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Chapter 27 : Immunogenetics of the Host Response to Bacteria in Mice

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Abstract:

This chapter presents an overview of the specific mouse loci identified as playing a key role in susceptibility to infection with human bacterial pathogens. The role of natural resistance-associated macrophage protein 1 (Nramp1) in host defenses against clinically relevant strains of and was addressed in genetic studies in humans from areas of endemic tuberculosis (The Gambia) and leprosy (South Vietnam) infection, using informative markers derived from the NRAMP1 gene region. Mice bearing naturally occurring (Nramp1) or experimentally induced (Nramp1) mutations at Nramp1 are extremely susceptible to intravenous or subcutaneous infection with low doses of serovar (10 CFU), with uncontrolled bacterial replication in the spleen and liver of susceptible mice leading to uniform death within 4 to 5 days of infection. induces apoptosis during infection of permissive human macrophages and in alveolar epithelial cell lines. Avirulent mutants cannot induce either apoptosis or caspase 3 activation, and specific inhibition of caspase 3 activity can block both -induced apoptosis and cytopathogenicity. Hence, it seems likely that the number of described susceptibility and resistance loci for divergent bacterial infections in the mouse will increase dramatically over the coming years.

Citation: Gros P, Schurr E. 2002. Immunogenetics of the Host Response to Bacteria in Mice, p 407-420. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch27

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1. Abel, L.,, V. D. Lap,, J. Oberti,, N. Y. Thuc,, V. V. Cua,, M. Guillod- Bataille,, E. Schurr,, and P. Lagrange. 1995. Complex segregation analysis of leprosy in Southern Vietnam. Genet. Epidemiol. 12: 63 70.
2. Abel, L.,, F. O. Sanchez,, J. Oberti,, N. V. Thuc,, L. V. Hoa,, V. D. Lap,, E. Skamene,, P. H. Lagrange,, and E. Schurr. 1998. Susceptibility to leprosy is linked to the human NRAMP1 gene. J. Infect. Dis. 177: 133 145.
3. Agranoff, D.,, I. M., Monahan,, J. A. Mangan,, P. D. Butcher,, and S. Krishna. 1999. Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family J. Exp. Med. 190: 717 724.
4. Alcais, A.,, F. O. Sanchez,, N. Y. Thuc,, V. D. Lap,, J. Oberti,, P. H. Lagrange,, E. Schurr,, and L. Abel. 2000. Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy sibships. J. Infect. Dis. 181: 302 308.
5. Aliprantis, A. O.,, R. B. Yang,, M. R. Mark,, S. Suggett,, B. Devaux,, J. D. Radolf,, G. R. Klimpel,, P. Godowski,, and A. Zychlinsky. 1999. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor 2. Science 285: 736 739.
6. Andrews, N. C. 1999. Disorders of iron metabolism. N. Engl. J. Med. 341: 1986 1995.
7. Apt, A. S.,, V. G. Avdienko,, B. V. Nikonenko,, I. B. Kramnik,, A. M. Moroz,, and E. Skamene. 1993. Distinct H-2 complex control of mortality, and immune responses to tuberculosis infection in virgin and BCG-vaccinated mice. Clin. Exp. Immunol. 94: 322 329.
8. Arias, M.,, M. Rojas,, J. Zabaleta,, S. C. Rodriguez,, L. Paris,, L. F. Barrera,, and L. F. Garcia. 1997. Inhibition of virulent M. tuberculosis by Bcgr and Bcgs macrophages correlates with nitric oxide production. J. Infect. Dis. 176: 1552 1560.
9. Beckers, M.-C.,, E. Ernst,, E. Diez,, C. Morissette,, F. Gervais,, K. Hunter,, D. Housman,, S.-I. Yoshida,, E. Skamene,, and P. Gros. 1997. High-resolution linkage map of mouse chromosome 13 in the vicinity of the host resistance locus Lgn1. Genomics 39: 254 263.
10. Bellamy, R.,, C. Ruwende,, T. Corrah,, K. P. McAdam,, H. C. Whittle,, and A. V. Hill. 1998. Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N. Engl. J. Med. 338: 640 644.
