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Chapter 2 : Nonhuman Reservoirs of Enterococci

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Abstract:

This chapter describes the occurrence of different enterococcal species among animal reservoirs. It reviews the importance of enterococci as pathogens in animals, the occurrence of antimicrobial resistance and resistance genes among enterococci from nonhuman sources, and the potential transfer of enterococci and their resistance genes to humans. Enterococci are associated with most mammals and birds, and some sporadic reports exist on the isolation of enterococci from reptiles and insects. In addition, enterococcal species can be found in soil, on plants, and in water. Pulsed-field gel electrophoresis (PFGE) is one of the most widely applied methods for detecting the clonal spread of enterococci. Enterococci have been implicated in a number of infections in animals, mainly mastitis in cattle, and diarrhea. Birds are mainly infected by , , and . Compared to the very large number of studies of enterococci of human origin, there are only limited studies on the occurrence of antimicrobial resistance and resistance genes among enterococci isolated from animals, food, or the environment. An overview of the occurrence of resistance to a few selected antimicrobial agents, in different countries and from different reservoirs, is given in the chapter. An overview of resistance genes and transposons detected among enterococci from nonhuman sources is also presented. Aminoglycosides are important in the treatment of infections with enterococci in humans. Enterococci inhabiting nonhuman reservoirs appear to play a critical role in the acquisition and dissemination of antibiotic resistance determinants.

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2

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Figure 1

Distribution of different enterococcal species among selected animal species. Adapted from references .

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
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Figure 2

Changes in the occurrence of glycopeptide-resistant . in different reservoirs and countries in Europe following the ban on the use of avoparcin for growth promotion. (A) GRE among broilers (hatched bars) and pigs (open bars) in Denmark. (B) GRE in nonhospitalized humans in Germany. (C) Prevalence of GRE in The Netherlands in 1997 (hatched bars) and 1999 (open bars). (D) GRE from poultry meat samples in Italy. Adapted from references 13, 94, 129, 206. Different methodologies were used in the studies, and the incidences are not directly comparable between studies.

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
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Figure 3

Ecological relationships between different reservoirs.

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
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Image of Figure 4
Figure 4

(Top) Gene cluster of Tn. prototype. (Bottom) Insertions: I, according to reference ; II, according to reference ; III, according to reference ; IV, according to reference ; and V, according to reference .

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
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Figure 5

Ten overlapping fragments of prototype VanA element Tn. amplified with primers p1 to p19 ( ). IR, inverted repeat.

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
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Figure 6

Scheme of long PCR of Tn1546-like elements ( ).

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
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Figure 7

Structure of the 5.5-kb fragment of plasmid pUW1965 ( ). The thin lines indicate identities on the DNA level with sequences given below (identities in %). Open reading frames (ORF) with identities with corresponding protein sequences from databases are given as black arrows.

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
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References

