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Abstract:

The study of Borna disease virus (BDV) and BD has broad impact on diverse areas of biology and medicine, notably on molecular genetics of RNA virus, neurobiology, biological psychiatry, and public health. In this chapter, author briefly summarizes the history of BD and BDV research in the past century and showcases the direction of BDV science as we enter a new century. The chapter outlines the spread of BDV research from central Europe throughout the world over the past 2 decades. Diagnosis of BDV infection in animals is now evaluated by several alternative methods using serological and molecular techniques. The research interest in BDV moved to include Asia in the middle of the 1980s, with specific interests in virus infection and human neuropsychiatric diseases. The establishment of sensitive immunoassays using infected culture cells also contributed to the characterization of virus specific antibodies. These assays were relevant for the diagnostic investigations and the characterization of viral antigens. An animal model using rats was also widely applied for understanding BDV biology. Animal models of monkeys, cats, and ponies have provided new insights into the neuropathogenicity of BDV. Experimental infections have clearly shown that BDV can cause behavioral and neuroanatomical disturbances without immune-mediated brain destruction. The direct effects and mechanisms of BDV infection on brain dysfunction, in the absence of immunopathological brain injury, need to be determined for a better understanding of BD pathogenesis but also for a better understanding of the links between BDV, human infection, and noninflammatory neuropsychiatric diseases.

Citation: Tomonaga K, Carbone K. 2002. Borna Disease Virus: Spanning a Century of Science, p 1-21. In Carbone K (ed), Borna Disease Virus and Its Role in Neurobehavioral Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817909.ch1

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Spread of BDV research throughout the world. Total numbers of publications concerning BDV from European regions of endemicity (Germany and Switzerland), European regions of nonendemicity, North America, and Asia between 1980 and 2000 as indicated by the PubMed search program at the National Library of Medicine website are shown. Papers containing authors in different areas were counted in each area.

Citation: Tomonaga K, Carbone K. 2002. Borna Disease Virus: Spanning a Century of Science, p 1-21. In Carbone K (ed), Borna Disease Virus and Its Role in Neurobehavioral Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817909.ch1
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Key issues in understanding the neuropathogenesis of BDV.

Citation: Tomonaga K, Carbone K. 2002. Borna Disease Virus: Spanning a Century of Science, p 1-21. In Carbone K (ed), Borna Disease Virus and Its Role in Neurobehavioral Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817909.ch1
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References

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1. Allmang, U.,, M. Hofer,, S. Herzog,, K. Bechter,, and P. Staeheli. 2001. Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value. Mol. Psychiatry 6:329333.
2. Amsterdam, J. D.,, A. Winokur,, W. Dyson,, S. Herzog,, F. Gonzalez,, R. Rott,, and H. Koprowski. 1985. Borna disease virus. A possible etiologic factor in human affective disorders? Arch. Gen. Psychiatry 42:10931096.
3. Bautista, J. R.,, S. A. Rubin,, T. H. Moran,, G. J. Schwartz,, and K. M. Carbone. 1995. Developmental injury to the cerebellum following perinatal Borna disease virus infection. Dev. Brain Res. 90:4553.
4. Becht, H.,, and J. Richt,. 1996. Borna disease, p. 235244. In M. J. Studdert (ed.), Virus Diseases of Equines. Elsevier Science Publishers BV, Amsterdam, The Netherlands.
5. Berg, A. L.,, and M. Berg. 1998. A variant form of feline Borna disease. J. Comp. Pathol. 119:323331.
6. Bilzer, T.,, and L. Stitz. 1994. Immune-mediated brain atrophy. CD8+T cells contribute to tissue destruction during Borna disease. J. Immunol. 153:818823.
7. Bode, L. 1995. Human infections with Borna disease virus and potential pathogenic implications. Curr. Top. Microbiol. Immunol. 190:103130.
8. Bode, L.,, R. Dürrwald,, F. A. Rantam,, R. Ferszt,, and H. Ludwig. 1996. First isolates of infectious human Borna disease virus from patients with mood disorders. Mol. Psychiatry 1:200212.
9. Bornand, J. V.,, R. Fatzer,, K. Melzer,, D. G. Jmaa,, P. Caplazi,, and F. Ehrensperger. 1998. A case of Borna disease in a cat. Eur. J. Vet. Pathol. 4:3335.
