10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses

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10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, Page 1 of 2

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Epidemic encephalitis was first recognized in the form of von Economo’s encephalitis lethargica (EL) in the same decade as World War I and the great pandemic of influenza. More recently, enterovirus 71 (EV-71) has caused outbreaks of hand-foot-and-mouth (HFM) disease in association with a rapidly lethal brain stem encephalitis. Molecular techniques have clarified the relationships of the 66 enteroviruses now recognized. EV-70 and EV-71 have significant effects on the nervous system. Infection with EV-70 can result in the rapid appearance of an acute hemorrhagic conjunctivitis (AHC). Among the nonpolio enteroviruses, echoviruses 30, 11, 7, and 9, EV-70 and EV-71, and coxsackievirus B5 are the most common neurotropic and neurovirulent agents. Recent studies, including clinical trials, have demonstrated the activity of the compound pleconaril against many clinically significant enteroviruses. The differential diagnosis is broad and includes the polyneuritis of Guillain-Barrė, other enteroviruses, and other viral causes of brain stem encephalitis. The disease was often characterized by the development of new manifestations after an apparently disease-free interval. Most significant among the late manifestations was postencephalitic Parkinsonism. Certain cases have had a relationship to viral infection, such as the fatigue associated with Epstein-Barr virus infection, or have followed viral infection, such as the postviral fatigue syndrome. In considering the potential role of viruses, Greenlee and Rose concluded that the chronic fatigue syndrome is a heterogeneous group of disorders and that "a complex relationship may exist between the physical, psychological, and social factors leading to chronic incapacitation."

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
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Image of FIGURE 10.1

Low-power view of myelin-stained section of the cervical spinal cord in acute poliomyelitis. There is pallor reflecting edema and inflammation selectively affecting the anterior horns (arrows).

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
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Image of FIGURE 10.2

Low-power view of myelin-stained section of the medulla in acute bulbar poliomyelitis. Pallor of staining reflecting edema and inflammation is seen in focal regions of the reticular formation (arrows).

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
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Image of FIGURE 10.3

Focus of neuronophagia in the tegmentum of the pons in acute poliomyelitis. Lymphocytic cuffing is seen around a small vessel, top right. Hematoxylin and eosin stain.

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
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Image of FIGURE 10.4

Perivascular cuffing in acute poliomyelitis. The section has been treated with an antibody to IgA and shows plasma containing IgA and lymphocytes in the perivascular space and neuropil. Counterstained with hematoxylin.

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
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Image of FIGURE 10.5

Case of EL with 1 week history; male aged 15 years. Periaqueductal region of midbrain with ependymal surface at top left. Intense congestion with red cell diapedesis and parenchymal inflammation. Hematoxylin and eosin.

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
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Image of FIGURE 10.6

Substantia nigra from same case as Fig. 10.5. Degenerate pigmented neurons are surrounded by inflammatory cells (arrows). Hematoxylin and eosin stain.

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
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Image of FIGURE 10.7

(a) Lower-power view of substantia nigra from the same case as Fig. 1.7. The few large neurons present represent the severely depleted neuronal population, (b) Normal substantia nigra for comparison. Luxol fast blue/cresyl violet stain.