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1. Aarestrup, F. M. 1995. Occurrence of glycopeptide resistance among Enterococcus faeciu. isolates from conventional and ecological poultry farms. Microb. Drug Res. 1: 255 257.
2. Aarestrup, F. M. 1998. Association between decreased susceptibility to a new antibiotic for treatment of human diseases, everninomicin (SCH 27899), and resistance to an antibiotic used for growth promotion in animals, avilamycin. Microb. Drug Resist. 4: 137 141.
3. Aarestrup, F. M. 2000. Characterization of glycopeptide-resistant Enterococcus faeciu. (GRE) from broilers and pigs in Denmark: genetic evidence that persistence of GRE in pig herds is associated with coselection by resistance to macrolides. J. Clin. Microbiol 38: 2774 2777.
4. Aarestrup, F. M.,, Y. Agerso,, P. Gerner-Smidt,, M. Madsen,, and L. B. Jensen. 2000. Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecali. and Enterococcus faeciu. from humans in the community, broilers and pigs in Denmark. Diagn. Microbiol. Infect. Dis. 37: 127 137.
5. Aarestrup, F. M.,, R. Ahrens,, M. Madsen,, L. V. Pallesen,, R. L. Poulsen,, and H. Westh. 1996. Glycopeptide susceptibility among Danish Enterococcus faeciu. and Enterococcus faecali. isolates of animal and human origin and PCR identification of genes within the VanA cluster. Antimicrob. Agents Chemother. 40: 1938 1940.
6. Aarestrup, F. M.,, F. Bager,, and J. S. Andersen. 2000. Association between the use of avilamycin for growth promotion and the occurrence of resistance among Enterococcus faeciu. from broilers: epidemiological study and changes over time. Microb. Drug Resist. 6: 71 75.
7. Aarestrup, F. M.,, F. Bager,, and J. S. Andersen. 2000. The association between the use of avilamycin for growth promotion and the occurrence of resistance among Enterococcus faeciu.. Microb. Drug Resist. 6: 71 75.
8. Aarestrup, F. M.,, F. Bager,, N. E. Jensen,, M. Madsen,, A. Meyling,, and H. C. Wegener. 1998. Surveillance of antimicrobial resistance in bacteria isolated from food animals to antimicrobial growth promoters and related therapeutic agents in Denmark. APMIS 106: 606 622.
9. Aarestrup, F. M.,, F. Bager,, N. E. Jensen,, M. Madsen,, A. Meyling,, and H. C. Wegener. 1998. Resistance to antimicrobial agents used for animal therapy in pathogenic-, zoonotic- and indicator bacteria isolated from different food animals in Denmark: a baseline study for the Danish Integrated Antimicrobial Resistance Monitoring Programme (DANMAP). APMIS 106: 745 770.
10. Aarestrup, F. M.,, and B. Carstensen. 1998. Effect of tylosin used as a growth promoter on the occurrence of macrolide-resistant enterococci and staphylococci in pigs. Microb. Drug Resist. 4: 307 312.
11. Aarestrup, F. M.,, and L. B. Jensen. 2000. Presence of variations in ribosomal protein L16 corresponding to susceptibility of enterococci to oligosaccharides (avilamycin and evemimicin). Antimicrob. Agents Chemother. 44: 3425 3427.
12. Aarestrup, F. M.,, H. Kruse,, E. Tast,, A. M. Hammerum,, and L. B. Jensen. 2000. Associations between the use of antimicrobial agents for growth promotion and the occurrence of resistance among Enterococcus faeciu. from broilers and pigs in Denmark, Finland, and Norway. Microb. Drug Resist. 6: 63 70.
13. Aarestrup, F. M.,, A. M. Seyfarth,, H. D. Emborg,, K. Pedersen,, R. S. Hendriksen,, and F. Bager. 2001. Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in fecal enterococci from food animals in Denmark. Antimicrob. Agents Chemother. 45: 2054 2059.
14. Aarestrup, F. M.,, H. C. Wegener,, V. T. Rosdahl,, and N. E. Jensen. 1995. Staphylococcal and other bacterial species associated with intramammary infections in Danish dairy herds. Acta Vet. Scand. 36: 475 487.
15. Arthur, M.,, and P. Courvalin. 1993. Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob. Agents Chemother. 37: 1563 1571.
16. Arthur, M.,, P. Reynolds,, and P. Courvalin. 1996. Glycopeptide resistance in enterococci. Trends Microbiol. 4: 401 407.
17. Bager, F.,, F. M. Aarestrup,, M. Madsen,, and H. C. Wegener. 1999. Glycopeptide resistance in Enterococcus faeciu. in broilers and pigs following discontinued use of avoparcin. Microb. Drug Resist. 5: 53 56.
18. Bager, F.,, M. Madsen,, J. Christensen,, and F. M. Aarestrup. 1997. Avoparcin used as a growth promoter is associated with the occurrence of vancomycin-resistant Enterococcus faeciu. on Danish poultry and pig farms. Prev. Vet. Med. 31: 95 112.
19. Barnes, E. M. 1958. The effect of antibiotic supplements on the faecal streptococci (Lanceheld group D) of poultry. Br. Vet. J. 114: 333.
20. Bates, J.,, J. Z. Jordens,, and D. T. Griffiths. 1994. Farm animals as a putative reservoir for vancomycin-resistant enterococcal infection in man. J. Antimicrob. Chemother. 34: 507 514.
21. Bates, J.,, J. Z. Jordens,, and J. B. Selkon. 1993. Evidence for an animal origin of vancomycin-resistant enterococci. Lancet 342: 490 491.
22. Bauer, S.,, A. Tholen,, J. Overmann,, and A. Brune. 2000 C haracterization of abundance and diversity of lactic acid bacteria in the hindgut of wood- and soil-feeding termites by molecular and culture-dependent techniques. Arch. Microbiol. 173: 126 137.
23. Berchieri, A. 1999. Intestinal colonization of a human subject by vancomycin-resistant Enterococcus faecium. Clin. Microbiol. Infect. 5: 97 100.
24. Bingen, E. H.,, E. Denamur,, N. Y. Lambert-Zechovsky,, and J. Elion. 1991. Evidence for the genetic unrelatedness of nosocomial vancomycin-resistant Enterococcus faeciu. strains in a pediatric hospital. J. Clin. Microbiol. 29: 1888 1892.
25. Boerlin, P.,, S. Eugster,, F. Gaschen,, R. Straub,, and P. Schawalder. 2001. Transmission of opportunistic pathogens in a veterinary teaching hospital. Vet. Microbiol. 82: 347 359.
26. Borgen, K.,, G. S. Simonsen,, A. Sundsfjord,, Y. Wasteson, 0. Olsvik, and H. Kruse. 2000. Continuing high prevalence of VanA-type vancomycin-resistant enterococci on Norwegian poultry farms three years after avoparcin was banned. J. Appl. Microbiol. 89: 478 485.
27. Boyle, J. F.,, S. A. Soumakis,, A. Rendo,, J. A. Herrington,, D. G. Gianarkis,, B. E. Thurberg,, and B. G. Painter. 1993. Epidemiologic analysis and genotypic characterization of a nosocomial outbreak of vancomycin-resistant enterococci. J. Clin. Microbiol. 31: 1280 1285.
28. Bozdogen, B.,, and R. Leclercq. 1999. Effects of genes encoding resistance to streptogramins A and B on the activity of quinupristin/dalfopristin against Enterococcus faeciu.. Antimicrob. Agents Chemother. 43: 2720 2725.
29. Burkhardt, J. E.,, E. B. Janovitz,, T. L. Bowersock,, and R. Higgins. 1993. Septicemic Enterococcu. infection in an adult llama. J. Vet. Diagn. Invest. 5: 106 109.
29a. Butaye, P. Personal communication.
30. Butaye, P.,, L. A. Devriese,, H. Goossens,, M. Ieven,, and F. Haesebrouck. 1999. Enterococci with acquired vancomycin resistance in pigs and chickens of different age groups. Antimicrob. Agents Chemother. 43: 365 366.
31. Butaye, P.,, L. A. Devriese,, and F. Haesebrouck. 1999. Glycopeptide resistance in Enterococcus faeciu. strains from animals and humans. Res. Med. Microbiol. 10: 235 243.
32. Butaye, P.,, L. A. Devriese,, and F. Haesebrouck. 1999. Phenotypic distinction in Enterococcus faeciu. and Enterococcus faecali. strains between susceptibility and resistance to growth-enhancing antibiotics. Antimicrob. Agents Chemother. 43: 2569 2570.
