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Chapter 11 : Innate Immunity and Viral Infections

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Abstract:

This chapter reviews the current understanding of the induction and function of innate immune responses to viral infections. The focus is on the characteristics unique to or best characterized in the context of viral rather than nonviral infections. This chapter is organized into six sections. The first reviews the literature on induction of innate cytokine proteins during in vivo infections. The second presents the known molecular pathways to cytokine induction. The third is an overview of biochemical pathways activated by key innate cytokines. The last three sections integrate this information to examine functions of innate cytokines in regulating endogenous immune responses, the accessing of innate cytokines by adaptive immune responses, and the contributions of innate cytokines to viral pathogenesis. The ability of IL-6 to induce secretion of glucocorticoids (GCs) and therefore limit the extent of the pathologic inflammatory reactions, as demonstrated in mice infected with murine cytomegalovirus (MCMV), may contribute to such a protective effect. In MCMV infections, MIP-1α is required for induction of an early natural killer (NK)-cell infiltration into livers. It is now clear that systemic proinflammatory cytokines can be part of acute primary responses to some viruses and are likely to contribute to disease during adaptive responses to a number of viral infections.

Citation: Biron C, Dalod M, Salazar-Mather T. 2002. Innate Immunity and Viral Infections, p 139-160. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch11

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Figure 1

Distinguishing features of general pathways of innate to adaptive immune responses during infections with viruses, bacteria and intracellular protozoa, and parasites. Initial host cytokine responses to infectious agents are induced as a result of recognition, by specific receptors expressed in or on host cells, of unique microbial structures. Many viral infections induce innate cytokine responses overlapping with those seen during infections with bacteria or intracellular protozoa. These include IL-12 and NK-cell IFN- production, responses important for promoting downstream Th1-type responses with CD4 T-cell IFN- production. Responses to viruses can have dominant early IFN-/ production induced by unique viral products. This response is associated with NK cell cytotoxicity but not IFN- production. There are prominent downstream CD8 T-cell responses including IFN- production and cytotoxic T-lymphocyte (CTL) function during many viral infections. Challenges with certain organisms of the viral, bacterial, or protozoan parasite classes also induce the proinflammatory cytokine cascade including TNF. Responses to extracellular parasites fail to elicit an early IL-12 production and are linked to Th2 responses with CD4 T-cell IL-4 and IL-5 production. The patterns are idealized, and there can be overlap. Ig, immunoglobulin. Adapted from Biron and Sen, 2001.

Citation: Biron C, Dalod M, Salazar-Mather T. 2002. Innate Immunity and Viral Infections, p 139-160. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch11
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Image of Figure 2
Figure 2

Simplified model of the pathways for signaling through the IFN-/ and IFN- receptors to reach major target responses. There are specific heterodimeric receptors for these cytokines. These are linked to particular but overlapping kinases and STAT molecules to transmit the signal from cytokine exposure to the nucleus of the cell. IFN-/ are particularly effective at activating a number of well-characterized biochemical pathways blocking viral replication. These include the 2-5(A) synthetase /RNase L system, ADAR, and Mx proteins. A variety of immunoregulatory effects also appear to be preferentially elicited in response to IFN-/ compared to IFN-. These include up-regulation of other IFN-/ genes. IFN- appears to be particularly effective at inducing NOS2 and a family of GTPases with antimicrobial functions. It also has unique function for promoting antigen-processing and presentation pathways to both class I and class II MHC molecules and inducing the expression of a variety of chemokines including Mig.

Citation: Biron C, Dalod M, Salazar-Mather T. 2002. Innate Immunity and Viral Infections, p 139-160. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch11
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Figure 3

Chemokine-to-cytokine-to-chemokine cascade using innate NK-cell responses to direct localization of downstream adaptive responses. The model is based on studies of MCMV infections in livers. In the first step, NK cells are activated, in response to IL-12, to produce IFN- in a variety of host compartments. This production subsides rapidly in the periphery. In the second step, the expression of the chemokine MIP-1 is induced in response to viral challenge signals in the liver and promotes the recruitment of NK cells from the blood to the liver. In the third step, NK cells surround and sequester MCMV-infected cells, forming distinctive clusters of inflammatory foci. These events also serve to localize and sustain the production of IFN-. In the fourth step, there is induction of the -inducible chemokine Mig in response to localized production of IFN-. In the last step, Mig may be involved in the downstream recruitment of activated T cells into liver.

Citation: Biron C, Dalod M, Salazar-Mather T. 2002. Innate Immunity and Viral Infections, p 139-160. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch11
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References

