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Chapter 3 : Bovine Viral Diarrhea Virus in Mixed Infections

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Abstract:

Bovine viral diarrhea virus (BVDV) is classified in the genus within the family, which also contains the and genera. Infection of cattle with BVDV induces three disease conditions that range from clinically inapparent to clinically severe. The conditions are termed as congenital persistent infection, mucosal disease, and acute bovine viral diarrhea (BVD). Mucosal disease is a sequel of congenital persistent infection and is caused by a “mixed” infection of noncytopathic BVDV and cytopathic BVDV. Acute BVD occurs after birth and is induced by primary postnatal infection with either cytopathic or noncytopathic BVDV. Acute BVDV may result in respiratory, enteric, and/or reproductive disease. The severity of disease varies from clinically inapparent to fatal and depends on the virulence of the viral strain, physical and environmental stressors, and intercurrent infection with other pathogens. During acute or persistent infection with BVDV, viral replication occurs in a variety of cell types located in the integument, alimentary canal, nervous system, respiratory tract, and immune system. Although many cell types are permissive for viral replication, BVDV has a predilection for cells of the immune system. Viral replication in lymphoid cells may directly, or indirectly, alter immune function and enhance severity of disease during mixed infections of BVDV or mixed infections of BVDV with other pathogens. This chapter provides examples of mixed infections involving BVDV, and discusses the role BVDV may have in enhancing disease processes during a mixed infection.

Citation: Bolin S. 2002. Bovine Viral Diarrhea Virus in Mixed Infections, p 33-50. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch3

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Bovine respiratory syncytial virus
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FIGURE 1

The genomic organization of BVDV. The pestivirus genomic RNA lacks a 5΄ cap and 3΄ poly(A) tail. The long 5΄-untranslated region (UTR) has an internal ribosome entry site for initiation of translation. The viral structural proteins are named C (the capsid protein), E, E1, and E2. (The last three proteins are in the viral envelope.) Viral-neutralizing antibody reacts primarily with E2, but some viral-neutralizing antibody reacts with E. Antigenic similarity between BVDV usually is assessed by using monoclonal or polyclonal antibody against E2. Both noncytopathic BVDV and cytopathic BVDV produce the nonstructural protein NS2-3. However, the NS2-3 protein of cytopathic BVDV is cleaved to form the NS-2 and NS-3 proteins. Expression of the NS3 protein is considered the molecular marker for cytopathic BVDV (see references , and ).

Citation: Bolin S. 2002. Bovine Viral Diarrhea Virus in Mixed Infections, p 33-50. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch3
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References

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1. Alves, D.,, B. McEwan,, M. Hazlett,, G. Maxie,, and N. Anderson. 1996. Trends in bovine abortions submitted to the Ontario Ministry of Agriculture, Food and Rural Affairs, 1993-1995. Can. Vet. J. 37: 287 289.
2. Ames, T. R. 1986. The causative agent of BVD: its epidemiology and pathogenesis. Vet. Med. 81: 848 869.
3. Archambault, D.,, C. Beliveau,, Y. Couture,, and S. Carman. 2000. Clinical response and immunomodulation following experimental challenge of calves with type 2 noncytopathogenic bovine viral diarrhea virus. Vet. Res. 31: 215 227.
4. Atluru, D.,, S. Gudapaty,, W. Xue,, F. Gurria,, M. M. Chengappa,, D. S. McVey,, H. C. Minocha,, and S. Atluru. 1992. In vitro inhibition of 5-lipoxygenase metabolite, leukotriene B4, in bovine mononuclear cells by bovine viral diarrhea virus. Vet. Immunol. Immunopathol. 31: 49 59.
5. Atluru, D.,, W. Xue,, S. Polam,, S. Atluru,, F. Blecha,, and H. C. Minocha. 1990. In vitro interactions of cytokines and bovine viral diarrhea virus in phytohemagglutinin-stimulated bovine mononuclear cells. Vet. Immunol. Immunopathol. 25: 47 59.
6. Baker, J. C. 1995. The clinical manifestations of bovine viral diarrhea infection. Vet. Clin. N. Am. Food Anim. Pract. 11: 425 445.
7. Baszler, T. V.,, J. F. Evermann,, P. S. Kaylor,, T. C. Byington,, and P. M. Dilbeck. 1995. Diagnosis of naturally occurring bovine viral diarrhea virus infections in ruminants using monoclonal antibody-based immunohistochemistry. Vet. Pathol. 32: 609 618.
8. Baule, C.,, G. Kulcsar,, K. Belak,, M. Albert,, C. Mittelholzer,, T. Soos,, L. Kucsera,, and S. Belak. 2001. Pathogenesis of primary respiratory disease induced by isolates from a new genetic cluster of bovine viral diarrhea virus type I. J. Clin. Microbiol. 39: 146 153.
9. Becher, P.,, M. Orlich,, M. Konig,, and H. J. Thiel. 1999. Nonhomologous RNA recombination in bovine viral diarrhea virus: molecular characterization of a variety of subgenomic RNAs isolated during an outbreak of fatal mucosal disease. J. Virol. 73: 5646 5653.
10. Becher, P.,, M. Orlich,, and H. J. Thiel. 1998. Ribosomal S27a coding sequences upstream of ubiquitin coding sequences in the genome of a pestivirus. J. Virol. 72: 8697 8704.
11. Becher, P.,, M. Orlich,, and H. J. Thiel. 2001. RNA recombination between persisting pestivirus and a vaccine strain: generation of cytopathogenic virus and induction of lethal disease. J. Virol. 75: 6256 6264.
12. Bezek, D. M.,, D. Stoffregen,, and M. Posso. 1995. Effect of cytopathic bovine viral diarrhea virus (BVDV) superinfection on viral antigen association with platelets, viremia, and specific antibody levels in two heifers persistently infected with noncytopathic BVDV. J. Vet. Diagn. Investig. 7: 395 397.
