A.,, and R. N. Jones. 2000. MYSTIC (Meropenem Yearly Susceptibility Test Information Collection) results from the Americas: resistance implications in the treatment of serious infections. J. Antimicrob. Chemother. 46: 25 37.
124. Prosser, B. L. T.,, and G. Beskid. 1995. Multicenter in vitro comparative study of fluoroquinolones against 25,129 grampositive and gram-negative clinical isolates. Diagn. Microbiol. Infect. Dis. 21: 33 45.
125. Roblin, P. M.,, T. Reznik,, A. Kutlin,, and M. R. Hammerschlag. 1999. In vitro activities of gemifloxacin (SB 265805, LB20304) against recent isolates of Chlamydia pneumoniae . Antimicrob. Agents Chemother. 43: 2806 2807.
126. Roychoudhury, S.,, C. E. Catrenich,, E. J. Mcintosh,, H. D. McKeever,, K. M. Makin,, P. M. Koenigs,, and B. Ledoussal. 2001. Quinolone resistance in staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates. Antimicrob. Agents Chemother. 45: 1115 1120.
127. Ruiz-Serrano, M. J.,, L. Alcala,, L. Martinez,, M. Diaz,, M. Marin,, M. J. Gonzalez-Abad,, and E. Bouza. 2000. In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs. Antimicrob. Agents Chemother. 44: 2567 2568.
128. Sahm, D. F.,, I. A. Critchley,, L. J. Kelly,, J. A. Karlowsky,, D. C. Mayfield,, C. Thornsberry,, Y. R. Mauriz,, and J. Kahn. 2001. Evaluation of current activities of fluoroquinolones against gram-negative bacilli using centralized in vitro testing and electronic surveillance. Antimicrob. Agents Chemother. 45: 267 274.
129. Sahm, D. F.,, M. E. Jones,, M. L. Hickey,, D. R. Diakun,, S. V. Mani,, and C. Thornsberry. 2000. Resistance surveillance of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated in Asia and Europe 1997-1998. J. Antimicrob. Chemother. 45: 457 466.
130. Sahm, D. F.,, J. A. Karlowsky,, L. J. Kelly,, I. A. Critchley,, M. E. Jones,, C. Thornsberry,, Y. Mauriz,, and J. Kahn. 2001. Need for annual surveillance of antimicrobial resistance in Streptococcus pneumoniae in the United States: 2-year longitudinal analysis. Antimicrob. Agents Chemother. 45: 1037 1042.
131. Saravolatz, L.,, O. Manzor,, C. Check,, J. Pawlak,, and B. Belian. 2001. Antimicrobial activity of moxifloxacin, gatifloxacin and six fluoroquinolones against Streptococcus pneumoniae . J. Antimicrob. Chemother. 47: 875 877.
132. Schmitz, F.-J.,, M. Boos,, S. Mayer,, D. Hafher,, H. Jagusch,, J. Verhoef,, and A. C. Fluit. 2001. Propensity of fluoroquinolones with different moieties at position 8 to cause resistance development in clinical isolates of Streptococcus pneumoniae . Antimicrob. Agents Chemother. 45: 2666 2667.
133. Schmitz, F. J.,, A. C. Fluit,, D. Hafner,, A. Beeck,, A. M. Perdikouli,, M. Boos,, S. Scheuring,, J. Verhoef,, K. Kohrer,, and C. von Eiff. 2000. Development of resistance to ciprofloxacin, rifampin, and mupirocin in methicillin-susceptible and -resistant Staphylococcus aureus isolates. Antimicrob. Agents Chemother. 44: 3229 3231.
134. SENTRY participants group (Latin America), A. Gales,, H. Sader,, and R. N. Jones. 2001. Activities of BMS 284756 (T- 3811) against Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae isolates from SENTRY Antimicrobial Surveillance Program Medical Centers in Latin America (1999). Antimicrob. Agents Chemother. 45: 1463 1466.
135. Skinner, P. S.,, S. K. Furney,, D. A. Kleinert,, and I. M. Orme. 1995. Comparison of activities of fluoroquinolones in murine macrophages infected with Mycobacterium tuberculosis . Antimicrob. Agents Chemother. 39: 750 753.
136. Smith, K. E.,, J. M. Besser,, C. W. Hedberg,, F. T. Leano,, J. B. Bender,, J. H. Wicklund,, B. P. Johnson,, K. A. Moore,, M. T. Osterholm. 1999. Quinolone-resistant Campylobacter jejuni infections in Minnesota, 1992-1998. N. Engl. J. Med. 340: 1525 1532.
137. Soussy, C.-J.,, M. Cluzel,, M.-C. Ploy,, M.-D. Kitzis,, C. Morel,, A. Bryskier,, and P. Courvalin. 1999. In-vitro antibacterial activity of levofloxacin against hospital isolates: a multicenter study. J. Antimicrob. Chemother. 43( Suppl. C): 43 50.
138. Takahata, M.,, J. Mitsuyama,, Y. Yamashiro,, M. Yonezawa,, H. Araki,, Y . Todo,, S. Minami,, Y. Watanabe,, and H. Narita. 1999. In vitro and in vivo antimicrobial activities of T- 3811ME, a novel Des-F (6)-quinolone. Antimicrob. Agents Chemother. 43: 1077 1084.
139. Takahata, M.,, M. Shimakura,, R. Hori,, K. Kizawa,, Y. Todo,, S. Minami,, Y. Watanabe,, and H. Narita. 2001. In vitro and in vivo efficacies of T-3811ME (BMS-284756) against Mycoplasma pneumoniae . Antimicrob. Agents Chemother 45: 312 315.
140. Teng, L.-J.,, P.-R. Hsueh,, S.-W. Ho,, and K. -T Luh. 2001. High prevalence of inducible erythromycin resistance among Streptococcus bovis isolates in Taiwan. Antimicrob. Agents Chemother. 45: 3362 3365.
141. Threlfall, E. J.,, and L. R. Ward. 2001. Decreased susceptibility to ciprofloxacin in Salmonella enterica serotype Typhi, United Kingdom. Emerg. Infect. Dis. 7: 448 450.
142. Threlfall, E. J.,, L. R. Ward,, J. A. Skinner,, H. R. Smith,, and S. Lacey. 1999. Ciprofloxacin-resistant Salmonella typhi and treatment failure. Lancet 353: 1590 1591.
143. Ullmann, U.,, S. Schubert,, and R. Krausse. 1999. Comparative in-vitro activity of levofloxacin, other fluoroquinolones, doxycycline and erythromycin against Ureaplasma urealyticum and Mycoplasma hominis . J. Antimicrob. Chemother. 43( Suppl. C): 33 36.
144. Verhaegen, J., , and L. Verbist. 1999. In-vitro activities of 16 non-p-lactam antibiotics against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae . J. Antimicrob. Chemother. 43: 563 567.
145. Visalli, M. A.,, S. Bajaksouzian,, M. R. Jacobs,, and P. C. Appelbaum. 1997. Comparative activity of trovafloxacin, alone and in combination with other agents, against gramnegative nonfermentative rods. Antimicrob. Agents Chemother. 41: 1475 1481.
146. Wakabayashi, E.,, and S. Mitsuhashi. 1994. In vitro antibacterial activity of AM-1155, a novel 6-fluoro-8-methoxy quinolone. Antimicrob. Agents Chemother. 35: 594 601.
147. Whitney, C. G.,, M. M. Farley,, J. Hadler,, L. H. Harrison,, C. Lexau,, A. Reingold,, L. Lefkowitz,, P. R. Cieslak,, M. Cetron,, E. R. Zell,, J. H. Jorgensen,, and A. Schuchat. 2000. Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. N. Engl. J. Med. 343: 1917 1924.
148. Wilcox, M. H.,, W. Fawley,, J. Freeman,, and J. Brayson. 2000. In vitro activity of new generation fluoroquinolones against genotypically distinct and indistinguishable Clostridium difficile isolates. J. Antimicrob. Chemother. 46: 551 555.
149. Wise, R.,, and J. M. Andrews. 1997. The activity of grepafloxacin against respiratory pathogens in the UK. J. Antimicrob. Chemother. 40( Suppl. A): 27 30.
150. Wise, R.,, and J. M. Andrews. 1999. The in-vitro activity and tentative breakpoint of gemifloxacin, a new fluroquinolone. J. Antimicrob. Chemother. 44: 679 688.
151. Wise, R.,, N. P. Brenwald,, J. M. Andrews,, and F. Boswell. 1997. The activity of the methylpiperazinyl fluoroquinolone CG 5501: a comparison with other fluoroquinolones. J. Antimicrob. Chemother. 39: 447 452.
152. Zabinski, R. A.,, K. J. Walker,, A. J. Larsson,, J. A. Moody,, G. W. Kaatz,, and J. C. Rotschafer. 1995. Effect of Aerobic and Anaerobic environments on antistaphylococcal activities of five fluoroquinolones. Antimicrob. Agents Chemother 39: 507 512.
153. Zhao, B. Y.,, R. Pine,, J. Domagala,, and K. Drlica. 1999. Fluoroquinolone action against clinical Isolates of Mycobacterium tuberculosis: Effects of a C-8 methoxyl group on survival in liquid media and in human macrophages. Antimicrob. Agents Chemother. 43: 661 666.