/content/book/10.1128/9781555817978.chap11
1. Ahmed, R.,, and C. A. Biron,. 1998. Immunity to viruses, p. 12951334. In W. E. Paul (ed.), Fundamental Immunology, 4th ed. Lippincott-Raven Publishers, Philadelphia, Pa.
2. Akira, S. 2000. The role of IL-18 in innate immunity. Curr. Opin. Immunol. 12:5963.
3. Appay, V.,, D. F. Nixon,, S. M. Donahoe,, G. M. Gillespie,, T. Dong,, A. King,, G. S. Ogg,, H. M. Spiegel,, C. Conlon,, C. A. Spina,, D. V. Havlir,, D. D. Richman,, A. Waters,, P. Easterbrook,, A. J. McMichael,, and S. L. Rowland-Jones. 2000. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med. 192:6376.
4. Ashkar, S.,, G. F. Weber,, V. Panoutsakopoulou,, M. E. Sanchirico,, M. Jansson,, S. Zawaideh,, S. R. Rittling,, D. T. Denhardt,, M. J. Glimcher,, and H. Cantor. 2000. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science 287:860864.
5. Azimi, N.,, K. Brown,, R. N. Bamford,, Y. Tagaya,, U. Siebenlist,, and T. A. Waldmann. 1998. Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site. Proc. Natl. Acad. Sci. USA 95: 24522457.
6. Azimi, N.,, S. Jacobson,, T. Leist,, and T. A. Waldmann. 1999. Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/ tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2 /15R beta receptor. J. Immunol. 163:40644072.
7. Bachmann, M. F.,, M. Barner,, A. Viola,, and M. Kopf. 1999a. Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection. Eur. J. Immunol. 29:291299.
8. Bachmann, M. F.,, B. R. Wong,, R. Josien,, R. M. Steinman,, A. Oxenius,, and Y. Choi. 1999b. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J. Exp. Med. 189:10251031.
9. Ballas, Z. K.,, W. L. Rasmussen,, and A. M. Krieg. 1996. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:18401845.
10. Biglino, A.,, A. Sinicco,, B. Forno,, A. M. Pollono,, M. Sciandra,, C. Martini,, P. Pich,, and P. Gioannini. 1996. Serum cytokine profiles in acute primary HIV-1 infection and in infectious mononucleosis. Clin. Immunol. Immunopathol. 78:6169.
11. Biron, C. A.,, K. B. Nguyen,, G. C. Pien,, L. P. Cousens,, and T. P. Salazar-Mather. 1999. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17:189220.
12. Biron, C. A.,, and G. C. Sen,. 2001. Interferons and other cytokines, p. 321351. In D. Knipe,, P. Howley,, D. Griffin,, R. Lamb,, M. Martin,, and S. Straus (ed.), Fields Virology, 4th ed. Lippincott, Williams & Wilkins, Philadelphia, Pa.
13. Blanco-Quiros, A.,, H. Gonzalez,, E. Arranz,, and S. Lapena. 1999. Decreased interleukin-12 levels in umbilical cord blood in children who developed acute bronchiolitis. Pediatr. Pulmonol. 28:175180.
14. Boehm, U.,, T. Klamp,, M. Groot,, and J. C. Howard. 1997. Cellular responses to interferon-gamma. Annu. Rev. Immunol. 15:749795.
15. Brewster, F. E.,, K. S. Byron,, and J. L. Sullivan. 1985. Immunoregulation during acute infection with Epstein-Barr virus: dynamics of interferon and 2′,5′-oligoadenylate synthetase activity. J. Infect. Dis. 151:11091115.
16. Brinkmann, V.,, T. Geiger,, S. Alkan,, and C. H. Heusser. 1993. Interferon alpha increases the frequency of interferon gammaproducing human CD4+ T cells. J. Exp. Med. 178:16551663.
17. Bukowski, J. F.,, C. A. Biron,, and R. M. Welsh. 1983. Elevated natural killer cell-mediated cytotoxicity, plasma interferon, and tumor cell rejection in mice persistently infected with lymphocytic choriomeningitis virus. J. Immunol. 131:991996.
18. Butz, E. A.,, and M. J. Bevan. 1998. Massive expansion of antigenspecific CD8+ T cells during an acute virus infection. Immunity 8:167175.
19. Carlow, D. A.,, S. J. Teh,, and H. S. Teh. 1998. Specific antiviral activity demonstrated by TGTP, a member of a new family of interferon-induced GTPases. J. Immunol. 161:23482355.
20. Cella, M.,, D. Jarrossay,, F. Facchetti,, O. Alebardi,, H. Nakajima,, A. Lanzavecchia,, and M. Colonna. 1999. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5:919923.
21. Chandel, N. S.,, W. C. Trzyna,, D. S. McClintock,, and P. T. Schumacker. 2000. Role of oxidants in NF-kappaB activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J. Immunol. 165:10131021.
22. Chaturvedi, U. C.,, R. Agarwal,, E. A. Elbishbishi,, and A. S. Mustafa. 2000. Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis. FEMS Immunol. Med. Microbiol. 28:183188.
23. Cho, S. S.,, C. M. Bacon,, C. Sudarshan,, R. C. Rees,, D. Finbloom,, R. Pine,, and J. J. O’Shea. 1996. Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J. Immunol. 157:47814789.
24. Chonmaitree, T.,, N. J. Roberts, Jr.,, R. G. Douglas, Jr.,, C. B. Hall,, and R. L. Simons. 1981. Interferon production by human mononuclear leukocytes: differences between respiratory syncytial virus and influenza viruses. Infect. Immun. 32:300303.
25. Clayette, P.,, R. Le Grand,, O. Noack,, B. Vaslin,, R. Le Naour,, O. Benveniste,, F. Theodoro,, P. Fretier,, and D. Dormont. 1995. Tumor necrosis factor-alpha in serum of macaques during SIVmac251 acute infection. J. Med. Primatol. 24:94100.
