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Chapter 9 : Abscesses

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Abstract:

Abscesses that develop as a result of introduction of the normal endogenous flora into a normally sterile body site are often polymicrobial in nature. These flora can gain access to the sterile site by direct extension or secondary to laceration or perforation. Due to the uniqueness of the normal endogenous flora at the various body sites, the microbiology of such abscesses is generally predictable. This chapter describes the specific microbiology of polymicrobial abscesses that occur at various body sites. It also reviews the data that demonstrate the synergy between the aerobic and anaerobic components of these abscesses, and highlights the role of the bacterial capsule as a virulence factor that enhances the formation of an abscess.

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9

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Figures

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FIGURE 1

Distribution of organisms in abscesses, wounds, burns, and decubitus ulcers.

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
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Image of FIGURE 2
FIGURE 2

Dynamics of pili and capsule of group.

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
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Image of FIGURE 3
FIGURE 3

Encapsulation cycle of group after passage in mice. Helper is viable bacteria or formolized bacteria or capsular material.

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
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Image of FIGURE 4
FIGURE 4

Number of and (log10 CFU) in s.c. abscesses induced by single and combined bacteria in mice. A mutual significant enhancement of growth of both and () was noted in mixed infection compared with the number of these isolates when each was inoculated alone (> 0.05). Similar mutual increases were also noticed in combinations of and with ( ).

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
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Image of FIGURE 5
FIGURE 5

Change in number of aerobes when mixed in an abscess with The increase in number of aerobic or facultative bacteria is illustrated by this bar graph ( ).

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
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References

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Tables

Generic image for table
TABLE 1

Microbiologic characteristics of 676 cutaneous abscesses

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
Generic image for table
TABLE 2

Predominant isolates in abscesses at various body sites

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
Generic image for table
TABLE 3

Predominant isolates from abscesses

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
Generic image for table
TABLE 6

Average numbers of encapsulated and nonencapsulated spp. in mixed abscesses with

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
Generic image for table
TABLE 4

Synergy between anaerobic and aerobic and facultative bacteria

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
Generic image for table
TABLE 5

Synergy between anaerobic bacteria

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9
Generic image for table
TABLE 7

Average numbers of facultative and aerobic bacteria in subcutaneous abscesses induced by each organism alone combined with group

Citation: Brook I. 2002. Abscesses, p 153-168. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch9

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