13. Bielefeldt Ohmann, H. 1988. BVD virus antigens in tissues of persistently viraemic, clinically normal cattle: implications for the pathogenesis of clinically fatal disease. Acta Vet. Scand. 29: 77 84.
14. Bielefeldt Ohmann, H. 1987. Double-immunolabeling systems for phenotyping of immune cells harboring bovine viral diarrhea virus. J. Histochem. Cytochem. 35: 627 633.
15. Bielefeldt Ohmann, H. 1988. In situ characterization of mononuclear leukocytes in skin and digestive tract of persistently bovine viral diarrhea virus-infected clinically healthy calves and calves with mucosal disease. Vet. Pathol. 25: 304 309.
16. Bielefeldt Ohmann, H. 1983. Pathogenesis of bovine viral diarrhea: distribution and significance of BVDV antigen in diseased calves. Res. Vet. Sci. 34: 5 8.
17. Bielefeldt Ohmann, H.,, B. Bloch,, W. C. Davis,, and J. Askaa. 1988. BVD-virus infection in peripheral blood mononuclear cells from persistently viraemic calves studied by correlative immunoelectron microscopy. Zentbl. Vetmed. Reine B 35: 477 492.
18. Bielefeldt Ohmann, H.,, L. Ronsholt,, and B. Bloch. 1987. Demonstration of bovine viral diarrhoea virus in peripheral blood mononuclear cells of persistently infected, clinically normal cattle. J. Gen. Virol. 68: 1971 1982.
19. Bielefeldt-Ohmann, H. 1995. The pathologies of bovine viral diarrhea virus infection. A window on the pathogenesis. Vet. Clin. N. Am. Food Anim. Pract. 11: 447 476.
20. Bitsch, V.,, K. E. Hansen,, and L. Ronsholt. 2000. Experiences from the Danish programme for eradication of bovine virus diarrhoea (BVD) 1994-1998 with special reference to legislation and causes of infection. Vet. Microbiol. 77: 137 143.
21. Bitsch, V.,, and L. Ronsholt. 1995. Control of bovine viral diarrhea virus infection without vaccines. Vet. Clin. N. Am. Food Anim. Pract. 11: 627 640.
22. Bjorkman, C.,, S. Alenius,, U. Manuelsson,, and A. Uggla. 2000. Neospora caninum and bovine virus diarrhoea virus infections in Swedish dairy cows in relation to abortion. Vet. J. 159: 201 206.
23. Bolin, S. R. 1995. Control of bovine viral diarrhea infection by use of vaccination. Vet. Clin. N. Am. Food Anim. Pract. 11: 615 625.
24. Bolin, S. R. 1988. Viral and viral protein specificity of antibodies induced in cows persistently infected with noncytopathic bovine viral diarrhea virus after vaccination with cytopathic bovine viral diarrhea virus. Am. J. Vet. Res. 49: 1040 1044.
25. Bolin, S. R.,, A. W. McClurkin,, and M. F. Coria. 1985. Effects of bovine viral diarrhea virus on the percentages and absolute numbers of circulating B and T lymphocytes in cattle. Am. J. Vet. Res. 46: 884 886.
26. Bolin, S. R.,, A. W. McClurkin,, and M. F. Coria. 1985. Frequency of persistent bovine viral diarrhea virus infection in selected cattle herds. Am. J. Vet. Res. 46: 2385 2387.
27. Bolin, S. R.,, A. W. McClurkin,, R. C. Cutlip,, and M. F. Coria. 1985. Response of cattle persistently infected with noncytopathic bovine viral diarrhea virus to vaccination for bovine viral diarrhea and to subsequent challenge exposure with cytopathic bovine viral diarrhea virus. Am. J. Vet. Res. 46: 2467 2470.
28. Bolin, S. R.,, A. W. McClurkin,, R. C. Cutlip,, and M. F. Coria. 1985. Severe clinical disease induced in cattle persistently infected with noncytopathic bovine viral diarrhea virus by superinfection with cytopathic bovine viral diarrhea virus. Am. J. Vet. Res. 46: 573 576.
29. Bolin, S. R.,, and J. F. Ridpath. 1992. Differences in virulence between two noncytopathic bovine viral diarrhea viruses in calves. Am. J. Vet. Res. 53: 2157 2163.
30. Bolin, S. R.,, and J. F. Ridpath. 1990. Frequency of association of noncytopathic bovine viral diarrhea virus with bovine neutrophils and mononuclear leukocytes before and after treatment with trypsin. Am. J. Vet. Res. 51: 1847 1851.
31. Bolin, S. R.,, J. M. Sacks,, and S. V. Crowder. 1987. Frequency of association of noncytopathic bovine viral diarrhea virus with mononuclear leukocytes from persistently infected cattle. Am. J. Vet. Res. 48: 1441 1445.
32. Brock, K. V.,, D. L. Grooms,, J. Ridpath,, and S. R. Bolin. 1998. Changes in levels of viremia in cattle persistently infected with bovine viral diarrhea virus. J. Vet. Diagn. Investig. 10: 22 26.
33. Brodersen, B. W.,, and C. L. Kelling. 1999. Alteration of leukocyte populations in calves concurrently infected with bovine respiratory syncytial virus and bovine viral diarrhea virus. Viral Immunol. 12: 323 334.
34. Brodersen, B. W.,, and C. L. Kelling. 1998. Effect of concurrent experimentally induced bovine respiratory syncytial virus and bovine viral diarrhea virus infection on respiratory tract and enteric diseases in calves. Am. J. Vet. Res. 59: 1423 1430.
35. Brown, G. B.,, S. R. Bolin,, D. E. Frank,, and J. A. Roth. 1991. Defective function of leukocytes from cattle persistently infected with bovine viral diarrhea virus, and the influence of recombinant cytokines. Am. J. Vet. Res. 52: 381 387.
36. Brownlie, J. 1991. The pathways for bovine virus diarrhoea virus biotypes in the pathogenesis of disease. Arch. Virol. Suppl. 3: 79 96.
