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Chapter 5 : Concomitant Infections with Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Types 1 and 2

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Concomitant Infections with Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Types 1 and 2, Page 1 of 2

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Abstract:

Two distinct families of human retroviruses, the human immunodeficiency viruses (HIVs) and human T-lymphotropic viruses (HTLVs), cause significant infections worldwide. The viruses have common modes of transmission, both vertically and horizontally, and share an in vivo tropism for cells of the immune system, and in particular, T lymphocytes. As a result a significant number of individuals worldwide have coinfection. At present, it is unclear if coinfection influences the natural history of infection or alters the pathogenicity of an individual virus and/or if this results in the development of unique clinical features. This chapter summarizes one's current understanding of these issues with a specific focus on the influence of the HTLVs on the progression and outcome of HIV type 1 (HIV-1) infection. In contrast to HTLV type 1 (HTLV-1), the role of HTLV type 2 (HTLV-2) in human disease remains poorly defined; however, increasing evidence shows that the infection may also be associated with rare lymphoproliferative and a spectrum of neurological disorders. In addition, several epidemiological studies have suggested that underlying HTLV-2 infection may predispose to the development of a wide range of bacterial infections. The major limitations of many of these studies are that they have often been based on individual case reports and that many patients have also had concomitant HIV-1 infection. The chapter summarizes the clinical disorders that have been associated with HTLV-2 infection, and discusses the role and impact of HIV-1 coinfection.

Citation: Araujo A, Sheehy N, Hall W, Takahashi H. 2002. Concomitant Infections with Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Types 1 and 2, p 75-97. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch5

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References

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1. Arango, C.,, E. Maloney,, M. T. Rugeles,, E. Bernal,, C. Bernal,, I. Borrero,, S. Herrera,, M. Restrepo,, A. Espinal,, and W. A. Blattner. 1999. HTLV-I and HTLV-II coexist among the Embera and Inga Amerindians of Colombia. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 20:102103.
2. Baba, M.,, T. Imai,, T. Yoshida,, and O. Yoshie. 1996. Constitutive expression of various chemokine genes in human T-cell lines infected with human T-cell leukemia virus type 1: role of the viral transactivator Tax. Int. J. Cancer 66:124129.
3. Bartholomew, C.,, W. Blattner,, and F. Cleghorn. 1987. Progression to AIDS in homosexual men co-infected with HIV and HTLV-I in Trinidad. Lancet ii:1469.
4. Bazarbachi, A.,, and O. Hermine. 2001. Treatment of adult T-cell leukaemia/lymphoma: current strategy and future perspectives. Virus Res. 78:7992.
5. Beilke, M. A.,, S. Japa,, and D. G. Vinson. 1998. HTLV-I and HTLV-II virus expression increase with HIV-1 coinfection. J. Acquir. Immune Defic. Syndr. Hum. Retrovir. 15:391397.
6. Berger, J. R.,, S. Raffanti,, A. Svenningsson,, M. McCarty,, S. Snodgrass,, and L. Resnick. 1991. The role of HLTV in HIV-1 neurologic disease. Neurology 41:197202.
7. Berger, J. R.,, A. Svenningsson,, S. Raffanti,, and L. Resnick. 1991. Tropical spasticparaparesis- like illness occurring in a patient dually infected with HIV-1 and HTLV-II. Neurology 41:8587.
8. Bessinger, R.,, M. Beilke,, P. Kissinger,, C. Jarrott,, and O. F. Tabak. 1997. Retroviral coinfections at a New Orleans HIV outpatient clinic. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 14:6771.
9. Biddison, W. E.,, R. Kubota,, T. Kawanishi,, D. D. Taub,, W. W. Cruikshank,, D. M. Center,, E. W. Connor,, U. Utz,, and S. Jacobson. 1997. Human T cell leukemia virus type I (HTLV-I)-specific DC8+ clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase. J. Immunol. 159:20182025..
10. Biggar, R. J.,, Z. Buskell-Bales,, P. N. Yakshe,, D. Caussy,, G. Gridley,, and L. Seeff. 1991. Antibody to human retroviruses among drug users in three east coast American cities, 1972-1976. J. Infect. Dis. 16:5763.
11. Biggar, R. J.,, M. E. Taylor,, J. V. Neel,, B. Hjelle,, P. H. Levine,, F. L. Black,, G. M. Shaw,, P. M. Sharp,, and B. H. Hahn. 1996. Genetic variants of human T-lymphotropic virus type II in American Indian groups. Virology 216:165173.
12. Biglione, M.,, A. Gessain,, S. Quiruelas,, O. Fay,, M. A. Taborda,, E. Fernandez,, S. Lupo,, A. Panzita,, and G. de The. 1993. Endemic HTLV-II infection among Tobas and Matacos Amerindians from North Argentina. J. Acquir. Immune Defic. Syndr. 6:631633.
13. Black, F. L.,, R. J. Biggar,, R. B. Lal,, A. A. Gabbai,, and J. P. Filho. 1996. Twenty-five years of HTLV type II follow-up with a possible case of tropical spastic paraparesis in the Kayapo, a Brazilian Indian tribe. AIDS Res. Hum. Retrovir. 12:16231627.
14. Black, F. L.,, R. J. Biggar,, J. V. Neel,, E. M. Maloney,, and D. J. Waters. 1994. Endemic transmission of HTLV type II among Kayapo Indans of Brazil. AIDS Res. Hum. Retrovir. 10: 11651171.
15. Böhnlein, E.,, M. Siekevitz,, D. W. Ballard,, J. W. Lowenthal,, L. Rimsky,, H. Rogerd,, J. Hoffman,, Y. Wano,, B. R. Franza,, and W. C. Greene. 1989. Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins. J. Virol. 63:15781586.
16. Brabin, L.,, B. J. Brabin,, R. R. Doherty,, I. D. Gust,, M. P. Alpers,, R. Fujino,, J. Imai,, and Y. Hinuma. 1989. Patterns of migration indicate sexual transmission of HTLV-I infection in non-pregnant women in Papua New Guinea. Int. J. Cancer 44:5962.
17. Brauweiler, A.,, J. E. Garrus,, J. C. Reed,, and J. K. Nyborg. 1997. Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells. Virology 231:135140.
18. Briggs, N. C.,, R. J. Battjes,, K. P. Cantor,, W. A. Blattner,, F. M. Yellin,, S. Wilson,, A. L. Ritz,, S. H. Weiss,, and J. J. Goedert. 1995. Seroprevalence of human T cell lymphotropic virus type II infection, with or without human immunodeficiency virus type 1 coinfection, among US intravenous drug users. J. Infect. Dis. 172:5158.
19. Brites, C.,, W. Harrington, Jr.,, C. Pedroso,, E. Martins-Netto,, and R. Badaro. 1997. Epidemiological characteristics of HTLV-I and II coinfection in Brazilian subjects infected by HIV-1. Braz. J. Infect. Dis. 1:4247.
20. Brites, C.,, C. Pedroso,, E. Netto,, W. Harrington, Jr.,, B. Galvao-Castro,, J. C. Couto- Fernandez,, D. Pedral-Sampaio,, M. Morgado,, R. Teixeira,, and R. Badaro. 1998. Co-infection by HTLV-I/II is associated with increased viral load in PBMC of HIV-1 infected patients in Bahia, Brazil. Braz. J. Infect. Dis. 2:7077..
21. Buttner, A.,, G. Mall,, R. Penning,, and S. Weis. 2000. The neuropathology of heroin abuse. Forensic Sci. Int. 113:435442.
22. Cartier, L.,, F. Araya,, J. L. Castillo,, V. Zaninovic,, M. Hayami,, T. Miura,, J. Imai,, S. Sonoda,, H. Shiraki,, K. Miyamoto,, and K. Tajima. 1993. Southernmost carriers of HTLVI/ II in the world. Jpn. J. Cancer Res. 84:13.