11. Berk, R. S.,, K. Beisel,, and L. D. Hazlett. 1981. Genetic studies of murine corneal response to Pseudomonas aeruginosa. Infect. Immun. 34: 1 5.
12. Bradley D. J.,, B. A. Taylor,, J. Blackwell,, E. P. Evans,, and J. Freeman. 1979. Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin. Exp. Immunol. 37: 7 14.
13. Brett, S. J.,, and J. Ivanyi. 1990. Genetic influences on the immune repertoire following tuberculosis infection in mice. Immunology 71: 113 119.
14. Brett, S. J.,, J. M. Orrell,, J. Swanson-Beck,, and J. Ivanyi. 1992. Influence of H2 genes on growth of Mycobacterium tuberculosis in the lungs of chronically infected mice. Immunology 76: 129 132.
15. Brown, I. N.,, A. A. Glynn,, and J. Plant. 1982. Inbred mouse strain resistance to Mycobacterium lepraemurium follows the Ity / Lsh pattern. Immunology 47: 149 156.
16. Buu, N. T.,, M. Cellier,, P. Gros,, and E. Schurr. 1995. Identification of a highly polymorphic length variant in the 3′ UTR of NRAMP1. Immunogenetics 42: 428 429.
17. Canonne-Hergaux, F.,, S. Gruenheid,, P. Ponka,, and P. Gros. 1999. Cellular and sub-cellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by iron. Blood 93: 4406 4417.
18. Cellier, M.,, A. Belouchi,, and P. Gros. 1996. Resistance to intracellular infections: comparative genome of NRAMP. Trends Genet. 12: 201 204.
19. Cellier, M.,, G. Govoni,, S. Vidal,, N. Groulx,, J. Liu,, F. Sanchez,, E. Skamene,, E. Schurr,, and P. Gros. 1994. The human NRAMP gene: cDNA cloning, chromosomal mapping, genomic organization and tissue specific expression. J. Exp. Med. 180: 1741 1752.
20. Cellier, M.,, G. Prive,, A. Belouchi,, T. Kwan,, V. Rodrigues,, W. Chia,, and P. Gros. 1995. The natural resistance associated macrophage protein (Nramp) defines a new family of membrane proteins conserved throughout evolution. Proc. Natl. Acad. Sci. USA 92: 10089 10094.
21. Cellier, M.,, C. Shustik,, W. Dalton,, E. Rich,, J. Hu,, D. Malo,, E. Schurr,, and P. Gros. 1997. The human NRAMP1 gene as a marker of professional primary phagocytes: studies in blood cells and in induced HL-60 promyelocytic leukemia. J. Leukoc. Biol. 61: 96 105.
22. Cheers, C.,, I. F. C. McKenzie,, T. E. Mandel,, and Y. Y. Chan,. 1980. A single gene controlling natural resistance to murine listeriosis, p. 141 147. In E. Skamene,, P. A. L. Kongshavn,, and M. Landy (ed.), Genetic Control of Natural Resistance to Infection and Malignancy. Academic Press, Inc., New York, N.Y.
23. Chen, X.-Z.,, J.-B. Peng,, A. Cohen,, H. Nelson,, N. Nelson,, and M. Hediger. 1999. Yeast SMF1 mediates H +-coupled iron uptake with concomitant uncoupled cation currents. J. Biol. Chem. 274: 35089 35094.
24. Crocker, P. R.,, J. M. Blackwell,, and D. J. Bradley. 1984. Expression of the natural resistance gene Lsh in resident liver macrophages. Infect. Immun. 43: 1033 1040.
25. Darvasi, A.,, A. Weinreb,, V. Minke,, J. I. Weller,, and M. Soller. 1993. Detecting marker QTL linkage and estimating QTL gene effects and map location using a saturated genetic map. Genetics 134: 943 951.
26. De Chastellier, C.,, C. Frehel,, C. Offreso,, and E. Skamene. 1993. Implication of phagosome-lysosome fusion in restriction of Mycobacterium avium growth in bone marrow macrophages from genetically resistant mice. Infect. Immun. 61: 3775 3784.
27. Denis, M.,, A. Forget,, M. Pelletier,, F. Gervais,, and E. Skamene. 1990. Killing of Mycobacterium smegmatis by macrophages from genetically susceptible and resistant mice. J. Leukoc. Biol. 47: 25 30.
