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Chapter 42 : Control of Mobile DNA

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Abstract:

Transposons are almost invisible genetically. There are two reasons for this genetic invisibility. First, transposons and retrotransposons generally move at extremely low frequencies, and second, they participate in illegitimate recombination events at frequencies much lower than anticipated from homology. Transposons and retrotransposons comprise half or more of the maize genome. The major difference between the maize and sorghum regions is the presence of very large continuous blocks of retrotransposons in maize that are not present in sorghum. Importantly, no retrotransposons have been found in the corresponding flanking sequence in sorghum. Recent work in a wide variety of organisms has begun to reveal previously unsuspected, and often interconnected, mechanisms for monitoring both gene expression levels and gene redundancy. Moreover, it is becoming increasingly evident that such mechanisms are central to controlling the expression and transposition of mobile elements. The results of recent studies on the classical epigenetic phenomenon of R locus paramutation in maize have revealed that local endoreduplication of a chromosomal segment both triggers silencing and can render the endoreduplicated locus capable of silencing an active allele of the gene on a homolog. Although the successful constitution of a transposon from the recognition sequences used in immunoglobulin gene rearrangement and the RAG1 and RAG2 proteins was interpreted as evidence that the V(D)J recombination system evolved from an ancient mobile DNA element, the fact is that the critical components of a transposon and a site-specific rearrangement system are the same.

Citation: Fedoroff N. 2002. Control of Mobile DNA, p 997-1007. In Craig N, Craigie R, Gellert M, Lambowitz A (ed), Mobile DNA II. ASM Press, Washington, DC. doi: 10.1128/9781555817954.ch42

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DNA Transposons
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Chromosome Structure
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Neurospora crassa
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Saccharomyces cerevisiae
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References

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1. Anderson, R. P.,, and J. R. Roth. 1977. Tandem genetic duplications in phage and bacteria. Annu. Rev. Microbiol. 31:473505.
2. Bailey, J. A.,, L. Carrel,, A. Chakravarti,, and E. E. Eichler. 2000. Molecular evidence for a relationship between LINE- 1 elements and X chromosome inactivation: the Lyon repeat hypothesis. Proc. Natl. Acad. Sci. USA 97:66346639.
3. Banks, J. A.,, and N. Fedoroff. 1989. Patterns of developmental and heritable change in methylation of the Suppressor- mutator transposable element. Dev. Genet. 10:425437.
4. Bass, B. L. 2000. Double-stranded RNA as a template for gene silencing. Cell 101:235238.
5. Bennett, M. D.,, J. B. Smith,, and J. S. Heslop-Harrison. 1982. Nuclear DNA amounts in angiosperms. Proc. R. Soc. Lond. Biol. Sci. 216:179199.
6. Bennetzen, J. L.,, P. San Miguel,, M. Chen,, A. Tikhonov,, M. Francki,, and Z. Avramova. 1998. Grass genomes. Proc. Natl. Acad. Sci. USA 95:19751978.
7. Bennetzen, J. L.,, K. Schrick,, P. S. Springer,, W. E. Brown,, and P. SanMiguel. 1994. Active maize genes are unmodified and flanked by diverse classes of modified, highly repetitive DNA. Genome 37:565576.
8. Bingham, P. M. 1997. Cosuppression comes to the animals. Cell 90:385387.
9. Bird, A. P. 1995. Gene number, noise reduction and biological complexity. Trends Genet. 11:94100.
10. Bureau, T. E.,, P. C. Ronald,, and S. R. Wessler. 1996. A computer-based systematic survey reveals the predominance of small inverted-repeat elements in wild-type rice genes. Proc. Natl. Acad. Sci. USA 93:85248529.
11. Bureau, T. E.,, and S. R. Wessler. 1992. Tourist: a large family of small inverted repeat elements frequently associated with maize genes. Plant Cell 4:12831294.