23. Castillo, L. C.,, F. Gracia,, G. C. Roman,, P. Levine,, W. C. Reeves,, and J. Kaplan. 2000. Spinocerebellar syndrome in patients infected with human T-lymphotropic virus types I and II (HTLV-I/HTLV-II): report of 3 cases from Panama. Acta Neurol. Scand. 101:405412.
24. Casoli, C.,, E. Vicenzi,, A. Cimarelli,, G. Magnani,, P. Ciancianaini,, E. Cattaneo,, P. Dall’Aglio,, G. Poli,, and U. Bertazzoni. 2000. HTLV-II downregulates HIV-1 replication in IL-2-stimulated primary PBMC of coinfected individuals through expression of MIP-1alpha. Blood 95:27602769.
25. Cereseto, A.,, F. Diella,, J. C. Mulloy,, A. Cara,, P. Michieli,, R. Grassmann,, G. Franchini,, and M. E. Klotman. 1996. p 53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells. Blood 88:15511560.
26. Cesaire, R.,, A. Dehee,, A. Lezin,, N. Desire,, O. Bourdonne,, F. Dantin,, O. Bera,, D. Smadja,, S. Abel,, A. Cabie,, G. Sobesky,, and J. C. Nicolas. 2001. Quantification of HTLV type I and HIV type 1 DNA load in coinfected patients: HIV type 1 infection does not alter HTLV type 1 proviral amount in the peripheral blood compartment. AIDS Res. Hum. Retrovir. 17:799805.
27. Cheng, H.,, J. Tarnok,, and W. P. Parks. 1998. Human immunodeficiency virus type 1 genome activation induced by human T-cell leukemia virus type 1 Tax protein is through cooperation of NF-κB and Tat. J. Virol. 72:69116916.
28. Cimarelli, A.,, C. A. Duclos,, A. Gessain,, E. Cattaneo,, C. Casoli,, M. Biglione,, P. Mauclere,, and U. Bertazzoni. 1995. Quantification of HTLV-II proviral copies by competitive polymerase chain reaction in peripheral blood mononuclear cells of Italian injecting drug users, central Africans, and Amerindians. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 10:198204.
29. Cocchi, F.,, A. L. De Vico,, A. Garzino- Demo,, S. K. Arya,, R. C. Gallo,, and P. Lusso. 1995. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:18111815.
30. Connor, R. I.,, K. E. Sheridan,, D. Ceradini,, S. Choe,, and N. R. Landau. 1997. Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals. J. Exp. Med. 185:621628.
31. De Cabral, M. B.,, M. E. Vera,, M. Samudio,, A. R. Arias,, A. Cabello,, R. Moreno,, I. Zapiola,, M. B. Bouzas,, and G. Muchinik. 1998. HTLV-I/II antibodies among three different Indian groups from Paraguay. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 19:548549.
32. Delaporte, E.,, J. Louwagie,, M. Peeters,, N. Montplaisir,, L. d’Auriol,, Y. Ville,, L. Bedjabaga,, B. Larouze,, G. Van der Groen,, and P. Piot. 1991. Evidence of HTLV-II infection in central Africa. AIDS 6:771772.
33. Delaporte, E.,, N. Monplaisir,, J. Louwagie,, M. Peeters,, Y. Martin-Prevel,, J. P. Louis,, A. Trebucq,, L. Bedjabaga,, S. Ossari,, C. Honore,, B. Larouze,, L. Dauriol,, G. Vandergroen,, and P. Piot. 1991. Prevalence of HTLV-I and HTLV-II infection in Gabon, Africa: comparison of the serological and PCR results. Int. J. Cancer 49:373376.
34. De Rossi, A.,, D. Saggioro,, M. L. Calabro,, R. Cenzato,, and L. Chieco-Bianchi. 1991. Reciprocal activation of human T-lymphotropic viruses in HTLV-I-transformed cells superinfected with HIV-1. J. Acquir. Immune Defic. Syndr. 4:380385.
35. Donegan, E.,, M. P. Busch,, J. A. Galleshaw,, G. M. Shaw,, and J. W. Mosley. 1990. Transfusion of blood components from a donor with human T-lymphotropic virus type II (HTLV-II) infection. The Transfusion Safety Study Group. Ann. Intern. Med. 113:555556.
36. Dooneief, G.,, R. Marlink,, K. Bell,, K. Marder,, B. Renjifo,, Y. Stern,, and R. Mayeux. 1996. Neurologic consequences of HTLV-II infection in injection-drug users. Neurology 46:15561560.
37. Dragic, T.,, V. Litwin,, G. P. Allaway,, S. R. Martin,, Y. Huang,, K. A. Nagashima,, C. Cayanan,, P. J. Maddon,, R. A. Koup,, J. P. Moore,, and W. A. Paxton. 1996. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667673.
38. Dube, D. K.,, M. P. Sherman,, N. K. Saksena,, V. Bryz-Gornia,, J. Mendelson,, J. Love,, C. B. Arnold,, T. Spicer,, S. Dube,, J. B. Glaser,, A. E. Williams,, M. Nishimura,, S. Jacobsen,, J. F. Ferrer,, N. Del Pino,, S. Quiruelas,, and B. J. Poiesz. 1993. Genetic heterogeneity in human T-cell leukemia/lymphoma virus type II. J. Virol. 67:11751184.
39. Duenas-Barajas, E.,, J. E. Bernal,, D. R. Vaught,, I. Briceno,, C. Duran,, R. Yanagihara,, and D. C. Gajdusek. 1992. Coexistence of human T-lymphotropic virus types I and II among the Wayuu Indians from the Guajira Region of Colombia. AIDS Res. Hum. Retrovir. 8:18511855.
40. Egan, J. F.,, B. O’Leary,, M. J. Lewis,, F. Mulcahy,, N. Sheehy,, H. Hasegawa,, F. Fitzpatrick,, J. J. O’Connor,, J. O’Riordan,, and W. W. Hall. 1999. High rate of human T lymphotropic virus type IIa infection in HIV type 1- infected intravenous drug abusers in Ireland. AIDS Res. Hum. Retrovir. 15:699705.
41. Ehrlich, G. D.,, J. B. Glaser,, K. La Vigne,, D. Quan,, D. Mildvan,, J. J. Sninsky,, S. Kwok,, L. Papsidero,, and B. J. Poiesz. 1989. Prevalence of human T-cell leukemia/lymphoma virus (HTLV) type II infection among high-risk individuals: type-specific identification of HTLVs by polymerase chain reaction. Blood 74:16581664.
42. Eiraku, N.,, P. Novoa,, M. da Costa Ferreira,, C. Monken,, R. Ishak,, O. da Costa Ferreira,, S. W. Zhu,, R. Lorenco,, M. Ishak,, V. Azvedo,, J. Guerreiro,, M. P. de Oliveira,, P. Loureiro,, N. Hammerschlak,, S. Ijichi,, and W. W. Hall. 1996. Identification and characterization of a new and distinct molecular subtype of human T-cell lymphotropic virus type 2. J. Virol. 70:14811492.
43. El-Sabban, M. E.,, R. Nasr,, G. Dbaibo,, O. Hermine,, N. Abboushi,, F. Quignon,, J. C. Ameisen,, F. Bex,, H. de The,, and A. Bazarbachi. 2000. Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with tax down-regulation and reversal of NF-kappa B activation. Blood 96:28492855.
44. Eskild, A.,, H. H. Samdal,, and B. Heger. 1996. Co-infection with HIV-1/HTLV-II and the risk of progression to AIDS and death. The Oslo HIV Cohort Study Group. APMIS 104: 666672.
45. Etzel, A.,, G. Y. Shibata,, M. Rozman,, M. L. Jorge,, C. D. Damas,, and A. A. Segurado. 2001. HTLV-1 and HTLV-2 infections in HIV-infected individuals from Santos, Brazil: seroprevalence and risk factors. J. Acquir. Immune Defic. Syndr. 26:185190.