37. Brownlie, J.,, and M. C. Clarke. 1993. Experimental and spontaneous mucosal disease of cattle: a validation of Koch’s postulates in the definition of pathogenesis. Intervirology 35: 51 59.
38. Brownlie, J.,, M. C. Clarke,, and C. J. Howard. 1989. Experimental infection of cattle in early pregnancy with a cytopathic strain of bovine virus diarrhoea virus. Res. Vet. Sci. 46: 307 311.
39. Brownlie, J.,, M. C. Clarke,, and C. J. Howard. 1984. Experimental production of fatal mucosal disease in cattle. Vet. Rec. 114: 535 536.
40. Bruschke, C. J.,, A. Haghparast,, A. Hoek,, V. P. Rutten,, G. H. Wentink,, P. A. van Rijn,, and J. T. van Oirschot. 1998. The immune response of cattle, persistently infected with noncytopathic BVDV, after superinfection with antigenically semi-homologous cytopathic BVDV. Vet. Immunol. Immunopathol. 62: 37 50.
41. Bruschke, C. J.,, K. Weerdmeester,, J. T. Van Oirschot,, and P. A. Van Rijn. 1998. Distribution of bovine virus diarrhoea virus in tissues and white blood cells of cattle during acute infection. Vet. Microbiol. 64: 23 32.
42. Buckner, R.,, and H. D. Grunder. 1995. Clinical, serological and virological findings in cattle with acute, sub-acute and chronic mucosal disease. Bovine Pract. 29: 119 124.
43. Carman, S.,, T. van Dreumel,, J. Ridpath,, M. Hazlett,, D. Alves,, E. Dubovi,, R. Tremblay,, S. Bolin,, A. Godkin,, and N. Anderson. 1998. Severe acute bovine viral diarrhea in Ontario, 1993-1995. J. Vet. Diagn. Investig. 10: 27 35.
44. Collen, T.,, A. J. Douglas,, D. J. Paton,, G. Zhang,, and W. I. Morrison. 2000. Single amino acid differences are sufficient for CD4(+) T-cell recognition of a heterologous virus by cattle persistently infected with bovine viral diarrhea virus. Virology 276: 70 82.
45. Collins, M. E.,, M. Desport,, and J. Brownlie. 1999. Bovine viral diarrhea virus quasispecies during persistent infection. Virology 259: 85 98.
46. Corapi, W. V.,, R. O. Donis,, and E. J. Dubovi. 1988. Monoclonal antibody analyses of cytopathic and noncytopathic viruses from fatal bovine viral diarrhea virus infections. J. Virol. 62: 2823 2827.
47. Corapi, W. V.,, R. D. Elliott,, T. W. French,, D. G. Arthur,, D. M. Bezek,, and E. J. Dubovi. 1990. Thrombocytopenia and hemorrhages in veal calves infected with bovine viral diarrhea virus. J. Am. Vet. Med. Assoc. 196: 590 596.
48. Corapi, W. V.,, T. W. French,, and E. J. Dubovi. 1989. Severe thrombocytopenia in young calves experimentally infected with noncytopathic bovine viral diarrhea virus. J. Virol. 63: 3934 3943.
49. Coria, M. F.,, and A. W. McClurkin. 1978. Specific immune tolerance in an apparently healthy bull persistently infected with bovine viral diarrhea virus. J. Am. Vet. Med. Assoc. 172: 449 451.
50. Coulibaly, C. O. Z.,, B. Liess,, G. Trautwein,, and G. Schleuter. 1986. Quantitative analysis of immunoglobulins G1 and G2 in blood samples of cattle persistently infected with bovine virus diarrhoea virus. J. Vet. Med. Ser. B 33: 685 696.
51. de Verdier Klingenberg, K. 2000. Enhancement of clinical signs in experimentally rotavirus infected calves by combined viral infections. Vet. Rec. 147: 717 719.
52. Done, J. T.,, S. Terlecki,, C. Richardson,, J. W. Harkness,, J. J. Sands,, D. S. Patterson,, D. Sweasey,, I. G. Shaw,, C. E. Winkler,, and S. J. Duffell. 1980. Bovine virus diarrhoea-mucosal disease virus: pathogenicity for the fetal calf following maternal infection. Vet. Rec. 106: 473 479.
53. Donis, R. O. 1995. Molecular biology of bovine viral diarrhea virus and its interactions with the host. Vet. Clin. N. Am. Food Anim. Pract. 11: 393 423.
54. Donis, R. O.,, and E. J. Dubovi. 1987. Differences in virus-induced polypeptides in cells infected by cytopathic and noncytopathic biotypes of bovine virus diarrhea-mucosal disease virus. Virology 158: 168 173.
55. Donis, R. O.,, and E. J. Dubovi. 1987. Molecular specificity of the antibody responses of cattle naturally and experimentally infected with cytopathic and noncytopathic bovine viral diarrhea virus biotypes. Am. J. Vet. Res. 48: 1549 1554.
56. Edwards, S.,, T. W. Drew,, and S. E. Bushnell. 1987. Prevalence of bovine virus diarrhoea virus viraemia. Vet. Rec. 120: 71.
57. Ellis, J. A.,, W. C. Davis,, E. L. Belden,, and D. L. Pratt. 1988. Flow cytofluorimetric analysis of lymphocyte subset alterations in cattle infected with bovine viral diarrhea virus. Vet. Pathol. 25: 231 236.
58. Ellis, J. A.,, K. H. West,, V. S. Cortese,, S. L. Myers,, S. Carman,, K. M. Martin,, and D. M. Haines. 1998. Lesions and distribution of viral antigen following an experimental infection of young seronegative calves with virulent bovine virus diarrhea virus-type II. Can. J. Vet. Res. 62: 161 169.
59. Elvander, M.,, C. Baule,, M. Persson,, L. Egyed,, A. Ballagi-Pordany,, S. Belak,, and S. Alenius. 1998. An experimental study of a concurrent primary infection with bovine respiratory syncytial virus (BRSV) and bovine viral diarrhoea virus (BVDV) in calves. Acta Vet. Scand. 39: 251 264.