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
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1. Acheson, E. D. 1959. The clinical syndrome variously called benign myalgic encephalomyelitis, Iceland disease and epidemic neuromyasthenia. Am. J. Med. 26:569595.
2. Ahmed, E.,, J. A. Singleton,, and A. L. Franks. 2001. Influenza vaccination for healthy young adults. N. Engl. J. Med. 345:15431547.
3. Aiba, H.,, M. Mochizuki,, M. Kimura,, and H. Hojo. 2001. Predictive value of serum interleukin-6 level in influenza virus associated encephalopathy. Neurology 57:295299.
4. Alexander, J. P., Jr.,, L. Baden,, M. A. Pallansch,, and L. J. Anderson. 1994. Enteroviral infections and neurologic disease-United States, 1977-1991. J. Infect. Dis. 169:905908.
5. Al-Mateen, M.,, M. Gibbs,, R. Dietrich,, W. G. Mitchell,, and J. H. Menkes. 1988. Encephalitis lethargica-like illness in a girl with mycoplasma infection. Neurology 38:11551158.
6. Anonymous. 1970. Laboratory reports. Br. Med. J. 1:311.
7. Baker, A. B.,, H. A. Matzke,, and J. R. Brown. 1950. Poliomyelitis. III. Bulbar poliomyelitis: a study of medullary function. Arch. Neurol. Psychiatr. 63:257281.
8. Blinzinger, K.,, J. Simon,, D. Magrath,, and L. Boulger. 1969. Poliovirus crystals within the endoplasmic reticulum of endothelial and mononuclear cells in the monkey spinal cord. Science 163:13361337.
9. Blondel, B.,, G. Duncan,, T. Couderc,, E. Delpeyroux,, N. Pavio,, and F. Colbere-Garapin. 1998. Molecular aspects of poliovirus biology with a special focus on the interactions with nerve cells. J. Neurovirol. 4:126.
10. Blunt, S. B.,, R. J. M. Lane,, N. Turjanski,, and G. D. Perkin. 1997. Clinical features and management of two cases of encephalitis lethargica. Movement Disorders 12:354359.
11. Bodian, D., 1972. Poliomyelitis, p. 23232344. In J. Minackler (ed.), Pathology of the Nervous System. McGraw-Hill, New York, NY.
12. Bodian, D.,, and H. A. Howe. 1940. An experimental study of the role of neurons in the dissemination of poliomyelitis virus in the nervous system. Brain 63:135162.
13. Bodian, D.,, and H. A. Howe. 1941. Experimental studies on intraneural spread of poliomyelitis virus. Bull. Johns Hopkins Hosp. 68:248267.
14. Brahdy, M. B.,, and M. Lenarsky. 1934- Difficulty in swallowing in acute epidemic poliomyelitis. JAMA 103:229234.
15. Buzzard, E. F.,, and J. G. Greenfield. 1919. Lethargic encephalitis; its sequelae and morbid anatomy. Brain 42:305308.
16. Cappel, R.,, L. Thiry,, and G. Clinet. 1975. Viral antibodies in the CSF after acute CNS infections. Arch. Neurol. 32:629631.
17. Casals, J.,, J. T. S. Elizan,, and M. D. Yahr. 1998. Post-encephalitic Parkinsonism-a review. J. Neural Transm. 105:645676.
18. Center for Disease Control. 1981. Encephalitis Surveillance Annual Summary 1978. Center for Disease Control, Atlanta, Ga.
19. Centers for Disease Control and Prevention. 1997. Nonpolio enterovirus surveillance-United States, 1993-1996. Morb. Mortal. Wkly. Rep. 46:748750.
20. Centers for Disease Control and Prevention. 1999a. Outbreak of Hendra-like Virus-Malaysia and Singapore, 1998-1999. Morb. Mortal. Wkly. Rep. 48:265269.
21. Centers for Disease Control and Prevention. 1999b. Update: outbreak of Nipah Virus-Malaysia and Singapore, 1999. Morb. Mortal. Wkly. Rep. 48:335337.
22. Centers for Disease Control and Prevention. 2000a. Enterovirus surveillance-United States, 1997-1999. Morb. Mortal. Wkly. Rep. 49:913916.
23. Centers for Disease Control and Prevention. 2000b. Poliomyelitis prevention in the United States. Updated recommendations of the Advisory Committee on Immunization Practices (ACIP). Morb. Mortal. Wkly. Rep. 49(RR-5):l22.
24. Centers for Disease Control and Prevention. 2001a. Enterovirus type 13-United States, 2001. Morb. Mortal. Wkly. Rep. 50:777780.
25. Centers for Disease Control and Prevention. 2001b. Progress toward poliomyelitis eradication-West and Central Africa, 1999— 2000. Morb. Mortal. Wkly. Rep. 50:481485.