33. Butaye, P.,, L. A. Devriese,, and F. Haesebrouck. 2000. Comparison of direct and indirect enrichment methods for the selective isolation of vancomycin-resistant enterococci from the faeces of pigs and poultry. Microb. Drug Resist. 5: 131 134.
34. Butaye, P.,, L. A. Devriese,, and F. Haesebrouck. 2001. Differences in antibiotic resistance patterns of Enterococcus faecali. and Enterococcus faeciu. strains isolated from farm and pet animals. Antimicrob. Agents Chemother. 45: 1374 1378.
35. Butaye, P.,, K. Van Damme,, L. A. Devriese,, L. Van Damme,, M. Baele,, S. Lauwers,, and F. Haesebrouck. 2000. In vitro susceptibility of Enterococcus faeciu. isolated from food to growth-promoting and therapeutic antibiotics. Int. J. Food Microbiol. 54: 181 187.
36. Butaye, P.,, P. Verleyen,, L. A. Devriese,, H. Van Bree,, and F. Haesebrouck. 2000. Enterococcus faecali. infection after orthopedic surgery in a dog. Vlaams Diergen. Tijdschr. 69: 42 43.
37. Buzzetti, F.,, F. Eisenberg,, H. N. Grant,, W. Keller-Schierlein,, W. Voser,, and H. Zahner. 1968. Avilamycin. Experientia 24: 320 323.
38. Cardona, C. J.,, A. A. Bickford,, B. R. Charlton,, and G. L. Cooper. 1993. Enterococcus duran. infection in young chickens associated with bacteremia and encephalomalacia. Avian Dis. 37: 234 239.
39. Carr, J.,, and J. R. Walton. 1993. Bacterial flora of the urinary tract of pigs associated with cystitis and pyelonephritis. Vet. Rec. 132: 575 577.
40. Casadewall, B.,, and P. Courvalin. 1999. Characterization of the van. glycopeptide resistance gene cluster from Enterococcus faeciu. BM 4339. J. Bacteriol. 181: 3644 3648.
41. Chadwick, R. P.,, N. Woodford,, R. A. Banell,, and B. A. Oppenheim. 1996. Glycopeptide-resistant enterococci isolated from uncooked meat. J. Antimicrob. Chemother. 38: 908 909.
42. Cheng, W.,, and J.-C. Chen. 1998. Isolation and characterization of an Enterococcus-lik. bacterium causing muscle necrosis and mortality in Macrobrachium rosenbergi. in Taiwan. Dis. Aquat. Org. 34: 93 101.
43. Cheon, D. S.,, and C. Chae. 1996. Outbreak of diarrhea associated with Enterococcus duran. in piglets. J. Vet. Diagn. Invest. 8: 123 124.
44. Chow, J. W.,, A. Kuritza,, D. M. Shlaes,, M. Green,, D. F. Sahm,, and M. J. Zervos. 1993. Clonal spread of vancomycin-resistant Enterococcus faeciu. between patients in three hospitals in two states. J. Clin. Microbiol. 31: 1609 1611.
45. Chow, J. W.,, M. J. Zervos,, S. A. Lemer,, L. A. Thal,, S. M. Donabedian,, D. D. Jaworski,, S. Tsai,, K. J. Shaw,, and D. B. Clewell. 1997. A novel gentamicin resistance gene in Enterococcu.. Antimicrob. Agents Chemother. 41: 511 514.
46. Christie, P. J.,, J. N. Davidson,, R. P. Novick,, and G. M. Dunny. 1983. Effects of tylosin feeding on the antibiotic resistance of selected gram-positive bacteria in pigs. Am. J. Vet. Res. 44: 126 128.
47. Clark, N. C.,, R. C. Cooksey,, B. C. Hill,, J. M. Swenson,, and F. C. Tenover. 1993. Characterization of glycopeptide-resistant enterococci from U.S. hospitals. Antimicrob. Agents Chemother. 37: 2311 2317.
48. Collins, J. E.,, M. E. Bergeland,, C. J. Lindeman,, and J. R. Duimstra. 1988. Enterococcus (Streptococcus) duran. adherence in the small intestine of a diarrheic pup. Vet. Pathol. 25: 396 398.
49. Collins, M. D.,, R. R. Facklam,, J. A. Farrow,, and R. Williamson. 1989. Entero coccus raffinosu. sp. nov., Enterococcus solitariu. sp. nov. and Enterococcus pseu-doaviu. sp. nov. FEMS Microbiol Lett. 48: 283 288.
50. Coque, T. M.,, J. F. Tomayko,, S. C. Ricke,, P. C. Okhyusen,, and B. E. Murray. 1996. Vancomycin-resistant enterococci from nosocomial, community, and animal sources in the United States. Antimicrob. Agents Chemother. 40: 2605 2609.
51. Cruz Colque, J. I.,, L. A. Devriese,, and F. Haesebrouck. 1993. Streptococci and enterococci associated with tonsils of cattle. Lett. Appl. Microbiol. 16: 72 74.
52. Del Campo, R.,, C. Tenorio,, R. Jiménez-Diaz,, C. Rubio,, R. Gomez-Lus,, F. Ba-quero,, and C. Torres. 2001. Bacteriocin production in vancomycin-resistant and vancomycin-susceptible Enterococcu. isolates of different origin. Antimicrob. Agents Chemother. 45: 905 912.
53. Descheemaeker, P. R. M.,, S. Chapelle,, L. A. Devriese,, P. Butaye,, P. Vandamme,, and H. Goossens. 1999. Comparison of glycopeptide-resistant Enterococcus faeciu. isolates and glycopeptide resistance genes of human and animal origins. Antimicrob. Agents Chemother. 43: 2032 2037.
54. De Vaux, A.,, G. Laguerre,, C. Diviès,, and H. Prévost. 1998. Enterococcus asin. sp. nov. isolated from the caecum of donkeys (Equus asinus.. Int. J. Syst. Bacteriol. 48: 383 387.
55. Devriese, L. A.,, M. Baele,, and P. Butaye,. 2000. The genus Enterococcus. I. M. Dworkin,, S. Falkow,, E. Rosenberg,, K.-H. Schleiffer,, E. Stackebrandt (ed.), The Prokaryotes. An Evolving Electronic Resource for the Microbiological Community. Springer Verlag, New York, N.Y.
55a. Devriese, L. A.,, M. Baele,, and P. Butaye. Unpublished data.
56. Devriese, L. A.,, K. Ceyssens,, and F. Haesebrouck. 1991. Characteristics of Enterococcus cecoru. strains from the intestines of different animal species. Lett. Appl. Microbiol. 12: 137 139.
57. Devriese, L. A.,, K. Ceyssens,, U. M. Rodrigues,, and M. D. Collins. 1990. Enterococcus columba., a species from pigeon intestines. FEMS Microbiol. Lett. 71: 247 252.
58. Devriese, L. A.,, J. I. Cruz Colque,, P. De Herdt,, and F. Haesebrouck. 1992. Identification and composition of the tonsillar and anal enterococcal flora of dogs and cats. J. Appl. Bacteriol. 73: 421 425.
59. Devriese, L. A.,, J. I. Cruz Colque,, F. Haesebrouck,, M. Desmidt,, E. Uyttebroek,, and R. Ducatelle. 1992. Enterococcus hira. in septicaemia of psittacine birds. Vet. Rec. 130: 558 559.
60. Devriese, L. A.,, P. De Herdt,, E. Uyttebroek,, C. Lepoudre,, R. Ducatelle,, P. Dom,, and F. Haesebrouck. 1994. Streptococcal and enterococcal infections in birds. Vlaams Diergen. Tijdschr. 63: 109 111.
61. Devriese, L. A.,, R. Ducatelle,, E. Uyttebroek,, and F. Haesebrouck. 1991. Enterococcus hira. infection and focal necrosis of the brain of chicks. Vet. Rec. 129: 316.
62. Devriese, L.,, G. N. Dutta,, J. A. E. Farrow,, A. Van De Kerckhove,, and B. A. Phillis. 1983. Streptococcus cecoru., a new species from chickens. Int. J. Syst. Bacteriol. 33: 772 776.
63. Devriese, L. A.,, J. Hommez,, H. Laevens,, B. Pot,, P. Vandamme,, and F. Haesebrouck. 1999. Identification of aesculin-hydrolyzing streptococci, lactococci, aerococci and enterococci from subclinical intramammary infections in dairy cows. Vet. Microbiol. 70: 87 94.
64. Devriese, L. A.,, J. Hommez,, B. Pot,, and F. Haesebrouck. 1994. Identification and composition of the streptococcal and enterococcal flora of tonsils, intestines and faeces of pigs. J. Appl. Bacteriol. 77: 31 36.
65. Devriese, L. A.,, J. Hommez,, R. Wijfels,, and F. Haesebrouck. 1991. Composition of the enterococcal and streptococcal intestinal flora of poultry. J. Appl. Microbiol. 71: 46 50.
66. Devriese, L. A.,, M. Ieven,, H. Goossens,, P. Vandamme,, B. Pot,, J. Hommez,, and F. Haesebrouck. 1996. Presence of vancomycin-resistant enterococci in farm and pet animals. Antimicrob. Agents Chemother. 40: 2285 2287.
67. Devriese, L. A.,, L. Laurier,, P. De Herdt,, and F. Haesebrouck. 1992. Enterococcal and streptococcal species isolated from faeces of calves, young cattle and dairy cows. J. Appl. Bacteriol. 72: 29 31.