46. Fantry, L.,, E. De Jonge,, P. G. Auwaerter,, and H. M. Lederman. 1995. Immunodeficiency and elevated CD4 T lymphocyte counts in two patients coinfected with human immunodeficiency virus and human lymphotropic virus type I. Clin. Infect. Dis. 21:14661468.
47. Feigal, E.,, E. Murphy,, K. Vranizan,, P. Bacchetti,, R. Chaisson,, J. E. Drummond,, W. Blattner,, M. McGrath,, J. Greenspan,, and A. Moss. 1991. Human T cell lymphotropic virus types I and II in intravenous drug users in San Francisco: risk factors associated with seropositivity. J. Infect. Dis. 164:3642.
48. Ferrer, J. F.,, N. Del Pino,, E. Esteban,, M. P. Sherman,, S. Dube,, D. K. Dube,, M. A. Basombrio,, E. Pimentel,, A. Segovia,, S. Quirulas,, and B. J. Poiesz. 1993. High rate of infection with the human T-cell leukemia retrovirus type II in four Indian populations of Argentina. Virology 197:576584.
49. Franchini, G. 1995. Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection. Blood 86:36193639.
50. Froment, A.,, E. Delaporte,, M. C. Dazza,, and B. Larouze. 1993. HTLV-II among pygmies from Cameroon. AIDS Res. Hum. Retrovir. 9:707.
51. Fujiyama, C.,, T. Fujiyoshi,, T. Miura,, S. Yashiki,, D. Matsumoto,, V. Zaninovic,, O. Blanco,, W. Harrington, Jr.,, J. J. Byrnes,, M. Hayami,, K. Tajima,, and S. Sonoda. 1993. A new endemic focus of human T lymphotropic virus type II carriers among Orinoco natives in Colombia. J. Infect. Dis. 168:10751077.
52. Fukushima, Y.,, M. J. Lewis,, C. Monken,, K. Komuro,, S. Kusagawa,, H. Sato,, Y. Takebe,, S. Yamazaki,, T. H. Nguyen,, A. Hoang,, T. L. Hoang,, M. Honda,, and W. W. Hall. 1998. Identification and molecular characterization of human T lymphotropic virus type II infections in intravenous drug abusers in the former South Vietnam. AIDS Res. Hum. Retrovir. 14:537540.
53. Fukushima, Y.,, H. Takahashi,, W. W. Hall,, T. Nakasone,, S. Nakata,, P. Song,, D. D. Duc,, B. Hien,, N. X. Quang,, T. N. Trinh,, K. Nishioka,, K. Kitamura,, K. Komuro,, A. Vahlne,, and M. Honda. 1995. Extraordinary high rate of HTLV type II seropositivity in intravenous drug abusers in south Vietnam. AIDS Res. Hum. Retrovir. 11:637645.
54. Garcia-Lerma, J. G.,, S. Nidtha,, and W. Heneine. 2001. Susceptibility of human T cell leukemia virus type 1 to reverse-transcriptase inhibitors: evidence for resistance to lamivudine. J. Infect. Dis. 184:507510.
55. Gasmi, M.,, S. Fillon,, K. Leriche,, C. Neisson- Vernant,, and C. Desgranges. 1997. Zidovudine treatment is not associated with HTLV- 1 reverse transcriptase gene mutations in HTLV-I/HIV-1 co-infected patients. Antivir. Ther. 2:9197.
56. Gessain, A.,, F. Barin,, J. C. Vernant,, O. Gout,, L. Maurs,, A. Calender,, and G. de The. 1985. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet ii:407410.
57. Gessain, A.,, P. Mauclere,, A. Froment,, M. Biglione,, J. Y. Le Hesran,, F. Tekaia,, J. Millan,, and G. de The. 1995. Isolation and molecular characterization of a human T-cell lymphotropic virus type II (HTLV-II), subtype B, from a healthy Pygmy living in a remote area of Cameroon: an ancient origin for HTLV-II in Africa. Proc. Natl. Acad. Sci. USA 25:40414045.
58. Giacomo, M.,, E. G. Franco,, C. Claudio,, C. Carlo,, D. A. Anna,, D. Anna,, and F. Franco. 1995. Human T-cell leukemia virus type II infection among high risk groups and its influence on HIV-1 disease progression. Eur. J. Epidemiol. 11:527533.
59. Gill, P. S.,, W. Harrington, Jr.,, M . H. Kaplan,, R. C. Ribeiro,, J. M. Bennett,, H. A. Liebman,, M. Bernstein-Singer,, B. M. Espina,, L. Cabral,, S. Allen,, S. Kornblau,, M. C. Pike,, and A. M. Levine. 1995. Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine. N. Engl. J. Med. 332:17441748.
60. Giri, A.,, P. Markham,, L. Digilio,, G. Hurteau,, R. C. Gallo,, and G. Franchini. 1994. Isolation of a novel simian T-cell lymphotropic virus from Pan paniscus that is distantly related to the human T-cell leukemia/lymphotropic virus types I and II. J. Virol. 68: 83928395.
61. Goedert, J. J.,, M. W. Fung,, S. Felton,, R. J. Battjes,, and E. A. Engels. 2001. Cause-specific mortality associated with HIV AND HTLV-II infections among injecting drug users in the USA. AIDS 15:12951302.
62. Gongora-Biachi, R. A.,, R. B. Lal,, D. L. Rudolph,, C. Castro-Sansores,, P. Gonzalez- Martinez,, and N. Pavia-Ruz. 1997. Low prevalence of HTLV-II in Mayan Indians in the Yucatan Peninsula, Mexico. Arch. Med. Res. 28:555558.
63. Gotuzzo, E.,, J. Escamilla,, I. A. Phillips,, J. Sanchez,, F. S. Wignall,, and J. Antigoni. 1992. The impact of human T-lymphotrophic virus type I/II infection on the prognosis of sexually acquired cases of acquired immunodeficiency syndrome. Arch. Intern. Med. 152:14291432.
64. Goubau, P.,, J. Desmyter,, J. Ghesquiere,, and B. Kasereka. 1992. HTLV-II among pygmies. Nature 359:201.
65. Goubau, P.,, H. F. Liu,, G. G. De Lange,, A. M. Vandamme,, and J. Desmyter. 1993. HTLV-II seroprevalence in pygmies across Africa since 1970. AIDS Res. Hum. Retrovir. 9:709713.
66. Goubau, P.,, A. Vandamme,, K. Beuselinck,, and J. Desmyter. 1996. Proviral HTLV-I and HTLV-II in the Efe pygmies of northeastern Zaire. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12:208209.
67. Gout, O.,, A. Gessain,, M. Iba-Zizen,, S. Kouzan,, F. Bolgert,, G. de The,, and O. Lyon-Caen. 1991. The effect of zidovudine on chronic myelopathy associated with HTLV-1. J. Neurol. 238:108109.
68. Grassmann, R.,, C. Dengler,, I. Muller- Fleckenstein,, B. Fleckenstein,, K. McGuire,, M. C. Dokhelar,, J. G. Sodroski,, and W. A. Haseltine. 1989. Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc. Natl. Acad. Sci. USA 86:33513355.
69. Guimaraes, M. L.,, F. I. Bastos,, P. R. Telles,, B. Galvao-Castro,, R. S. Diaz,, V. Bongertz,, and M. G. Morgado. 2001. Retrovirus infections in a sample of injecting drug users in Rio de Janeiro City, Brazil: prevalence of HIV-1 subtypes, and co-infection with HTLV-I/II. J. Clin. Virol. 21:143151.
70. Hall, W. W.,, R. Ishak,, S. W. Zhu,, P. Novoa,, N. Eiraku,, H. Takahashi,, M. D. Ferreira,, V. Azevedo,, M. O. Ishak,, O. D. Ferreira,, C. Monken,, and T. Kurata. 1996. Human T lymphotropic virus type II (HTLV-II): epidemiology, molecular properties, and clinical features of infection. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 13:204214.