60. Fray, M. D.,, M. C. Clarke,, L. H. Thomas,, J. W. McCauley,, and B. Charleston. 1998. Prolonged nasal shedding and viraemia of cytopathogenic bovine virus diarrhoea virus in experimental late-onset mucosal disease. Vet. Rec. 143: 608 611.
61. Fredriksen, B.,, T. Sandvik,, T. Loken,, and S. A. Odegaard. 1999. Level and duration of serum antibodies in cattle infected experimentally and naturally with bovine virus diarrhoea virus. Vet. Rec. 144: 111 114.
62. Fritzemeier, J.,, I. Greiser-Wilke,, L. Hass,, E. Pituco,, V. Moennig,, and B. Liess. 1995. Experimentally induced “late onset” mucosal disease: characterization of the cytopathic viruses isolated. Vet. Microbiol. 46: 285 294.
63. Fritzemeier, J.,, L. Haas,, E. Liebler,, V. Moennig,, and I. Greiser-Wilke. 1997. The development of early vs. late onset mucosal disease is a consequence of two different pathogenic mechanisms. Arch. Virol. 142: 1335 1350.
64. Fulton, R. W.,, C. W. Purdy,, A. W. Confer,, J. T. Saliki,, R. W. Loan,, R. E. Briggs,, and L. J. Burge. 2000. Bovine viral diarrhea viral infections in feeder calves with respiratory disease: interactions with Pasteurella spp., parainfluenza-3 virus, and bovine respiratory syncytial virus. Can. J. Vet. Res. 64: 151 159.
65. Gillespie, J. H.,, K. M. Lee,, J. A. Baker,, and K. McEntee. 1960. A cytopathogenic strain of virus diarrhea virus. Cornell Vet. 50: 73 79.
66. Graham, D. A.,, M. Elvander,, B. M. Adair,, and M. Merza. 1998. Influence of concurrent BVDV infection on the IgM response of calves experimentally infected with bovine respiratory syncytial virus. Vet. Rec. 143: 198 199.
67. Graham, D. A.,, J. McShane,, K. A. Mawhinney,, I. E. McLaren,, B. M. Adair,, and M. Merza. 1998. Evaluation of a single dilution ELISA system for detection of seroconversion to bovine viral diarrhea virus, bovine respiratory syncytial virus, parainfluenza-3 virus, and infectious bovine rhinotracheitis virus: comparison with testing by virus neutralization and hemagglutination inhibition. J. Vet. Diagn. Investig. 10: 43 48.
68. Greig, A.,, I. R. Gibson,, P. F. Nettleton,, and J. A. Herring. 1981. Disease outbreak in calves caused by a mixed infection with infectious bovine rhinotracheitis virus and bovine virus diarrhoea virus. Vet. Rec. 108: 480.
69. Greiser-Wilke, I.,, L. Haas,, K. Dittmar,, B. Liess,, and V. Moennig. 1993. RNA insertions and gene duplications in the nonstructural protein p125 region of pestivirus strains and isolates in vitro and in vivo. Virology 193: 977 980.
70. Greiser-Wilke, I.,, E. Liebler,, L. Haas,, B. Liess,, J. Pohlenz,, and V. Moennig. 1993. Distribution of cytopathogenic and noncytopathogenic bovine virus diarrhea virus in tissues from a calf with experimentally induced mucosal disease using antigenic and genetic markers. Arch. Virol. 7(Suppl.): 295 302.
71. Grooms, D. L. 1998. Role of bovine viral diarrhea virus in the bovine respiratory disease complex. Bovine Pract. 32: 7 12.
72. Grooms, D. L.,, J. C. Baker,, and T. R. Ames 2002,. Diseases caused by bovine virus diarrhea virus, p. 707 714. In B. P. Smith (ed.), Large Animal Internal Medicine: Diseases of Horses, Cattle, Sheep, and Goats, 3rd ed. Mosby, St. Louis, Mo.
73. Hoff, H. S.,, and R. O. Donis. 1997. Induction of apoptosis and cleavage of poly(ADP-ribose) polymerase by cytopathic bovine viral diarrhea virus infection. Virus Res. 49: 101 113.
74. Houe, H. 1999. Epidemiological features and economical importance of bovine virus diarrhoea virus (BVDV) infections. Vet. Microbiol. 64: 89 107.
75. Houe, H. 1995. Epidemiology of bovine viral diarrhea virus. Vet. Clin. N. Am. Food Anim. Pract. 11: 521 547.
76. Houe, H. 1993. Survivorship of animals persistently infected with bovine virus diarrhoea virus (BVDV). Prev. Vet. Med. 15: 275 283.
77. Houe, H.,, J. C. Baker,, R. K. Maes,, H. Wuryastuti,, R. Wasito,, P. L. Ruegg,, and J. W. Lloyd. 1995. Prevalence of cattle persistently infected with bovine viral diarrhea virus in 20 dairy herds in two counties in central Michigan and comparison of prevalence of antibody-positive cattle among herds with different infection and vaccination status. J. Vet. Diagn. Investig. 7: 321 326.
78. Houe, H.,, and I. Heron. 1993. Immune response to other agents of calves persistently infected with bovine virus diarrhoea virus (BVDV). Acta Vet. Scand. 34: 305 310.
79. Houe, H.,, and A. Meyling. 1991. Prevalence of bovine viral diarrhoea (BVD) in 19 Danish dairy herds and estimation of incidence of infection in early pregnancy. Prev. Vet. Med. 11: 9 16.
80. Howard, C. J.,, J. Brownlie,, and M. C. Clarke. 1987. Comparison by the neutralisation assay of pairs of non-cytopathogenic and cytopathogenic strains of bovine virus diarrhoea virus isolated from cases of mucosal disease. Vet. Microbiol. 13: 361 369.
81. Howard, C. J.,, J. Brownlie,, and L. H. Thomas. 1986. Prevalence of bovine virus diarrhoea virus viraemia in cattle in the UK. Vet. Rec. 119: 628 629.