10. Briese, T.,, J. C. de la Torre,, A. Lewis,, H. Ludwig,, and W. I. Lipkin. 1992. Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells. Proc. Natl. Acad. Sci. USA 89:1148611489.
11. Briese, T.,, C. G. Hatalski,, S. Kliche,, Y. S. Park,, and W. I. Lipkin. 1995. Enzyme-linked immunosorbent assay for detecting antibodies to Borna disease virus-specific proteins. J. Clin. Microbiol. 33:348351.
12. Briese, T.,, A. Schneemann,, A. J. Lewis,, Y. S. Park,, S. Kim,, H. Ludwig,, and W. I. Lipkin. 1994. Genomic organization of Borna disease virus. Proc. Natl. Acad. Sci. USA 91:43624366.
13. Caplazi, P.,, K. Meizer,, R. Goetzmann,, A. Rohner-Cotti,, V. Bracher,, K. Zlinszky,, and F. Ehrensperger. 1999. Borna disease in Switzerland and in the principality of Liechtenstein. Schweiz. Arch. Tierheilkd. 141:521527.
14. Carbone, K. M. 2001. Borna disease virus and human disease. Clin. Microbiol. Rev. 14:513527.
15. Carbone, K. M.,, C. S. Duchala,, J. W. Griffin,, A. L. Kincaid,, and O. Narayan. 1987. Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation. J. Virol. 61:34313440.
16. Carbone, K. M.,, T. R. Moench,, and W. I. Lipkin. 1991a. Borna disease virus replicates in astrocytes, Schwann cells and ependymal cells in persistently infected rats: location of viral genomic and messenger RNAs by in situ hybridization. J. Neuropathol. Exp. Neurol. 50: 205214.
17. Carbone, K. M.,, S. W. Park,, S. A. Rubin,, R. W. Waltrip II,, and G. B. Vogelsang. 1991b. Borna disease: association with a maturation defect in the cellular immune response. J. Virol. 65:61546164.
18. Cubitt, B.,, C. Oldstone,, and J. C. de la Torre. 1994. Sequence and genome organization of Borna disease virus. J. Virol. 68:13821396.
19. Czygan, M.,, W. Hallensleben,, M. Hofer,, S. Pollak,, C. Sauder,, T. Bilzer,, I. Blümcke,, P. Riederer,, B. Bogerts,, P. Falkai,, M. J. Schwarz,, E. Masliah,, P. Staeheli,, F. T. Hufert,, and K. Lieb. 1999. Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders. J. Infect. Dis. 180:16951699.
20. Dauphin, G.,, V. Legay,, C. Sailleau,, S. Smondack,, S. Hammoumi,, and S. Zientara. 2001. Evidence of Borna disease virus genome detection in French domestic animals and in foxes (Vulpes vulpes). J. Gen. Virol. 82:21992204.
21. Degiorgis, M.-P.,, A.-L. Berg,, C. HårdAfSegerstad,, T. Mörner,, M. Johansson,, and M. Berg. 2000. Borna disease in a free-ranging lynx (Lynx lynx). J. Clin. Microbiol. 38:30873091.
22. de la Torre, J. C.,, L. Bode,, R. Dürrwald,, B. Cubitt,, and H. Ludwig. 1996. Sequence characterization of human Borna disease virus. Virus Res. 44:3344.
23. delaTorre, J. C.,, K. M. Carbone,, and W. I. Lipkin. 1990. Molecular characterization of the Borna disease agent. Virology 179:853856.
24. Dittrich, W.,, L. Bode,, H. Ludwig,, M. Kao,, and K. Schneider. 1989. Learning deficiencies in Borna disease virus-infected but clinically healthy rats. Biol. Psychiatry 26:818828.
25. Elford, W. J.,, and I. A. Galloway. 1933. Filtration of the virus of Borna disease through graded collodion membranes. Br. J. Exp. Pathol. 14:196205.
26. Fu, Z. F.,, J. D. Amsterdam,, M. Kao,, V. Shankar,, H. Koprowski,, and B. Dietzschold. 1993. Detection of Borna disease virus-reactive antibodies from patients with affective disorders by western immunoblot technique. J. Affect. Disord. 27:6168.
27. Gonzalez-Dunia, D.,, M. Watanabe,, S. Syan,, M. Mallory,, E. Masliah,, and J. C. de la Torre. 2000. Synaptic pathology in Borna disease virus persistent infection. J. Virol. 74:34413448.