26. Centers for Disease Control and Prevention. 2002a. Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices. Morb. Mortal. Wkly. Rep. 51(RR-3):131, plus inside and outside covers.
27. Centers for Disease Control and Prevention. 2002b. Enterovirus Surveillance—United States, 2000-2001. Morb. Mortal. Wkly. Rep. 51:10471049.
28. Chang, L.-Y.,, T.-Y. Lin,, K.-H. Hsu,, Y.-C. Huang,, K.-L. Lin,, C. Hsueh,, S.-R. Shih,, H.-C. Ning,, M.-S. Hwang,, H. S. Wang,, and C.-Y. Lee. 1999. Clinical features and risk factors of pulmonary edema after Enterovirus 71-related hand, foot and mouth disease. Lancet 354:16821686.
29. Chong, H.-T.,, A. Kamarulzamen,, C.-T. Tan,, K.-J. Goh,, T. Thayaparan,, S. R. Kunjapan,, N.-K. Chew,, K.-B. Chua,, and S.-K. Lam. 2001. Treatment of acute Nipah encephalitis with ribavirin. Ann. Neurol. 49:810813.
30. Chua, K. B.,, K. J. Goh,, K. T. Wong,, A. Kamarulzaman,, P. S. K. Tan,, T. G. Ksiazek,, S. R. Zaki,, G. Paul,, S. K. Lam,, and C. T. Tan. 1999. Fatal encephalitis due to Nipah Virus among pig-farmers in Malaysia. Lancet 354:12571259.
31. Chua, K. B.,, W. J. Bellini,, P. A. Rota,, B. H. Harcourt,, A. Tamin,, S. K. Lam,, T. G. Ksiazek,, R. E. Rollin,, S. R. Zaki,, W.-J. Shieh,, C. S. Goldsmith,, D. J. Gubler,, J. T. Roehrig,, B. Eaton,, A. R. Gould,, J. Olson,, H. Field,, P. Daniels,, A. E. Ling,, C. J. Peters,, L. J. Anderson,, and B. W. J. Mahy. 2000. Nipah virus: a recently emergent deadly paramyxovirus. Science 288:14321435.
32. Couch, R. B. 2000. Prevention and treatment of influenza. N. Engl.J.Med. 343:17781787.
33. Cox, N. J.,, and K. Subbarao. 1999. Influenza A. Lancet 354:12771282.
34. Dalakas, M. C 1995. The post-polio syndrome as an evolved clinical entity: definition and clinical description. Ann. N.Y. Acad. Sci. 753:6880.
35. Dalakas, M. C. 1999. Why drugs fail in post-polio syndrome. Lessons from another clinical trial. Neurology 53:11661167.
36. Dalldorf, G.,, and J. L. Melnick,. 1965. Coxsackie viruses, p. 474512. In F. L. Horsfall, and L. Tamin (ed.), Viral and Rickettsial Infections of Man, 4th ed. B. Lippincott Co., Philadelphia, Pa.
37. Davenport, F., 1982. Influenza viruses, p. 373396. In A. S. Evans (ed.), Viral Infections of Humans. Epidemiology and Control, 2nd ed. Plenum Press, New York, N.Y.
38. Davis, L. E.,, and M. Kornfeld. 1980. Influenza A virus and Reye's Syndrome in adults. J. Neurol. Neurosurg. Psychiatr. 43:516521.
39. Davis, L. E.,, K. S. Blisard,, and M. Kornfeld. 1990. The Influenza B virus mouse model of Reye's Syndrome: clinical, virologic, and morphologic studies of an encephalopathy. J. Neurol. Sci. 97:221231.
40. Debre, R., 1970. Lethargic encephalitis or von Economo's disease, p. 193202. In R. Debre, and J. Cellars (ed.), Clinical Virology, The Evaluation and Management of Human Viral Infections. W. B. Saunders & Co., Philadelphia, Pa.
41. Delorme, L.,, and P. J. Middleton. 1979. Influenza A virus associated with acute encephalopathy. Am. J. Dis. Child. 133:822824.
42. Dick, G. W. A.,, A. M. Best,, A. J. Haddow,, and K. C. Smithburn. 1948. Meningoencephalomyelitis. A hitherto unknown virus affecting man. Lancet ii:286289.
43. Dowdle, W. R. 2001. Polio eradication: turning the dream into reality. ASM News 67:397402.
44. Editorial. 1970. Epidemic malaise. Br. Med. J. 1:12.
45. Editorial. 1978. Epidemic myalgic encephalomyelitis. Br. Med. J. 2:14361437.
46. Elliott, H. C. 1947. Studies on motor cells of spinal cord; poliomyelitis lesion in spinal motor nuclei in acute cases. Am. J. Pathol. 23:313325.
47. Enserink, M. 2000. Malaysian researchers trace Nipah Virus outbreak to bats (News). Science 289:518519.
48. Esiri, M. M. 1980. Poliomyelitis: immunoglobulin containing cells in the central nervous system in acute and convalescent phases of human disease. Clin. Exp. Immunol. 40:4248.
49. Esiri, M. M.,, and M. Swash. 1984- Absence of herpes simplex virus antigen in brain in Encephalitis Lethargica. J. Neurol. Neurosurg. Psychiatr. 47:10491050.
50. Farrar, J. J. 1999. Commentary. Nipah-Virus encephalitis-investigation of a new infection. Lancet 354:12221223.