28. Dietrich, W. F.,, D. M. Damron,, R. R. Isberg,, E. S. Lander,, and M. S. Swanson. 1995. Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13. Genomics 26: 443 450.
29. Diez, E.,, M.-C. Beckers,, E. Ernst,, C. J. DiDonato,, L. R. Simard,, C. Morissette,, F. Gervais,, S.-I. Yoshida,, and P. Gros. 1997. Genetic and physical mapping of the mouse host resistance locus Lgn1. Mamm. Genome 8: 682 685.
30. Diez, E.,, Z. Yaraghi,, A. MacKenzie,, and P. Gros. 2000. The apoptosis inhibitor protein NAIP: constitutive and inducible expression in macrophages, and candidacy for the host resistance locus Lgn1. J. Immunol. 164: 1470 1477.
31. D’Sousa, J.,, P. W. Cheah,, P. Gros,, W. Chia,, and V. Rodrigues. 1999. Functional complementation of the malvolio mutation in the taste pathway of Drosophila by the human natural resistance- associated macrophage protein 1 (NRAMP-1). J. Exp. Biol. 202: 1909 1915.
32. Endrizzi, M.,, S. Huang,, J. M. Scharf,, A. R. Kelter,, B. Wirth,, L. M. Kunkel,, W. Miller,, and W. F. Dietrich. 1999. Comparative sequence analysis of the mouse and human Lgn1/SMA interval. Genomics 60: 137 151.
33. Farcich, E. A.,, and E. H. Morgan. 1992. Diminished iron acquisition by cells and tissues of Belgrade laboratory rats. Am. J. Physiol. 262: R220.
34. Fleming, M. D.,, M. A. Romano,, M. A. Su,, L. M. Garrick,, M. D. Garrick,, and N. C. Andrews. 1998. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. USA 95: 1148 1153.
35. Fleming, M. D.,, C. C. Trenor III,, M. A. Su,, D. Foernzler,, D. R. Beier,, W. F. Dietrich,, and N. C. Andrews. 1997. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16: 383 386.
36. Flynn, J. L.,, J. Chan,, K. J. Triebold,, D. K. Dalton,, T. A. Stewart,, and B. R. Bloom. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178: 2249 2254.
37. Flynn, J. L.,, M. M. Goldstein,, J. Chan,, K. Pfeffer,, C. J. Lowenstein,, R. Schreiber,, T. W. Mak,, and B. R. Bloom. 1995. Tumor necrosis factor alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2: 561 572.
38. Flynn, J. L.,, M. M. Goldstein,, K. J. Triebold,, B. Koller,, and B. R. Bloom. 1992. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA 89: 12013 12017.
39. Gao, L. Y.,, and Y. A. Kwaik. 1999a. Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity. Infect. Immun. 67: 862 870.
40. Gao, L.-Y.,, and Y. A. Kwaik. 1999b. Activation of caspase 3 during Legionella pneumophila-induced apoptosis. Infect. Immun. 67: 4886 4894.
41. Gervais, F.,, M. M. Stevenson,, and E. Skamene. 1984. Genetic control of resistance to Listeria monocytogenes:regulation of leukocyte inflammatory responses by the Hc locus. J. Immunol. 132: 2078 2083.
42. Gotto, Y.,, E. Buschman,, and E. Skamene. 1989. Regulation of host resistance to Mycobacterium intracellulare in vivo and in vitro by the Bcg gene. Immunogenetics 30: 218 221.
43. Govoni, G.,, F. Canonne-Hergaux,, C. G. Pfeifer,, S. Marcus,, S. Mills,, D. Hackam,, S. Grinstein,, D. Malo,, B. Finlay,, and P. Gros. 1999. Functional expression of Nramp1 in vitro after transfection into the murine macrophage line RAW264.7. Infect. Immun. 67: 2225 2232.
44. Govoni, G.,, S. Gauthier,, N. N. Iscove,, and P. Gros. 1997. Cell specific and inducible Nramp1 gene expression in macrophages in vitro and in vivo J. Leukoc. Biol. 62: 277 286.