26. Conn, C. A.,, J. L. McClellan,, H. F. Maassab,, C. W. Smitka,, J. A. Majde,, and M. J. Kluger. 1995. Cytokines and the acute phase response to influenza virus in mice. Am. J. Physiol. 268:R78R84.
27. Cook, D. N.,, M. A. Beck,, T. M. Coffman,, S. L. Kirby,, J. F. Sheridan,, I. B. Pragnell,, and O. Smithies. 1995. Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science 269:15831585.
28. Cousens, L. P.,, J. S. Orange,, and C. A. Biron. 1995. Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection. J. Immunol. 155:56905699.
29. Cousens, L. P.,, J. S. Orange,, H. C. Su,, and C. A. Biron. 1997. Interferon-alpha / beta inhibition of interleukin 12 and interferon- gamma production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94:634639.
30. Cousens, L. P.,, R. Peterson,, S. Hsu,, A. Dorner,, J. D. Altman,, R. Ahmed,, and C. A. Biron. 1999. Two roads diverged: interferon alpha / beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection. J. Exp. Med. 189:13151328.
31. Dalod, M.,, M. Dupuis,, J. C. Deschemin,, C. Goujard,, C. Deveau,, L. Meyer,, N. Ngo,, C. Rouzioux,, J. G. Guillet,, J. F. Delfraissy,, M. Sinet,, and A. Venet. 1999a. Weak anti-HIV CD8(+)T-cell effector activity in HIV primary infection. J. Clin. Investig. 104:14311439.
32. Dalod, M.,, M. Sinet,, J. C. Deschemin,, S. Fiorentino,, A. Venet,, and J. G. Guillet. 1999b. Altered ex vivo balance between CD28(+) and CD28(−) cells within HIV-specific CD8(+) T cells of HIV-seropositive patients. Eur. J. Immunol. 29:3844.
33. Darnell, J. E., Jr.,, I. M. Kerr,, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:14151421.
34. Deonarain, R.,, A. Alcami,, M. Alexiou,, M. J. Dallman,, D. R. Gewert,, and A. C. Porter. 2000. Impaired antiviral response and alpha / beta interferon induction in mice lacking beta interferon. J. Virol. 74:34043409.
35. Der, S. D.,, A. Zhou,, B. R. Williams,, and R. H. Silverman. 1998. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc. Natl. Acad. Sci. USA 95:1562315628.
36. Diefenbach, A.,, H. Schindler,, N. Donhauser,, E. Lorenz,, T. Laskay,, J. MacMicking,, M. Rollinghoff,, I. Gresser,, and C. Bogdan. 1998. Type 1 interferon (IFNalpha / beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 8:7787.
37. Doughty, L. A.,, K. B. Nguyen,, J. E. Durbin,, and C. A. Biron. 2001. A role for IFN-α /β in virus infection-induced sensitization to endotoxin. J. Immunol. 166:26582664.
38. Durbin, J. E.,, A. Fernandez-Sesma,, C. K. Lee,, T. D. Rao,, A. B. Frey,, T. M. Moran,, S. Vukmanovic,, A. Garcia-Sastre,, and D. E. Levy. 2000. Type I IFN modulates innate and specific antiviral immunity. J. Immunol. 164:42204228.
39. Eloranta, M. L.,, and G. V. Alm. 1999. Splenic marginal metallophilic macrophages and marginal zone macrophages are the major interferon-alpha / beta producers in mice upon intravenous challenge with herpes simplex virus. Scand. J. Immunol. 49: 391394.
40. Erlandsson, L.,, R. Blumenthal,, M. L. Eloranta,, H. Engel,, G. Alm,, S. Weiss,, and T. Leanderson. 1998. Interferon-beta is required for interferon-alpha production in mouse fibroblasts. Curr. Biol. 8:223226.
41. Farber, J. M. 1990. A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc. Natl. Acad. Sci. USA 87:52385242.
42. Farrar, J. D.,, J. D. Smith,, T. L. Murphy,, S. Leung,, G. R. Stark,, and K. M. Murphy. 2000. Selective loss of type I interferoninduced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat. Immunol. 1:6569.
43. Fehniger, T. A.,, and M. A. Caligiuri. 2001. Interleukin 15: biology and relevance to human disease. Blood 97:1432.
44. Ferbas, J.,, J. Navratil,, A. Logar,, and C. Rinaldo. 1995. Selective decrease in human immunodeficiency virus type 1 (HIV-1)- induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection. Clin. Diagn. Lab. Immunol. 2:138142.
45. Flynn, K. J.,, G. T. Belz,, J. D. Altman,, R. Ahmed,, D. L. Woodland,, and P. C. Doherty. 1998. Virus-specific CD8+ T cells in primary and secondary influenza pneumonia. Immunity 8:683691.
46. Fruh, K.,, and Y. Yang. 1999. Antigen presentation by MHC class I and its regulation by interferon gamma. Curr. Opin. Immunol. 11:7681.
47. Gaines, H.,, M. A. von Sydow,, L. V. von Stedingk,, G. Biberfeld,, B. Bottiger,, L. O. Hansson,, P. Lundbergh,, A. B. Sonnerborg,, J. Wasserman,, and O. O. Strannegaard. 1990. Immunological changes in primary HIV-1 infection. AIDS 4:995999.
48. Garcia-Sastre, A.,, R. K. Durbin,, H. Zheng,, P. Palese,, R. Gertner,, D. E. Levy,, and J. E. Durbin. 1998. The role of interferon in influenza virus tissue tropism. J. Virol. 72:85508558.
49. Giavedoni, L. D.,, M. C. Velasquillo,, L. M. Parodi,, G. B. Hubbard,, and V. L. Hodara. 2000. Cytokine expression, natural killer cell activation, and phenotypic changes in lymphoid cells from rhesus macaques during acute infection with pathogenic simian immunodeficiency virus. J. Virol. 74:16481657.
50. Gollob, J. A.,, H. Kawasaki,, and J. Ritz. 1997. Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin- 12 receptor expression. Eur. J. Immunol. 27:647652.