71. Hall, W. W.,, M. H. Kaplan,, S. Z. Salahuddin,, N. Oyaizu,, C. Gurgo,, M. Coronesi,, K. Nagashima,, and R. C. Gallo,. 1990. Concomitant infections with human T-cell leukemia viruses (HTLVs) and human immunodeficiency virus (HIV): identification of HTLV-II infection in intravenous drug abusers (IVDUs), p. 115127. In W. A. Blattner (ed.), Human Retrovirology: HTLV. Raven Press, New York, N.Y.
72. Hall, W. W.,, H. Takahashi,, C. Liu,, M. H. Kaplan,, O. Scheewind,, S. Ijichi,, K. Nagashima,, and R. C. Gallo. 1992. Multiple isolates and characteristics of human T-cell leukemia virus type II. J. Virol. 66:24562463.
73. Harrington, W. Jr.,, W. Sheremata,, B. Hjelle,, D. K. Dube,, P. Bradshaw,, S. K. H. Foung,, S. Snodgrass,, A. Towdter,, L. Cabral,, and B. Poiesz. 1993. Spastic ataxia associated with human T-cell lymphotropic virus type II infection. Ann. Neurol. 33:411414.
74. Harrison, L. H.,, T. C. Quinn,, and M. Schechter. 1997. Human T cell lymphotropic virus type I does not increase human immunodeficiency virus viral load in vivo. J. Infect. Dis. 175:438440.
75. Harrison, L. H.,, B. Vaz,, D. M. Taveira,, T. C. Quinn,, C. J. Gibbs,, S. H. de Souza,, J. C. McArthur,, and M. Schechter. 1997. Myelopathy among Brazilians coinfected with human T-cell lymphotropic virus type I and HIV. Neurology 48:1318.
76. Hattori, T.,, A. Koito,, K. Takatsuki,, S. Ikematsu,, J. Matsuda,, H. Mori,, M. Fukui,, K. Akashi,, and K. Matsumoto. 1989. Frequent infection with human T-cell lymphotropic virus type I in patients with AIDS but not in carriers of human immunodeficiency virus type 1. J. Acquir. Immune Defic. Syndr. 2:272276.
77. Hermine, O.,, D. Bouscary,, A. Gessain,, P. Turlure,, V. Leblond,, N. Franck,, A. Buzyn- Veil,, B. Rio,, E. Macintyre,, F. Dreyfus,, and A. Bazarbachi. 1995. Brief report: treatment of adult T-cell leukemia-lymphoma with zidovudine and interferon alfa. N. Engl. J. Med. 332: 17491751.
78. Hershow, R. C.,, N. Galai,, K. Fukuda,, J. Graber,, D. Vlahov,, G. Rezza,, R. S. Klein,, D. C. Des Jarlais,, C. Vitek,, R. Khabbaz,, S. Freels,, R. Zuckerman,, P. Pezzotti,, and J. E. Kaplan. 1996. An international collaborative study of the effects of coinfection with human T-lymphotropic virus type II on human immunodeficiency virus type 1 disease progression in injection drug users. J. Infect. Dis. 174:309317.
79. Hino, S.,, K. Yamaguchi,, S. Katamine,, H. Sugiyama,, T. Amagasaki,, K. Kinoshita,, Y. Yoshida,, H. Doi,, Y. Tsuji,, and T. Miyamoto. 1985. Mother-to-child transmission of human T-cell leukemia virus type-I. Jpn. J. Cancer Res. 76:474480.
80. Hjelle, B.,, O. Appenzeller,, R. Mills,, S. Alexander,, N. Torrez-Martinez,, R. Jahnke,, and G. Ross. 1992. Chronic neurodegenerative disease associated with HTLV-II infection. Lancet 339:645646.
81. Hjelle, B.,, S. Cyrus,, and S. G. Swenson. 1992. Evidence for sexual transmission of human T lymphotropic virus type II. Ann. Intern. Med. 116:9091.
82. Hjelle, B.,, R. Mills,, G. Mertz,, and S. Swenson. 1990. Transmission of HTLV-II via blood transfusion. Vox Sang. 59:119122.
83. Hjelle, B.,, S. W. Zhu,, H. Takahashi,, S. Ijichi,, and W. W. Hall. 1993. Endemic human T cell leukemia virus type II infection in southwestern US Indians involves two prototype variants of virus. J. Infect. Dis. 168:737740.
84. Ibrahim, F.,, G. de The,, and A. Gessain. 1995. Isolation and characterization of a new simian T-cell leukemia virus type 1 from naturally infected Celebes macaques (Macaca tonkeana): complete nucleotide sequence and phylogenetic relationship with the Australo-Melanesian human T-cell leukemia virus type 1. J. Virol. 69:69806993.
85. Ijichi, S.,, M. B. Ramundo,, H. Takahashi,, and W. W. Hall. 1992. In vivo cellular tropism of human T cell leukemia virus type II (HTLV-II). J. Exp. Med. 176:293296.
86. Ijichi, S.,, K. Tajima,, V. Zaninovic,, F. E. Leon,, Y. Katahira,, S. Sonoda,, T. Miura,, M. Hayami,, and W. W. Hall. 1993. Identification of human T cell leukemia virus type IIb infection in the Wayu, an aboriginal population of Colombia. Jpn. J. Cancer Res. 84:12151218.
87. Ishak, R.,, W. J. Harrington,, V. N. Azevedo,, N. Eiraku,, M. O. G. Ishak,, J. F. Guerreiro,, S. B. Santos,, T. Kubo,, C. Monken,, S. Alexander,, and W. W. Hall. 1995. Identification of human T cell lymphotropic virus type IIa infection in the Kayapo, an indigenous population of Brazil. AIDS Res. Hum. Retrovir. 11:813821.
88. Jacobson, S.,, T. Lehky,, M. Nishimura,, S. Robinson,, and D. E. McFarlin. 1993. Isolation of HTLV-II from a patient with chronic progressive neurological disease indistinguishable from HTLV-I associated myelopathy/tropical spastic paraparesis. Ann. Neurol. 33:392395.
89. Jeffery, K. J.,, A. A. Siddiqui,, M. Bunce,, A. L. Lloyd,, A. M. Vine,, A. D. Witkover,, S. Izumo,, K. Usuku,, K. I. Welsh,, M. Osame,, and C. R. Bangham. 2000. The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection. J. Immunol. 165:72787284.
90. Jeffery, K. J.,, K. Usuku,, S. E. Hall,, W. Matsumoto,, G. P. Taylor,, J. Procter,, M. Bunce,, G. S. Ogg,, K. I. Welsh,, J. N. Weber,, A. L. Lloyd,, M. A. Nowak,, M. Nagai,, M. D. Kodama,, S. Izumo,, M. Osame,, and C. R. Bangham. 1999. HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc. Natl. Acad. Sci. USA 96:38483853.
91. Jin, D. Y.,, F. Spencer,, and K. T. Jeang. 1998. Human T cell leukemia virus type 1 oncoprotein Tax targets in human mitotic checkpoint protein MAD1. Cell 93:8191.
92. Kajiyama, W.,, S. Kashiwagi,, J. Hayashi,, H. Nomura,, H. Ikematsu,, and K. Okochi. 1986. Intrafamilial clustering of anti-ATLA-positive persons. Am. J. Epidemiol. 124:800806.
93. Kalyanaraman, V. S.,, M. G. Sarngadharan,, M. Robert-Guroff,, I. Miyoshi,, D. Golde,, and R. C. Gallo. 1982. A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science 218:571573.
94. Kaplan, J. E.,, E. Abrams,, N. Shaffer,, R. O. Cannon,, A. Kaul,, K. Krasinski,, M. Bamji,, T. M. Hartley,, B. Roberts,, B. Kilbourne,, P. Thomas,, M. Rogers,, W. Heneine, and The NYC Perinatal HIV Transmission Collaborative Study. 1992. Low risk of mother-to-child transmission of human T lymphotropic virus type II in non-breast-fed infants. J. Infect. Dis. 166: 892895.
