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Chapter 34 : Pneumonia: Three Cases in an Oncological Hospital

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Abstract:

is known as an important cause of nosocomial pneumonia. This chapter discusses three cases in an oncological hospital. A 47-year-old woman with malignant non-Hodgkin lymphoma, was hospitalized for more than 10 days, treated with high-dose chemotherapy. During treatment she developed a pneumonia, with a positive urinary antigen test (Biotest enzyme immunoassay urinary antigen). Despite therapy with macrolides and fluoroquinolones, the patient died from respiratory failure 1 week after the diagnosis. Immediately after the detection of the first case of pneumonia, the water distribution system was sampled in several sites, including the shower in the patient’s room, the intake from the municipal water supply, the water storage tank, and some distant outlets. A therapy with macrolides and fluoroquinolones was effective in curing another patient with high-risk breast carcinoma being treated with high-dose chemotherapy. It is remarkable that the diagnosis has always been performed by the detection of the urinary antigen, although the colonizing subtype was of the serogroup 2-14. A 54-year old man had received appropriate chemotherapy and general condition was improving, but at the end of the month, the patient developed pneumonia, as documented by a positive urinary antigen. Despite macrolide and fluoroquinolone treatment, the patient died 5 days later. The flush and heat decontamination method is not effective in eradicating from the hot water distribution system, and it is therefore mandatory to keep surveillance measures for early diagnosis and prompt treatment of possible new cases.

Citation: Giglio M, Scuri M, Passerini R, Sandri M. 2002. Pneumonia: Three Cases in an Oncological Hospital, p 193-195. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch34

Key Concept Ranking

Legionella pneumophila
0.7156819
Enzyme Immunoassay
0.51311934
0.7156819
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FIGURE 1

Percentage of positive results in water distribution system samples.

Citation: Giglio M, Scuri M, Passerini R, Sandri M. 2002. Pneumonia: Three Cases in an Oncological Hospital, p 193-195. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch34
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References

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1. Ezzeddine, H.,, C. Van Ossel,, M. Delmee,, and C. Wauters. 1989. Legionella spp. in a hospital hot water system: effect of control measures. J. Hosp. Infect. 13:121131.
2. Fallon, R. J. 1980. Nosocomial infection with Legionella pneumophila. J. Hosp. Infect. 1:299305.
3. Harrison, T.,, S. Uldum,, S. Alexiou-Daniel,, J. Bangsborg,, S. Bernander,, V. Drasar,, J. Etienne,, J. Helbig,, D. Lindsay,, I. Lochman,, T. Marquez,, F. de Ory,, I. Tartakovskii,, G. Wewalka,, and F. Fehrenbach. 1998. A multi-center evaluation of the Biotest legionella urinary antigen EIA. Clin. Microbiol. Infect. 4:359365.
4. Kusnetov, J. M.,, H. R. Jousimiens Somer,, A. I. Nevalainen,, and P. J. Martikainen. 1994. Isolation of Legionella from water samples using various culture methods. J. Appl. Bacteriol. 76:155162.
5. Lepine, L. A.,, D. B. Jernigan,, J. C. Butler,, J. M. Pruckler,, R. F. Benson,, G. Kim,, J. L. Hadler,, M. L. Cartter,, and B. S. Fields. 1998. A recurrent outbreak of nosocomial Legionnaires' disease detected by urinary antigen testing: evidence for long-term colonization of a hospital plumbing system. Infect. Control Hosp. Epidemiol. 19:905910.
6. Muraca, P. V.,, V. Yu,, and A. Goetz. 1990. Disinfection of water distribution systems for legionella: a review of application procedures and methodologies. Infect. Control Hosp. Epidemiol. 11: 7988.
7. Pedro Botet, M. L.,, M. Sabria-Leal,, N. Sopena,, J. M. Manterola,, J. Morera,, R. Blavia,, E. Padilla,, L. Matas,, and J. M. Gimeno. 1998. Role of immunosuppression in the evolution of legionnaires’ disease. Clin. Infect. Dis. 26:1419.
8. Stout, J. E.,, and V. L. Yu. 1997. Legionellosis. N. Engl. J. Med. 337:682687.
9. Vincent-Houdek, M.,, H. L. Muytjens,, G. P. Bongaerts,, and R. J. Van Ketel. 1993. Legionella monitoring: a continuing story of nosocomial infection prevention. J. Hosp. Infect. 25:117124.

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