68. Devriese, L. A.,, and B. Pot,. 1995. The genus Enterococcu., p. 327 367. I. B. J. B. Wood, and W. H. Holzapfel (ed.), The Genera of Lactic Acid Bacteri., vol. 2. Blackie Academic, London, United Kingdom.
69. Devriese, L. A.,, B. Pot,, and M. D. Collins. 1995. Phenotypic identification of the genus Enterococcu. and differentiation of phylogenetically distinct enterococcal species and species groups. J. Appl. Bacteriol. 75: 399 408.
70. Devriese, L. A.,, E. Uyttebroek,, R. Ducatelle,, N. Viaene,, J. Derij eke,, and D. Gevaert. 1990. Tracheitis due to Enterooccus faecali. in canaries. J. Assoc. Avian Vet. 4: 113 116.
71. Devriese, L. A.,, P. Vandamme,, B. Pot,, M. Vanrobaeys,, K. Kersters,, and F. Haesebrouck. 1998. Differentiation between Streptococcus gallolyticu. strains of human clinical and veterinary origins and Streptococcus bovi. strains from the intestinal tract of rumminants. J. Clin. Microbiol. 36: 3520 3523.
72. Devriese, L. A.,, A. Van De Kerckhove,, R. Kilpper-Balz,, and K. H. Schleiffer. 1987. Characterization and identification of Enterococcu. species isolated from the intestines of animals. Int. J. Syst. Bacteriol. 37: 257 259.
73. Doane, C. C.,, and J. J. Redys. 1970. Characteristics of motile strains of Streptococcus faecali. pathogenic to larvae of the gypsy moth. J. Invert. Pathol. 15: 420 430.
74. Drolet, R.,, R. Higgins,, and M. Jacques. 1990. L'enteropathie assoctee a Enterococcus (Streptococcus) duran. chez le porcelet. Mid. Vet. Quebec 20: 114 116.
75. Dutka-Malen, S.,, B. Blaimont,, G. Wauters,, and P. Courvalin. 1994. Emergence of high-level resistance to glycopeptides in Enterococcus gallinaru. and Enterococcus casseliflavu.. Antimicrob. Agents Chemother. 38: 1675 1677.
76. Dutta, G. N.,, and L. A. Devriese. 1982. Susceptibility of fecal streptococci of poultry origin to nine growth-promoting agents. Appl. Environ. Microbiol. 44: 832 837.
77. Eaton, T. J.,, and M. J. Gasson. 2001. Molecular screening of Enterococcu. virulence determinants and potential for genetic exchange between food and medical isolates. Appl. Environ. Microbiol. 67: 1628 1635.
78. Eldar, A.,, C. Ghittino,, L. Asanta,, E. Bozzetta,, M. Goria,, M. Prearo,, and H. Bercovier. 1996. Enterococcus seriolicid. is a junior synonym of Lactococcus garviea., a causative agent of septicemia and meningoencephalitis in fish. Curr. Microbiol. 32: 85 88.
79. Elliott, S. D.,, and E. M. Barnes. 1959. Changes in serological type and antibiotic resistance on Lancefield group D streptococci in chickens receiving dietary chlor-tetracycline. J. Gen. Microbiol. 20: 426 433.
80. El-Sukhon, S. N.,, and T. A. Abdul-Aziz. 1993. Experimental infection of chicks with Enterococcus hira.. Vet. Rec. 133: 144.
81. EMEA. 1999. Antibiotic resistance in the European Union associated with therapeutic use of veterinary medicines. Report and qualitative risk assessment by the Committee for Veterinary Medical Products, The European Agency for the Evaluation of Medical Products, 14 July 1999.
82. Endtz, H. P.,, N. van den Braak,, A. van Belkum,, J. A. Kluytmans,, J. G. Koeleman,, L. Spanjaard,, A. Voss,, A. J. Weersink,, C. M. Vandenbroucke-Grauls,, A. G. Buiting,, A. van Duin,, and H. A. Verbrugh. 1997. Fecal carriage of vancomycin-resistant enterococci in hospitalized patients and those living in the community in The Netherlands. J. Clin. Microbiol 35: 3026 3031.
83. Etheridge, M. E.,, and S. L. Vonderfecht. 1992. Diarrhea caused by a slow-growing Enterococcus-lik. agent in neonatal rats. Lab. Anim. Sci. 42: 548 550.
84. Etheridge, M. E.,, R. H. Yolken,, and S. L. Vonderfecht. 1988. Enterococcus hira. implicated as a cause of diarrhea in suckling rats. J. Clin. Microbiol. 26: 1741 1744.
85. Facklam, R. R.,, M. G. S. Carvalho,, M. M. B. Espinola,, D. Brenner,, A. Steigerwalt,, and L. M. Teixeira. 2000. Characterization of new enterococcal species potentially associated with enteric disorders in animals. 1st International ASM Conference on Enterococci, Banff, Canada, 27 February-2 March 2000.
85a. Fordts, B.,, H. Van Landuyt,, M. Leven,, P. Vandamme,, and H. Goossens. 1995. Vancomycin resistant enterococci colonizing the intestinal tract of hospitalized patients. J. Clin. Microbiol 33: 2842 2846.
86. Fotedar, R.,, U. Banerjee,, S. Singh,, Shriniwas,, and A. K. Verma. 1992. The housefly (Musca domestica. as a carrier of pathogenic microorganisms in a hospital environment. J. Hosp. Infect. 20: 209 215.
87. Franz, C. M. A. P.,, W. H. Holzapfel,, and M. E. Stiles. 1999. Enterococci at the crossroads of food safety? Int. J. Food Microbiol 47: 1 24.
88. Frei, A.,, D. Goldenberger,, and M. Teuber. 2001. Antimicrobial susceptibility of intestinal bacteria from Swiss poultry flocks before the ban of antimicrobial growth promoters. Syst. Appl Microbiol 24: 116 121.
89. Frieden, T. R.,, S. S. Munsiff,, D. E. Low,, B. M. Willey,, G. Williams,, Y. Faur,, W. Eisner,, S. Warren,, and B. Kreiswirth. 1993. Emergence of vancomycin-resistant enterococci in New York City. Lancet 342: 76 79.
90. Gambarotto, K.,, M.-C. Ploy,, F. Dupron,, M. Giangiobbe,, and F. Denis. 2001. Occurrence of vancomycin-resistant enterococci in pork and poultry products from a cattle-rearing area of France. J. Clin. Microbiol 39: 2354 2355.
91. Gambarotto, K.,, M.-C. Ploy,, P. Turlure,, C. Gr61aud,, C. Martin,, D. Bordessoule,, and F. Denis. 2000. Prevalence of vancomycin-resistant enterococci in fecal samples from hospitalized patients and nonhospitalized controls in a cattle-rearing area in France. J. Clin. Microbiol. 38: 620 624.
92. Gardam, M. A.,, and J. M. Conly. 1999. An update on the emergence of glycopeptide resistance in enterococci. Curr. Infect. Dis. Rep. 1: 319 327.
93. Goossens, H. 1998. Spread of vancomycin-resistant enterococci: differences between the United States and Europe. Infect. Control Hosp. Epidemiol. 19: 546 551.
94. Grosso, M. D.,, A. Caprioli,, P. Chinzari,, M. C. Fontana,, G. Pezzotti,, A. Manfrin,, E. D. Giannatale,, E. Goffredo,, and A. Pantosti. 2000. Detection and characterization of vancomycin-resistant enterococci in farm animals and raw meat products in Italy. Microb. Drug Resist. 6: 313 318.
95. Guthof, O. 1955. Uber eine neue serologische Gruppe alfa-hemolytischer Strep-tokokken (serologische Gruppe Q). Zentralbl. Bakteriol. Parasitenk. Infectionskr. Hyg. Abt. 1 Ong. 164: 60 69.
96. Haack, B. J.,, and R. E. Andrews, Jr. 2000. Isolation of Tn916-like elements from swine lot effluent. Can. J. Microbiol 46: 542 549.
97. Hammerum, A. M.,, S. Flannagan,, D. B. Clewell,, and L. B. Jensen. 2001. Mechanisms of horizontal transfer of the vat(D. and the erm(B. genes encoding streptogramin resistance. Antimicrob. Agents Chemother. 45: 3223 3225.
98. Hammerum, A. M.,, V. Fussing,, F. M. Aarestrup,, and H. C. Wegener. 2000. Characterization of vancomycin resistant and vancomycin sensitive Enterococcus faeciu. isolates from humans and food-animals by riboprinting and pulsed-held gel electrophoresis. J. Antimicrob. Chemother. 45: 677 680.
99. Hammerum, A. M.,, L. B. Jensen,, and F. M. Aarestrup. 1998. Detection of the sat. gene and transferability of virginiamycin resistance in Enterococcus faeciu. from food-animals. FEMS Microbiol. Lett. 168: 145 151.
100. Handwerger, S.,, B. Raucher,, D. Altarac,, J. Monka,, S. Marchione,, K. V. Singh,, B. E. Murray,, J. Wolff,, and B. Walters. 1993. Nosocomial outbreak due to Enterococcus faeciu. highly resistant to vancomycin, penicillin, and gentamicin. Clin. Infect. Dis. 16: 750 755.