45. Govoni, G.,, S. Vidal,, S. Gauthier,, E. Skamene,, D. Malo,, and P. Gros. 1996. The Bcg / Ity / Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele. Infect. Immun. 64: 2923 2929.
46. Greenwood, C. M. T.,, T. M. Fujiwara,, L. Boothroyd,, A. Fanning,, M. Miller,, E. Schurr,, and K. Morgan. 2000. Genetic epidemiology of tuberculosis susceptibility and analysis of linkage to chromosome 2q35 near NRAMP1 in a large Aboriginal Canadian family. Am. J. Hum. Genet. 67: 405 416.
47. Gros, P.,, E. Skamene,, and A. Forget. 1981. Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J. Immunol. 127: 2417 2422.
48. Gros, P.,, E. Skamene,, and A. Forget. 1983. Cellular mechanisms of genetically-controlled host resistance to Mycobacterium bovis (BCG). J. Immunol. 131: 1966 1973.
49. Groves, M. G.,, D. L. Rosenstreich,, B. A. Taylor,, and J. V. Osterman. 1980. Host defenses in experimental scrub typhus: mapping the gene that controls natural resistance in mice. J. Immunol. 125: 1395 1399.
50. Gruenheid, S.,, F. Canonne-Hergaux,, S. Gauthier,, D. J. Hackam,, S. Grinstein,, and P. Gros. 1999. The iron transport protein Nramp2 is an integral membrane protein that co-localizes with transferrin in recycling endosomes. J. Exp. Med. 189: 831 841.
51. Gruenheid, S.,, M. Cellier,, S. Vidal,, and P. Gros. 1995. Identification and characterization of a second mouse Nramp gene. Genomics 25: 514 525.
52. Gruenheid, S.,, E. Pinner,, M. Desjardins,, and P. Gros. 1997. Natural resistance to infection with intracellular parasites: the Nramp1 protein is recruited to the membrane of the phagosome. J. Exp. Med. 185: 717 730.
53. Gunshin, H.,, B. Mackenzie,, U. V. Berger,, Y. Gunshin,, M. F. Romero,, W. F. Boron,, S. Nussberger,, J. L. Gollan,, and M. A. Hediger. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482 488.
54. Hackam, D. J.,, O. D. Rotstein,, W.-J. Zhang,, S. Gruenheid,, P. Gros,, and S. Grinstein 1998. Host resistance to intracellular in fections: mutation at Nramp1 impair phagosomal acidification. J. Exp. Med. 188: 351 364.
55. Hagele, S.,, J. Hacker,, and B. C. Brand. 1998. Legionella pneumophila kills human phagocytes but not protozoan host cells by inducing apoptotic cell death. FEMS Microbiol. Lett. 169: 51 58.
56. Heppner, G,,. and D. W. Weiss. 1965. High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures J. Bacteriol. 90: 696 703.
57. Hirst, R. G.,, and M. E. Wallace. 1976. Inherited resistance to Corynebacterium kutscheri in mice. Infect. Immun. 14: 475 482.
58. Hoshino, K.,, O. Takeuchi,, T. Kawai,, H. Sanjo,, T. Ogawa,, Y. Takeda,, K. Takeda,, and S. Akira. 1999. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product J. Immunol. 162: 3749 3752.
59. Huang, S.,, J. M. Sharf,, J. D. Growney,, M. G. Endrizzi,, and W. F. Dietrich. 1999. The mouse Naip gene cluster on chromosome 13 encodes several distinct fucntional transcripts. Mamm. Genome 10: 1032 1035.
60. Jansen, R. C. 1993. Interval mapping of multiple quantitative trait loci. Genetics 135: 205 211.
61. Kirschning, C. J.,, H. Wesche,, T. M. Ayres,, and M. Rothe. 1998. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188: 2091 2097.
62. Kramnik, I.,, P. Demant,, and B. R. Bloom,. 1998. Susceptibility to tuberculosis as a complex genetic trait: analysis using recombinant congenic strains of mice, p. 120 137. In D. J. Chadwick, and G. Cardew (ed.), Genetics of Tuberculosis. Novartis Foundation Symposium 217. John Wiley & Sons, Inc., Chichester, United Kingdom.
