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Chapter 21 : Innate and Adaptive Immunity to

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Innate and Adaptive Immunity to , Page 1 of 2

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Abstract:

is a ubiquitous opportunistic pathogen that causes serious infection in humans, especially in immunocompromised individuals. Adaptive immunity consists of activated T cells, cytokines such as gamma interferon (IFN-γ), and activated macrophages that restrict the growth and spread of bacteria within its intracellular environment. Innate immunity to the bacteria, on the other hand, is perhaps even more complex and includes a variety of different host cells and cytokines. The innate immunity to infection limits the growth of the bacteria, which generally occurs in macrophage. Therefore, the regulation of growth in macrophages by proinflammatory cytokines, such as TNF-α, may be a main event in the early phase of infection. TNF-α, which is mainly produced by macrophages, is a potent cytokine and has extensive properties affecting the regulation of immunological and inflammatory cells. In general, the adaptive immunity to bacterial infections is characterized by the memory of the previous antigen stimulation, which is not necessarily the infection, and the transferable nature of the memory with lymphocytes.

Citation: Yamamoto Y, Klein T, Newton C, Friedman H. 2002. Innate and Adaptive Immunity to , p 109-119. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch21

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Tumor Necrosis Factor alpha
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Tumor Necrosis Factor
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FIGURE 1

antigens stimulate various levels of immunity mediated by cytokines. OmpS, outer-membrane protein; MSP, major secretory protein; Hsp60, 60-kD heat-shock protein.

Citation: Yamamoto Y, Klein T, Newton C, Friedman H. 2002. Innate and Adaptive Immunity to , p 109-119. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch21
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Image of FIGURE 2
FIGURE 2

Scheme of cytokine and chemokine induction through different receptors of macrophage by bacterial attachment. MLCK, myosin light chain kinase; CaM, calmodulin; AMM, -methyl-D-mannoside; R, receptor.

Citation: Yamamoto Y, Klein T, Newton C, Friedman H. 2002. Innate and Adaptive Immunity to , p 109-119. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch21
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Image of FIGURE 3
FIGURE 3

infection stimulates cells and cytokines of both innate and acquired immune response system. CMI, cell-mediated immunity.

Citation: Yamamoto Y, Klein T, Newton C, Friedman H. 2002. Innate and Adaptive Immunity to , p 109-119. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch21
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References

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