101. Handwerger, S.,, J. Skoble,, L. R Discotto,, and M. J. Pucci. 1995. Heterogeneity of the van. gene cluster in clinical isolates of enterococci from the northeastern United States. Antimicrob. Agents Chemother. 39: 362 368.
102. Haroche, J.,, J. Allignet,, S. Aubert,, A. E. van den Bogaard,, and N. El Sohl. 2000. sat., conferring resistance to streptograrnin A, is widely distributed in Enterococcus faeciu. strains but not in staphylococci. Antimicrob. Agents Chemother. 44: 190 191.
102a. Hasman, H.,, and F. M. Aarestrup. Unpublished results.
103. Harvey, J.,, and L. Mason. 1998. The Use and Misuse of Antibiotics in UK Agriculture. Soil Association, Bristol, United Kingdom.
104. Hayes, J. R.,, A. C. Mcintosh,, S. Qaiyumi,, J. A. Johnson,, L. L. English,, L. E. Carr,, D. D. Wagner,, and S. W. Joseph. 2001. High-frequency recovery of quin-upristin-dalfopristin-resistant Enterococcus faeciu. isolates from the poultry production environment. J. Clin. Microbiol. 39: 2298 2299.
105. Helie, P.,, and R. Higgins. 1999. Diarrhea associated with Enterococcus faeciu. in an adult cat. J. Vet. Diagn. Invest. 11: 457 458.
106. Herrero, I. A.,, T. Teshager,, J. Garde,, M. A. Moreno,, and L. Dominguez. 2000. Prevalence of vancomycin-resistant Enterococcus faeciu. (VREF) in pig faeces from slaughterhouses in Spain. Prev. Vet. Med. 47: 255 262.
107. Hinton, M.,, A. Kaukas,, S. K. Lim,, and A. H. Linton. 1986. Preliminary observations on the influence of antibiotics on the ecology of Escherichia col. and the enterococci in the faecal flora of healthy young chickens. J. Antimicrob. Chemother. 18 (Suppl C): 165 173.
108. Hoover, D.,, S. A. Bendele,, S. R. Wightman,, C. Z. Thompson,, and J. A. Hoyt. 1985. Streptococcal enteropathy in infant rats. Lab. Anim. Sci. 35: 635 641.
109. Ike, Y.,, K. Tanimoto,, Y. Ozawa,, T. Nomura,, S. Fujimoto,, and H. Tomita. 1999. Vancomycin-resistant enterococci in imported chickens in Japan. Lancet 353: 1854.
110. Jacobsen, B. L.,, M. Skou,, A. M. Hammerum,, and L. B. Jensen. 1999. Horizontal transfer of the sat. gene encoding streptograrnin A resistance between isogenic Enterococcus faeciu. strains in the gastrointestinal tract of gnotobiotic rats. Microb. Ecol. Health Dis. 11: 241 247.
111. Jacoby, G. A.,, and G. L. Archer. 1991. New mechanisms of bacterial resistance to antimicrobial agents. N. Engl. J. Med. 324: 601 612.
112. Jay, J. M. 1996. Modern Food Microbiolog., 5th ed., p. 395 400. Chapman and Hall, New York, N.Y.
113. Jayarao, B. M.,, and S. P. Oliver. 1992. Aminoglycoside-resistant Streptococcu. and Enterococcu. species isolated from bovine mammary secretions. J. Dairy Sci. 75: 991 997.
114. Jensen, L. B. 1998. Differences in the occurrence of two base pair variants of Tn2546 from vancomycin-resistant enterococci from humans, pigs and poultry. Antimicrob. Agents Chemother. 42: 2463 2464.
115. Jensen, L. B.,, P. Ahrens,, L. Dons,, R. Jones,, A. M. Hammerum,, and F. M. Aarestrup. 1998. Molecular analysis of Tn154. in Enterococcus faeciu. isolated from animals and humans. J. Clin. Microbiol. 36: 437 442.
116. Jensen, L. B.,, N. Frimodt-Moller,, and F. M. Aarestrup. 1999. Presence of erm gene classes in gram-positive bacteria of animal and human origin in Denmark. FEMS Microbiol. Lett. 170: 151 158.
117. Jensen, L. B.,, A. M. Hammerum,, and F. M. Aarestrup. 2000. Linkage of vat(E. and erm(B. in streptogramin-resistant Enterococcus faeciu. isolates from Europe. Antimicrob. Agents Chemother. 44: 2231 2232.
118. Jensen, L. B.,, A. M. Hammerum,, F. M. Aarestrup,, A. van den Bogaard,, and E. E. Stobberingh. 1998. Occurrence of sat. and vg. genes in streptogramin-resistant Enterococcus faeciu. isolates of animal and human origins in The Netherlands. Antimicrob. Agents Chemother. 42: 3330 3331.
119. Jensen, L. B.,, A. M. Hammerum,, R. L. Poulsen,, and H. Westh. 1999. Vancomycin-resistant Enterococcus faeciu. strains with highly similar pulsed-held gel electrophoresis patterns containing similar Tnl546-like elements isolated from a hospitalized patient and pigs in Denmark. Antimicrob. Agents Chemother. 43: 724 725.
120. Jergens, L. B.,, F. M. Moore,, J. C. Prueter,, and P. J. Yankauskas. 1991. Adherent gram-positive cocci on the intestinal villi of two dogs with gastrointestinal disease. J. Am. Vet. Med. Assoc. 198: 1950 1952.
121. Johnson, S. P.,, S. Nolan,, and F. M. D. Gulland. 1998. Antimicrobial susceptibility of bacteria isolated from pinnipeds in central and northern California. J. Zoo Wildlife Med. 29: 288 294.
122. Johnsson, E.,, and P. Conway,. 1992. Probiotics for pigs, p. 259 316. I. R. Fuller (ed.), Probiotics, the Scientific Basis. Chapman & Hall, London, United Kingdom.
123. Karanfil, L. V.,, M. Murphy,, A. Josephson,, R. Gaynes,, L. Mandel,, B. C. Hill,, and J. M. Swenson. 1992. A cluster of vancomycin-resistant Enterococcus faeciu. in an intensive care unit. Infect. Control Hosp. Epidemiol. 13: 195 200.
124. Kaukas, A.,, M. Hinton,, and A. H. Linton. 1987. The effect of ampicillin and tylosin in the faecal enterococci of healthy young chickens. J. Appl. Microbiol. 62: 441 447.
125. Keane, K. A.,, B. M. Jayarao,, B. E. Gillespie,, and S. P. Oliver. 1995. Polymerase chain reaction-based DNA fingerprinting of Enterococcus faeciu. isolated from intramammary infections of dairy cows. Prev. Vet. Med. 23: 87 94.
126. Kearns, A. M.,, R. Freeman,, and N. F. Lightfoot. 1995. Nosocomial enterococci: resistance to heat and sodium hypochlorite. J. Hosp. Infect. 30: 193 199.
127. Kirst, H. A. 1997. Macrolide antibiotics in food-animal health. Exp. Opin. Invest. Drugs 6: 103 117.
128. Kirst, H. A.,, D. G. Thompson,, and T. I. Nicas. 1998. Historical yearly usage of vancomycin. Antimicrob. Agents Chemother. 42: 1303 1304.
129. I. Klare, D. Badstubner,, C. Konstabel,, G. Bohme,, H. Claus,, and W. Witte. 1999. Decreased incidence of VanA-type vancomycin-resistant enterococci isolated from poultry meat and from fecal samples of humans in the community after discontinuation of avoparcin usage in animal husbandry. Microb. Drug Resist. 5: 45 52.
130. Klare, I.,, H. Heier,, H. Claus,, G. Bohme,, S. Marin,, G. Seltmann,, R. Hakenbeck,, V. Antanassova,, and W. Witte. 1995. Enterococcus faeciu. strains with vanA.mediated high-level glycopeptide resistance isolated from animal food-stuffs and fecal samples of humans in the community. Microb. Drug Res. 1: 265 272.
131. Klare, I.,, H. Heier,, H. Claus,, R. Reissbrodt,, and W. Witte. 1995. vanA-mediated high-level glycopeptide resistance in Enterococcus faeciu. from animal husbandry. FEMS Microbiol. Lett. 125: 165 172.
132. Klare, I.,, H. Heier,, H. Claus,, and W. Witte. 1993. Environmental strains of Enterococcus faeciu. with inducible high-level resistance to glycopeptides. FEMS Microbiol Lett. 106: 23 90.
133. Klare, L.,, and W. Witte. 1997. Glykopeptidresistente Enterokokken: Auftreten, Verbreitung, Resistenzübertragung, Bedeutung. Wien. Klin. Wochenschr. 109: 293 300.
134. Klastrup, O. 1963. Mastitis control in Denmark. Procedures and experiences. Bull. Off. Epiz. 60: 501 511.
135. Klein, G.,, A. Pack,, and G. Reuter. 1998. Antibiotic resistance patterns of enterococci and occurrence of vancomycin-resistant enterococci in raw minced beef and pork in Germany. Appl. Environ. Microbiol. 64: 1825 1830.