Tables

Generic image for table
Table 1

Susceptibility of to earlier fluoroquinolones

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
Generic image for table
Table 2

Susceptibility of to more recent quinolone antimicrobials

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
Generic image for table
Table 3

Susceptibility of nonfermenting organisms to fluoroquinolones

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
Generic image for table
Table 4

Activities of fluoroquinolones against miscellaneous gram-negative bacteria

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
Generic image for table
Table 5

Susceptibilities of gastrointestinal tract pathogens to fluoroquinolone antimicrobials

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
Generic image for table
Table 6

Susceptibility of gram-negative and atypical respiratory pathogens to quinolone antimicrobials

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
Generic image for table
Table 7

Susceptibility of gram-positive bacteria to U.S. approved fluoroquinolone antimicrobials ref-type="table-fn" rid="tfn5-7>

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
Generic image for table
Table 8

Susceptibility of gram-positive bacteria to investigational quinolone antimicrobials

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
Generic image for table
Table 10

Expected susceptibilities of genital pathogens to fluoroquinolones

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5
Generic image for table
Table 9

Susceptibilities of anaerobic bacteria to fluoroquinolones

Citation: Thauvin-Eliopoulos C, Eliopoulos G. 2003. Activity In Vitro of the Quinolones, p 91-111. In Hooper D, Rubinstein E (ed), Quinolone Antimicrobial Agents, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817817.Ch5

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