51. Flewett, T. H.,, and J. G. Hoult. 1958. Influenzal encephalopathy and post influenzal encephalitis. Lancet ii:1115.
52. Ford, D. J.,, S. L. Ropka,, G. H. Collins,, and B. Jubelt. 2002. The neuropathology observed in wild-type mice inoculated with human poliovirus mirrors human paralytic poliomyelitis. Microb. Pathog. 33:97107.
53. Frankova, V.,, A. Jirasek,, and B. Tumova. 1977. Type A influenza: postmortem virus isolations from different organs in human lethal cases. Arch. Virol. 53:265268.
54. Freistadt, M. S.,, D. A. Stoltz,, and K. E. Eberle. 1995. Role of poliovirus receptors in the spread of the infection. Ann. N. Y. Acad. Sci. 753:3747.
55. Fujii, Y.,, M. Kuriyama,, Y. Konishi,, and M. Sudo. 1992. MRI and SPECT in influenzal encephalitis. Pediatr. Neurol. 8:133136.
56. Fujimoto, S.,, M. Kobayashi,, O. Uemura,, M. Iwasa,, T. Ando,, T. Katoh,, C. Nakamura,, N. Maki,, H. Togari,, and Y. Wada. 1998. PCR on spinal fluid to show influenza associated acute encephalopathy or encephalitis. Lancet 352:873875.
57. Furtado, D. 1958. Encephalite par grippe asiatique. Rev. Neurol. 98:192205.
58. Gibbs, F. A.,, E. L. Gibbs,, P. R. Carpenter,, and H. W. Spies. 1962. Electroencephalographic study of patients with acute aseptic meningitis. Pediatrics 29:181186.
59. Gilbert, G. L.,, K. E. Dickson,, M.-J. Waters,, M. L. Kennett,, S. A. Land,, and M. Sneddon. 1988. Outbreak of Enterovirus 71 infection in Victoria, Australia, with a high incidence of neurologic involvement. Pediatr. Infect. Dis. J. 7:484488.
60. Goh, K. J.,, C. T. Tan,, N. K. Chew,, R. S. K. Tan,, A. Kamarulzaman,, S. A. Sarji,, K. T. Wong,, B. J. J. Abdullah,, K. B. Chua,, and S. K. Lam. 2000. Clinical features of Nipah Virus Encephalitis among pig farmers in Malaysia. N. Engl. J. Med. 342:12291235.
61. Greenlee, J. E.,, and J. W. Rose. 2000. Controversies in neurological infectious diseases. Semin. Neurol. 20:375386.
62. Grist, N. R.,, E. J. Bell,, and F. Assaad. 1978. Enterovirus in human diseases. Prog. Med. Virol. 24:114157.
63. Hall, A. J. 1924. Epidemic Encephalitis (Encephalitis Lethargica). John Wright and Sons Ltd., Bristol, United Kingdom.
64. Hall, C. B. 2001. Respiratory syncytial virus and parainfluenza virus. N. Engl. J. Med. 344:19171928. (Discussion,345:1132, 1133.)
65. Hallervorden, J. 1935. Anatomische Untersuchugen zur Pathogenese des postencephalitischen Parkinsonisms. D. Z. Nervenheilk. 136:6877.
66. Harada, K. 1966. Zur morphologischen Differenzierung hamorrhagischer Encephalitiden. D. Z. Nervenheilk. 188:142186.
67. Hayden, E. G.,, and P. Palese,. 1997. Influenza virus, p. 911942. In D. G. Richman,, R. J. Whitley,, and E. G. Hayden (ed.), Clinical Virology. Churchill Livingstone, New York, N.Y.
68. Haynes, R. E.,, H. G. Cramblett,, and H. J. Kronfal. 1969. Echovirus 9 meningoencephalitis in infants and children. JAMA 208:16571660.
69. Heathfield, K. W. G.,, R. Pilsworth,, J. Wall,, and J. A. N. Corseffis. 1967. Coxsackie B5 infections in Essex 1965 with particular reference to the nervous system. Q.J. Med. 36:579595.
70. Hirayama, K.,, H. Salazaki,, S. Murakami,, S. Yonezawa,, K. Fujimoto,, T. Seto,, K. Tanaka,, H. Hattori,, O. Matsuoka,, and R. Murata. 1999. Sequential MRI, SPECT and PET in respiratory syncytial virus encephalitis. Pediatr. Radiol. 29:282286.
71. Ho, M.,, E.-R. Chen,, K.-H. Hsu,, S.-J. Twu,, K.-T. Chen,, S.-F. Tsai,, J.-R. Wang,, and S.-R. Shih for the Taiwan Enterovirus Epidemic Working Group. 1999. An epidemic of enterovirus 71 infection in Taiwan. N. Engl. J. Med. 341:929935.
72. Horstmann, D. M.,, and N. Yamada. 1968. Enterovirus infections of the central nervous system. Res. Publ. Assoc. Res. Nerv. Ment. Dis. 44:236253.
73. Hoult, J. G.,, and T. H. Flewett. 1960. Influenzal encephalopathy and post-influenzal encephalitis. Histological and other observations. Br. Med. J. 1:18471850.
74. Howard, R. S.,, and A. J. Lees. 1987. Encephalitis lethargica. A report of four recent cases. Brain 110:1933.