136. Krizamova, H.,, Z. Koppel,, M. Halasa,, M. Beseda,, and J. Horvath. 1978. The etiology of foul brood. Vet. Med. (Praha) 23: 633 640.
137. Kiihn, I.,, L. G. Burman,, S. Haeggman,, K. Thullus,, and B. E. Murray. 1995. Biochemical fingerprinting compared with ribotyping and pulsed-held gel electrophoresis of DNA for epidemiological typing of enterococci. J. Clin. Microbiol 33: 2812 2817.
138. Kusuda, R.,, K. Kawai,, F. Salati,, C. R. Banner,, and J. L. Fryer. 1991. Enterococcus seriolicid. sp. nov., a fish pathogen. Int. J. Syst. Bacteriol. 41: 406 409.
139. Landman, W. J. M.,, A. E. J. M. van den Bogaard,, P. Doornenbal,, P. C. J. Tooten,, A. R. W. Elbers,, and E. Grays. 1998. The role of various agents in chicken amyloid arthropathy. Int. J. Exp. Clin. Invest. 5: 266 278.
140. Landman, W. J. M.,, K. T. Veldman,, D. J. Mevius,, and P. Doornenbal. 2000. Contamination of Marek's disease vaccine suspensions with Enterococcus faecali. and its possible role in amyloid arthropathy. Avian Pathol. 29: 21 25.
141. Leclerc, H.,, L. A. Devriese,, and D. A. A. Mossel. 1996. Taxonomical changes in intestinal (faecal) enterococci and streptococci: consequences on their use as indicators of faecal contamination in drinking water. J. Appl Bacteriol 81: 459 466.
142. Leclercq, R.,, E. Derlot,, J. Duval,, and P. Courvalin. 1988. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faeciu.. N. Engl. J. Med. 319: 157 161.
143. Livornese, L. L.,, S. Dias,, C. Samel,, B. Romanowski,, S. Taylor,, P. May,, P. Pitsakis,, G. Woods,, D. Kaye,, M. E. Levison,, and C. C. Johnson. 1992. Hospital-acquired infection with vancomycin-resistant Enterococcus faeciu. transmitted by electronic thermometers. Ann. Intern. Med. 117: 112 116.
144. Lopez-Diaz, T. M.,, C. Alonso,, M. L. Roman,, and B. Moreno. 2000. Lactic acid bacteria isolated from a hand-made bleu cheese. Food Microbiol 17: 23 32.
145. Low, D. E. 1995. Quinupristin/dalfopristin: spectrum of activity, pharmacokinetics, and initial clinical experience. Microb. Drug Res. 1: 223 234.
146. Mann, P. A.,, L. Xiong,, A. S. Mankin,, A. S. Chau,, D. J. Najarian,, C. A. Mendrick,, C. A. Cramer,, F. M. Aarestrup,, R. S. Hare,, T. A. Black,, and P. M. McNicholas. Emt., a novel rRNA methyltransferase conferring high level evernimicin resistance. Mol. Microbiol. 41: 1349 1356.
147. Mannu, L.,, A. Paba,, M. Pes,, R. Floris,, M. F. Scintu, and L. Morelli. 2000. Strain typing among enterococci isolated from home-made Pecorino Sardo cheese. FEMS Microbiol. Lett. 170: 25 30.
148. Martin, J. D.,, and J. O. Mundt. 1972. Enterococci in insects. Appl. Microbiol. 24: 575 580.
149. Martinez-Murcia, A. J.,, and M. D. Collins. 1991. Enterococcus sulfureu., a new yellow pigmented Enterococcu. species. FEMS Microbiol. Lett. 80: 69 74.
150. McDonald, L. C.,, S. Rossiter,, C. Mackinson,, Y. Y. Wang,, S. Johnson,, M. Sullivan,, R. Sokolow,, E. DeBess,, L. Gilbert,, J. A. Benson,, B. Hill,, and R. J. Angulo. 2001. Qumupristm-dalfopristin-resistant Enterococcus faeciu. on chicken and in human stool specimens. N. Engl. J. Med. 345: 1155 1160.
151. McNamee, R. T.,, and D. C. King. 1996. Endocarditis in broiler breeder rearers due to Enterococcus hira.. Vet. Rec. 138: 240.
152. Mellon, M.,, C. Benbrook,, and K. L. Benbrook. 2001. Hogging it. Estimates of antimicrobial abuse in livestock. Union of Concerned Scientists, Cambridge, Mass.
153. Mertz, J. L.,, J. S. Peloso,, B. J. Barker,, G. E. Babbitt,, J. L. Occolowitz,, V. L. Simson,, and R. M. Kline. 1986. Isolation and structural identification of nine avilamycins. J. Antibiot. 39: 877 887.
153a. Mevius, D. Personal communication.
154. Miele, A.,, M. Bandera,, and B. P. Goldstein. 1995. Use of primers selective for vancomycin resistance genes to determine va. genotype in enterococci and to study gene organization in van. isolates. Antimicrob. Agents Chemother. 39: 1772 1778.
155. Montecalvo, M. A.,, H. Horowitz,, C. Gedris,, C. Carbonaro,, F. C. Tenover,, A. Issah,, P. Cook,, and G. P. Wormser. 1994. Outbreak of vancomycin-, ampicillin-, and aminoglycoside-resistant Enterococcus faeciu. bacteremia in an adult oncology unit. Antimicrob. Agents Chemother. 38: 1363 1367.
156. Morrison, D.,, N. Woodford,, S. P. Barrett,, P. Sisson,, and B. D. Cookson. 1999. DNA banding pattern polymorphism in vancomycin-resistant Enterococcus faeciu. and criteria for defining strains. J. Clin. Microbiol. 37: 1084 1091.
157. Niemi, R. M.,, S. I. Niemela,, D. H. Bamford,, J. Hantula,, T. Hyvarinen,, T. Forsten,, and A. Raateland. 1993. Presumptive fecal streptococci in environmental samples characterized by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Appl. Environ. Microbiol. 59: 2190 2196.
158. Nowlan, S. S.,, and R. H. Deibel. 1967. Group Q streptococci. I. Ecology, serology, physiology, and relationship to established enterococci. J. Bacteriol. 94: 291 296.
159. Paul, J. H.,, J. B. Rose,, S. Jiang,, C. Kellogg,, and E. A. Shinn. 1995. Occurrence of fecal indicator bacteria in surface waters and the subsurface aquifer in Key Largo, Florida. Appl. Environ. Microbiol. 61: 2235 2241.
160. Pavia, M.,, C. G. A. Nobile,, L. Salpietro,, and I. F. Angelillo. 2000. Vancomycin resistance and antibiotic susceptibility of enterococci in raw meat. J. Food Protect. 63: 912 915.
161. Pechére, J. C. 1996. Streptogramins—a unique class of antibiotics. Drugs 51: 13 19.
162. Poutrel, B.,, and H. Z. Ryniewicz. 1984. Evaluation of the API 20 Strep system for species identification of streptococci isolated from bovine mastitis. J. Clin. Microbiol. 19: 213 214.
163. Quednau, M.,, S. Ahrné,, and G. Moulin. 1999. Genomic relationships between Enterococcus faeciu. strains from different sources and with different antibiotic resistance profiles evaluated by restriction endonuclease analysis of total chromosomal DNA using EcoRI and PvuI.. Appl. Environ. Microbiol. 65: 1777 1780.
164. Quednau, M.,, S. Ahrné,, A. C. Petersson,, and G. Molin. 1998. Antibiotic-resistant strains of Enterococcu. isolated from Swedish and Danish retailed chicken and pork. J. Appl. Microbiol. 84: 1163 1170.
165. Radu, S.,, H. Toosa,, R. A. Rahim,, A. Reezal,, M. Ahmad,, A. N. Hamid,, G. Rusul,, and M. Nishibuchi. 2001. Occurrence of the van. and vanC2/C. genes in Enterococcu. species isolated from poultry sources in Malaysia. Diagn. Microbiol. Infect. Dis. 39: 145 153.
166. Randall, C. J.,, A. M. Wood,, and G. MacKenzie. 1993. Encephalomalacia in first-week chicks. Vet. Rec. 132: 419.
167. Rende-Fournier, R.,, R. Leclercq,, M. Galimand,, J. Duval,, and P. Courvalin. 1993. Identification of the sat. gene encoding a streptograrnin A acetyltrans-ferase in Enterococcus faeciu.. Antimicrob. Agents Chemother. 37: 2119 2125.
168. Ricaurte, J. C.,, H. W. Boucher,, G. S. Turett,, R. C. Moellering,, V. J. Labombardi,, and J. W. Kislak. 2001. Chloramphenicol treatment for vancomycin-resistant Enterococcus faeciu. bacteremia. Clin. Microbiol. Infect. 7: 17 21.
169. Rice, E. W.,, J. W. Messer,, C. H. Johnson,, and D. J. Reasoner. 1995. Occurrence of high-level aminoglycoside resistance in environmental isolates of enterococci. Appl. Environ. Microbiol. 61: 374 376.
170. Rogers, D. G.,, D. H. Zeman,, and E. D. Erickson. 1992. Diarrhea associated with Enterococcus duran. in calves. J. Vet. Diagn. Invest. 4: 471 472.