12. Bureau, T. E.,, and S. R. Wessler. 1994. Mobile inverted-repeat elements of the Tourist family are associated with the genes of many cereal grasses. Proc. Natl. Acad. Sci. USA 91:14111415.
13. Bureau, T. E.,, and S. R. Wessler. 1994. Stowaway: a new family of inverted repeat elements associated with the genes of both monocotyledonous and dicotyledonous plants. Plant Cell 6:907916.
14. Chandler, V. L.,, and V. Walbot. 1986. DNA modification of a maize transposable element correlates with loss of activity. Proc. Natl. Acad. Sci. USA 83:17671771.
15. Clemens, J. C.,, C. A. Worby,, N. Simonson-Leff,, M. Muda,, T. Maehama,, B. A. Hemmings,, and J. E. Dixon. 2000. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc. Natl. Acad.Sci. USA 97:64996503.
16. Cogoni, C.,, J. T. Irelan,, M. Schumacher,, T. J. Schmidhauser,, E. U. Selker,, and G. Macino. 1996. Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation. EMBO J. 15:31533163.
17. Cogoni, C.,, and G. Macino. 1997. Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgeneinduced gene silencing in Neurospora crassa. Proc. Natl. Acad. Sci. USA 94:1023310238.
18. Cogoni, C.,, and G. Macino. 1999. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase. Nature 399:166169.
19. Cogoni, C.,, and G. Macino. 1999. Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase. Science 286:23422344.
20. Consonni, G.,, F. Geuna,, G. Gavazzi,, and C. Tonelli. 1993. Molecular homology among members of the R gene family in maize. Plant J. 3:335346.
21. Dang, V. D.,, M. J. Benedik,, K. Ekwall,, J. Choi,, R. C. Allshire,, and H. L. Levin. 1999. A new member of the Sin3 family of corepressors is essential for cell viability and required for retroelement propagation in fission yeast. Mol. Cell. Biol. 19:23512365.
22. de Vries, H. 1905. Species and Varieties: Their Origin by Mutation. Open Court Publishing Co., Chicago, Ill.
23. Doolittle, W. F.,, and C. Sapienza. 1980. Selfish genes, the phenotype paradigm and genome evolution. Nature 284:601603.
24. Emerson, R. A. 1914. The inheritance of a recurring somatic variation in variegated ears of maize. Am. Nat. 48:87115.
25. Emerson, R. A. 1917. Genetical studies of variegated pericarp in maize. Genetics 2:135.
26. Emerson, R. A. 1929. The frequency of somatic mutation in variegated pericarp of maize. Genetics 14:488511.
27. Engels, W. R. 1996. P elements in Drosophila. Curr. Top. Microbiol. Immunol. 204:103123.
28. Engels, W. R. 1997. Invasions of P elements. Genetics 145:1115.
29. Fedoroff, N., 1989. Maize transposable elements, p. 375411. In M. M. Howe, and D. E. Berg (ed.), Mobile DNA. American Society for Microbiology, Washington, D.C.
30. Fedoroff, N.,, D. Furtek,, and O. Nelson. 1984. Cloning of the Bronze locus in maize by a simple and generalizable procedure using the transposable controlling element Ac. Proc. Natl. Acad. Sci. USA 81:38253829.
31. Fedoroff, N.,, S. Wessler,, and M. Shure. 1983. Isolation of the transposable maize controlling elements Ac and Ds. Cell 35:243251.
32. Fedoroff, N. V., 1998. The discovery of transposable elements, p. 89104. In S.-D. Kung, and S.-F. Yang (ed.), Discoveries in Plant Biology. World Scientific Publishing Co., Singapore.
33. Ferguson-Smith, A. C.,, H. Sasaki,, B. M. Cattanach,, and M. A. Surani. 1993. Parental-origin-specific epigenetic modification of the mouse H19 gene. Nature 362:751775.
