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Session 4: Antimicrobial Mechanisms and Defenses

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Abstract:

This section is a session on antimicrobial mechanisms and defenses. Bacillus JK and Enterococcus faecium participate actively here. Thermotoga maritime first presents some background information concerning the antibiotic onslaught being waged by humans. Human inventiveness in discovering new agents has been heralded as one of the marvels of the modern age. However, equally as ingenious have been the ways in which prokaryotes have, in turn, evolved mechanisms of resistance against most of these new agents. This is the focus of the presentation. Bacillus JK speaks for the ‘newly emerging’ antibiotic-resistant organisms—Stomatococcus, Bacillus cereus, Leuconostoc, Rhodococcus, Stenotrophomonas, Moraxella catarrhalis, and Burkholderia cepacia, among others— as well as for those who have long been recognized by humans. E. faecium attempts to make as clear as possible how the Enterococcus clan has been able to withstand the antibiotics thrown at them. An outline of the various mechanisms is discussed in the section. According to the presentation, ineffective use of disinfectants will continue, when with applications at critical times the humans could have literally removed the bacteria from the environment. The overutilization of antibiotics will not be tempered, as ill patients will demand such treatment when it may not be needed, and doctors will over rather than undertreat in order to avoid the plague of attorneys. Such indiscriminate use of antibiotics gives them repeated opportunities to marshal new defenses.

Citation: Koneman E. 2002. Session 4: Antimicrobial Mechanisms and Defenses, p 129-163. In The Other End of the Microscope. ASM Press, Washington, DC. doi: 10.1128/9781555817930.ch6
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Citation: Koneman E. 2002. Session 4: Antimicrobial Mechanisms and Defenses, p 129-163. In The Other End of the Microscope. ASM Press, Washington, DC. doi: 10.1128/9781555817930.ch6
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Citation: Koneman E. 2002. Session 4: Antimicrobial Mechanisms and Defenses, p 129-163. In The Other End of the Microscope. ASM Press, Washington, DC. doi: 10.1128/9781555817930.ch6
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Citation: Koneman E. 2002. Session 4: Antimicrobial Mechanisms and Defenses, p 129-163. In The Other End of the Microscope. ASM Press, Washington, DC. doi: 10.1128/9781555817930.ch6
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THE PENICILLIN COWBOY

Citation: Koneman E. 2002. Session 4: Antimicrobial Mechanisms and Defenses, p 129-163. In The Other End of the Microscope. ASM Press, Washington, DC. doi: 10.1128/9781555817930.ch6
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Citation: Koneman E. 2002. Session 4: Antimicrobial Mechanisms and Defenses, p 129-163. In The Other End of the Microscope. ASM Press, Washington, DC. doi: 10.1128/9781555817930.ch6
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Citation: Koneman E. 2002. Session 4: Antimicrobial Mechanisms and Defenses, p 129-163. In The Other End of the Microscope. ASM Press, Washington, DC. doi: 10.1128/9781555817930.ch6
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