82. Jeffery, M.,, and R. A. Hogg. 1988. Concurrent bovine virus diarrhoea virus and Campylobacter fetus infection in an aborted bovine fetus. Vet. Rec. 122: 89 90.
83. Jensen, J.,, and R. D. Schultz. 1991. Effect of infection by bovine viral diarrhea virus (BVDV) in vitro on interleukin-1 activity of bovine monocytes. Vet. Immunol. Immunopathol. 29: 251 265.
84. Kahrs, R. F.,, R. Bartholomew,, J. A. House,, and G. M. Ward. 1970. Epidemiological investigation of bovine diarrhea-mucosal disease in an unvaccinated dairy herd. Cornell Vet. 60: 16 22.
85. Ketelsen, A. T.,, D. W. Johnson,, and C. C. Muscoplat. 1979. Depression of bovine monocyte chemotactic responses by bovine viral diarrhea virus. Infect. Immun. 25: 565 568.
86. Kirkbride, C. A. 1992. Etiologic agents detected in a 10-year study of bovine abortions and stillbirths. J. Vet. Diagn. Investig. 4: 175 180.
87. Kirkbride, C. A. 1992. Viral agents and associated lesions detected in a 10-year study of bovine abortions and stillbirths. J. Vet. Diagn. Investig. 4: 374 379.
88. Kirkland, P. D.,, S. G. Mackintosh,, and A. Moyle. 1994. The outcome of widespread use of semen from a bull persistently infected with pestivirus. Vet. Rec. 135: 527 529.
89. Kummerer, B. M.,, and G. Meyers. 2000. Correlation between point mutations in NS2 and the viability and cytopathogenicity of Bovine viral diarrhea virus strain Oregon analyzed with an infectious cDNA clone. J. Virol. 74: 390 400.
90. Kummerer, B. M.,, D. Stoll,, and G. Meyers. 1998. Bovine viral diarrhea virus strain Oregon: a novel mechanism for processing of NS2-3 based on point mutations. J. Virol. 72: 4127 4138.
91. Kummerer, B. M.,, N. Tautz,, P. Becher,, H. Thiel,, and G. Meyers. 2000. The genetic basis for cytopathogenicity of pestiviruses. Vet. Microbiol. 77: 117 128.
92. Lamontagne, L.,, P. Lafortune,, and M. Fournel. 1989. Modulation of the cellular immune responses to T-cell-dependent and T cell-independent antigens in lambs with induced bovine viral diarrhea virus infection. Am. J. Vet. Res. 50: 1604 1608.
93. Larsson, B. 1988. Increased suppressor cell activity in cattle persistently infected with bovine virus diarrhoea virus. J. Vet. Med. Ser. B 35: 271 279.
94. Lee, K. M.,, and J. H. Gillespie. 1957. Propagation of virus diarrhea virus of cattle in tissue culture. Am. J. Vet. Res. 18: 952 955.
95. Lee, S. C.,, I. E. Borgmann,, and N. A. Gobin. 1994. A severe outbreak of mucosal disease in central Alberta. Can. Vet. J. 35: 641 642.
96. Liebler, E. M.,, C. Kusters,, and J. F. Pohlenz. 1996. Experimental mucosal disease in cattle: changes in the number of lymphocytes and plasma cells in the mucosa of the small and large intestine. Vet. Immunol. Immunopathol. 55: 93 105.
97. Liebler, E. M.,, C. Kusters,, and J. F. Pohlenz. 1995. Experimental mucosal disease in cattle: changes of lymphocyte subpopulations in Peyer’s patches and in lymphoid nodules of large intestine. Vet. Immunol. Immunopathol. 48: 233 248.
98. Liebler, E. M.,, J. Waschbusch,, J. F. Pohlenz,, V. Moennig,, and B. Liess. 1991. Distribution of antigen of noncytopathogenic and cytopathogenic bovine virus diarrhea virus biotypes in the intestinal tract of calves following experimental production of mucosal disease. Arch. Virol. Suppl. 3: 109 124.
99. Liebler-Tenorio, E. M.,, I. Greiser-Wilke,, and J. F. Pohlenz. 1997. Organ and tissue distribution of the antigen of the cytopathogenic bovine virus diarrhea virus in the early and advanced phase of experimental mucosal disease. Arch. Virol. 142: 1613 1634.
100. Liebler-Tenorio, E. M.,, A. Lanwehr,, I. Greiser-Wilke,, B. I. Loehr,, and J. Pohlenz. 2000. Comparative investigation of tissue alterations and distribution of BVD-viral antigen in cattle with early onset versus late onset mucosal disease. Vet. Microbiol. 77: 163 174.
101. Liess, B.,, H.-R. Frey,, H. Kittsteiner,, F. Baumann,, and W. Neumann. 1974. Obser- vations and investigation on mucosal disease of cattle, a late stage of BVD-MD virus infection with immunobiologic explanation and criteria of a slow virus infection. Dtsch. Tierarztl. Wochenschr. 81: 481 487.
102. Liess, B.,, H. R. Frey,, S. Orban,, and S. M. Hafez. 1983. Bovine virus diarrhea (BVD)— “mucosal disease”: persistent BVD field virus infection in serologically selected cattle. Dtsch. Tierarztl. Wochenschr. 90: 261 266.
103. Liess, B.,, S. Orban,, H. R. Frey,, G. Trautwein,, W. Wiefel,, and H. Blindow. 1984. Studies on transplacental transmissibility of a bovine virus diarrhoea (BVD) vaccine virus in cattle. II. Inoculation of pregnant cows without detectable neutralizing antibodies to BVD virus 90-229 days before parturition (51st to 190th day of gestation). Zentbl. Vetmed. Reihe B 31: 669 681.
104. Liu, L.,, H. D. Lehmkuhl,, and M. L. Kaeberle. 1999. Synergistic effects of bovine respiratory syncytial virus and non-cytopathic bovine viral diarrhea virus infection on selected bovine alveolar macrophage functions. Can. J. Vet. Res. 63: 41 48.