34. Fire, A. 1999. RNA-triggered gene silencing. Trends Genet. 15:358363.
35. Fire, A.,, S. Xu,, M. K. Montgomery,, S. A. Kostas,, S. E. Driver,, and C. C. Mello. 1998. Potent and specific genetic interference by double-strandedRNAin Caenorhabditis elegans. Nature 391:806811.
36. Flavell, A. J. 1992. Ty1-copia group retrotransposons and the evolution of retroelements in the eukaryotes. Genetica 86:203214.
37. Furner, I. J.,, M. A. Sheikh,, and C. E. Collett. 1998. Gene silencing and homology-dependent gene silencing in Arabidopsis: genetic modifiers and DNA methylation. Genetics 149:651662.
38. Gale, M. D.,, and K. M. Devos. 1998. Plant comparative genetics after 10 years. Science 282:656659.
39. Garrick, D.,, S. Fiering,, D. I. Martin,, and E. Whitelaw. 1998. Repeat-induced gene silencing in mammals. Nat. Genet. 18:5659.
40. Goldschmidt, R. 1938. Physiological Genetics. McGraw-Hill, New York, N.Y.
41. Gorbunova, V.,, and A. A. Levy. 1997. Non-homologous DNA end joining in plant cells is associated with deletions and filler DNA insertions. Nucleic Acids Res. 25:46504657.
42. Hamilton, A. J.,, and D. C. Baulcombe. 1999. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286:950952.
43. Hammond, S. M.,, E. Bernstein,, D. Beach,, and G. J. Hannon. 2000. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404:293296.
44. Heard, E.,, P. Clerc,, and P. Avner. 1997. X-chromosome inactivation in mammals. Annu. Rev. Genet. 31:571610.
45. Henikoff, S. 1998. Conspiracy of silence among repeated transgenes. Bioessays 20:532535.
46. Henikoff, S.,, and P. M. Meneely. 1993. Unwinding dosage compensation Cell 72:12.
47. Hiom, K.,, M. Melek,, and M. Gellert. 1998. DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations. Cell 94:463470.
48. Hirochika, H.,, H. Okamoto,, and T. Kakutani. 2000. Silencing of retrotransposons in Arabidopsis and reactivation by the ddm1 mutation. Plant Cell 12:357369.
49. Hollick, J. B.,, J. E. Dorweiller,, and V. L. Chandler. 1997. Paramutation and related allelic interactions. Trends Genet. 13:302308.
50. Hunter, C. P. 1999. Genetics: a touch of elegance with RNAi. Curr. Biol. 9:R440R442.
51. Hunter, C. P. 2000. Gene silencing: shrinking the black box of RNAi. Curr. Biol. 10:R137R140.
52. Jakowitsch, J.,, I. Papp,, E. A. Moscone,, J. van der Winden,, M. Matzke,, and A. J. Matzke. 1999. Molecular and cytogenetic characterization of a transgene locus that induces silencing and methylation of homologous promoters in trans. Plant J. 17:131140.
53. Jeddeloh, J. A.,, J. Bender,, and E. J. Richards. 1998. The DNA methylation locus DDM1 is required for maintenance of gene silencing in Arabidopsis. Genes Dev. 12:17141725.
54. Jeddeloh, J. A.,, T. L. Stokes,, and E. J. Richards. 1999. Maintenance of genomic methylation requires a SWI2/SNF2-like protein. Nat. Genet. 22:9497.
55. Jensen, S.,, L. Cavarec,, M. P. Gassama,, and T. Heidmann. 1995. Defective I elements introduced into Drosophila as transgenes can regulate reactivity and prevent I-R hybrid dysgenesis. Mol. Gen. Genet. 248:381390.
56. Jensen, S.,, M.-P. Gassama,, and T. Heidmann. 1999. Taming of transposable elements by homology-dependent gene silencing. Nat. Genet. 21:209215.
57. Jones, A. L.,, C. L. Thomas,, and A. J. Maule. 1998. De novo methylation and co-suppression induced by a cytoplasmically replicating plant RNA virus. EMBO J. 17:63856393.
