Chapter 6 : Phagocytes and Anti-Infective Immunity

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This chapter presents an overview of the role played by phagocytes in anti-infective immunity. It describes the various types and functions of phagocytic cells, the mechanisms they utilize for microbial recognition, uptake, and killing; and their involvement with the adaptive immune system. Where appropriate, the authors demonstrate how pathogens have overcome the various anti-infective phagocyte functions and indicate where these microbial mechanisms have aided the understanding of phagocyte cell biology. Phagocytes can contribute to the generation of autoimmune diseases by presenting microbial epitopes to lymphocytes which are cross-reactive to self molecules. The respiratory burst of phagocytes that culminates in the production of reactive oxygen intermediates is one of the best characterized antimicrobial defenses. A central role of phagocytes, particularly dendritic cells (DC), in the generation of adaptive immunity is that of antigen presentation. Phagocytes play a central role in anti-infective immunity, which is important in all aspects of the immune response.

Citation: Brown G, Gordon S. 2002. Phagocytes and Anti-Infective Immunity, p 79-92. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch6

Key Concept Ranking

Infection and Immunity
Immune Systems
Adaptive Immune System
Major Histocompatibility Complex
Innate Immune System
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Figure 1

Properties and ligands of selected PRRs. Abbreviations: LBP, LPS-binding protein; LTA, lipoteichoic acid; LDL, low-density lipoprotein; ICAM-1, intercellular cell adhesion molecule 1. The structures of the various receptors are reprinted, with permission, from 2nd edition ( ).

Citation: Brown G, Gordon S. 2002. Phagocytes and Anti-Infective Immunity, p 79-92. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch6
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Figure 2

FcγR and their isoforms. Shown are the tyrosine residues present in the ITAM (striped box) or ITIM (shaded box), which become phosphorylated after receptor cross-linking. The ITAM and ITIM sequences are also indicated.

Citation: Brown G, Gordon S. 2002. Phagocytes and Anti-Infective Immunity, p 79-92. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch6
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Figure 3

Schematic representation of phagocytosis and phagosomal maturation. Also shown are the strategies used by microbes to evade or modulate these processes.

Citation: Brown G, Gordon S. 2002. Phagocytes and Anti-Infective Immunity, p 79-92. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch6
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Figure 4

Schematic representation of the antigen-processing and antigen presentation pathways for MHC class I, MHC class II, and CD1 molecules. Dashed arrows indicate putative and/or unknown pathways.

Citation: Brown G, Gordon S. 2002. Phagocytes and Anti-Infective Immunity, p 79-92. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch6
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Table 1

Mechanisms and examples of M functions

Citation: Brown G, Gordon S. 2002. Phagocytes and Anti-Infective Immunity, p 79-92. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch6
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Table 2

Selected cytokines important in anti-infective immunity

Citation: Brown G, Gordon S. 2002. Phagocytes and Anti-Infective Immunity, p 79-92. In Kaufmann S, Sher A, Ahmed R (ed), Immunology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817978.ch6

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