105. Loehr, B. I.,, H. R. Frey,, V. Moennig,, and I. Greiser-Wilke. 1998. Experimental induction of mucosal disease: consequences of superinfection of persistently infected cattle with different strains of cytopathogenic bovine viral diarrhea virus. Arch. Virol. 143: 667 679.
106. Loken, T.,, H. Gamlem,, and O. Lysbakken. 1989. An outbreak of mucosal disease in a dairy herd. Acta. Vet. Scand. 30: 321 327.
107. Lopez, O. J.,, F. A. Osorio,, C. L. Kelling,, and R. O. Donis. 1993. Presence of bovine viral diarrhoea virus in lymphoid cell populations of persistently infected cattle. J. Gen. Virol. 74: 925 929.
108. Markham, R. J.,, and M. L. Ramnaraine. 1985. Release of immunosuppressive substances from tissue culture cells infected with bovine viral diarrhea virus. Am. J. Vet. Res. 46: 879 883.
109. Marshall, D. J.,, R. A. Moxley,, and C. L. Kelling. 1996. Distribution of virus and viral antigen in specific pathogen-free calves following inoculation with noncytopathic bovine viral diarrhea virus. Vet. Pathol. 33: 311 318.
110. Martin, S. W.,, K. G. Bateman,, P. E. Shewen,, S. Rosendal,, J. G. Bohac,, and M. Thorburn. 1990. A group level analysis of the associations between antibodies to seven putative pathogens and respiratory disease and weight gain in Ontario feedlot calves. Can. J. Vet. Res. 54: 337 342.
111. Martin, S. W.,, E. Nagy,, D. Armstrong,, and S. Rosendal. 1999. The associations of viral and mycoplasmal antibody titers with respiratory disease and weight gain in feedlot calves. Can. Vet. J. 40: 560 570.
112. McClurkin, A. W.,, S. R. Bolin,, and M. F. Coria. 1985. Isolation of cytopathic and noncytopathic bovine viral diarrhea virus from the spleen of cattle acutely and chronically affected with bovine viral diarrhea. J. Am. Vet. Med. Assoc. 186: 568 569.
113. McClurkin, A. W.,, E. T. Littledike,, R. C. Cutlip,, G. H. Frank,, M. F. Coria,, and S. R. Bolin. 1984. Production of cattle immunotolerant to bovine viral diarrhea virus. Can. J. Comp. Med. 48: 156 161.
114. McKercher, D. G.,, J. K. Saito,, G. L. Crenshaw,, and R. B. Bushnell. 1968. Complications in cattle following vaccination with a combined bovine viral diarrhea-infectious bovine rhinotracheitis vaccine. J. Am. Vet. Med. Assoc. 152: 1621 1624.
115. Meyers, G.,, T. Rumenapf,, N. Tautz,, E. J. Dubovi,, and H. J. Thiel. 1991. Insertion of cellular sequences in the genome of bovine viral diarrhea virus. Arch. Virol. Suppl. 3: 133 142.
116. Meyers, G.,, D. Stoll,, and M. Gunn. 1998. Insertion of a sequence encoding light chain 3 of microtubule-associated proteins 1A and 1B in a pestivirus genome: connection with virus cytopathogenicity and induction of lethal disease in cattle. J. Virol. 72: 4139 4148.
117. Meyers, G.,, N. Tautz,, E. J. Dubovi,, and H. J. Thiel. 1991. Viral cytopathogenicity correlated with integration of ubiquitin-coding sequences. Virology 180: 602 616.
118. Meyers, G.,, and H.-J. Theil. 1996. Molecular characterization of pestiviruses. Adv. Virus Res. 47: 53 118.
119. Moennig, V.,, H. R. Frey,, E. Liebler,, J. Pohlenz,, and B. Liess. 1990. Reproduction of mucosal disease with cytopathogenic bovine viral diarrhoea virus selected in vitro. Vet. Rec. 127: 200 203.
120. Murray, R. D. 1991. Lesions in aborted fetuses and placenta associated with bovine viral diarrhoea virus infection. Arch. Virol. Suppl. 3: 217 224.
121. Olchowy, T. W.,, D. O. Slauson,, and P. N. Bochsler. 1997. Induction of procoagulant activity in virus infected bovine alveolar macrophages and the effect of lipopolysaccharide. Vet. Immunol. Immunopathol. 58: 27 37.
122. Penny, C. D.,, J. C. Low,, P. F. Nettleton,, P. R. Scott,, N. D. Sargison,, W. D. Strachan,, and P. C. Honeyman. 1996. Concurrent bovine viral diarrhoea virus and Salmonella typhimurium DT104 infection in a group of pregnant dairy heifers. Vet. Rec. 138: 485 489.
123. Peter, C. P.,, D. E. Tyler,, and F. K. Ramsey. 1967. Characteristics of a condition following vaccination with bovine virus diarrhea vaccine. J. Am. Vet. Med. Assoc. 150: 46 52.
124. Pocock, D. H.,, C. J. Howard,, M. C. Clarke,, and J. Brownlie. 1987. Variation in the intracellular polypeptide profiles from different isolates of bovine virus diarrhoea virus. Arch. Virol. 94: 43 53.
125. Pollreisz, J. H.,, C. L. Kelling,, B. W. Brodersen,, L. J. Perino,, V. L. Cooper,, and A. R. Doster. 1997. Potentiation of bovine repiratory syncytial virus infection in calves by bovine viral diarrhea virus. Bovine Pract. 31: 32 38.
126. Pospisil, Z.,, M. Machatkova,, J. Mensik,, L. Rodak,, and G. Muller. 1975. Decline in the phytohemagglutinin responsiveness of lymphocytes from calves infected experimentally with bovine viral diarrhoea-mucosal disease virus and parainfluenza 3 virus. Acta Vet. Brno 44: 369 375.
127. Potgieter, L. N. 1997. Bovine respiratory tract disease caused by bovine viral diarrhea virus. Vet. Clin. N. Am. Food Anim. Pract. 13: 471 481.