58. Jones, L.,, A. J. Hamilton,, O. Voinnet,, C. L. Thomas,, A. J. Maule,, and D. C. Baulcombe. 1999. RNA-DNA interactions and DNA methylation in post-transcriptional gene silencing. Plant Cell 11:22912302.
59. Kang, X. L.,, F. Yadao,, R. D. Gietz,, and B. A. Kunz. 1992. Elimination of the yeast RAD6 ubiquitin conjugase enhances base-pair transitions and G.C----T.A transversions as well as transposition of the Ty element: implications for the control of spontaneous mutation. Genetics 130:285294.
60. Keller, B.,, and C. Feuillet. 2000. Colinearity and gene density in grass genomes. Trends Plant Sci. 5:246251.
61. Kelley, R. L.,, V. H. Meller,, P. R. Gordadze,, G. Roman,, R. L. Davis,, and M. I. Kuroda. 1999. Epigenetic spreading of the Drosophila dosage compensation complex from roX RNA genes into flanking chromatin. Cell 98:513522.
62. Kennerdell, J. R.,, and R. W. Carthew. 1998. Use of dsRNAmediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95:10171026.
63. Kermicle, J. L.,, W. B. Eggleston,, and M. Alleman. 1995. Organization of paramutagenicity in R-stippled maize. Genetics 141:361372.
64. Ketting, R. F.,, H. A. Haverkamp,, H. G. A. M. van Luenen,, and R. H. A. Plasterk. 1999. mut-7 of C. elegans required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell 99:133141.
65. Ketting, R. F.,, and R. H. Plasterk. 2000. A genetic link between co-suppression and RNA interference in C. elegans. Nature 404:296298.
66. Koch, A. L. 1979. Selection and recombination in populations containing tandem multiple genes. J. Mol. Evol. 14:273285.
67. Kooter, J. M.,, M. A. Matzke,, and P. Meyer. 1999. Listening to the silent genes: transgene silencing, gene regulation and pathogen control. Trends Plant Sci. 4:340347.
68. Kricker, M. C.,, J. W. Drake,, and M. Radman. 1992. Duplication- targetedDNAmethylation and mutagenesis in the evolution of eukaryotic chromosomes. Proc. Natl. Acad. Sci. USA 89:10751079.
69. Lagercrantz, U. 1998. Comparative mapping between Arabidopsis thaliana and Brassica nigra indicates that Brassica genomes have evolved through extensive genome replication accompanied by chromosome fusions and frequent rearrangements. Genetics 150:12171228.
70. Lahn, B. T.,, and D. C. Page. 1999. Four evolutionary strata on the human X chromosome. Science 286:964967.
71. Lahn, B. T.,, and D. C. Page. 1999. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y choromosome. Nat. Genet. 21:429433.
72. Liang, F.,, M. Han,, P. J. Romanienko,, and M. Jasin. 1998. Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc. Natl. Acad. Sci. USA 95:51725177.
73. Lohmann, J. U.,, I. Endl,, and T. C. Bosch. 1999. Silencing of developmental genes in Hydra. Dev. Biol. 214:211214.
74. Ludwig, S. R.,, L. F. Habera,, S. L. Dellaporta,, and S. R. Wessler. 1989. Lc, a member of the maize R gene family responsible for tissue-specific anthocyanin production, encodes a protein similar to transcriptional activators and contains the mychomology region. Proc. Natl. Acad. Sci. USA 86: 70927096.
75. Luff, B.,, L. Pawlowski,, and J. Bender. 1999. An inverted repeat triggers cytosine methylation of identical sequences in Arabidopsis. Mol. Cell 3:505511.
76. Lyon, M. F. 1993. Epigenetic inheritance in mammals. Trends Genet. 9:123128.
77. Lyon, M. F. 1998. X-chromosome inactivation: a repeat hypothesis. Cytogenet. Cell. Genet. 80:133137.
78. Maloisel, L.,, and J. L. Rossignol. 1998. Suppression of crossing- over by DNA methylation in Ascobolus. Genes Dev. 12:13811389.