51. Graham, M. B.,, D. K. Dalton,, D. Giltinan,, V. L. Braciale,, T. A. Stewart,, and T. J. Braciale. 1993. Response to influenza infection in mice with a targeted disruption in the interferon gamma gene. J. Exp. Med. 178:17251732.
52. Gray, C. M.,, L. Morris,, J. Murray,, J. Keeton,, S. Shalekoff,, S. F. Lyons,, P. Sonnenberg,, and D. J. Martin. 1996. Identification of cell subsets expressing intracytoplasmic cytokines within HIV- 1-infected lymph nodes. AIDS 10:14671475.
53. Green, J. A.,, R. P. Charette,, T. J. Yeh,, and C. B. Smith. 1982. Presence of interferon in acute- and convalescent-phase sera of humans with influenza or influenza-like illness of undetermined etiology. J. Infect. Dis. 145:837841.
54. Green, S.,, D. W. Vaughn,, S. Kalayanarooj,, S. Nimmannitya,, S. Suntayakorn,, A. Nisalak,, R. Lew,, B. L. Innis,, I. Kurane,, A. L. Rothman,, and F. A. Ennis. 1999. Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. J. Infect. Dis. 179:755762.
55. Grundy, J. E.,, J. Trapman,, J. E. Allan,, G. R. Shellam,, and C. J. Melief. 1982. Evidence for a protective role of interferon in resistance to murine cytomegalovirus and its control by non-H- 2-linked genes. Infect. Immun. 37:143150.
56. Guidotti, L. G.,, H. McClary,, J. M. Loudis,, and F. V. Chisari. 2000. Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice. J. Exp. Med. 191:12471252.
57. Gurunathan, S.,, L. Stobie,, C. Prussin,, D. L. Sacks,, N. Glaichenhaus,, D. J. Fowell,, R. M. Locksley,, J. T. Chang,, C. Y. Wu,, and R. A. Seder. 2000. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. J. Immunol. 165:915924.
58. Gutierrez-Ramos, J. C.,, and H. Bluethmann. 1997. Molecules and mechanisms operating in septic shock: lessons from knockout mice. Immunol. Today 18:329334.
59. Hacker, U. T.,, T. Jelinek,, S. Erhardt,, A. Eigler,, G. Hartmann,, H. D. Nothdurft,, and S. Endres. 1998. In vivo synthesis of tumor necrosis factor-alpha in healthy humans after live yellow fever vaccination. J. Infect. Dis. 177:774778.
60. Hall, C. B.,, R. G. Douglas, Jr.,, R. L. Simons,, and J. M. Geiman. 1978. Interferon production in children with respiratory syncytial, influenza, and parainfluenza virus infections. J. Pediatr. 93:2832.
61. Hayden, F. G.,, R. Fritz,, M. C. Lobo,, W. Alvord,, W. Strober,, and S. E. Straus. 1998. Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. J. Clin. Investig. 101:643649.
62. He, J.,, H. Ichimura,, T. Iida,, M. Minami,, K. Kobayashi,, M. Kita,, C. Sotozono,, Y. I. Tagawa,, Y. Iwakura,, and J. Imanishi. 1999. Kinetics of cytokine production in the cornea and trigeminal ganglion of C57BL/6 mice after corneal HSV-1 infection. J. Interferon Cytokine Res. 19:609615.
63. Hennet, T.,, H. J. Ziltener,, K. Frei,, and E. Peterhans. 1992. A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. J. Immunol. 149:932939.
64. Hilkens, C. M.,, P. Kalinski,, M. de Boer,, and M. L. Kapsenberg. 1997. Human dendritic cells require exogenous interleukin-12- inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype. Blood 90:19201926.
65. Humar, A.,, P. St Louis,, T. Mazzulli,, A. McGeer,, J. Lipton,, H. Messner,, and K. S. MacDonald. 1999. Elevated serum cytokines are associated with cytomegalovirus infection and disease in bone marrow transplant recipients. J. Infect. Dis. 179:484488.
66. Hussell, T.,, and P. J. Openshaw. 1998. Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection. J. Gen. Virol. 79:25932601.
67. Ignatiev, G. M.,, A. A. Dadaeva,, S. V. Luchko,, and A. A. Chepurnov. 2000. Immune and pathophysiological processes in baboons experimentally infected with Ebola virus adapted to guinea pigs. Immunol. Lett. 71:131140.
68. Ihle, J. N. 1995. Cytokine receptor signalling. Nature 377:591594.
69. Ishikawa, R.,, and C. A. Biron. 1993. IFN induction and associated changes in splenic leukocyte distribution. J. Immunol. 150:37133727.
70. Jassoy, C.,, T. Harrer,, T. Rosenthal,, B. A. Navia,, J. Worth,, R. P. Johnson,, and B. D. Walker. 1993. Human immunodeficiency virus type 1-specific cytotoxic T lymphocytes release gamma interferon, tumor necrosis factor alpha (TNF-α), and TNF-β when they encounter their target antigens. J. Virol. 67:28442852.
71. Juang, Y.,, W. Lowther,, M. Kellum,, W. C. Au,, R. Lin,, J. Hiscott,, and P. M. Pitha. 1998. Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3. Proc. Natl. Acad. Sci. USA 95:98379842.
72. Kagi, D.,, and H. Hengartner. 1996. Different roles for cytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses. Curr. Opin. Immunol. 8:472477.
73. Kanangat, S.,, J. Thomas,, S. Gangappa,, J. S. Babu,, and B. T. Rouse. 1996. Herpes simplex virus type 1-mediated upregulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection. J. Immunol. 156:11101116.
74. Kanerva, M.,, A. Vaheri,, J. Mustonen,, and J. Partanen. 1998. High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virusinduced nephropathia epidemica. Scand. J. Infect. Dis. 30:532534.