128. Potgieter, L. N. 1995. Immunology of bovine viral diarrhea virus. Vet. Clin. N. Am. Food Anim. Pract. 11: 501 520.
129. Potgieter, L. N.,, M. D. McCracken,, F. M. Hopkins,, and J. S. Guy. 1985. Comparison of the pneumopathogenicity of two strains of bovine viral diarrhea virus. Am. J. Vet. Res. 46: 151 153.
130. Potgieter, L. N.,, M. D. McCracken,, F. M. Hopkins,, and R. D. Walker. 1984. Effect of bovine viral diarrhea virus infection on the distribution of infectious bovine rhinotracheitis virus in calves. Am. J. Vet. Res. 45: 687 690.
131. Potgieter, L. N.,, M. D. McCracken,, F. M. Hopkins,, R. D. Walker,, and J. S. Guy. 1984. Experimental production of bovine respiratory tract disease with bovine viral diarrhea virus. Am. J. Vet. Res. 45: 1582 1585.
132. Pritchard, G. C.,, E. D. Borland,, L. Wood,, and D. G. Pritchard. 1989. Severe disease in a dairy herd associated with acute infection with bovine virus diarrhoea virus, Leptospira hardjo and Coxiella burnetii. Vet. Rec. 124: 625 629.
133. Qi, F.,, J. F. Ridpath,, and E. S. Berry. 1998. Insertion of a bovine SMT3B gene in NS4B and duplication of NS3 in a bovine viral diarrhea virus genome correlate with the cytopathogenicity of the virus. Virus Res. 57: 1 9.
134. Qi, F.,, J. F. Ridpath,, T. Lewis,, S. R. Bolin,, and E. S. Berry. 1992. Analysis of the bovine viral diarrhea virus genome for possible cellular insertions. Virology 189: 285 292.
135. Ramsey, F. K.,, and W. H. Chivers. 1953. Mucosal disease of cattle. N. Am. Vet. 34: 629 633.
136. Ramsey, F. K.,, and W. H. Chivers. 1957. Pathology of a mucosal disease of cattle. J. Am. Vet. Med. Assoc. 130: 381 383.
137. Rebhun, W. C.,, T. W. French,, J. A. Perdrizet,, E. J. Dubovi,, S. G. Dill,, and L. F. Karcher. 1989. Thrombocytopenia associated with acute bovine virus diarrhea infection in cattle. J. Vet. Intern. Med. 3: 42 46.
138. Richer, L.,, P. Marois,, and L. Lamontagne. 1988. Association of bovine viral diarrhea virus with multiple viral infections in bovine respiratory disease outbreaks. Can. Vet. J. 29: 713 717.
139. Ridpath, J. F.,, and S. R. Bolin. 1995. Delayed onset postvaccinal mucosal disease as a result of genetic recombination between genotype 1 and genotype 2 BVDV. Virology 212: 259 262.
140. Ridpath, J. F.,, and S. R. Bolin. 1991. Hybridization analysis of genomic variability among isolates of bovine viral diarrhoea virus using cDNA probes. Mol. Cell. Probes 5: 291 298.
141. Ridpath, J. F.,, T. L. Lewis,, S. R. Bolin,, and E. S. Berry. 1991. Antigenic and genomic comparison between non-cytopathic and cytopathic bovine viral diarrhoea viruses isolated from cattle that had spontaneous mucosal disease. J. Gen. Virol. 72: 725 729.
142. Roeder, P. L.,, and T. W. Drew. 1984. Mucosal disease of cattle: a late sequel to fetal infection. Vet. Rec. 114: 309 313.
143. Rosenquist, B. D.,, J. E. English,, D. W. Johnson,, and R. W. Loan. 1970. Mixed viral etiology of a shipping fever epizootic in cattle. Am. J. Vet. Res. 31: 989 994.
144. Rosner, S. F. 1968. Complications following vaccination of cattle against infectious bovine rhinotracheitis, bovine viral diarrhea-mucosal disease, and parainfluenza type 3. J. Am. Vet. Med. Assoc. 152: 898 902.
145. Rossi, C. R.,, and G. K. Kiesel. 1977. Susceptibility of bovine macrophage and tracheal-ring cultures to bovine viruses. Am. J. Vet. Res. 38: 1705 1708.
146. Roth, J. A.,, S. R. Bolin,, and D. E. Frank. 1986. Lymphocyte blastogenesis and neutrophil function in cattle persistently infected with bovine viral diarrhea virus. Am. J. Vet. Res. 47: 1139 1141.
147. Roth, J. A.,, and M. L. Kaeberle. 1983. Suppression of neutrophil and lymphocyte function induced by a vaccinal strain of bovine viral diarrhea virus with and without the admin- istration of ACTH. Am. J. Vet. Res. 44: 2366 2372.
148. Roth, J. A.,, M. L. Kaeberle,, and R. W. Griffith. 1981. Effects of bovine viral diarrhea virus infection on bovine polymorphonuclear leukocyte function. Am. J. Vet. Res. 42: 244 250.
149. Schweizer, M.,, and E. Peterhans. 2001. Noncytopathic bovine viral diarrhea virus inhibits double-stranded RNA-induced apoptosis and interferon synthesis. J. Virol. 75: 4692 4698.
150. Schweizer, M.,, and E. Peterhans. 1999. Oxidative stress in cells infected with bovine viral diarrhoea virus: a crucial step in the induction of apoptosis. J. Gen. Virol. 80: 1147 1155.
151. Sentsui, H.,, T. Nishimori,, R. Kirisawa,, and A. Morooka. 2001. Mucosal disease induced in cattle persistently infected with bovine viral diarrhea virus by antigenically different cytopathic virus. Arch. Virol. 146: 993 1006.
152. Shimizu, M.,, K. Satou,, N. Nishioka,, T. Yoshino,, E. Momotani,, and Y. Ishikawa. 1989. Serological characterization of viruses isolated from experimental mucosal disease. Vet. Microbiol. 19: 13 21.