79. Martienssen, R. 1996. Epigenetic phenomena: paramutation and gene silencing in plants. Curr. Biol. 6:810813.
80. Martienssen, R.,, and V. Irish. 1999. Copying out our ABCs: the role of gene redundancy in interpreting genetic hierarchies. Trends Genet. 15:435437.
81. Masson, P.,, R. Surosky,, J. A. Kingsbury,, and N. V. Fedoroff. 1987. Genetic and molecular analysis of the Spm-dependent a-m2 alleles of the maize a locus. Genetics 117:117137.
82. Matzke, A. J.,, F. Neuhuber,, Y. D. Park,, P. F. Ambros,, and M. A. Matzke. 1994. Homology-dependent gene silencing in transgenic plants: epistatic silencing loci contain multiple copies of methylated transgenes. Mol. Gen. Genet. 244:219229.
83. McClintock, B. 1946. Maize genetics. Carnegie Inst. Wash. Year Book 45:176186.
84. McClintock, B. 1947. Cytogenetic studie of maize and Neurospora. Carnegie Inst. Wash. Year Book 46:146152.
85. McClintock, B. 1948. Mutable loci in maize. Carnegie Inst. Wash. Year Book 47:155169.
86. McClintock, B. 1949. Mutable loci in maize. Carnegie Inst. Wash Year Book 48:142154.
87. McClintock, B. 1951. Mutable loci in maize. Carnegie Inst. Wash. Year Book 50:174181.
88. McClintock, B. 1954. Mutations in maize and chromosomal aberrations in Neurospora. Carnegie Inst. Wash. Year Book 53:254260.
89. McClintock, B. 1962. Topographical relations between elements of control systems in maize. Carnegie Inst. Wash. Year Book 61:448461.
90. McClintock, B. 1978. Mechanisms that rapidly reorganize the genome. Stadler Genet. Symp. 10:2548.
91. McClintock, B. 1987>. The Discovery and Characterization of Transposable Elements. Garland Publishing, Inc., New York, N.Y.
92. Michelmore, R. W.,, and B. C. Meyers. 1998. Clusters of resistance genes in plants evolve by divergent selection and a birth-and-death process. Genome Res. 8:11131130.
93. Misquitta, L.,, and B. M. Paterson. 1999. Targeted disruption of gene function in Drosophila by RNA interference (RNAi): a role for nautilus in embryonic somatic muscle formation. Proc. Natl. Acad. Sci. USA 96:14511456.
94. Mittelsten Scheid, O.,, K. Afsar,, and J. Paszkowski. 1998. Release of epigenetic gene silencing by trans-acting mutations in Arabidopsis. Proc. Natl. Acad. Sci. USA 95:632637.
95. Montgomery, M. K.,, S. Xu,, and A. Fire. 1998. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 95:1550215507.
96. Morita, M.,, A. Umemoto,, H. Watanabe,, N. Nakazono,, and Y. Sugino. 1999. Generation of new transposons in vivo: an evolutionary role for the ‘‘staggered’’ head-to-head dimer and one-ended transposition. Mol. Gen. Genet. 261:953957.
97. Ngo, H.,, C. Tschudi,, K. Gull,, and E. Ullu. 1998. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc. Natl. Acad. Sci. USA 95:1468714692.
98. Noma, K.,, E. Ohtsubo,, and H. Ohtsubo. 1999. Non-LTR retrotransposons (LINEs) as ubiquitous components of plant genomes. Mol. Gen. Genet. 261:7179.
99. Orgel, L. E.,, and F. H. C. Crick. 1980. Selfish DNA: the ultimate parasite. Nature 284:604607.
100. Pal-Bhadra, M.,, U. Bhadra,, and J. A. Birchler. 1997. Cosuppression in Drosophila: gene silencing of alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent. Cell 90:479490.