171. Rollins, L. D.,, L. N. Lee,, and D. J. LeBlanc. 1985. Evidence for a disseminated erythromycin resistance determinant mediated by Tn927-like sequences among group D streptococci isolated from pigs, chickens, and humans. Antimicrob. Agents Chemother. 27: 439 444.
172. Romalde, J. L.,, B. Magarinos,, S. Nunez,, J. L. Barja,, and A. E. Toranzo. 1996. Host range susceptibility of Enterococcu. sp. strains isolated from diseased turbot: possible routes of infection. Appl. Environ. Microbiol. 62: 607 611.
173. Sader, H. S.,, M. A. Pfaller,, F. C. Tenover,, R. J. Hollis,, and R. N. Jones. 1994. Evaluation and characterization of multiresistant Enterococcus faeciu. from 12 U.S. medical centers. J. Clin. Microbiol. 32: 2840 2842.
174. Saika, P. K.,, G. N. Dutta,, L. A. Devriese,, and C. C. Kalita. 1995. Characterization and antimicrobial susceptibility of Enterococcu. species from the intestines of ducks in Assam. Res. Vet. Sci. 58: 228 289.
175. Schmidt-Madsen, P.,, O. Klastrup,, S. J. Olsen,, and P. S. Pedersen. 1974. Herd incidence of bovine mastitis in four Danish dairy districts. Nord. Vet. Med. 26: 473 482.
176. Schouten, M. A.,, and A. Voss. 1997. VRE and meat. Lancet 349: 1258.
177. Schouten, M. A.,, R. J. Willems,, W. A. Kraak,, J. Top,, J. A. Hoogkamp-Korstanje,, and A. Voss. 2001. Molecular analysis of Tn2546-like elements in vancomycin-resistant enterococci isolated from patients in Europe shows geographic transposon type clustering. Antimicrob. Agents Chemother. 45: 986 999.
178. Seo, K.,, D. Song,, M. J. Gwyther,, and Y. Park. 1999. Development of multiplex PCR for detection of vancomycin resistant enterococci (VRE) and epidemiological application in Korea. Korean J. Vet. Res. 39: 343 352.
179. Shaw, K. J.,, P. N. Rather,, R. S. Hare,, and G. H. Miller. 1993. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol. Rev. 57: 138 163.
180. Silverman, J.,, L. A. Thai,, M. B. Perri,, G. Bostic,, and M. J. Zervos. 1998. Epidemiologic evaluation of antimicrobial resistance in community-acquired enterococci. J. Clin. Microbiol. 36: 830 832.
181. Simonsen, G. S.,, H. Haaiheim,, K. H. Dahl,, H. Kruse,, A. Lovseth,, O. Olsvik,, and A. Sundsfjord. 1998. Transmission of VanA-type vancomycin-resistant enterococci and van. resistance elements between chickens and humans at avoparcin-exposed farms. Microb. Drug Resist. 4: 313 318.
182. Skolnick, A. 1991. New insights into how bacteria develop antibiotic resistance. JAMA 265: 14 16.
183. Sobiraj, A.,, A. Kron,, U. Schollmeyer,, and K. Failing. 1997. Federal investigations on the distribution and in vitro resistance of udder pathogenic bacteria in the milk of cows with subclinical mastitis. Tierarztl. Prax. 25: 108 115.
184. Soltani, M.,, D. Beighton,, J. Philpott-Howard,, and V. Woodford. 2000. Mechanisms of resistance to qumupristm/dalfopristin among isolates of Enterococcus faeciu. from animals, raw meat, and hospital patients in western Europe. Antimicrob. Agents Chemother. 44: 435 436.
185. Sorensen, T. L.,, M. Blom,, D. L. Monnet,, N. Frimodt-Moller,, R. L. Poulsen,, and F. Espersen. 2001. Transient intestinal carriage after ingestion of antibiotic-resistant Enterococcus faeciu. from chicken and pork. N. Engl. J. Med. 345: 1161 1166.
186. Sramova, H.,, M. Daniel,, V. Absolonova,, D. Dedicova,, Z. Jedlickova,, H. Lhotova,, P. Petras,, M. Podzimkova,, and V. Subertova. 1992. Epidemiological role of arthropods detectable in health facilities. J. Hosp. Infect. 20: 281 292.
187. Starr, M. P.,, and D. M. Reynolds. 1951. Streptomycin resistance of coliform bacteria from turkeys fed streptomycin, p. 15. 51st General Meeting, The Society of American Bacteriologists, Chicago, Ill., 27-31 May 1951.
188. Stern, C. S.,, M. G. S. Carvalho,, and L. M. Teixeira. 1994. Characterization of enterococci isolated from human and nonhuman sources in Brazil. Diagn. Microbiol. Infect. Dis. 20: 61 67.
189. Stobberingh, E.,, A. V. D. Bogaard,, N. London,, C. Driessen,, J. Top,, and R. Willems. 1999. Enterococci with glycopeptide resistance in turkeys, turkey farmers, turkey slaughterers, and (sub)urban residents in the south of The Netherlands: evidence for transmission of vancomycin resistance from animals to humans? Antimicrob. Agents Chemother. 43: 2215 2221.
190. Suzzi, G.,, M. Caruso,, F. Gardini,, A. Lombardi,, L. Vannini,, M. E. Guerzoni,, C. Andrighetto,, and M. T. Lanorte. 2000. A survey of the enterococci isolated from an artisanal Italian goat's cheese (semicotto caprino). J. Appl. Microbiol. 89: 267 274.
190a. Svec, P. Personal communication.
191. Svec, P.,, L. A. Devriese,, I. Sedlacek,, M. Baele,, M. Vancanneyt,, F. Haesebrouck,, J. Swings,, and J. Doskar. 2001. Enterococcus haemoperoxidu. sp. nov. and Enterococccus moraviensi. sp. nov., new species isolated from water. Int. J. Syst. Evol. Microbiol. 51: 1567 1574.
192. Svec, P.,, and I. Sedlacek. 1999. Occurrence of Enterococcu. spp. in waters. Folia Microbiol. 44: 3 10.
193. Swann, M. M. 1969. Joint Committee on the Use of Antibiotics in Animal Husbandry and Veterinary Medicine. H.M.S.O., London, United Kingdom.
194. Teixeira, L. M.,, M. G. Carvalho,, M. M. Espinola,, A. G. Steigerwalt,, M. P. Douglas,, D. J. Brenner,, and R. R. Facklam. 2001. Enterococcus porcinu. sp. nov. and Enterococcus ratt. sp. nov., associated with enteric disorders in animals. Int. J. Syst. Evol. Microbiol. 51: 1737 1743.
195. Teixeira, L. M.,, V. L. Merquior,, M. C. Vianni,, M. G. Carvalho,, S. E. Fraca-lanzza,, A. G. Steigerwalt,, D. J. Brenner,, and R. R. Facklam. 1996. Phenotypic and genotypic characterization of atypical Lactococcus garviea. strains isolated from water buffalos with subclinical mastitis and confirmation of L. garviea. as a senior subjective synonym of Enterococcus seriolicid.. Int. J. Syst. Bacteriol. 46: 664 668.
196. Thai, L. A.,, J. W. Chow,, R. Mahayni,, H. Bonilla,, M. B. Perri,, S. A. Donabe-dian,, J. Silverman,, S. Taber,, and M. J. Zervos. 1995. Characterization of antimicrobial resistance in enterococci from animal origin. Antimicrob. Agents Chemother. 39: 2112 2115.
197. Toranzo, A. E.,, J. M. Cutrin,, J. L. Romalde,, S. Nunez,, and J. L. Barja. 1995. Antigenic characterization of Enterococcu. strains pathogenic for turbot and their relationship with other gram positive bacteria. Dis. Aquat. Org. 21: 187 191.
198. Toranzo, A. E.,, S. Devesa,, P. Heinen,, A. Riaza,, S. Nunez,, and J. L. Barja. 1994. Streptococcosis in cultured turbot caused by an Enterococcus-lik. bacterium. Bull Eur. Assoc. Fish Pathol. 14: 19 23.
199. Torres, C.,, J. A. Reguera,, M. J. Sanmartin,, J. C. Perez-Diaz,, and F. Baquero. 1994. vanA-mediated vancomycin-resistant Enterococcu. spp. in sewage. J. Antimicrob. Chemother. 33: 553 561.
200. Trieu-Cuot, P.,, G. de Cespedes,, F. Bentorcha,, F. Delbos,, E. Gaspar,, and T. Horaud. 1993. Study of heterogeneity of chloramphenicol acetyltransferase (CAT) genes in streptococci and enterococci by polymerase chain reaction: characterization of a new CAT determinant. Antimicrob. Agents Chemother. 37: 2593 2598.
201. Tzipori, S.,, J. Hayes,, L. Sims,, and M. Withers. 1984. Streptococcus durans. an unexpected enteropathogen of foals. J. Infect. Dis. 150: 589 593.
202. Ulrich, A.,, and T. Müller. 1998. Heterogeneity of plant associated streptococci as characterized by phenotypic features and restriction analysis of PCR amplified 16S rDNA. J. Appl. Microbiol. 84: 293 303.