95. Kaplan, J. E.,, R. F. Khabbaz,, E. L. Murphy,, S. Hermansen,, C. Roberts,, R. Lal,, W. Heneine,, D. Wright,, L. Matijas,, R. Thomson,, D. Rudolph,, W. M. Switzer,, S. Kleinman,, M. Busch,, and G. B. Schreiber. 1996. Male-to-female transmission of human T-cell lymphotropic virus types I and II: association with viral load. The Retrovirus Epidemiology Donor Study Group. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12:193201.
96. Kaplan, M. H.,, W. W. Hall,, M. Susin,, S. Pahwa,, S. Z. Salahuddin,, C. Heilman,, J. Fetten,, M. Coronesi,, B. F. Farber,, and S. Smith. 1991. Syndrome of severe skin disease, eosinophilia, and dermatopathic lymphadenopathy in patients with HTLV-II complicating human immunodeficiency virus infection. Am. J. Med. 91:300309.
97. Khabbaz, R. F.,, D. Hartel,, M. Lairmore,, C. R. Horsburgh,, E. E. Schoenbaum,, B. Roberts,, T. M. Hartley,, and G. Friedland. 1991. Human T lymphotropic virus type II (HTLV-II) infection in a cohort of New York intravenous drug users: an old infection? J. Infect. Dis. 163:252256.
98. Khabbaz, R. F.,, I. M. Onorato,, R. O. Cannon,, T. M. Hartley,, B. Roberts,, B. Hosein,, and J. E. Kaplan. 1992. Seroprevalence of HTLV-1 and HTLV-2 among intravenous drug users and persons in clinics for sexually transmitted diseases. N. Engl. J. Med. 326:375380.
99. Kusuhara, K.,, S. Sonoda,, K. Takahashi,, K. Tokugawa,, J. Fukushige,, and K. Ueda. 1987. Mother-to-child transmission of human T-cell leukemia virus type I (HTLV-I): a fifteen-year follow-up study in Okinawa, Japan. Int. J. Cancer. 40:755757.
100. Lairmore, M. D.,, S. Jacobson,, F. Gracia,, B. K. De,, L. Castillo,, M. Arreategui,, B. D. Roberts,, P. H. Levine,, W. A. Blattner,, and J. E. Kaplan. 1990. Isolation of human T-cell lymphotropic virus type 2 from Guaymi Indians in Panama. Proc. Natl. Acad. Sci. USA 87:88408844.
101. Lal, R. B.,, R. A. Gongora-Biachi,, D. Pardi,, W. M. Switzer,, I. Goldman,, and A. F. Lal. 1993. Evidence for mother-to-child transmission of human T lymphotropic virus type II. J. Infect. Dis. 168:586591.
102. Lal, R. B.,, S. M. Owen,, D. L. Rudolph,, C. Dawson,, and H. Prince. 1995. In vivo cellular tropism of human T-lymphotropic virus type II is not restricted to CD8+ cells. Virology 210:441447.
103. Lal, R. B.,, D. Rudolph,, C. Buckner,, D. Pardi,, and W. C. Hooper. 1993. Infection with human T-lymphotropic viruses leads to constitutive expression of leukemia inhibitory factor and interleukin-6. Blood 81:18271832.
104. Lawson, V. A.,, J. Y. Lee,, J. C. Doultree,, J. A. Marshall,, and D. A. Mc Phee. 2000. Visualisation of phenotypically mixed HIV-1 and HTLV-I virus particles by electron microscopy. J. Biomed. Sci. 7:7174.
105. Lee, H.,, K. B. Idler,, P. Swanson,, J. J. Aparicio,, K. K. Chin,, J. P. Lax,, M. Nguyen,, T. Mann,, G. Leckie,, A. Zanetti,, G. Marinucci,, I. S. Y. Chen,, and J. D. Rosenblatt. 1993. Complete nucleotide sequence of HTLV-II isolate NRA: comparison of envelope sequence variation of HTLV-II isolates from U.S. blood donors and U.S. and Italian i.v. drug users. Virology 196:5769.
106. Lee, H. H.,, P. Swanson,, J. D. Rosenblatt,, I. S. Y. Chen,, W. C. Sherwood,, D. E. Smith,, G. E. Tegtmeier,, L. P. Fernando,, C. T. Fang,, M. Osame,, and S. H. Kleinman. 1991. Relative prevalence and risk factors of HTLV-I and HTLV-II infection in US blood donors. Lancet 337:14351439.
107. Lee, H.,, P. Swanson,, V. S. Shorty,, J. A. Zack,, J. D. Rosenblatt,, and I. S. Chen. 1989. High rate of HTLV-II infection in seropositive i.v. drug abusers in New Orleans. Science 244:471475.
108. Lefrere, J. J.,, A. M. Courouce,, M. Mariotti,, E. Wattel,, O. Prou,, F. Bouchardeau,, and P. Lambin. 1990. Rapid progression to AIDS in dual HIV-1/HTLV-I infection. Lancet 336:509.
109. Lehky, T. J.,, N. Flerlage,, D. Katz,, S. Houff,, W. W. Hall,, K. Ishii,, C. Monken,, S. Dhib-Jalbut,, H. F. McFarland,, and S. Jacobson. 1996. Human T-cell lymphotropic virus type II-associated myelopathy: clinical and immunologic profiles. Ann. Neurol. 40:714723.
110. Leon-Ponte, M.,, O. Noya,, N. Bianco,, and G. Echeverria de Perez. 1996. Highly endemic human T-lymphotropic virus type II (HTLV-II) infection in a Venezuelan Guahibo Amerindian group. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 13:281286.
111. Levine, P. H.,, S. Jacobson,, R. Elliott,, A. Cavallero,, G. Colclough,, C. Dorry,, C. Stephenson,, R. M. Knigge,, J. Drummond,, M. Nishimura,, M. E. Taylor,, S. Wiktor,, and G. M. Shaw. 1993. HTLV-II infection in Florida Indians. AIDS Res. Hum. Retrovir. 9:123127.
112. Lewis, M. J.,, V. W. Gautier,, X. P. Wang,, M. H. Kaplan,, and W. W. Hall. 2000. Spontaneous production of C-C chemokines by individuals infected with human T lymphotropic virus type II (HTLV-II) alone and HTLVII/ HIV-1 co-infected individuals. J. Immunol. 165:41274132.
113. Lewis, M. J.,, P. Novoa,, R. Ishak,, M. Ishak,, M. Salemi,, A. M. Vandamme,, M. H. Kaplan,, and W. W. Hall. 2000. Isolation, cloning, and complete nucleotide sequence of a phenotypically distinct Brazilian isolate of human T-lymphotropic virus type II (HTLV-II). Virology 271:142154.
114. Lin, M. T.,, B. T. Nguyen,, T. V. Binh,, T. V. Be,, T. Y. Chiang,, L. H. Tseng,, Y. C. Yang,, K. H. Lin,, and Y. C. Chen. 1997. Human T-lymphotropic virus type II infection in Vietnamese thalassemic patients. Arch. Virol. 142:14291440.
115. Liu, H. F.,, A. M. Vandamme,, M. Van Brussel,, J. Desmyter,, and P. Goubau. 1994. New retroviruses in human and simian T-lymphotropic viruses. Lancet 344:265266.
116. Loughran, T. P. Jr.,, T. Coyle,, M. P. Sherman,, G. Starkebaum,, G. D. Ehrlich,, F. W. Ruscetti,, and B. J. Poiesz. 1992. Detection of human T-cell leukemia/lymphoma virus, type II, in a patient with large granular lymphocyte leukemia. Blood 80:11161119.
117. Low, K. G.,, L. F. Dorner,, D. B. Fernando,, J. Grossman,, K. T. Jeang,, and M. J. Comb. 1997. Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a. J. Virol. 71:19561962.