28. Haga, S.,, M. Yoshimura,, Y. Motoi,, K. Arima,, T. Aizawa,, K. Ikuta,, M. Tashiro,, and K. Ikeda. 1997. Detection of Borna disease virus genome in normal human brain tissue. Brain Res. 770:307309.
29. Hagiwara, K.,, M. Asakawa,, L. Liao,, W. Jiang,, S. Yan,, J. Chai,, Y. Oku,, K. Ikuta,, and M. Ito. 2001. Seroprevalence of Borna disease virus in domestic animals in Xinjiang, China. Vet. Microbiol. 80:383389.
30. Hallensleben, W.,, M. Schwemmle,, J. Hausmann,, L. Stitz,, B. Volk,, A. Pagenstecher,, and P. Staeheli. 1998. Borna disease virus-induced neurological disorder in mice: infection of neonates results in immunopathology. J. Virol. 72:43794386.
31. Herzog, S.,, K. Frese,, J. A. Richt,, and R. Rott. 1994. Ein Beitrag zur Epizootiologie der Bornaschen Krankheit beim Pferd. Wien. Tierarzti. Monatsschr. 81:374379.
32. Herzog, S.,, C. Kompter,, K. Frese,, and R. Rott. 1984. Replication of Borna disease virus in rats: age-dependent differences in tissue distribution. Med. Microbiol. Immunol. 173:171177.
33. Herzog, S.,, and R. Rott. 1980. Replication of Borna disease virus in cell cultures. Med. Microbiol. Immunol. 168:153158.
34. Hirano, N.,, M. Kao,, and H. Ludwig. 1983. Persistent, tolerant or subacute infection in Borna disease virus-infected rats. J. Gen. Virol. 64:15211530.
35. Hornig, M.,, H. Weissenböck,, N. Horscroft,, and W. I. Lipkin. 1999. An infection-based model of neurodevelopmental damage. Proc. Natl. Acad. Sci. USA 96:1210212107.
36. Ikuta, K. 1997. Possible association of Borna disease virus with human diseases. Uirusu 47:3747.
37. Iwata, Y.,, K. Takahashi,, X. Peng,, K. Fukuda,, K. Ohno,, T. Ogawa,, K. Gonda,, N. Mori,, S. Niwa,, and S. Shigeta. 1998. Detection and sequence analysis of Borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors. J. Virol. 72:1004410049.
38. Joest, E.,, and K. Degen. 1911. Untersuchngen über die pathologische Histologie, Pathogenese und postmortale Diagnose der seuchenhaften Gehirn-Rückenmarksentzündung (Bornasche Krankheit) des Pferdes. Z. Infekt. Krankh. Haustiere 9:198.
39. Jordan, I.,, and W. I. Lipkin. 2001. Borna disease virus. Rev. Med. Virol. 11:3757.
40. Kamitani, W.,, Y. Shoya,, T. Kobayashi,, M. Watanabe,, B. J. Lee,, G. Zhang,, K. Tomonaga,, and K. Ikuta. 2001. Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/ HMG-1. J. Virol. 75:87428751.
41. Kao, M.,, A. N. Hamir,, C. E. Rupprecht,, Z. F. Fu,, V. Shankar,, H. Koprowski,, and B. Dietzschold. 1993. Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA. Vet. Rec. 132:241244.
42. Kim, Y. K.,, S. H. Kim,, S. H. Choi,, Y. H. Ko,, L. Kim,, M. S. Lee,, K. Y. Suh,, D. I. Kwak,, K. J. Song,, Y. J. Lee,, R. Yanagihara,, and J. W. Song. 1999. Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea. J. Neurovirol. 5:196199.
43. Kishi, M.,, T. Nakaya,, Y. Nakamura,, Q. Zhong,, K. Ikeda,, M. Senjo,, M. Kakinuma,, S. Kato,, and K. Ikuta. 1995. Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells. FEBS Lett. 364:293297.
44. Lieb, K.,, W. Hallensleben,, M. Czygan,, L. Stitz,, P. Staeheli, and the Bornavirus Study Group. 1997. No Borna disease virus-specific RNA detected in blood from psychiatric patients in different regions of Germany. Lancet 350:1002.
45. Lipkin, W. I.,, G. H. Travis,, K. M. Carbone,, and M. C. Wilson. 1990. Isolation and characterization of Borna disease agent cDNA clones. Proc. Natl. Acad. Sci. USA 87:41844188.