101. Pal-Bhadra, M.,, U. Bhadra,, and J. A. Birchler. 1999. Cosuppression of nonhomologous transgenes in Drosophila involves mutually related endogenous sequences. Cell 99:3546.
102. Palauqui, J. C.,, T. Elmayan,, J. M. Pollien,, and H. Vaucheret. 1997. Systemic acquired silencing: transgene-specific posttranscriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions. EMBO J. 16:47384745.
103. Panning, B.,, and R. Jaenisch. 1998. RNA and the epigenetic regulation of X chromosome inactivation. Cell 93:305308.
104. Park, Y. D.,, I. Papp,, E. A. Moscone,, V. A. Iglesias,, H. Vaucheret,, A. J. Matzke,, and M. A. Matzke. 1996. Gene silencing mediated by promoter homology occurs at the level of transcription and results in meiotically heritable alterations in methylation and gene activity. Plant J. 9:183194.
105. Pereira, A.,, Z. Schwarz-Sommer,, A. Gierl,, I. Bertram,, P. A. Peterson,, and H. Saedler. 1985. Genetic and molecular analysis of the Enhancer (En) transposable element system of Zea mays. EMBO J. 4:1723.
106. Perelson, A. S.,, and G. I. Bell. 1977. Mathematical models for the evolution of multigene families by unequal crossing over. Nature 265:304310.
107. Perrot, G. H.,, and K. C. Cone. 1989. Nucleotide sequence of the maize R-S gene. Nucleic Acids Res. 17:8003.
108. Petrov, D. A.,, and D. L. Hartl. 1998. High rate of DNA loss in the Drosophila melanogaster and Drosophila virilis species groups. Mol. Biol. Evol. 15:293302.
109. Pirrotta, V. 1997. Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression. Trends Genet. 13:314318.
110. Purugganan, M. D.,, and S. R. Wessler. 1994. Molecular evolution of magellan, a maize Ty3/gypsy-like retrotransposon. Proc. Natl. Acad. Sci. USA 91:1167411678.
111. Qian, Z.,, H. Huang,, J. Y. Hong,, C. L. Burck,, S. D. Johnston,, J. Berman,, A. Carol,, and S. W. Liebman. 1998. Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins. Mol. Cell. Biol. 18:47834792.
112. Rabinowicz, P. D.,, E. L. Braun,, A. D. Wolfe,, B. Bowen,, and E. Grotewold. 1999. Maize R2R3 Myb genes: sequence analysis reveals amplification in the higher plants. Genetics 153: 427444.
113. Radman, M. 1991. Avoidance of inter-repeat recombination by sequence divergence and a mechanism of neutral evolution. Biochimie 73:357361.
114. Reik, W.,, and J. Walter. 1998. Imprinting mechanisms in mammals Curr. Opin. Genet. Dev. 8:154164.
115. Rhoades, M. M. 1936. The effect of varying gene dosage on aleurone colour in maize. J. Genet. 33:347354.
116. Rhoades, M. M. 1938. Effect of the Dt gene on the mutability of the a1 allele in maize. Genetics 23:377397.
117. Riechmann, J. L.,, and E. M. Meyerowitz. 1998. The AP2/ EREBP family of plant transcription factors. Biol. Chem. 379:633646.
118. Rio, D. C. 1991. Regulation of Drosophila P element transposition. Trends Genet. 7:282287.
119. Romero, D.,, and R. Palacios. 1997. Gene amplification and genome plasticity in prokaryotes. Annu. Rev. Genet. 31:91111.
120. Rossignol, J. L.,, and G. Faugeron. 1994. Gene inactivation triggered by recognition between DNA repeats. Experientia 50:307317.
121. Rossignol, J. L.,, and G. Faugeron. 1995. MIP: an epigenetic gene silencing process in Ascobolus immersus. Curr. Top. Microbiol. Immunol. 197:179191.