75. Huang, C.-C.,, C.-C. Liu,, Y.-C. Chang,, C.-Y. Chen,, S.-T. Wang,, and T.-F. Yeh. 1999. Neurologic complications in children with Enterovirus 71 infection. N. Engl. J. Med. 341:936942.
76. Hung, T.-P.,, S.-M. Sung,, H.-C. Liang,, D. Landsborough,, and I. J. Green. 1976. Radiculomyelitis following acute haemorrhagic conjunctivitis. Brain 99:771790.
77. Ishimaru, Y.,, S. Nakano,, K. Yamaoka,, and S. Takami. 1980. Outbreak of Hand, Foot, and Mouth Disease by Enterovirus 71. High incidence of complication disorders of central nervous system. Arch. Dis. Child. 55:583588.
78. Ito, Y.,, T. Ichiyama,, H. Kimura,, M. Shibata,, N. Ishiwada,, H. Kuroki,, S. Furukuwa,, and T. Morishima. 1999. Detection of influenza virus RNA by reverse transcription-PCR and proinflammatory cytokines in influenza-virus-associated encephalopathy. J. Med. Virol. 58:420425.
79. John, T. J. 2000. The final stages of the global eradication of polio. N. Engl. J. Med. 343:806807.
80. Jubelt, B.,, and J. C. Agre. 2000. Characteristics and management of post-polio syndrome. JAMA 284:412414.
81. Jubelt, B.,, G. Gallez-Hawkins,, O. Narayan,, and R. T. Johnson. 1980. Pathogenesis of human poliovirus infection in mice. I. Clinical and pathological studies. J. Neuropathol. Exp. Neurol. 39:138148.
82. Kasai, T.,, T. Togashi,, and T. Morishima. 2000. Encephalopathy associated with influenza epidemics. Lancet 355:15581559.
83. Kennedy, S. 1998. Morbillivirus infections in aquatic mammals. J. Comp. Pathol. 119:201225.
84. Kennett, M. L.,, C. J. Birch,, F. A. Lewis,, A. P. Yung,, S. A. Locarnini,, and I. D. Gust. 1974. Enterovirus-71 infection in Melbourne. Bull. W. H. O. 51:609615.
85. Kew, O.,, V. Morris-Glasgow,, M. Landaverde,, C. Burns,, J. Shaw,, Z. Garib,, J. Andre,, E. Blackman,, C. J. Freeman,, J. Jorba,, R. Sutter,, G. Tambini,, L. Venczel,, C. Pedreira,, F. Laender,, H. Shimuzu,, T. Yoneyama,, T. Miyamura,, H. van der Avoort,, M. S. Oberste,, D. Kilpatrick,, S. Cochi,, M. Pallansch,, and C. de Quadros. 2002. Outbreak of poliomyelitis in Hispaniola associated with circulating type I vaccine-derived poliovirus. Science 296:356359.
86. Kiley, M.,, and M. M. Esiri. 2001. A contemporary case of encephalitis lethargica. Clin. Neuropathol. 20:27.
87. Kimura, S.,, T. Kobayashi,, H. Osaka,, C. Shimizu,, S. Uebara,, and N. Ohtuki. 1995. Serial magnetic resonance imaging in postinfectious focal encephalitis due to influenza virus. J. Neurol. Sci. 131:7477.
88. Kono, R.,, A. Sasagawa,, H. Kodama,, N. Uchida,, Y. Akao,, J. Mukoyama,, and T. Fujreau. 1973. Neurovirulence of acute-haemorrhagic-conjunctivitis virus in monkeys. Lancet i:6163.
89. Krugman, S.,, and R. Ward. 1968. Enteroviral infections, p. 5689. In Infectious Diseases of Children, 4th ed. CV Mosby Co., St. Louis, Mo.
90. Landry, M. L.,, S. N. S. Fonseca,, S. Cohen,, and C. W. Bogue. 1995. Fatal enterovirus type 71 infection: rapid diagnosis and diagnostic pitfalls. Pediatr. Infect. Dis. J. 14:10951100.
91. Langmuir, A. D.,, D. J. Bregman,, L. T. Kurland,, N. Nathanson,, and M. Victor. 1984- An epidemiologic and clinical evaluation of Guillain-Barre syndrome reported in association with the administration of Swine influenza vaccines. Am. J. Epidemiol. 119:841879.
92. Lee, K.-E.,, T. Umapathi,, C.-B. Tan,, H. T.-L. Tjia,, T.-S. Cua,, H. M.-L. Oh,, K.-M. Fock,, A. Kurup,, A. K.-Y. Tan,, and W.-L. Lee. 1999. The neurological manifestations of Nipah virus encephalitis, a novel paramyxovirus. Ann. Neurol. 46: 428432.
93. Leitch, A. G. 1995. Neurasthenia, myalgic encephalitis or cryptogenic chronic fatigue syndrome? Q.J. Med. 88:447450.
94. Lepow, M. L.,, N. Coyne,, L. B. Thompson,, D. H. Carver,, and E. C. Robbins. 1962. A clinical, epidemiological and laboratory investigation of aseptic meningitis during the four year period 1955-1958. II. The clinical disease and its sequelae. N. Engl. J. Med. 266:11881193.