46. Ludwig, H.,, and L. Bode. 2000. Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. Rev. Sci. Tech. 19:259288.
47. Lundgren, A. L.,, and H. Ludwig. 1993. Clinically diseased cats with non-suppurative meningoencephalomyelitis have Borna disease virus-specific antibodies. Acta Vet. Scand. 34:101103.
48. Malkinson, M.,, Y. Weisman,, E. Ashash,, L. Bode,, and H. Ludwig. 1993. Borna disease in ostriches. Vet. Rec. 133:304.
49. Nakamura, Y.,, S. Asahi,, T. Nakaya,, M. K. Bahmani,, S. Saitoh,, K. Yasui,, H. Mayama,, K. Hagiwara,, C. Ishihara,, and K. Ikuta. 1996. Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from domestic cats in Japan. J. Clin. Microbiol. 34:188191.
50. Nakamura, Y.,, H. Takahashi,, Y. Shoya,, T. Nakaya,, M. Watanabe,, K. Tomonaga,, K. Iwahashi,, K. Ameno,, N. Momiyama,, H. Taniyama,, T. Sata,, T. Kurata,, J. C. de la Torre,, and K. Ikuta. 2000. Isolation of Borna disease virus from human brain tissue. J. Virol. 74:46014611.
51. Narayan, O.,, S. Herzog,, K. Frese,, H. Scheefers,, and R. Rott. 1983a. Behavioral disease in rats caused by immunopathological responses to persistent Borna virus in the brain. Science 220:14011403.
52. Narayan, O.,, S. Herzog,, K. Frese,, H. Scheefers,, and R. Rott. 1983b. Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J. Infect. Dis. 148:305315.
53. Nicolau, S.,, and I. A. Galloway. 1928. Borna disease and enzootic encephalomyelitis of sheep and cattle. Rep. Ser. Med. Res. Counc. 121:790.
54. Nitzschke, E. 1963. Untersuchungen über die experimentelle Bornavirus-Infektion bei der Ratte. Zentbl. Vetmed. Reihe B 10:470527.
55. Nowotny, N.,, J. Kolodziejek,, C. O. Jehle,, A. Suchy,, P. Staeheli,, and M. Schwemmle. 2000. Isolation and characterization of a new subtype of Borna disease virus. J. Virol. 74:56555658.
56. Nowotny, N.,, and H. Weissenböck. 1995. Description of feline nonsuppurative meningoencephalomyelitis (“staggering disease”) and studies of its etiology. J. Clin. Microbiol. 33: 16681669.
57. Okamoto, M.,, H. Furuoka,, K. Hagiwara,, W. Kamitani,, R. Kirisawa,, K. Ikuta,, and H. Taniyama. 2002a. Borna disease in a heifer in Japan. Vet. Rec. 150:1618.
58. Okamoto, M.,, Y. Kagawa,, W. Kamitani,, K. Hagiwara,, R. Kirisawa,, H. Iwai,, K. Ikuta,, and H. Taniyama. 2002b. Borna disease in a dog in Japan. J. Comp. Pathol. 126:312317.
59. Pauli, G.,, J. Grunmach,, and H. Ludwig. 1984. Focus-immunoassay for Borna disease virus-specific antigens. Zentbl. Vetmed. (B) 31:552557.
60. Pauli, G.,, and H. Ludwig. 1985. Increase of virus yields and releases of Borna disease virus from persistently infected cells. Virus Res. 2:2933.
61. Planz, O.,, T. Bilzer,, M. Sobbe,, and L. Stitz. 1993. Lysis of major histocompatibility complex class I-bearing cells in Borna disease virus-induced degenerative encephalopathy. J. Exp. Med. 178:163174.
62. Planz, O.,, C. Rentzsch,, A. Batra,, A. Batra,, T. Winkler,, M. Büttner,, H.-J. Rziha,, and L. Stitz. 1999. Pathogenesis of Borna disease virus: granulocyte fractions of psychiatric patients harbor infectious virus in the absence of antiviral antibodies. J. Virol. 73:62516256.
63. Plata-Salaman, C. R.,, S. E. Ilyin,, D. Gayle,, A. Romanovitch,, and K. M. Carbone. 1999. Persistent Borna disease virus infection of neonatal rats causes brain regional changes of mRNAs for cytokines, cytokine receptor components and neuropeptides. Brain Res. Bull. 49:441451.