153. Sopp, P.,, L. B. Hooper,, M. C. Clarke,, C. J. Howard,, and J. Brownlie. 1994. Detection of bovine viral diarrhoea virus p80 protein in subpopulations of bovine leukocytes. J. Gen. Virol. 75: 1189 1194.
154. Steck, F.,, S. Lazary,, H. Fey,, A. Wandeler,, C. Huggler,, G. Oppliger,, H. Baumberger,, R. Kaderli,, and J. Martig. 1980. Immune responsiveness in cattle fatally affected by bovine virus diarrhea-mucosal disease. Zentrbl. Vetmed. Reine B 27: 429 445.
155. Taylor, L. F.,, J. Van Donkersgoed,, E. J. Dubovi,, R. J. Harland,, J. V. van den Hurk,, C. S. Ribble,, and E. D. Janzen. 1995. The prevalence of bovine viral diarrhea virus infection in a population of feedlot calves in western Canada. Can. J. Vet. Res. 59: 87 93.
156. Taylor, L. F.,, J. Van Donkersgoed,, O. M. Radostits,, C. W. Booker,, E. J. Dubovi,, J. V. van den Hurk,, and E. D. Janzen. 1994. Investigation of an outbreak of mucosal disease in a beef cattle herd in southwestern Saskatchewan. Can. Vet. J. 35: 425 432.
157. Teichmann, U.,, E. M. Liebler-Tenorio,, and J. F. Pohlenz. 2000. Ultrastructural changes in follicles of small-intestinal aggregated lymphoid nodules in early and advanced phases of experimentally induced mucosal diseases in calves. Am. J. Vet. Res. 61: 174 182.
158. Thoen, C. O.,, and K. J. Waite. 1990. Some immune responses in cattle exposed to Mycobacterium paratuberculosis after injection with modified-live bovine viral diarrhea virus vaccine. J. Vet. Diagn. Investig. 2: 176 179.
159. Underdahl, N. R.,, O. D. Grace,, and A. B. Horlein. 1957. Cultivation of a cytopathogenic agent from bovine mucosal disease. Proc. Soc. Exp. Biol. Med. 94: 795 797.
160. van Regenmortel, M. H. V.,, C. M. Fauquet,, D. H. L. Bishop,, E. B. Carstens,, M. K. Estes,, S. M. Lemon,, J. Maniloff,, M. A. Mayo,, D. J. McGeoch,, C. R. Pringle,, and R. B. Wickner (ed.). 2000. Virus Taxonomy: Classification and Nomenclature of Viruses. Seventh Report of the International Committee on Taxonomy of Viruses. Academic Press, San Diego, Calif.
161. Vassilev, V. B.,, and R. O. Donis. 2000. Bovine viral diarrhea virus induced apoptosis correlates with increased intracellular viral RNA accumulation. Virus Res. 69: 95 107.
162. Vilcek, S.,, I. Greiser-Wilke,, P. Nettleton,, and D. J. Paton. 2000. Cellular insertions in the NS2-3 genome region of cytopathic bovine viral diarrhoea virus (BVDV) isolates. Vet. Microbiol. 77: 129 136.
163. Walz, P. H.,, T. G. Bell,, J. L. Wells,, D. L. Grooms,, L. Kaiser,, R. K. Maes,, and J. C. Baker. 2001. Relationship between degree of viremia and disease manifestation in calves with experimentally induced bovine viral diarrhea virus infection. Am. J. Vet. Res. 62: 1095 1103.
164. Welsh, M. D.,, B. M. Adair,, and J. C. Foster. 1995. Effect of BVD virus infection on alveolar macrophage functions. Vet. Immunol. Immunopathol. 46: 195 210.
165. Westenbrink, F.,, P. J. Straver,, T. G. Kimman,, and P. W. de Leeuw. 1989. Development of a neutralising antibody response to an inoculated cytopathic strain of bovine virus diarrhoea virus. Vet. Rec. 125: 262 265.
166. Wilhelmsen, C. L.,, S. R. Bolin,, J. F. Ridpath,, N. F. Cheville,, and J. P. Kluge. 1990. Experimental primary postnatal bovine viral diarrhea viral infections in six-month-old calves. Vet. Pathol. 27: 235 243.
167. Wilhelmsen, C. L.,, S. R. Bolin,, J. F. Ridpath,, N. F. Cheville,, and J. P. Kluge. 1991. Lesions and localization of viral antigen in tissues of cattle with experimentally induced or naturally acquired mucosal disease, or with naturally acquired chronic bovine viral diarrhea. Am. J. Vet. Res. 52: 269 275.
168. Wittum, T. E.,, D. M. Grotelueschen,, K. V. Brock,, W. G. Kvasnicka,, J. G. Floyd,, C. L. Kelling,, and K. G. Odde. 2001. Persistent bovine viral diarrhoea virus infection in US beef herds. Prev. Vet. Med. 49: 83 94.
169. Woods, R. D.,, R. A. Kunkle,, J. F. Ridpath,, and S. R. Bolin. 1999. Bovine viral diarrhea virus isolated from fetal calf serum enhances pathogenicity of attenuated transmissible gastroenteritis virus in neonatal pigs. J. Vet. Diagn. Investig. 11: 400 407.
170. Wray, C.,, and P. L. Roeder. 1987. Effect of bovine virus diarrhoea-mucosal disease virus infection on salmonella infection in calves. Res. Vet. Sci. 42: 213 218.
171. Zhang, G.,, S. Aldridge,, M. C. Clarke,, and J. W. McCauley. 1996. Cell death induced by cytopathic bovine viral diarrhoea virus is mediated by apoptosis. J. Gen. Virol. 77: 1677 1681.

Tables

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TABLE 1

Origin of cytopathic BVDV in cattle persistently infected with noncytopathic BVDV, form of mucosal disease induced, production of virus-neutralizing antibody, and viral isolation post mortem

Citation: Bolin S. 2002. Bovine Viral Diarrhea Virus in Mixed Infections, p 33-50. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch3

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