75. Karp, C. L.,, C. A. Biron,, and D. N. Irani. 2000. Interferon beta in multiple sclerosis: is IL-12 suppression the key? Immunol. Today 21:2428.
76. Khan, I. A.,, J. A. MacLean,, F. S. Lee,, L. Casciotti,, E. DeHaan,, J. D. Schwartzman,, and A. D. Luster. 2000. IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection. Immunity 12:483494.
77. Khatissian, E.,, M. G. Tovey,, M. C. Cumont,, V. Monceaux,, P. Lebon,, L. Montagnier,, B. Hurtrel,, and L. Chakrabarti. 1996. The relationship between the interferon alpha response and viral burden in primary SIV infection. AIDS Res. Hum. Retroviruses 12:12731278.
78. Klimstra, W. B.,, K. D. Ryman,, K. A. Bernard,, K. B. Nguyen,, C. A. Biron,, and R. E. Johnston. 1999. Infection of neonatal mice with Sindbis virus results in a systemic inflammatory response syndrome. J. Virol. 73:1038710398.
79. Krakauer, T.,, J. W. Leduc,, and H. Krakauer. 1995. Serum levels of tumor necrosis factor-alpha, interleukin-1, and interleukin-6 in hemorrhagic fever with renal syndrome. Viral Immunol. 8:7579.
80. Kurane, I.,, B. L. Innis,, S. Nimmannitya,, A. Nisalak,, A. Meager,, and F. A. Ennis. 1993. High levels of interferon alpha in the sera of children with dengue virus infection. Am. J. Trop. Med. Hyg. 48:222229.
81. Lalvani, A.,, R. Brookes,, S. Hambleton,, W. J. Britton,, A. V. Hill,, and A. J. McMichael. 1997. Rapid effector function in CD8+ memory T cells. J. Exp. Med. 186:859865.
82. Lebel-Binay, S.,, A. Berger,, F. Zinzindohoue,, P. Cugnenc,, N. Thiounn,, W. H. Fridman,, and F. Pages. 2000. Interleukin-18: biological properties and clinical implications. Eur. Cytokine Netw. 11:1526.
83. Leib, D. A.,, T. E. Harrison,, K. M. Laslo,, M. A. Machalek,, N. J. Moorman,, and H. W. Virgin. 1999. Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo. J. Exp. Med. 189:663672.
84. Leroy, E. M.,, S. Baize,, V. E. Volchkov,, S. P. Fischer-Hoch,, M. Georges-Courbot,, J. Lansoud-Soukate,, M. Capron,, P. Debre,, J. B. McCormick,, and A. J. Georges. 2000. Human asymptomatic Ebola infection and strong inflammatory response. Lancet 355:22102215.
85. Lindahl, P.,, I. Gresser,, P. Leary,, and M. Tovey. 1976. Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells. Proc. Natl. Acad. Sci. USA 73:12841287.
86. Linde, A.,, B. Andersson,, S. B. Svenson,, H. Ahrne,, M. Carlsson,, P. Forsberg,, H. Hugo,, A. Karstorp,, R. Lenkei,, A. Lindwall, et al. 1992. Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome. J. Infect. Dis. 165:9941000.
87. Linderholm, M.,, C. Ahlm,, B. Settergren,, A. Waage,, and A. Tarnvik. 1996. Elevated plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-6, and IL 10 in patients with hemorrhagic fever with renal syndrome. J. Infect. Dis. 173:3843.
88. MacMicking, J.,, Q. W. Xie,, and C. Nathan. 1997. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15:323350.
89. Manetti, R.,, F. Annunziato,, L. Tomasevic,, V. Gianno,, P. Parronchi,, S. Romagnani,, and E. Maggi. 1995. Polyinosinic acid: polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferonalpha and interleukin-12. Eur. J. Immunol. 25:26562660.
90. Marie, I.,, J. E. Durbin,, and D. E. Levy. 1998. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J. 17:66606669.
91. Marshall, J. D.,, J. Chehimi,, G. Gri,, J. R. Kostman,, L. J. Montaner,, and G. Trinchieri. 1999. The interleukin-12-mediated pathway of immune events is dysfunctional in human immunodeficiency virus-infected individuals. Blood 94:10031011.
92. McRae, B. L.,, R. T. Semnani,, M. P. Hayes,, and G. A. van Seventer. 1998. Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development. J. Immunol 160:42984304.
93. Mikloska, Z.,, V. A. Danis,, S. Adams,, A. R. Lloyd,, D. L. Adrian,, and A. L. Cunningham. 1998. In vivo production of cytokines and beta (C-C) chemokines in human recurrent herpes simplex lesions—do herpes simplex virus-infected keratinocytes contribute to their production? J. Infect. Dis. 177:827838.
94. Milone, M. C.,, and P. Fitzgerald-Bocarsly. 1998. The mannose receptor mediates induction of IFN-alpha in peripheral blood dendritic cells by enveloped RNA and DNA viruses. J. Immunol. 161:23912399.
95. Monteiro, J. M.,, C. Harvey,, and G. Trinchieri. 1998. Role of interleukin-12 in primary influenza virus infection. J. Virol. 72:48254831.
96. Mori, M.,, A. L. Rothman,, I. Kurane,, J. M. Montoya,, K. B. Nolte,, J. E. Norman,, D. C. Waite,, F. T. Koster,, and F. A. Ennis. 1999. High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. J. Infect. Dis. 179:295302.
97. Muller, U.,, U. Steinhoff,, L. F. Reis,, S. Hemmi,, J. Pavlovic,, R. M. Zinkernagel,, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:19181921.
98. Murali-Krishna, K.,, J. D. Altman,, M. Suresh,, D. J. Sourdive,, A. J. Zajac,, J. D. Miller,, J. Slansky,, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177187.
99. Murphy, K. M.,, W. Ouyang,, J. D. Farrar,, J. Yang,, S. Ranganath,, H. Asnagli,, M. Afkarian,, and T. L. Murphy. 2000. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18:451494.