95. Lim, C. C. T.,, Y. Y. Sitoh,, E. Hui,, K. E. Lee,, B. S. P. Ang,, E. Lim,, W. E. H. Lim,, H. M. L. Oh,, P. A. Tambyah,, J. S. L. Wong,, C. B. Tan,, and T. S. G. Chee. 2000. Nipah viral encephalitis or Japanese encephalitis? MR findings in a new zoonotic disease. Am. J. Neuroradiol. 21:455461.
96. Linneman, C. C., Jr.,, L. Shea,, J. C. Partinj,, W. K. Schubert,, and G. M. Schiff. 1975. Reye's syndrome: epidemiologic and viral studies 1963-74. Am. J. Epidemiol 101:517526.
97. Lum, L. C. S.,, K. T. Wong,, S. K. Lam,, K. B. Chua,, A. Y. T. Goh,, W. W. L. Lim,, B. B. Ong,, G. Paul,, S. AbuBakar,, and M. Lambert. 1998. Fatal Enterovirus 71 encephalomyelitis. J. Pediatr. 133:795798.
98. Mace, S. E. 2002. Bronchiolitis: an update. Resid. Staff Physician 48:5057.
99. Matheson Commission. 1939. Epidemic Encephalitis. Etiology, Epidemiology, Treatment. Third Report of the Matheson Commission. Columbia University Press, New York, N.Y.
100. McCall, S.,, J. M. Henry,, A. H. Reid,, and J. K. Taubenberger. 2001. Influenza RNA not detected in archival brain tissues from acute encephalitis lethargica cases or in postencephalitic Parkinson cases. J. Neuropathol. Exp. Neurol. 60:696704.
101. McCullers, J. A.,, S. Facchinis,, P. J. Chesney,, and R. G. Webster. 1999. Influenza B encephalitis. Clin. Infect. Dis. 28:989900.
102. McEvedy, C. P.,, and A. W. Beard. 1970. Concept of benign myalgic encephalomyelitis. Br. Med. J. 1:1115.
103. McMinn, P.,, I. Stratov,, L. Nagara,, and S. Davis. 2001. Neurological manifestations of Enterovirus 71 infection in children during an outbreak of Hand, Foot, and Mouth Disease in Western Australia. Clin. Infect. Dis. 32:236242.
104. Mellon, A. F.,, R. E. Appleton,, D. Gardner-Medwin,, and A. Aynsley-Groen. 1991. Encephalitis lethargica-like illness in a five year old child. Dev. Med. Child. Neurol. 33:158161.
105. Melnick, J. L. 1996. Current status of poliovirus infections. Clin. Microbiol. Rev. 9:293300.
106. Merritt, H. H. 1967. Acute anterior poliomyelitis, p. 5566. In A Textbook of Neurology, 4th ed. Lea and Febiger, Philadelphia, Pa.
107. Mizuguchi, M.,, J. Abe,, S. Noma,, K. Yoshida,, T. Yamanaka,, and S. Kamoshita. 1995. Acute necrotizing encephalopathy of childhood: a new syndrome presenting with multifocal symmetric brain lesions. J. Neurol. Neurosurg. Psychiatr. 58:555561.
108. Modlin, J. E.,, and D. J. Coffey,. 1997. Poliomyelitis, polio vaccines, and the post-poliomyelitis syndome, p. 5772. In W. M. Scheld,, R. J. Whitley,, and D. T. Durack (ed.), Infections of the Central Nervous System. Lippincott-Raven, Philadelphia, Pa.
109. Modlin, J. E.,, R. Dagan,, L. E. Berlin,, D. M. Virshup,, R. H. Yolken,, and M. Menegus. 1991. Focal encephalitis with enterovirus infections. Pediatrics 88:841845.
110. Muir, P.,, U. Mammerer,, K. Korn,, M. N. Mulders,, T. Poyry,, B. Weissbrich,, R. Randolph,, G. M. Gleator,, and A. M. van Loon for the European Union Concerted Actionon Virus Meningitis and Encephalitis. 1998. Molecular typing of enteroviruses: current status and future requirements. Clin. Microbiol. Rev. 11:202227.
111. Mulder, D. W.,, R. A. Rosenbaum,, and D. D. Layton, Jr. 1972. Late progression of poliomyelitis or forme fruste amyotrophic lateral sclerosis? Mayo Clin. Proc. 47:756761.
112. Murray, K.,, P. Selleck,, R. Hooper,, A. Hyatt,, A. Gould,, A. Gleeson,, H. Westbury,, L. Hiley,, L. Selvey,, B. Rodwell,, and P. Ketterer. 1995. A morbillivirus that caused fatal disease in horses and humans. Science 268:9497.
113. Nagai, T.,, A. Yagishita,, Y. Tsuchiya,, S. Asumura,, H. Kurokawa,, and N. Matsuo. 1993. Symmetrical thalamic lesions on CT in influenza A virus infection presenting with or without Reye's syndrome. Brain Dev. 15:6773.
114. Nagy, G.,, S. Takatsy,, E. Kukan,, I. Mihaly,, and I. Domok. 1982. Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978. Arch. Virol. 71:217227.
115. Natelson, B. H. 2001. Chronic fatigue syndrome. JAMA 285:25572559.
116. Nathanson, N.,, and D. Bodian. 1962. Experimental poliomyelitis following intramuscular virus injection. 3. The effect of passive antibody on paralysis and viraemia. Bull. Johns Hopkins Hosp. 111:198220.