63. Lavebratt, C.,, A. Apt,, B. V. Nikonenko,, M. Schalling,, and E. Schurr. 1999. Severity of tuberculosis is linked to distal chromosome 3 and proximal chromosome 9. J. Infect. Dis. 180: 150 155.
64. Lefebvre, S.,, L. Burglen,, S. Reboullet,, O. Clermont,, P. Burlet,, L. Viollet,, B. Benichou,, C. Cruaud,, P. Millasseau,, M. Zeviani,, D. Le Paslier,, J. Frezal,, D. Cohen,, J. Weissenbach,, A. Munnich,, and J. Melki. 1995. Identification and characterization of a spinal muscular atrophy-determining gene. Cell 80: 155 165.
65. Lemaitre, B.,, E. Nicolas,, L. Michaud,, J.-M. Reichhart,, and J. A. Hoffman. 1996. The dorsoventral regulatory gene cassette spatzle / Toll / cactus controls the potent anti-fungal response in Drosophila adults. Cell 86: 973 983.
66. Lissner, C. R.,, R. N. Swanson,, and A. D. O’Brien. 1983. Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro. J. Immunol. 131: 3006 3013.
67. Lissner, C. R.,, D. L. Weinstein,, and A. D. O’Brien. 1985. Mouse chromosome 1 Ity locus regulates microbicidal activity of isolated peritoneal macrophages against a diverse group of intracellular and extracellular bacteria. J. Immunol. 135: 544 547.
68. Liston, P.,, N. Roy,, K. Tamai,, C. Lefebvre,, S. Baird,, G. Cherton- Horvat,, R. Farahani,, M. McLean,, J.-E. Ikeda,, A. MacKenzie,, and R. G. Korneluk. 1996. Suppression of apoptosis in mammalian cells by Naip and a related family of IAP genes. Nature 379: 349 353.
69. Liu, J.,, M. T. Fujiwara,, N. T. Buu,, F. Sanchez,, M. Cellier,, A. Paradis,, D. Frappier,, P. Gros,, E. Skamene,, K. Morgan,, and E. Schurr. 1995. Identification of polymorphisms and sequence variants in the human natural resistance-associated macrophage protein ( NRAMP) gene, a candidate gene for susceptibility to tuberculosis. Am. J. Hum. Genet. 56: 845 853.
70. Lundrigan, M. D.,, J. E. Arceneaux,, W. Zhu,, and B. R. Byers. 1997. Enhanced hydrogen peroxide sensitivity and altered stress protein expression in iron-starved Mycobacterium smegmatis. Biometals 10: 215 225.
71. Lynch, C. J.,, C. H. Pierce-Chase,, and R. Dubos. 1965. A genetic study of susceptibility to experimental tuberculosis in mice infected with mammalian tubercle bacilli. J. Exp. Med. 121: 1051 1070.
72. MacMicking, J. D.,, R. J. North,, R. LaCourse,, J. S. Mudgett,, S. K. Shah,, and C. F. Nathan. 1997. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl. Acad. Sci. USA 94: 5243 5248.
73. Makui, H.,, E. Roig,, S. T. Cole,, J. D. Helmann,, P. Gros,, and M. Cellier. 2000. Identification of Escherichia coli K-12 Nramp ( mntH) as a selective divalent metal ion transporter. Mol. Microbiol. 35: 1065 1078.
74. Malo, D.,, S. Vidal,, J. Lieman,, D. C. Ward,, and P. Gros. 1993b. Physical delineation of the minimal chromosomal segment encompassing the host resistance locus Bcg. Genomics 17: 667 675.
75. Malo, D.,, S. Vidal,, E. Skamene,, and P. Gros. 1993a. High resolution linkage map in the vicinity of the host resistance locus Bcg on mouse chromosome 1. Genomics 16: 655 663.
76. Malo, D.,, K. Vogan,, S. Vidal,, J. Hu,, M. Cellier,, E. Schurr,, A. Fuks,, K. Morgan,, and P. Gros. 1994. Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites. Genomics 23: 51 61.