100. Nakayama, T.,, S. Sonoda,, T. Urano,, K. Sasaki,, N. Maehara,, and S. Makino. 1993. Detection of alpha-interferon in nasopharyngeal secretions and sera in children infected with respiratory syncytial virus. Pediatr. Infect. Dis. J. 12:925929.
101. Nansen, A.,, and A. Randrup-Thomsen. 2001. Viral infections cause rapid sensitization to lipopolysaccharide: central role of IFN-α /β. J. Immunol. 166:982988.
102. Nguyen, K. B.,, and C. A. Biron. 1999. Synergism for cytokinemediated disease during concurrent endotoxin and viral challenges: roles for NK and T cell IFN-gamma production. J. Immunol. 162:52385246.
103. Nguyen, K. B.,, L. P. Cousens,, L. A. Doughty,, G. C. Pien,, J. E. Durbin,, and C. A. Biron. 2000. Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox. Nat. Immunology 1:7076.
104. Noah, T. L.,, F. W. Henderson,, I. A. Wortman,, R. B. Devlin,, J. Handy,, H. S. Koren,, and S. Becker. 1995. Nasal cytokine production in viral acute upper respiratory infection of childhood. J. Infect. Dis. 171:584592.
105. Orange, J. S.,, and C. A. Biron. 1996a. An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections. J. Immunol. 156:11381142.
106. Orange, J. S.,, and C. A. Biron. 1996b. Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J. Immunol. 156:47464756.
107. Orange, J. S.,, T. P. Salazar-Mather,, S. M. Opal,, and C. A. Biron. 1997. Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection. J. Virol. 71:92489258.
108. Orange, J. S.,, T. P. Salazar-Mather,, S. M. Opal,, R. L. Spencer,, A. H. Miller,, B. S. McEwen,, and C. A. Biron. 1995a. Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J. Exp. Med. 181:901914.
109. Orange, J. S.,, B. Wang,, C. Terhorst,, and C. A. Biron. 1995b. Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med. 182:10451056.
110. Orange, J. S.,, S. F. Wolf,, and C. A. Biron. 1994. Effects of IL-12 on the response and susceptibility to experimental viral infections. J. Immunol. 152:12531264.
111. Ouyang, W.,, S. H. Ranganath,, K. Weindel,, D. Bhattacharya,, T. L. Murphy,, W. C. Sha,, and K. M. Murphy. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4- independent mechanism. Immunity 9:745755.
112. Oxenius, A.,, U. Karrer,, R. M. Zinkernagel,, and H. Hengartner. 1999. IL-12 is not required for induction of type 1 cytokine responses in viral infections. J. Immunol. 162:965973.
113. Park, A. Y.,, B. D. Hondowicz,, and P. Scott. 2000. IL-12 is required to maintain a Th1 response during Leishmania major infection. J. Immunol. 165:896902.
114. Pfeffer, L. M.,, C. A. Dinarello,, R. B. Herberman,, B. R. Williams,, E. C. Borden,, R. Bordens,, M. R. Walter,, T. L. Nagabhushan,, P. P. Trotta,, and S. Pestka. 1998. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res. 58:24892499.
115. Pien, G. C.,, and C. A. Biron. 2000. Compartmental differences in NK cell responsiveness to IL-12 during lymphocytic choriomeningitis virus infection. J. Immunol. 164:9941001.
116. Pien, G. C.,, A. R. Satoskar,, K. Takeda,, S. Akira,, and C. A. Biron. 2000. Selective IL-18 requirements for induction of compartmental IFN-γ responses during viral infection. J. Immunol. 165:47874791.
117. Poli, G.,, P. Biswas,, and A. S. Fauci. 1994. Interferons in the pathogenesis and treatment of human immunodeficiency virus infection. Antiviral Res. 24:221233.
118. Quaranta, M. G.,, B. Camponeschi,, E. Straface,, W. Malorni,, and M. Viora. 1999. Induction of interleukin-15 production by HIV-1 nef protein: a role in the proliferation of uninfected cells. Exp. Cell Res. 250:112121.
119. Ramana, C. V.,, N. Grammatikakis,, M. Chernov,, H. Nguyen,, K. C. Goh,, B. R. Williams,, and G. R. Stark. 2000. Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO J. 19:263272.
120. Reinhardt, B.,, R. Jaspert,, M. Niedrig,, C. Kostner,, and J. L’Age- Stehr. 1998. Development of viremia and humoral and cellular parameters of immune activation after vaccination with yellow fever virus strain 17D: a model of human flavivirus infection. J. Med. Virol. 56:159167.
121. Reiss, C. S.,, and T. Komatsu. 1998. Does nitric oxide play a critical role in viral infections? J. Virol. 72:45474551.
122. Ridge, J. P.,, F. Di Rosa,, and P. Matzinger. 1998. A conditioned dendritic cell can be a temporal bridge between a CD4+ Thelper and a T-killer cell. Nature 393:474478.
123. Rizzardi, G. P.,, W. Barcellini,, G. Tambussi,, F. Lillo,, M. Malnati,, L. Perrin,, and A. Lazzarin. 1996. Plasma levels of soluble CD30, tumour necrosis factor (TNF)-alpha and TNF receptors during primary HIV-1 infection: correlation with HIV-1 RNA and the clinical outcome. AIDS 10:F45F50.
124. Roake, J. A.,, A. S. Rao,, P. J. Morris,, C. P. Larsen,, D. F. Hankins,, and J. M. Austyn. 1995. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J. Exp. Med. 181:22372247.
125. Roberts, N. J., Jr.,, J. Hiscott,, and D. J. Signs. 1992. The limited role of the human interferon system response to respiratory syncytial virus challenge: analysis and comparison to influenza virus challenge. Microb. Pathog. 12:409414.