117. Nathanson, N.,, and P. Fine. 2002. Poliomyelitis eradication—a dangerous endgame. Science 296:269270.
118. Ng, Y. T.,, C. Cox,, J. Atkins,, and I. J. Butler. 2001. Encephalopathy associated with respiratory syncytial virus bronchiolitis. J. Child. Neurol. 16:105108.
119. Oberste, M. S.,, K. Maher,, D. R. Kilpatrick,, and M. A. Pallansch. 1999. Molecular evolution of the human enteroviruses: correlation of serotype with VPI sequence and application to picornavirus classification. J. Virol. 73:19411948.
120. Olson, J. G.,, C. Rupprecht,, P. E. Rollin,, U. S. An,, M. Niezgoda,, T. Clemins,, J. Walston,, and T. G. Ksiazek. 2002. Antibodies to Nipah-like virus in bats (Pteropus lylei). Cambodia. Emerg. Infect. Dis. 8:987991.
121. Oseasohn, R.,, L. Adelson,, and M. Kaji. 1959. Clinicopathologic study of thirty-three fatal cases of Asian influenza. N. Engl. J. Med. 26:509518.
122. O'Sullivan, J. D.,, A. M. Altworth,, D. L. Paterson,, T. M. Snow,, R. Boots,, L. J. Gleeson,, A. R. Gould,, A. D. Hyatt,, and J. Bradfield. 1997. Fatal encephalitis due to novel paramyxovirus transmitted from horses. Lancet 349:9395.
123. Paton, N. I.,, Y. S. Leo,, S. R. Zaki,, A. P. Auchus,, K. E. Lee,, A. E. Ling,, S. K. Chew,, B. Ang,, P. E. Rollin,, T. Umapathi,, I. Sng,, C. C. Lee,, E. Lim,, and T. G. Ksiazek. 1999. Outbreak of Nipah-virus infection among abattoir workers in Singapore. Lancet 354:12531256.
124. Paul, J. R. 1966. Clinical Epidemiology, revised ed. University of Chicago Press, Chicago, III.
125. Peatfield, R. C. 1987. Basal ganglia damage and subcortical dementia after possible insidious Coxsackie Virus Encephalitis. Acta Neurol. Scand. 76:340345.
126. Pevear, D. C.,, T. M. Tull,, M. E. Seipel,, and J. M. Groarke. 1999. Activity of pleconaril against enteroviruses. Antimicrob. Agents Chemother. 43:21092115.
127. Rail, D.,, C. Scholtz,, and M. Swash. 1981. Post-encephalitic parkinsonism: current experience. J. Neurol. Neurosurg. Psychiatr. 44:670676.
128. Ramlow, J.,, M. Alexander,, R. LaPorte,, C. Kaufman,, and L. Kuller. 1992. Epidemiology of the post-polio syndrome. Am. J. Epidem. 136:769786.
129. Reid, A. H.,, S. McCall,, J. M. Henry,, and J. K. Taubenberger. 2001. Experimenting on the past: the enigma of von Economo's encephalitis lethargica. J. Neuropathol. Exp. Neurol. 60:663670.
130. Rose, E.,, and P. Prabhakar. 1982. Influenza A Virus associated neurological disorders in Jamaica. West Ind. Med. J. 31:2933.
131. Rotbart, H. A. 1995. Enteroviral infections of the central nervous system. Clin. Infect. Dis. 20:971981.
132. Rotbart, H., 1997. Enteroviruses, p. 9971023. In D. D. Richman,, R. J. Whitley,, and F. G. Hayden (ed.), Clinical Virology. Churchill Livingstone, New York, N.Y.
133. Rotbart, H. A.,, and A. D. Webster for the Pleconaril Treatment Registry Group. 2001. Treatment of potentially life-threatening enterovirus infections with pleconaril. Clin. Infect. Dis. 32:228235.
134. Sabin, A. B. 1956. Pathogenesis of poliomyelitis. Reappraisal in the light of new data. Science 123:11511157.
135. Sacks, O. 1973. Awakenings. Duckworth, London, United Kingdom.
136. Schmidt, N. J.,, E. H. Lennette,, and H. H. Ho. 1974. An apparently new enterovirus isolated from patients with disease of the central nervous system. J. Infect. Dis. 129:304309.
137. Sharpe, M. C.,, L. C Archard,, J. E. Banatvala,, A. W. Clare,, A. David,, R. H. T. Edwards,, K. E. H. Hawton,, H. P. Lambert,, R. J. M. Lane,, E. M. McDonald,, J. F. Mowbray,, D. J. Pearson,, T. E. A. Peto,, V. R. Preedy,, A. R. Smith,, D. G. Smith,, D. J. Taylor,, D. A. J. Tyreil,, S. Wessely,, and R. D. White. 1991. A report—chronic fatigue syndrome: guidelines for research. J. R. Soc. Med. 84:118121.
138. Shen, W.-C.,, H.-H. Chiu,, K. -C Chow,, and C.-H. Tsai. 1999. MR imaging findings of enteroviral encephalomyelitis: an outbreak in Taiwan. Am. J. Neuroradiol. 20:18891895.
139. Shimada, A.,, D. J. Lange,, and A. P. Hays. 1999. Amyotrophic lateral sclerosis in an adult following acute paralytic poliomyelitis in early childhood. Acta Neuropathol. (Berlin) 97:317321.