122. Sanchez Alvarado, A., and P. A. Newmark. 1999. Doublestranded RNA specifically disrupts gene expression during planarian regeneration. Proc. Natl. Acad. Sci. USA 96:50495054.
123. SanMiguel, P.,, B. S. Gaut,, A. Tikhonov,, Y. Nakajima,, and J. L. Bennetzen. 1998. The paleontology of intergene retrotransposons of maize. Nat. Genet. 20:4345.
124. SanMiguel, P.,, A. Tikhonov,, Y. K. Jin,, N. Motchoulskaia,, D. Zakharov,, A. Melake-Berhan,, P. S. Springer,, K. J. Edwards,, M. Lee,, Z. Avramova,, and J. L. Bennetzen. 1996. Nested retrotransposons in the intergenic regions of the maize genome. Science 274:765768.
125. Saxena, R.,, L. G. Brown,, T. Hawkins,, R. K. Alagappan,, H. Skaletsky,, M. P. Reeve,, R. Reijo,, S. Rozen,, M. B. Dinulos,, C. M. Disteche,, and D. C. Page. 1996. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. Nat. Genet. 14:292299.
126. Schiebel, W.,, T. Pelissier,, L. Riedel,, S. Thalmeir,, R. Schiebel,, D. Kempe,, F. Lottspeich,, H. L. Sanger,, and M. Wassenegger. 1998. Isolation of an RNA-directedRNApolymerase-specific cDNA clone from tomato. Plant Cell 10:20872101.
127. Schwartz, A.,, D. C. Chan,, L. G. Brown,, R. Alagappan,, D. Pettay,, C. Disteche,, B. McGillivray,, A. de la Chapelle,, and D. C. Page. 1998. Reconstructing hominid Y evolution: Xhomologous block, created by X-Y transposition, was disrupted by Yp inversion through LINE-LINE recombination. Hum. Mol. Genet. 7:111.
128. Schwartz-Sommer, Z.,, L. Leclercq,, E. Gobel,, and H. Saedler. 1987. CIN4, an insert altering the structure of the A1 gene in Zea mays, exhibits properties of nonviral retrotransposons. EMBO J. 6:38733880.
129. Selker, E. U. 1997. Epigenetic phenomena in filamentous fungi: useful paradigms or repeat-induced confusion? Trends Genet. 13:296301.
130. Selker, E. U. 1999. Gene silencing: repeats that count. Cell 97:157160.
131. Selker, E. U.,, and P. W. Garrett. 1988. DNA sequence duplications trigger gene inactivation in Neurospora crassa. Proc. Natl. Acad. Sci. USA 85:68706874.
132. Shepherd, N. S.,, Z. Schwarz-Sommer,, J. Blumberg vel Spalve,, M. Gupta,, U. Wienand,, and H. Saedler. 1984. Similarity of the Cin1 repetitive family of Zea mays to eukaryotic transposable elements. Nature 307:185187.
133. Sherman, J. M.,, and L. Pillus. 1997. An uncertain silence. Trends Genet. 13:308313.
134. Smardon, A.,, J. M. Spoerke,, S. C. Stacey,, M. E. Klein,, N. Mackin,, and E. M. Maine. 2000. EGO-1 is related to RNAdirectedRNApolymerase and functions in germ-line development and RNA interference in C. elegans. Curr. Biol. 10:169178.
135. Spell, M. L.,, G. Baran,, and S. R. Wessler. 1988. An RFLP adjacent to the maize waxy gene has the structure of a transposable element. Mol. Gen. Genet. 211:364366.
136. Suoniemi, A.,, D. Schmidt,, and A. H. Schulman. 1997. BARE- 1 insertion site preferences and evolutionary conservation of RNA and cDNA processing sites. Genetica 100:219230.
137. Suoniemi, A.,, J. Tanskanen,, and A. H. Schulman. 1998. Gypsy-like retrotransposons are widespread in the plant kingdom. Plant J. 13:699705.