64. Pletnikov, M. V.,, M. L. Jones,, S. A. Rubin,, T. H. Moran,, and K. M. Carbone. 2001. Rat model of autism spectrum disorders. Genetic background effects on Borna disease virus-induced developmental brain damage. Ann. N. Y. Acad. Sci. 939:318319.
65. Pletnikov, M. V.,, S. A. Rubin,, K. Vasudevan,, T. H. Moran,, and K. M. Carbone. 1999. Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism. Behav. Brain Res. 100:4350.
66. Reeves, N. A.,, C. R. Helps,, D. A. Gunn-Moore,, C. Blundell,, P. L. Finnemore,, G. R. Pearson,, and D. A. Harbour. 1998. Natural Borna disease virus infection in cats in the United Kingdom. Vet. Rec. 143:523526.
67. Richt, J. A.,, and R. Rott. 2001. Borna disease virus: a mystery as an emerging zoonotic pathogen. Vet. J. 161:2440.
68. Rott, R.,, and H. Becht. 1995. Natural and experimental Borna disease in animals. Curr. Top. Microbiol. Immunol. 190:1730.
69. Rott, R.,, S. Herzog,, K. Bechter,, and K. Frese. 1991. Borna disease, a possible hazard for man? Arch. Virol. 118:143149.
70. Rott, R.,, S. Herzog,, B. Fleischer,, A. Winokur,, J. Amsterdam,, W. Dyson,, and H. Koprowski. 1985. Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science 228:755756.
71. Rubin, S. A.,, P. Sylves,, M. Vogel,, M. Pletnikov,, T. H. Moran,, G. J. Schwartz,, and K. M. Carbone. 1999. Borna disease virus-induced hippocampal dentate gyrus damage is associated with spatial learning and memory deficits. Brain Res. Bull. 48:2330.
72. Salvatore, M.,, S. Morzunov,, M. Schwemmle,, W. I. Lipkin, and the Bornavirus Study Group. 1997. Borna disease virus in brains of North American and European people with schizophrenia and bipolar disorder. Lancet 349:18131814.
73. Sauder, C.,, and J. C. de la Torre. 1999. Cytokine expression in the rat central nervous system following perinatal Borna disease virus infection. J. Neuroimmunol. 96:2945.
74. Schädler, R.,, H. Diringer,, and H. Ludwig. 1985. Isolation and characterization of a 14500 molecular weight protein from brains and tissue cultures persistently infected with Borna disease virus. J. Gen. Virol. 66:24792484.
75. Schmidt, J. 1912. Untersuchungen über das klinische Verhalten der seuchenhaften Gehirn-Rückenmarksentzündung (Bornasche Krankheit) des Pferdes nebst Angaben über diesbezügliche therapeutische Versuche. Berl. Tierarztl. Wochenschr. 28:581586, 597603.
76. Schneider, P. A.,, A. Schneemann,, and W. I. Lipkin. 1994. RNA splicing in Borna disease virus, a nonsegmented, negative-strand RNA virus. J. Virol. 68:50075012.
77. Schwemmle, M.,, C. Jehle,, S. Formella,, and P. Staeheli. 1999. Sequence similarities between human Bornavirus isolates and laboratory strains question human origin. Lancet 354:19731974.
78. Shankar, V.,, M. Kao,, A. N. Hamir,, H. Sheng,, H. Koprowski,, and B. Dietzschold. 1992. Kinetics of virus spread and changes in levels of several cytokine mRNAs in the brain after intranasal infection of rats with Borna disease virus. J. Virol. 66:992998.
79. Sierra-Honigmann, A. M.,, S. A. Rubin,, M. G. Estafanous,, R. H. Yolken,, and K. M. Carbone. 1993. Borna disease virus in peripheral blood mononuclear and bone marrow cells of neonatally and chronically infected rats. J. Neuroimmunol. 45:3136.
80. Solbrig, M. V.,, J. H. Fallon,, and W. I. Lipkin. 1995. Behavioral disturbances and pharmacology of Borna disease. Curr. Top. Microbiol. Immunol. 190:9399.
81. Solbrig, M. V.,, G. F. Koob,, J. N. Joyce,, and W. I. Lipkin. 1996. A neural substrate of hyperactivity in Borna disease: changes in brain dopamine receptors. Virology 222:332338.