77. Marquet, S.,, P. Lepage,, T. Hudson,, J. M. Musser,, and E. Schurr. 2000. Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on human chromosome region 2q35. Mamm. Genome 11: 755 762.
78. McAdam, K. W.,, and J. L. Ryan. 1978. C57BL/10CR mice: nonresponders to activation by the lipid A moiety of bacterial lipopolysaccharide. J. Immunol. 120: 249 253.
79. Medina, E.,, and R. J. North. 1998. Resistance ranking of some common inbred mouse strains to Mycobacterium tuberculosis and relationship to major histocompatibility haplotype and Nramp1 genotype. Immunology 93: 270 274.
80. Medzhitov, R.,, P. Preston-Hurlburt,, and C. A. Janeway, Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394 397.
81. Muller, A.,, J. Hacker,, and B. C. Brand. 1996. Evidence for apoptosis of human macrophage-like HL-60 cells by Legionella pneumophila infection. Infect. Immun. 64: 4900 4906.
82. Musa, S. A.,, Y. Kim,, R. Hashim,, G. Wang,, C. Dimmer,, and D. W. Smith. 1987. Response of inbred mice to aerosol challenge with Mycobacterium tuberculosis. Infect. Immun. 55: 1862 1866.
83. Nikonenko, B. V.,, A. S. Apt,, A. M. Moroz,, and M. M. Averbakh,. 1985. Genetic analysis of susceptibility of mice to H37Rv tuberculosis infection: sensitivity versus relative resistance, p. 291 298. In E. Skamene (ed.), Genetic Control of Host Resistance to Infection and Malignancy. Alan R. Liss, New York, N.Y.
84. North, R. J.,, R. LaCourse,, L. Ryan,, and P. Gros. 1999. Consequence of Nramp1 deletion to Mycobacterium tuberculosis infection in mice. Infect. Immun. 67: 5811 5814.
85. Orgad, S.,, H. Nelson,, D. Segal,, and N. Nelson. 1998. Metal ions suppress the abnormal taste behavior of the Drosophila mutant malvolio. J. Exp. Biol. 201: 115 120.
86. Orme, I. M.,, and D. N. McMurray,. 1995. The immune response to tuberculosis in animal models, p. 269 280. In W. N. Rom,, S. M. Garay,, and S Little (ed.), Tuberculosis. Little, Brown, and Co., Boston, Mass.
87. Paramchuck, W. J.,, S. O. Ismail,, A. Bhatia,, and L. Gedamu. 1997. Cloning, characterization and overexpression of two iron superoxide dismutase cDNAs from Leishmania chagasi: role in pathogenesis. Mol. Biochem. Parasitol. 90: 203 221.
88. Patarca, R.,, G. J. Freeman,, R. P. Singh,, F. Y. Wei,, T. Durfee,, F. Blattner,, D. C. Regnier,, C. A. Kozak,, B. A. Mock,, and H. C. Morse III. 1989. Structural and functional studies of the early T lymphocyte activation 1 ( Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J. Exp. Med. 170: 145 161.
89. Pierce, C. R.,, J. Dubos,, and G. Middlebrook. 1947. Infection of mice with mammalian tubercle bacilli grown in Tween-albumin liquid medium. J. Exp. Med. 86: 159 165.
90. Pinner, E.,, S. Gruenheid,, M. Raymond,, and P. Gros. 1997. Functional complementation of the yeast divalent cation transporter family SMF by a member of the mammalian natural resistance associated macrophage family, Nramp2. J. Biol. Chem. 272: 28933 28938.
91. Plant, J.,, and A. A. Glynn. 1974. Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice. Nature 248: 345 348.
92. Plant, J.,, and A. A. Glynn. 1976. Genetics of resistance with Salmonella typhimurium in mice. J. Infect. Dis. 133: 72 78.
93. Poltorak, A.,, X. He,, I. Smirnova,, M. Y. Liu,, C. V. Huffel,, X. Du,, D. Birdwell,, E. Alejos,, M. Silva,, C. Galanos,, M. Freudenberg,, P. Ricciardi-Castagnoli,, B. Layton,, and B. Beutler. 1998a. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085 2088.