118. Lowis, G. W.,, W. A. Sheremata,, P. R. Wickman,, D. Dube,, K. Dube,, and B. J. Poiesz. 1999. HTLV-II risk factors in Native Americans in Florida. Neuroepidemiology 18:3747.
119. Lusso, P.,, F. Lori,, and R. C. Gallo. 1990. CD4-independent infection by human immunodeficiency virus type 1 after phenotypic mixing with human T-cell leukemia viruses. J. Virol. 64:63416344.
120. Machuca, A.,, B. Rodes,, and V. Soriano. 2001. The effect of antiretroviral therapy on HTLV infection. Virus Res. 78:93100.
121. Mahe, A.,, A. Gessain,, M. Huerre,, F. Valensi,, S. Keita,, and P. Bobin. 1994. Adult T-cell leukemia associated with HTLV-1 in a HIV-2 seropositive African. Ann. Dermatol. Venereol. 121:704709.
122. Maloney, E. M.,, R. J. Biggar,, J. V. Neel,, M. E. Taylor,, B. H. Hahn,, G. M. Shaw,, and W. A. Blattner. 1992. Endemic human T cell lymphotropic virus type II infection among isolated Brazilian Amerindians. J. Infect. Dis. 166:100107.
123. Martin, M. P.,, R. J. Biggar,, G. Hamlin- Green,, S. Staal,, and D. Mann. 1993. Large granular lymphocytosis in a patient infected with HTLV-II. AIDS Res. Hum. Retrovir. 9:715–719.
124. Masataka, B.,, T. Imai,, T. Yoshida,, and O. Yoshie. 1996. Constitutive expression of various chemokine genes in human T-cell lines infected with human T-cell leukemia virus type 1: role of the viral transactivator tax. Int. J. Cancer 66:124129.
125. Matutes, E.,, G. P. Taylor,, J. Cavenagh,, A. Pagliuca,, D. Bareford,, A. Domingo,, M. Hamblin,, S. Kelsey,, N. Mir,, and J. T. Reilly. 2001. Interferon alpha and zitlovudine therapy in adult T-cell leukaemia lymphoma: response and outcome in 15 patients. Br. J. Haematol. 113:779784.
126. Modahl, L. E.,, K. C. Young,, K. F. Varney,, H. Khayam-Bashi,, and E. L. Murphy. 1997. Are HTLV-II-seropositive injection drug users at increased risk of bacterial pneumonia, abscess, and lymphadenopathy? J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16:169175.
127. Moriuchi, H.,, and M. Moriuchi. 2000. In vitro induction of HIV-1 replication in resting CD4(+) T cells derived from individuals with undetectable plasma viremia upon stimulation with human T-cell leukemia virus type I. Virology 278:514519.
128. Moriuchi, H.,, M. Moriuchi,, and A. S. Fauci. 1998. Factors secreted by human T lymphotropic virus type I (HTLV-I)-infected cells can enhance or inhibit replication of HIV-1 in HTLV-I uninfected cells: implications for in vivo coinfection with HTLV-I and HIV-1. J. Exp. Med. 187:16891697.
129. Murphy, E. L. 1996. The clinical epidemiology of human T-lymphotropic virus type II (HTLV-II). J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 13:S215S219.
130. Murphy, E. L.,, D. DeVita,, H. Liu,, E. Vittinghoff,, P. Leung,, D. H. Ciccarone,, and B. R. Edlin. 2001. Risk factors for skin and soft-tissue abscesses among injection drug users: a case-control study. Clin. Infect. Dis. 33:3540.
131. Murphy, E. L.,, J. W. Engstrom,, K. Miller,, R. A. Sacher,, M. P. Busch,, and C. G. Hollingsworth. 1993. HTLV-II associated myelopathy in a 43 year old woman. Lancet. 371:757758.
132. Murphy, E. L.,, J. Fridey,, J. W. Smith,, J. Engstrom,, R. A. Sacher,, K. Miller,, J. Gibble,, J. Stevens,, R. Thomson,, D. Hansma,, J. Kaplan,, R. Khabbaz,, G. Nemo, and the REDS Investigators. 1997. HTLV-associated myelopathy in a cohort of HTLV-I and HTLVII infected blood donors. Neurology 48:315320.
133. Murphy, E. L.,, S. A. Glynn,, J. Fridey,, R. A. Sacher,, J. W. Smith,, D. J. Wright,, B. Newman,, J. W., Gibble,, D. I. Ameti,, C. C. Nass,, G. B. Schreiber,, G. J. Nemo, and the Retrovirus Epidemiology Donor Study (REDS) Study Group. 1997. Increased prevelance of infectious disease and other adverse outcomes in human T lymphotropic virus types I- and II-infected blood donors. J. Infect. Dis. 176:14681475.
134. Murphy, E. L.,, S. A. Glynn,, J. Fridey,, J. W. Smith,, R. A. Sacher,, C. C. Nass,, H. E. Ownby,, D. J. Wright,, and G. J. Nemo. 1999. Increased incidence of infectious diseases during prospective follow-up of human T-lymphotropic virus type II- and I-infected blood donors. Retrovirus Epidemiology Donor Study. Arch. Intern. Med. 159:14851491.
135. Nagal, M.,, and S. Jacobson. 2001. Immunopathogenesis of human T cell lymphotropic virus type I-associated myelopathy. Curr. Opin. Neurol. 14:381386.
136. Nagal, M.,, K. Usuku,, W. Matsumoto,, D. Kodama,, N. Takenouchi,, T. Moritoyo,, S. Hashiguchi,, M. Ichinose,, C. R. Bangham,, S. Izumo,, and M. Osame. 1998 Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J. Neurovirol. 4:586593.
137. Neiman, J.,, H. M. Haapaniemi,, and M. Hillbom. 2000. Neurological complications of drug abuse: pathophysiological mechanisms. Eur. J. Neurol. 7:595606.
138. Neuveut, C.,, K. G. Low,, F. Maldarelli,, I. Schmitt,, F. Majone,, R. Grassmann,, and K. T. Jeang. 1998. Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol. Cell. Biol. 18: 36203632.
139. Nicot, C.,, T. Astier-Gin,, and B. Guillemain. 1997. Activation of Bcl-2 expression in human endothelial cells chronically expressing the human T-cell lymphotropic virus type I. Virology 236:4753.
140. Okochi, K.,, H. Sato,, and Y. Hinuma. 1984. A retrospective study on transmission of adult T cell leukemia virus by blood transfusion: seroconversion in recipients. Vox Sang. 46:245253.
141. Oravecz, T.,, M. Pall,, and M. A. Norcross. 1996. Beta-chemokine inhibition of monocytotropic HIV-1 infection. Interference with a postbinding fusion step. J. Immunol. 157:13291332.
142. Osame, M.,, K. Usuku,, S. Izumo,, N. Ijichi,, H. Amitani,, A. Igata,, M. Matsumoto,, and M. Tara. 1986. HTLV-I associated myelopathy, a new clinical entity. Lancet i:10311032.
143. Page, J. B.,, S. H. Lai,, D. D. Chitwood,, N. G. Klimas,, P. C. Smith,, and M. A. Fletcher. 1990. HTLV-I/II seropositivity and death from AIDS among HIV-1 seropositive intravenous drug users. Lancet 335:14391441.
144. Pardi, D.,, W. M. Switzer,, K. G. Hadlock,, J. E. Kaplan,, R. B. Lal,, and T. M. Folks. 1993. Complete nucleotide sequence of an Amerindian human T-cell lymphotropic virus type II (HTLV-II) isolate: identification of a variant HTLV-II subtype b from a Guaymi Indian. J. Virol. 67:46594664.
145. Paxton, W. A.,, S. R. Martin,, D. Tse,, T. R. O’Brien,, J. Skurnick,, N. L. VanDevanter,, N. Padian,, J. F. Braun,, D. P. Kotler,, S. M. Wolinsky,, and R. A. Koup. 1996. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure. Nat. Med. 2:412417.
