Chapter 2 : Pathogens of Rats and Mice

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The observation that infectious diseases of laboratory rats and mice have been on the decline for decades could lead one to a general sense of complacency regarding the plethora of pathogens to which these animals are susceptible. This chapter presents a wide, although certainly not exhaustive, scope of natural pathogens of laboratory rats and mice, and their effects on host physiology. Potential research-altering effects of H-1 virus include hepatocellular necrosis in rats exposed to pathogens or chemicals causing liver injury; reduction of the incidence of -associated arthritis, although other copathogens could also be present; alteration of lipid metabolism; induction of a caspase-3-dependent apoptosis activation pathway in the cerebellum; and inhibition of human tumor cell growth in mice. All mice and rats should be certified free of all parvoviruses prior to entry into the animal facility. Sendai virus (SV) is one of the most important pathogens infecting laboratory mice and rats. is, without question, one of the most important pathogens infecting laboratory rats and mice, and is the cause of murine respiratory mycoplasmosis (MRM). The primary importance of Salmonella serotypes is as zoonotic agents and as pathogens in immunocompromised mice and rats. While many species of mites infest wild rodents, only three species of nonburrowing mites are commonly found on laboratory mice and rats. and infest mice, and infests rats.

Citation: Baker D. 2003. Pathogens of Rats and Mice, p 19-107. In Natural Pathogens of Laboratory Animals. ASM Press, Washington, DC. doi: 10.1128/9781555817824.ch2
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