140. Shindarov, L. M.,, M. P. Chumakov,, M. K. Voroshilova,, S. Bojinov,, S. M. Vasilenko,, I. Iordanov,, I. D. Kirov,, E. Kamenov,, E. V. Leshinskay,, G. Mitov,, I. A. Robinson,, S. Sivchev,, and S. T. Staikov. 1979. Epidemiological, clinical, and pathomorphological characteristics of epidemic poliomyelitis-like disease caused by Enterovirus 71. J. Hyg. Epidemiol. Microbiol. Immunol. 23:284295.
141. Simoes, E. A. E 1999. Respiratory syncytial virus infection. Lancet 354:847852.
142. Smith, R.,, J. P. Woodall,, E. Whitney,, R. Deibel,, M. A. Gross,, V. Smith,, and T. E Bast. 1974. Powassan virus infection: a report of three human cases of encephalitis. Am. J. Dis. Child. 127:691693.
143. Strikas, R. A.,, L. J. Anderson,, and R. A. Parker. 1986. Temporal and geographic patterns of isolates of nonpolio enterovirus in the United States, 1970-1983. J. Infect. Dis. 153:346351.
144. Sulkava, R.,, A. Rissanen,, and R. Pyhala. 1981. Post-influenzal encephalitis during the influenza A outbreak in 1979/1980. J. Neurol. Neurosurg. Psychiatr. 44:161163.
145. Tan, C. T.,, K. J. Goh,, K. T. Wong,, S. A. Sarji,, K. B. Chua,, N. K. Chew,, P. Murugasu,, Y. L. Loh,, H. T. Chong,, K. S. Tan,, T. Thayaparan,, S. Kumma,, and M. R. Jusoh. 2002. Relapsed and late-onset Nipah encephalitis. Ann. Neurol. 51:703708.
146. Thorsteinsson, G. 1997. Management of post-polio syndrome. Mayo Clin. Proc. 72:627638.
147. Tilney, F.,, and H. S. Howe. 1920. Epidemic Encephalitis (Encephalitis Lethargica). Paul B. Hoeber, New York, N.Y.
148. von Economo, C., 1917. Encephalitis lethargica. Wien. Klin. Wschr. 30:581585. Translated in Wilkins, R. H., and I. A. Brody. 1968. Encephalitis lethargica. Arch. Neurol. 18:324328.
149. von Economo, C. 1931. Encephalitis Lethargica: Its Sequelae and Treatment. Oxford University Press, London, United Kingdom.
150. Wells, C. E. C. 1971. Neurological complications of so-called "influenza." A winter study in south-east Wales. Br. Med. J. 1:369373.
151. Wenner, H. A. 1982. The enteroviruses: recent advances. Yale J. Biol. Med. 55:277282.
152. Windebank, A. J.,, W. J. Litchy,, and J. R. Daube. 1995. Prospective cohort study of polio survivors in Olmsted County, Minnesota. Ann. N. Y. Acad. Sci. 753:8186.
153. Wong, K. T.,, W.-J. Shien,, S. Kumar,, K. Norain,, W. Abdullah,, J. Guarner,, C. S. Goldsmith,, K. B. Chua,, S. K. Lam,, C. T. Tan,, K. J. Goh,, H. T. Chong,, R. Jusoh,, R. E. Rollin,, T. G. Ksiazek,, and S. R. Zaki. 2002. Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am. J. Pathol. 161:21532167.
154. World Health Organization. 1998. Surveillance of nonpoliomyelitis enteroviruses, 1993-1996. Wkly. Epidemiol. Rec. 29:220223.
155. World Health Organization. 2002. Acute neurological syndrome, Bangladesh. Followed by an account of Nipah virus. Wkly. Epidemiol. Rec.77:297299.
156. Wyatt, H. V. 1982. Any questions? Trop. Doctor 12:218.
157. Yan, J.-J.,, J.-R. Wang,, C.-C. Liu,, H.-B. Yang,, and I.-J. Su. 2000. An outbreak of Enterovirus 71 infection in Taiwan 1998: a comprehensive pathological, virological, and molecular study on a case of fulminant encephalitis. J. Clin. Virol. 17:1322.
158. Zeichhardt, H.,, and H.-P. Grunert,. 2000. Enteroviruses, p. 252269. In S. Specter,, R. L. Hodinka,, and S. A. Young (ed.), Clinical Virology Manual, 3rd ed. ASM Press, Washington, D.C.


Generic image for table
TABLE 10.1

Mechanisms of transmission of epidemic viral and putative viral diseases

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
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TABLE 10.2

Neurological syndromes associated with influenza

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10
Generic image for table
TABLE 10.3

Enterovirus syndromes

Citation: Booss J, Esiri M. 2003. 10 Influenza Virus, Enteroviruses, and Other Epidemic Viruses, p 143-162. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch10

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