146. Peters, A. A.,, M. B. Coulthart,, J. J. Oger,, D. J. Waters,, K. A. Crandall,, A. A. Baumgartner,, R. H. Ward,, and G. A. Dekaban. 2000. HTLV type I/II in British Columbia Amerindians: a seroprevalence study and sequence characterization of an HTLV type IIa isolate. AIDS Res. Hum. Retrovir. 16:883892.
147. Piot, P.,, M. Bartos,, P. D. Ghys,, N. Walker,, and B. Schwartlander. 2001. The global impact of HIV/AIDS. Nature 410:968973.
148. Pise-Masison, C. A.,, M. Radonovich,, K. Sakaguchi,, E. Appella,, and J. N. Brady. 1998. Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells. J. Virol. 72:63486355.
149. Pise-Masison, C. A.,, K. S. Choi,, M. Radonovich,, J. Dittmer,, S. J. Kim,, and J. N. Brady. 1998. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein. J. Virol. 72:11651170.
150. Poiesz, B.,, D. Dube,, S. Dube,, J. Love,, L. Papsidero,, A. Uner,, and R. Hutchinson. 2000. HTLV-II associated cutaneous T-cell lymphoma in a patient with HIV-1 infection. N. Engl. J. Med. 342:930936.
151. Raffanti, A.,, A. Svenningsson,, and L. Resnick. 1991. HIV-1 infection of CD4-negative cells via HTLV pseudovirions. AIDS 5:769783.
152. Richardson, J. H.,, A. J. Edwards,, J. K. Cruickshank,, P. Rudge,, and A. G. Dalgleish. 1990. In vivo cellular tropism of human T-cell leukemia virus type 1. J. Virol. 64:56825687.
153. Robert-Guroff, M.,, S. H. Weiss,, J. A. Giron,, A. M. Jennings,, H. M. Ginzburg,, I. B. Margolis,, W. A. Blattner,, and R. C. Gallo. 1986. Prevalence of antibodies to HTLV-I, -II, and -III in intravenous drug abusers from an AIDS endemic region. JAMA 255:31333137.
154. Rosenblatt, J. D.,, J. V. Giorgi,, D. W. Golde,, J. B. Ezra,, A. Wu,, C. D. Winberg,, J. Glaspy,, W. Wachsman,, and I. S. Chen. 1988. Integrated human T-cell leukemia virus II genome in CD8 + T cells from a patient with “atypical” hairy cell leukemia: evidence for distinct T and B cell lymphoproliferative disorders. Blood. 71:363369.
155. Rosenblatt, J. D.,, D. W. Golde,, W. Wachsman,, J. V. Giorgi,, A. Jacobs,, G. M. Schmidt,, S. Quan,, J. C. Gasson,, and I. S. Chen. 1986 A second isolate of HTLV-II associated with atypical hairy-cell leukemia. N. Engl. J. Med. 315:372377.
156. Rosenblatt, J. D.,, P. Tomkins,, M. Rosenthal,, A. Kacena,, G. Chan,, R. Valderama,, W. Harrington, Jr.,, E. Saxton,, A. Diagne,, J. Q. Zhao,, R. T. Mitsuyasu,, and R. H. Weisbart. 1992. Progressive spastic myelopathy in a patient co-infected with HIV-1 and HTLV-II: autoantibodies to the human homologue of rig in blood and cerebrospinal fluid. AIDS 6:11511158.
157. Safaelan, M.,, L. E. Wilson,, E. Taylor,, D. L. Thomas,, and D. Vlahov. 2000. HTLV-II and bacterial infections among injection drug users. J. Acquir. Immune Defic. Syndr. 24:483487.
158. Salemi, M.,, E. Cattaneo,, C. Casoli,, and U. Bertazzoni. 1995. Identification of IIa and IIb molecular subtypes of human T-cell lymphotropic virus type II among Italian injecting drug users. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 8:516520.
159. Salemi, M.,, M. Lewis,, J. F. Egan,, W. W. Hall,, J. Desmyter,, and A. M. Vandamme. 1999. Different population dynamics of human T cell lymphotropic virus type II in intravenous drug users compared with endemically infected tribes. Proc. Natl. Acad. Sci. USA 96:1325313258.
160. Salemi, M.,, A. M. Vandamme,, J. Desmyter,, C. Casoli,, and U. Bertazzoni. 1999. The origin and evolution of human T-cell lymphotropic virus type II (HTLV-II) and the relationship with its replication strategy. Gene 234:1121.
161. Salemi, M.,, S. Van Dooren,, E. Audenaert,, E. Delaporte,, P. Goubau,, J. Desmyter,, and A. M. Vandamme. 1998. Two new human T-lymphotropic virus type I phylogenetic subtypes in seroindeterminates, a Mbuti pygmy and a Gabonese, have closest relatives among African STLV-I strains. Virology 246:277287.
162. Santiago, F.,, E. Clark,, S. Chong,, C. Molina,, F. Mozafari,, R. Mahieux,, M. Fujii,, N. Azimi,, and F. Kashanchi. 1999. Transcriptional up-regulation of the cyclin D2 gene and acquisition of new cyclin-dependent kinase partners in human T-cell leukemia virus type 1- infected cells. J. Virol. 73:99179927.
163. Schechter, M.,, L. H. Moulton,, and L. H. Harrison. 1997. HIV viral load and CD4+ lymphocyte counts in subjects coinfected with HTLV-I and HIV-1. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 15:308311.
164. Schmitt, I.,, O. Rosin,, P. Rohwer,, M. Gossen,, and R. Grassmann. 1998. Stimulation of cyclin-dependent kinase activity and G1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein. J. Virol. 72:633640.
165. Schreiber, G. B.,, E. L. Murphy,, J. A. Horton,, D. J. Wright,, R. Garfein,, H. C. Chien,, and C. C. Nass. 1997. Risk factors for human T-cell lymphotropic virus types I and II (HTLVI and II) in blood donors: the Retrovirus Epidemiology Donor Study. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 14:263271.
166. Sheremata, W. A.,, D. Benedict,, D. C. Squilacote,, A. Sazant,, and E. DeFreitas. 1993. High-dose zidovudine induction in HTLV-I-associated myelopathy: safety and possible efficacy. Neurology 43:21252129.
167. Sheremata, W.,, W. J. Harrington, Jr.,, P. A. Bradshaw,, S. K. H. Foung,, J. R. Berger,, L. Resnick,, and B. J. Poiesz. 1993. Association of ‘(tropical) ataxic neuropathy’ with HTLV-II. Virus Res. 29:7177.
168. Shibata, D.,, R. K. Brynes,, A. Rabinowitz,, C. A. Hanson,, M. L. Slovak,, T. J. Spira,, and P. Gill. 1989. Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1). Ann. Intern. Med. 111:871875.
169. Shimoyama, M. 1991. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). Br. J. Haematol. 79:428437.
170. Siekewitz, M.,, S. F. Josephs,, M. Dukovitch,, N. Peffer,, F. Wong-Staal,, and W. C. Greene. 1987. Activation of the HIV-1 LTR by T-cell mitogens and the trans-activator protein of HTLV-I. Science 238:15571559.
171. Sobesky, M.,, P. Couppie,, R. Pradinaud,, M. C. Godard,, F. Alvarez,, B. Benoit,, B. Carme,, P. Lebeux, and GECVIG (Clinical HIV Study Group in Guiana). 2000. Coinfection with HIV and HTLV-I infection and survival in AIDS stage. French Guiana Study. Presse Med. 29:413416.
172. Song, K. J.,, V. R. Nerurkar,, N. Saitou,, A. Lazo,, J. R. Blakeslee,, I. Miyoshi,, and R. Yanagihara. 1994. Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa. Virology 199:5666.
173. Soriano, V.,, M. Gutierrez,, R. Bravo,, F. Diaz,, J. Olivan,, and J. Gonzalez-Lahoz. 1994. Severe myopathy in an injection drug user coinfected with human immunodeficiency virus type 1 and human T cell leukemia virus type II. Clin. Infect. Dis. 19:350351.