94. Poltorak, A.,, I. Smirnova,, X. He,, M. Y. Liu,, C. Van Huffel,, O. McNally,, D. Birdwell,, E. Alejos,, M. Silva,, X. Du,, P. Thompson,, E. K. Chan,, J. Ledesma,, B. Roe,, S. Clifton,, S. N. Vogel,, and B. Beutler. 1998b. Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol. Dis. 24: 340 355.
95. Qureshi, S. T.,, P. Gros,, and D. Malo. 1999a. Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes. Trends Genet. 15: 291 294.
96. Qureshi, S. T.,, L. Larivie`re,, G. Leveque,, S. Clermont,, K. Moore,, P. Gros,, and D. Malo. 1999b. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 ( Tlr4). J. Exp. Med. 189: 615 625.
97. Qureshi, S. T.,, L. Larivie`re,, G. Sebastiani,, S. Clermont,, E. Skamene,, P. Gros,, and D. Malo. 1996. A high-resolution map in the chromosomal region surrounding the Lps locus. Genomics 31: 283 294.
98. Raetz, C. R. H.,, R. J. Ulevitch,, S. D. Wright,, C. H. Sibley,, A. Ding,, and C. Nathan. 1991. Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J. 5: 2652 2660.
99. Rock, F.,, G. Hardiman,, J. C. Timans,, R. A. Kastelein,, and J. F. Bazan. 1998. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. USA 95: 588 593.
100. Rodrigues, V.,, P. Y. Cheah,, K. Ray,, and W. Chia. 1995. malvolio, the Drosophila homologue of mouse NRAMP-1( Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behavior. EMBO J. 14: 3007 3020.
101. Rosenstreich, D. L., 1985. Genetic control of the endotoxin response: C3H/HeJ mice, p. 82 122. In L. J. Berry, (ed.), Handbook of Endotoxin, vol. 3, Elsevier Biomedical Press, New York, N.Y.
102. Roy, N.,, M. S. Mahadevan,, M. D. McLean,, G. Shutler,, Z. Yaraghi,, R. Farahani,, S. Baird,, A. Besner-Johnston,, C. Lefebvre,, X. Kang,, M. Salih,, K. Tamai,, X. Guan,, P. Ioannou,, T. Crawford,, P. J. de Jong,, L. Surh,, J.-E. Ikeda,, R. G. Korneluk,, and A. MacKenzie. 1995. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80: 167 178.
103. Russell, E. S.,, D. J. Nash,, S. E. Bernstein,, E. L. Kent,, E. C. McFarland,, S. M. Matthews,, and M. S. Norwood. 1970. Characterization and genetic studies of microcytic anemia in house mouse. Blood 35: 838 850.
104. Scharf, J. M.,, D. Damron,, A. Frisella,, S. Bruno,, A. H. Beggs,, L. M. Kunkel,, and W. F. Dietrich. 1996. The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains copies of Naip exon 5. Genomics 38: 405 417.
105. Schurr, E.,, A. Forget,, E. Skamene,, and P. Gros. 1989. Identification and mapping of a linkage group overlapping the host resistance Bcg gene on mouse chromosome 1. J. Immunol. 142: 4507 4514.
106. Searle, S.,, and J. M. Blackwell. 1999. Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility. J. Med. Genet. 36: 295 299.
107. Sebastiani, G.,, L. Olien,, S. Gauthier,, E. Skamene,, K. Morgan,, P. Gros,, and D. Malo. 1998. Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in mice. Genomics 47: 180 186.
108. Singh, R. P.,, R. Patarca,, J. Schwartz,, P. Singh,, and H. Cantor. 1990. Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo. J. Exp. Med. 171: 1931 1942.
109. Skamene, E.,, P. Gros,, A. Forget,, P. A. L. Kongshavn,, C. St. Charles, and B. A. Taylor. 1982. Genetic regulation of resistance to intracellular pathogens. Nature 297: 506 509.
110. Skamene, E.,, P. Gros,, A. Forget,, P. J. Patel,, and M. Nesbitt. 1984. Regulation of resistance to leprosy by chromosome 1 locus in the mouse. Immunogenetics 19: 117 120.
111. Stach, J. L.,, P. Gros,, A. Forget,, and E. Skamene. 1984. Phenotypic expression of genetically controlled natural resistance to Mycobacterium bovis (BCG). J. Immunol. 132: 888 892.