138. Tabara, H.,, M. Sarkissian,, W. G. Kelly,, J. Fleenor,, A. Grishok,, L. Timmons,, A. Fire,, and C. C. Mello. 1999. The rde- 1 gene, RNA interference and transposon silencing in C. elegans. Cell 99:123132.
139. Tanksley, S. D.,, R. Bernatzky,, N. L. Lapitan,, and J. P. Prince. 1988. Conservation of gene repertoire but not gene order in pepper and tomato. Proc. Natl. Acad. Sci. USA 85:64196423.
140. Tanksley, S. D.,, M. W. Ganal,, J. P. Prince,, M. C. de Vicente,, M. W. Bonierbale,, P. Broun,, T. M. Fulton,, J. J. Giovannoni,, S. Grandillo,, G. B. Martin, et al. 1992. High density molecular linkage maps of the tomato and potato genomes. Genetics 132:11411160.
141. Tikhonov, A. P.,, P. J. SanMiguel,, Y. Nakajima,, N. M. Gorenstein,, J. L. Bennetzen,, and Z. Avramova. 1999. Colinearity and its exceptions in orthologous I regions of maize and sorghum. Proc. Natl. Acad. Sci. USA 96:74097414.
142. Timmons, L.,, and A. Fire. 1998. Specific interference by ingested dsRNA. Nature 395:854.
143. Tuschl, T.,, P. D. Zamore,, R. Lehmann,, D. P. Bartel,, and P. A. Sharp. 1999. Targeted mRNA degradation by doublestranded RNA in vitro. Genes Dev. 13:31913197.
144. Vaucheret, H.,, C. Beclin,, T. Elmayan,, F. Feuerbach,, C. Godon,, J. B. Morel,, P. Mourrain,, J. C. Palauqui,, and S. Vernhettes. 1998. Transgene-induced gene silencing in plants. Plant J. 16:651659.
145. Voinnet, O.,, P. Vain,, S. Angell,, and D. C. Baulcombe. 1998. Systemic spread of sequence-specific transgeneRNAdegradation in plants is initiated by localized introduction of ectopic promoterless DNA. Cell 95:177187.
146. Walker, E. L.,, T. P. Robbins,, T. E. Bureau,, J. Kermicle,, and S. L. Dellaporta. 1995. Transposon-mediated chromosomal rearrangements and gene duplications in the formation of the maize R-r complex. EMBO J. 14:23502363.
147. Wargelius, A.,, S. Ellingsen,, and A. Fjose. 1999. Doublestranded RNA induces specific developmental defects in zebrafish embryos. Biochem. Biophys. Res. Commun. 263:156161.
148. Wassenegger, M.,, S. Heimes,, L. Riedel,, and H. L. Sanger. 1994. RNA-directed de novo methylation of genomic sequences in plants. Cell 76:567576.
149. Watson, J. D.,, and F. H. C. Crick. 1953. Molecular structure of nucleic acids. Nature 171:737738.
150. Wessler, S. R.,, T. E. Bureau,, and S. E. White. 1995. LTR-retrotransposons and MITEs: important players in the evolution of plant genomes. Curr. Opin. Genet. Dev. 5:814821.
151. White, S. E.,, L. F. Habera,, and S. R. Wessler. 1994. Retrotransposons in the flanking regions of normal plant genes: a role for copia-like elements in the evolution of gene structure and expression. Proc. Natl. Acad. Sci. USA 91:1179211796.
152. Wianny, F.,, and M. Zernicka-Goetz. 2000. Specific interference with gene function by double-stranded RNA in early mouse development. Nat. Cell Biol. 2:7075.
153. Yoder, J. A.,, C. P. Walsh,, and T. H. Bestor. 1997. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 13:335340.
154. Zamore, P. D.,, T. Tuschl,, P. A. Sharp,, and D. P. Bartel. 2000. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101: 2533.

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