82. Staeheli, P.,, C. Sauder,, J. Hausmann,, F. Ehrensperger,, and M. Schwemmle. 2000. Epidemiology of Borna disease virus. J. Gen. Virol. 81:21232135.
83. Stitz, L.,, D. Soeder,, U. Deschl,, K. Frese,, and R. Rott. 1989. Inhibition of immune-mediated meningoencephalitis in persistently Borna disease virus-infected rats by cyclosporine A. J. Immunol. 143:42504256.
84. Taniyama, H. 2001. Borna disease of animals in Japan. J. Jpn. Vet. Med. Assoc. 54:16.
85. Taniyama, H.,, M. Okamoto,, K. Hirayama,, K. Hagiwara,, R. Kirisawa,, W. Kamitani,, N. Tsunoda,, and K. Ikuta. 2001. Equine Borna disease in Japan. Vet. Rec. 148:480482.
86. VandeWoude, S.,, J. A. Richt,, M. C. Zink,, R. Rott,, O. Narayan,, and J. E. Clements. 1990. A Borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases. Science 250:12781281.
87. von Sprockhoff, H.,, and E. Nitzschke. 1955. Unterschungen über das komplementbindende Antigen in Gehirnen bornavirus-infizierter Kaninchen. 1. Mitteilung: Nachweis eines löslichen Antigens. Zentbl. Vetmed. 2:185192.
88. Waelchi, R. O.,, F. Ehrensperger,, A. Metzler,, and C. Winder. 1985. Borna disease in a sheep. Vet. Rec. 117:499500.
89. Waltrip, R. W., II,, R. W. Buchanan, , W. T. Carpenter, Jr.,, B. Kirkpatrick,, A. Summerfelt,, A. Breier,, S. A. Rubin,, and K. M. Carbone. 1997. Borna disease virus antibodies and the deficit syndrome of schizophrenia. Schizophr. Res. 23:253257.
90. Waltrip, R. W., II,, R. W. Buchanan, , A. Summerfelt, , A. Breler, , W. T. Carpenter, Jr.,, N. L. Bryant,, S. A. Rubin,, and K. M. Carbone. 1995. Borna disease virus and schizophrenia. Psychiatry Res. 56:3344.
91. Watanabe, M.,, B. J. Lee,, W. Kamitani,, T. Kobayashi,, H. Taniyama,, K. Tomonaga,, and K. Ikuta. 2001. Neurological diseases and viral dynamics in the brains of neonatally Borna disease virus-infected gerbils. Virology 282:6576.
92. Weissenböck, H.,, N. Nowotny,, P. Caplazi,, J. Kolodziejek,, and F. Ehrensperger. 1998a. Borna disease in a dog with lethal meningoencephalitis. J. Clin. Microbiol. 36:21272130.
93. Weissenböck, H.,, A. Suchy,, P. Caplazi,, S. Herzog,, and N. Nowotny. 1998b. Borna disease in Austrian horses. Vet. Rec. 143:2122.
94. Yamaguchi, K.,, T. Sawada,, T. Naraki,, R. Igata-Yi,, H. Shiraki,, Y. Horii,, T. Ishii,, K. Ikeda,, N. Asou,, H. Okabe,, M. Mochizuki,, K. Takahashi,, S. Yamada,, K. Kubo,, S. Yashiki,, R. W. WaltripII,, and K. M. Carbone. 1999. Detection of Borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay. Clin. Diagn. Lab. Immunol. 6:696700.
95. Zwick, W., 1939. Bornasche Krankheit und Encephalomyelitis der Tiere, p. 252354. In E. Gildenmeister, , E. Haagen, , and O. Waldmann (ed.), Handbuch der Viruserkrankungen, vol. 2 . Gustav Fischer Verlag, Jena, Germany.
96. Zwick, W.,, and O. Seifried. 1925. Ubertragbarkeit der seuchenhaften Gehirnrückenmarksentzündung des Pferdes (Bornasche Krankheit) auf kleine Versuchstiere (Kaninchen). Berl. Tierarztl. Wochenschr. 41:129132.
97. Zwick, W.,, O. Seifried,, and J. Witte. 1927. Experimentelle Untersuchungen über die suchenhafte Gehirn- und Rückenmarksentzündung der Pferde (Bornasche Krankheit). Z. Infekt. Krankh. Haustiere 30:42136.

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