126. Rogge, L.,, L. Barberis-Maino,, M. Biffi,, N. Passini,, D. H. Presky,, U. Gubler,, and F. Sinigaglia. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825831.
127. Rogge, L.,, D. D’Ambrosio,, M. Biffi,, G. Penna,, L. J. Minetti,, D. H. Presky,, L. Adorini,, and F. Sinigaglia. 1998. The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. J. Immunol. 161:65676574.
128. Rosenberg, Y. J.,, A. Cafaro,, T. Brennan,, J. G. Greenhouse,, F. Villinger,, A. A. Ansari,, C. Brown,, K. McKinnon,, S. Bellah,, J. Yalley-Ogunro,, W. R. Elkins,, S. Gartner,, and M. G. Lewis. 1997. Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections. Int. Immunol. 9:703712.
129. Rossi, D.,, and A. Zlotnik. 2000. The biology of chemokines and their receptors. Annu. Rev. Immunol. 18:217242.
130. Ruzek, M. C.,, A. H. Miller,, S. M. Opal,, B. D. Pearce,, and C. A. Biron. 1997. Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection. J. Exp. Med. 185:11851192.
131. Ruzek, M. C.,, B. D. Pearce,, A. H. Miller,, and C. A. Biron. 1999. Endogenous glucocorticoids protect against cytokine-mediated lethality during viral infection. J. Immunol. 162:35273533.
132. Ryman, K. D.,, W. B. Klimstra,, K. B. Nguyen,, C. A. Biron,, and R. E. Johnston. 2000. Alpha/ beta interferon protects adult mice from fatal Sindbis virus infection and is an important determinant of cell and tissue tropism. J. Virol. 74:33663378.
133. Salazar-Mather, T. P.,, T. A. Hamilton,, and C. A. Biron. 2000. A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense. J. Clin. Investig. 105:985993.
134. Salazar-Mather, T. P.,, R. Ishikawa,, and C. A. Biron. 1996. NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection. J. Immunol. 157:30543064.
135. Salazar-Mather, T. P.,, J. S. Orange,, and C. A. Biron. 1998. Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1alpha (MIP-1alpha)-dependent pathways. J. Exp. Med. 187:114.
136. Sandberg, K.,, P. Kemper,, A. Stalder,, J. Zhang,, M. V. Hobbs,, J. L. Whitton,, and I. L. Campbell. 1994. Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-alpha / beta. J. Immunol. 153:220231.
137. Sareneva, T.,, S. Matikainen,, M. Kurimoto,, and I. Julkunen. 1998. Influenza A virus-induced IFN-alpha / beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells. J. Immunol. 160:60326038.
138. Schijns, V. E.,, B. L. Haagmans,, C. M. Wierda,, B. Kruithof,, I. A. Heijnen,, G. Alber,, and M. C. Horzinek. 1998. Mice lacking IL- 12 develop polarized Th1 cells during viral infection. J. Immunol. 160:39583964.
139. Setsuda, J.,, J. Teruya-Feldstein,, N. L. Harris,, J. A. Ferry,, L. Sorbara,, G. Gupta,, E. S. Jaffe,, and G. Tosato. 1999. Interleukin- 18, interferon-gamma, IP-10, and Mig expression in Epstein-Barr virus-induced infectious mononucleosis and posttransplant lymphoproliferative disease. Am. J. Pathol. 155:257265.
140. She, J.,, M. C. Ruzek,, P. Velupillai,, I. de Aos,, B. Wang,, D. A. Harn,, J. Sancho,, C. A. Biron,, and C. Terhorst. 1999. Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3zeta. Int. Immunol. 11:845857.
141. Sinicco, A.,, A. Biglino,, M. Sciandra,, B. Forno,, A. M. Pollono,, R. Raiteri,, and P. Gioannini. 1993. Cytokine network and acute primary HIV-1 infection. AIDS 7:11671172.
142. Srikiatkhachorn, A.,, and T. J. Braciale. 1997. Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J. Exp. Med. 186:421432.
143. Stark, G. R.,, I. M. Kerr,, B. R. Williams,, R. H. Silverman,, and R. D. Schreiber. 1998. How cells respond to interferons. Annu. Rev. Biochem. 67:227264.
144. Stepp, S. E.,, R. Dufourcq-Lagelouse,, F. Le Deist,, S. Bhawan,, S. Certain,, P. A. Mathew,, J. I. Henter,, M. Bennett,, A. Fischer,, G. de Saint Basile,, and V. Kumar. 1999. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 286:19571959.
145. Stobie, L.,, S. Gurunathan,, C. Prussin,, D. L. Sacks,, N. Glaichenhaus,, C. Y. Wu,, and R. A. Seder. 2000. The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/ effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc. Natl. Acad. Sci. USA 11:11.
146. Su, H. C.,, L. P. Cousens,, L. D. Fast,, M. K. Slifka,, R. D. Bungiro,, R. Ahmed,, and C. A. Biron. 1998. CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2. J. Immunol. 160:50075017.
147. Svedmyr, E.,, I. Ernberg,, J. Seeley,, O. Weiland,, G. Masucci,, K. Tsukuda,, R. Szigeti,, M. G. Masucci,, H. Blomogren,, and W. Berthold. 1984. Virologic, immunologic, and clinical observations on a patient during the incubation, acute, and convalescent phases of infectious mononucleosis. Clin. Immunol. Immunopathol. 30:437450.
148. Szabo, S. J.,, A. S. Dighe,, U. Gubler,, and K. M. Murphy. 1997a. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817824.
149. Szabo, S. J.,, L. H. Glimcher,, and I. C. Ho. 1997b. Genes that regulate interleukin-4 expression in T cells. Curr. Opin. Immunol. 9:776781.
150. Szabo, S. J.,, S. T. Kim,, G. L. Costa,, X. Zhang,, C. G. Fathman,, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:655669.