112. Stokes, R. W.,, I. Orme,, and F. M. Collins. 1986. Role of mononuclear phagocytes in expression of resistance and susceptibility to Mycobacterium avium infections in mice. Infect. Immun. 54: 811 819.
113. Sultzer, B. M. 1968. Genetic control of leukocyte responses to endotoxin. Nature 219: 1253 1254.
114. Supek, F.,, L. Supekova,, H. Nelson,, and N. Nelson. 1996. A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria. Proc. Natl. Acad. Sci. USA 93: 5105 5110.
115. Vidal, S.,, A. M. Belouchi,, M. Cellier,, B. Beatty,, and P. Gros. 1995b. Cloning and characterization of a second human NRAMP gene on chromosome 12q13. Mamm. Genome 6: 224 230.
116. Vidal, S.,, E. Pinner,, S. Gauthier,, P. Lepage,, and P. Gros. 1996. Nramp1 is an integral membrane phosphoglycoprotein absent from macrophages of inbred mouse strains susceptible to infection with intracellular parasites. J. Immunol. 157: 3559 3568.
117. Vidal., S.,, M. Tremblay,, G. Govoni,, G. Sebastiani,, D. Malo,, M. Olivier,, E. Skamene,, S. Jothy,, and P. Gros. 1995a. The Ity / Lsh/ Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J. Exp. Med. 182: 655 666.
118. Vidal, S. M.,, D. Malo,, K. Vogan,, E. Skamene,, and P. Gros. 1993. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73: 469 486.
119. Vogel, S. N., 1999. Genetic regulation of endotoxin responsiveness: the Lps gene revisited, p. 127 142. In H. Brade,, D. C. Morrison,, S. Opal,, and S. N. Vogel (ed.), Endotoxin in Health and Disease. Marcel Dekker, Inc., New York, N.Y.
120. Watson, J.,, K. Kelly,, M. Lergen,, and B. A. Taylor. 1978. The genetic mapping of a defective LPS response gene in C3H/HeJ mice. J. Immunol. 120: 422 424.
121. Watson, J.,, R. Riblet,, and B. A. Taylor. 1977. The response of recombinant inbred strains of mice to bacterial lipopolysaccharides. J. Immunol. 118: 2088 2093.
122. Welkos, S. L.,, and A. M. Friedlander. 1988. Pathogenesis and genetic control of resistance to the Sterne strain of Bacillus anthracis. Microb. Pathog. 4: 53 69.
123. Welkos, S. L.,, T. J. Keener,, and P. H. Gibbs. 1986. Differences in susceptibility of inbred mice to Bacillus anthracis. Infect. Immun. 51: 795 800.
124. Xu, D. G.,, S. J. Crocker,, J.-P. Doucet,, M. St. Jean, K. Tamai, A. Hakim, J.-E. Ikeda, P. Liston, C. S. Thompson, R. G. Korneluk, A. MacKenzie, and G. S. Robertson. 1997. Elevation of neuronal expression of NAIP reduces ischemic damage in the hippocampus. Nat. Med. 3: 997 1004.
125. Yamamoto, Y.,, T. W. Klein,, and H. Friedman. 1994. Legionella and macrophages. Immunol. Ser. 60: 329 348.
126. Yamamoto, Y.,, T. W. Klein,, C. A. Newton,, R. Widen,, and H. Friedman. 1988. Growth of Legionella pneumophila in thioglycolate- elicited peritoneal macrophages from A/ J mice. Infect. Immun. 56: 370 375.
127. Yang, R. B.,, M. R. Mark,, A. Gray,, A. Huang,, M. H. Xie,, M. Zhang,, A. Goddard,, W. I. Wood,, A. L. Gurney,, and P. J. Godowski. 1998. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395: 284 288.
128. Yaraghi, Z,, R. G. Korneluk,, and A. MacKenzie. 1998. Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein). Genomics 51: l07 113.
129. Yoshida, S.-I.,, Y. Goto,, Y. Mizuguchi,, K. Nomoto,, and E. Skamene. 1991. Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila replication in vitro. Infect. Immun. 59: 428 432.

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