174. Sugiyama, H.,, H. Doi,, K. Yamaguchi,, Y. Tsuji,, T. Miyamoto,, and S. Hino. 1986. Significance of postnatal mother-to-child transmission of human T-lymphotropic virus type-I on the development of adult T-cell leukemia/ lymphoma. J. Med. Virol. 20:253260.
175. Sullivan, M. T.,, A. E. Williams,, C. T. Fang,, T. Grandinetti,, B. J. Poiesz,, G. D. Ehrlich, and the American Red Cross HTLV-I/II Collaborative Study Group. 1991. Transmission of human T-lymphotropic virus types I and II by blood transfusion. A retrospective study of recipients of blood components (1983 through 1988). Arch. Intern. Med. 151:20432048.
176. Switzer, W. M.,, S. M. Owen,, D. A. Pieniazek,, V. R. Nerurkar,, E. Duenas-Barajas,, W. Heneine,, and R. B. Lal. 1995. Molecular analysis of human T-cell lymphotropic virus type II from Wayuu Indians of Colombia demonstrates two subtypes of HTLV-IIb. Virus Genes 10:153162.
177. Szabo, J.,, Z. Beck,, E. Csoman,, X. Liu,, I. Andriko,, J. Kiss,, A. Basci,, P. Ebbesen,, and F. D. Toth. 1999. Differential patterns of interaction between HIV type 1 and HTLV type I in monocyte-derived macrophages cultured in vitro: implications for in vivo coinfection with HIV type 1 and HTLV type I. AIDS Res. Hum. Retrovir. 15:16531666.
178. Takatsuki, K.,, K. Yamaguchi,, F. Kawano,, T. Hattori,, H. Nishimura,, H. Tsuda,, I. Sanada,, K. Nakada,, and Y. Itai. 1985. Clinical diversity in adult T-cell leukemia-lymphoma. Cancer Res. 45:4644s4645s.
179. Taylor, G. P.,, S. E. Hall,, S. Navarrete,, C. A. Michie,, R. Davis,, A. D. Witkover,, M. Rossor,, M. A. Nowak,, P. Rudge,, E. Matutes,, C. R. Bangham,, and J. N. Weber. 1999. Effect of lamivudine on human T-cell leukemia virus type 1 (HTLV-1) DNA copy number, T-cell phenotype, and anti-tax cytotoxic T-cell frequency in patients with HTLV- 1-associated myelopathy. J. Virol. 73:1028910295.
180. Tuppin, P.,, A. Gessain,, M. Kazanji,, R. Mahieux,, J. Y. Cosnefroy,, F. Tekaia,, M. C. Georges-Courbot,, A. Georges,, and G. de The. 1996. Evidence in Gabon for an intrafamilial clustering with mother-to-child and sexual transmission of a new molecular variant of human T-lymphotropic virus type-II subtype B. J. Med. Virol. 48:2232.
181. Vallejo, A.,, and A. Garcia-Saiz. 1994. Isolation and nucleotide sequence analysis of human T-cell lymphotropic virus type II in Spain. J. Acquir. Immune Defic. Syndr. 7:517519.
182. Van Brussel, M.,, M. Salemi,, H. F. Liu,, P. Goubau,, J. Desmyter,, and A. M. Vandamme. 1999. The discovery of two new divergent STLVs has implications for the evolution and epidemiology of HTLVs. Rev. Med. Virol. 9:155170.
183. Vandamme, A. M.,, H. F. Liu,, P. Goubau,, and J. Desmyter. 1994. Primate T-lymphotropic virus type I LTR sequence variation and its phylogenetic analysis: compatibility with an African origin of PTLV-I. Virology 202: 212223.
184. Vandamme, A. M.,, H. F. Liu,, M. Van Brussel,, W. De Meurichy,, J. Desmyter,, and P. Goubau. 1996. The presence of a divergent T-lymphotropic virus in a wild-caught pygmy chimpanzee (Pan paniscus) supports an African origin for the human T-lymphotropic/ simian T-lymphotropic group of viruses. J. Gen. Virol. 77:10891099.
185. Vandamme, A.-M.,, M. Salemi,, M. Van Brussel,, H.-F. Liu,, K. Van Laethem,, M. Van Ranst,, L. Michels,, J. Desmyter,, and P. Goubau. 1998. African origin of human T-lymphotropic virus type 2 (HTLV-2) supported by a potential new HTLV-2d subtype in Congolese Bambuti Efe Pygmies. J. Virol. 72:43274340.
186. Visconti, A.,, L. Visconti,, R. Bellocco,, N. Binkin,, G. Colluci,, L. Vernocchi,, M. Amendola,, and D. Ciaci. 1993. HTLVII/ HIV-I coinfection and risk for progression to AIDS among intravenous drug users. J. Acquir. Immune Defic. Syndr. 6:12281237.
187. Watanabe, T.,, M. Seiki,, Y. Hirayama,, and M. Yoshida. 1986. Human T-cell leukemia virus type I is a member of the African subtype of simian viruses (STLV). Virology 148:385388.
188. Watanabe, K. K.,, A. E. Williams,, G. B. Schreiber,, and H. E. Ownby. 2000. Infectious disease markers in young blood donors. Retrovirus Epidemiology Donor Study. Transfusion 40:954960.
189. Weiss, R. A. 2001. Gulliver’s travels in HIVland. Nature 410:963967.
190. Willy, R. J.,, C. M. Salas,, G. E. Macalino,, and J. D. Rich. 1999. Long-term non-progression of HIV-1 in a patient coinfected with HTLV-II. Diagn. Microbiol. Infect. Dis. 35:269270.
191. Woods, T. C.,, J. M. Graber,, R. C. Hershow,, R. F. Khabbaz,, J. E. Kaplan,, and W. Heneine. 1995. Investigation of proviral load in individuals infected with human T-lymphotropic virus type II. AIDS Res. Hum. Retrovir. 11:12351239.
192. Yashiki, S.,, T. Fujiyoshi,, N. Arima,, M. Osame,, M. Yoshinaga,, Y. Nagata,, M. Tara,, K. Nomura,, A. Utsunomiya,, S. Hanada,, K. Tajima,, and S. Sonoda. 2001. HLA-a*26, HLA-b*4002, HLA-b*4006, and HLA-b*4801 alleles predispose to adultTcell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8+ cytotoxic T lymphocytes. AIDS Res. Hum. Retrovir. 17:10471061.
193. Yoshida, M. 2001. Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu. Rev. Immunol. 19:475496.
194. Zack, J. A.,, A. J. Cann,, J. D. Lugo,, and I. S. Y. Chen. 1988. HIV-I production from peripheral blood cells after HTLV-I induced mitogenic stimulation. Science 240:10261029.
195. Zagury, D.,, A. Lachgar,, V. Chams,, L. S. Fall,, J. Bernard,, J. F. Zagury,, B. Bizzini,, A. Gringeri,, E. Santagostino,, J. Rappaport,, M. Feldman,, S. J. O’Brien,, A. Burny,, and R. C. Gallo. 1998. C-C chemokines, pivotal in protection against HIV type 1 infection. Proc. Natl. Acad. Sci. USA 95:38573861.
196. Zehender, G.,, C. De Maddalena,, M. Osio,, B. Cavalli,, C. Parravicini,, M. Moroni,, and M. Galli. 1995. High prevalence of human T cell lymphotropic virus type II infection in patients affected by human immunodeficiency virus type 1-associated predominantly sensory polyneuropathy. J. Infect. Dis. 172:15951598.
197. Zehender, G.,, L. Meroni,, S. Varchetta,, C. De Maddalena,, B. Cavalli,, M. Gianotto,, A. B. Bosisio,, C. Colasante,, G. Rizzardini,, M. Moroni,, and M. Galli. 1998. Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy. J. Virol. 72:7664