151. Tay, C. H.,, and R. M. Welsh. 1997. Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells. J. Virol. 71:267275.
152. Taylor, G. A.,, C. M. Collazo,, G. S. Yap,, K. Nguyen,, T. A. Gregorio,, L. S. Taylor,, B. Eagleson,, L. Secrest,, E. A. Southon,, S. W. Reid,, L. Tessarollo,, M. Bray,, D. W. McVicar,, K. L. Komschlies,, H. A. Young,, C. A. Biron,, A. Sher,, and G. F. Vande Woude. 2000. Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. Proc. Natl. Acad. Sci. USA 97:751755.
153. Taylor, G. A.,, M. Jeffers,, D. A. Largaespada,, N. A. Jenkins,, N. G. Copeland,, and G. F. Vande Woude. 1996. Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. J. Biol. Chem. 271:2039920405.
154. Tokunaga, T.,, O. Yano,, E. Kuramoto,, Y. Kimura,, T. Yamamoto,, T. Kataoka,, and S. Yamamoto. 1992. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol. Immunol. 36:5566.
155. Torseth, J. W.,, B. J. Nickoloff,, T. Y. Basham,, and T. C. Merigan. 1987. Beta interferon produced by keratinocytes in human cutaneous infection with herpes simplex virus. J. Infect. Dis. 155:641648.
156. Trgovcich, J.,, J. F. Aronson,, J. C. Eldridge,, and R. E. Johnston. 1999. TNFalpha, interferon, and stress response induction as a function of age-related susceptibility to fatal Sindbis virus infection of mice. Virology 263:339348.
157. Trinchieri, G. 1998. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. 70:83243.
158. Tumpey, T. M.,, H. Cheng,, D. N. Cook,, O. Smithies,, J. E. Oakes,, and R. N. Lausch. 1998. Absence of macrophage inflammatory protein-1alpha prevents the development of blinding herpes stromal keratitis. J. Virol. 72:37053710.
159. Vacheron, F.,, A. Rudent,, S. Perin,, C. Labarre,, A. M. Quero,, and M. Guenounou. 1990. Production of interleukin 1 and tumour necrosis factor activities in bronchoalveolar washings following infection of mice by influenza virus. J. Gen. Virol. 71:477479.
160. van den Broek, M. F.,, U. Muller,, S. Huang,, M. Aguet,, and R. M. Zinkernagel. 1995. Antiviral defense in mice lacking both alpha/ beta and gamma interferon receptors. J. Virol. 69:47924796.
161. Viljeck, J. 1964. Production of interferon by newborn and adult mice infected with Sindbis virus. Virology 22:651652.
162. Villinger, F.,, P. E. Rollin,, S. S. Brar,, N. F. Chikkala,, J. Winter,, J. B. Sundstrom,, S. R. Zaki,, R. Swanepoel,, A. A. Ansari,, and C. J. Peters. 1999. Markedly elevated levels of interferon (IFN)- gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J. Infect. Dis. 179:S188S191.
163. Waldmann, T. A.,, and Y. Tagaya. 1999. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu. Rev. Immunol. 17:1949.
164. Wang, B.,, H. Fujisawa,, L. Zhuang,, S. Kondo,, G. M. Shivji,, C. S. Kim,, T. W. Mak,, and D. N. Sauder. 1997. Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75. J. Immunol. 159:61486155.
165. Wathelet, M. G.,, C. H. Lin,, B. S. Parekh,, L. V. Ronco,, P. M. Howley,, and T. Maniatis. 1998. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol. Cell 1:507518.
166. Welsh, R. M., Jr. 1978. Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction. J. Exp. Med. 148:163181.
167. Wheelock, E. F.,, and W. A. Sibley. 1965. Circulating virus, interferon and antibody after vaccination with the 17-D strain of yellow-fever virus. N. Engl. J. Med. 273:194198.
168. Wong, P.,, C. W. Severns,, N. B. Guyer,, and T. M. Wright. 1994. A unique palindromic element mediates gamma interferon induction of mig gene expression. Mol. Cell. Biol. 14:914922.
169. Wright, T. M.,, and J. M. Farber. 1991. 5′ regulatory region of a novel cytokine gene mediates selective activation by interferon gamma. J. Exp. Med. 173:417422.
170. Wright-Browne, V.,, A. M. Schnee,, M. A. Jenkins,, P. F. Thall,, B. B. Aggarwal,, M. Talpaz,, and Z. Estrov. 1998. Serum cytokine levels in infectious mononucleosis at diagnosis and convalescence. Leuk. Lymphoma 30:583589.
171. Yap, G.,, M. Pesin,, and A. Sher. 2000. Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J. Immunol. 165:628631.
172. Yoshimoto, T.,, H. Nagase,, T. Yoneto,, J. Inoue,, and H. Nariuchi. 1998. Interleukin-12 expression in B cells by transformation with Epstein-Barr virus. Biochem. Biophys. Res. Commun. 252:556560.
173. Zhang, X.,, S. Sun,, I. Hwang,, D. F. Tough,, and J. Sprent. 1998. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8:591599.
174. Zimmermann, C.,, A. Prevost-Blondel,, C. Blaser,, and H. Pircher. 1999. Kinetics of the response of naive and memory CD8 T cells to antigen: similarities and differences. Eur. J. Immunol. 29:284290.

Tables

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Table 1

In vivo induction of innate cytokine protein expression early during viral infections.

Citation: Biron C, Dalod M, Salazar-Mather T. 2002. Innate Immunity and Viral Infections, p 139-160. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch11

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