203. Underdahl, N. R. 1983. The effect of feeding Streptococcus faeciu. upon Escherichia col. induced diarrhea in gnotobiotic pigs. Prog. Food Nutr. Sci. 7: 5 12.
204. Uttley, A. H.,, R. C. George,, J. Naidoo,, N. Woodford,, A. P. Johnson,, C. H. Collins,, D. Morrison,, A. J. Gilfillan,, L. E. Fitch,, and J. Heptonstall. 1989. High-level vancomycin-resistant enterococci causing hospital infections. Epidemiol. Infect. 103: 173 181.
205. Vancanneyt, M.,, C. Snauwaert,, I. Cleenwerck,, M. Baele,, P. Descheemaeker,, H. Goossens,, B. Pot,, P. Vandamme,, J. Swings,, F. Haesebrouck,, and L.A. Devriese. 2001. Enterococcus villoru. sp. nov., an enteroadherent bacterium associated with diarrhoea in piglets. Int. J. Syst. Evol Microbiol. 51: 393 400.
206. van den Bogaard, A. E.,, N. Bruinsma,, and E. E. Stobberingh. 2000. The effect of banning avoparcin on VRE carriage in The Netherlands. J. Antimicrob. Chemother. 46: 146 147.
207. van den Bogaard, A. E.,, L. B. Jensen,, and E. E. Stobberingh. 1997. Vancomycin-resistant enterococci in turkeys and farmers. N. Engl. J. Med. 337: 1558 1559.
208. van den Braak, N.,, D. Kreft,, A. van Belkum,, H. A. Verbrugh,, and H. P. Endtz. 1997. Vancomycin-resistant enterococci in vegetarians. Lancet 350: 146 147.
209. van den Braak, N.,, A. van Belkum,, M. van Keulen,, J. Vliegenthart,, H. A. Verbrugh,, and H. P. Endtz. 1998. Molecular characterization of vancomycin-resistant enterococci from hospitalized patients and poultry products in The Netherlands. J. Clin. Microbiol. 36: 1927 1932.
210. van der Auwera, P.,, N. Pensart,, V. Korten,, B. E. Murray,, and R. Leclercq. 1996. Influence of oral glycopeptides on the fecal flora of human volunteers: selection of highly glycopeptide-resistant enterococci. J. Hosp. Infect. 173: 1129 1136.
211. van Embden, J. D. A.,, H. W. B. Engel,, and B. Van Klingeren. 1977. Drug resistance in group D streptococci of clinical and nonclinical origin: prevalence, transferability, and plasmid properties. Antimicrob. Agents Chemother. 11: 925 932.
212. Wegener, H. C.,, M. Madsen,, N. Nielsen,, and F. M. Aarestrup. 1997. Isolation of vancomycin resistant Enterococcus faeciu. from food. Int. J. Food. Microbiol. 35: 57 66.
213. Weinstein, M. J.,, G. H. Wagman,, E. M. Oden,, G. M. Luedemann,, P. Sloane,, A. Murawski,, and J. Marquez. 1965. Purification and biological studies of everninomicin B. Antimicrob. Agents Chemother. 34: 821 827.
214. Welton, L. A.,, L. A. Thai,, M. B. Perri,, S. Donabedian,, J. McMahon,, J. W. Chow,, and M. J. Zervos. 1998. Antimicrobial resistance in enterococci isolated from turkey flocks fed virginiamycin. Antimicrob. Agents Chemother. 42: 705 708.
215. Wendt, C.,, C. Krause,, L. U. Xander,, D. Loffler,, and H. Floss. 1999. Prevalence of colonization with vancomycin-resistant enterococci in various populations in Berlin, Germany. J. Hosp. Infect. 42: 193 200.
216. Werner, G.,, B. Hildebrandt,, I. Klare,, and W. Witte. 2000. Linkage of determinants for streptogramin A, macrolide-lmcosaimde-streptogramin B, and chloramphenicol resistance on a conjugative plasmid in Enterococcus faeciu. and dissemination of this cluster among streptogramin resistant enterococci. Int. J. Med. Microbiol. 290: 543 548.
217. Werner, G.,, I. Klare,, H. Heier, K. H. Hinz, G. Bohme, M. Wendt, and W. Witte. 2000. Quimupristin/dalfopristin-resistant enterococci of the sat. and sat. genotypes from different ecological origins in Germany. Microb. Drug Res. 6: 37 47.
218. Werner, G.,, I. Klare,, and W. Witte. 1997. Arrangement of the van. gene cluster in enterococci of different ecological origin. FEMS Microbiol. Lett. 155: 55 61.
219. Werner, G.,, and W. Witte. 1999. Characterization of a new enterococcal gene, sat., encoding a putative acetyltransferase conferring resistance to streptogramin A compounds. Antimicrob. Agents Chemother. 43: 1813 1814.
220. Willems, R.,, W. Hogman,, J. Top,, M. van Santen-Verheuvel,, D. Tribe,, X. Man-zoiros,, C. Galliard,, C. Vandenbroucke-Grauls,, E. Mascini,, E. van Kregten,, J. van Embden,, and M. Bonten. 2001. Variant es. gene as a marker of a distinct genetic lineage of vancomycin-resistant Enterococcus faeciu. spreading in hospitals. Lancet 357: 853 854.
221. Willems, R.,, J. Top,, N. van den Braak,, A. van Belkum,, H. Endtz,, D. Mevius,, E. Stobberingh,, A. van den Bogaard,, and D. A. van Embden. 2000. Host specificity of vancomycin-resistant Enterococcus faeciu.. J. Infect. Dis. 182: 816 823.
222. Willems, R.,, J. Top,, N. van den Braak,, A. van Belkum,, D. J. Mevius,, J. Hen-driks,, M. vanSauten-Verheuvel,, and J. D. van Embden. 1999. Molecular diversity and evolutionary relationship of Tnl546 like elements in enterococci from humans and animals. Antimicrob. Agents Chemother. 43: 483 491.
223. Winslow, C.-E. A.,, and G. T. Palmer. 1910. A comparative study of intestinal streptococci from the horse, the cow and man. J. Infect. Dis. 7: 1 16.
224. Woodford, N.,, A. M. Adebiyi,, M. F. Palepon,, and B. Cookson. 1998. Diversity of van. glycopeptide resistance elements in enterococci from human and non-human sources. Antimicrob. Agents Chemother. 42: 502 508.
225. World Health Organization. 1997. The medical impact of the use of antimicrobials in food animals. Report of a WHO meeting, 13-17 October, Berlin, Germany.
226.WorldHealthOrganization. 2000. WHO global principles for the containment of antimicrobial resistance in animals intended for food. Report of a WHO consultation, 5-9 June, Geneva, Switzerland.
227. Yoshimura, H.,, M. Ishimaru,, Y. S. Endoh,, and A. Kojima. 2000. Antimicrobial susceptibilities of enterococci isolated from faeces of broilers and layer chickens. Lett. Appl. Microbiol. 31: 427 432.

Tables

Generic image for table
Table 1

Genetic relationship of 213 glycopeptide-resistant . strains from human and animal sources

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
Generic image for table
Table 2

Percentage distribution of . species among different animal species

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
Generic image for table
Table 3

Infections in animals caused by enterococci

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
Generic image for table
Table 4

Antibacterials used as growth promoters in European Union countries and the United States

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
Generic image for table
Table 5

Occurrence of macrolide, streptograrnin, and glycopeptide resistance among enterococcal isolates from nonhuman sources

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
Generic image for table
Table 6

Antimicrobial resistance genes and transposons found in enterococci of animal and environmental origin

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
Generic image for table
Table 7

Occurrence of glycopeptide-resistant . (.-mediated) outside hospitals in animals, in meat products, and in fecal samples of nonhospitalized humans in a provincial district of Germany

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2
Generic image for table
Table 8

Molecular typing of the . gene cluster of . from human and animal sources

Citation: Aarestrup F, Butaye P, Witte W. 2002. Nonhuman Reservoirs of Enterococci, p 55-99. In Gilmore M, Clewell D, Courvalin P, Dunny G, Murray B, Rice L (ed), The Enterococci. ASM Press, Washington, DC. doi: 10.1128/9781555817923.ch2

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