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Chapter 35 : Human Leukocyte Antigen Typing in -Positive Transplant Patients

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Human Leukocyte Antigen Typing in -Positive Transplant Patients, Page 1 of 2

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Abstract:

This chapter compares human leukocyte antigen (HLA) frequency and HLA haplotype frequency in -positive patients with frequencies in healthy individuals from a local panel (control group). Sputum, bronchoalveolar lavage (BAL), or urine obtained from 114 patients after solid organ (heart, kidney, liver, pancreas) transplantation were examined for the presence of by using the culture method (sputum, BAL), and the direct fluorescent antibody assay method (sputum, BAL), and by the detection of urinary antigen (urine) during the 4 months after transplantation. A buffered charcoal-yeast extract medium (OXOID) was the culture method used in parallel with BMPA and GVPC selective supplements. serotypes were determined by using microagglutination test. The monoclonal antibody of MONOFLUO IFA test kit was used for the direct fluorescent-antibody assay method. The urinary antigen was detected by using Urin antigen enzyme immunoassay. Differences were found in HLA-A antigen frequencies and HLA-B antigen frequencies between -positive patients and a control group. Differences in HLA A-B haplotypes and HLA A-B-DR haplotypes were not statistically significant between healthy individuals and -positive patients. Several published reports suggest that natural resistance or susceptibility to infection with might be genetically determined. However, no significant difference in HLA class II antigens and the frequencies of haplotypes HLA A-B and HLA A-B-DR was found between both defined groups.

Citation: Jaresova M, Bendukidze N, Ivaskova E, Striz I, Hlozanek I, Hatala M, Totusek P, Kocmoud Z. 2002. Human Leukocyte Antigen Typing in -Positive Transplant Patients, p 196-199. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch35

Key Concept Ranking

Legionella pneumophila
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Atypical Pneumonia
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Figures

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FIGURE 1

HLA-A antigen frequency. , control group; , -positive patients.

Citation: Jaresova M, Bendukidze N, Ivaskova E, Striz I, Hlozanek I, Hatala M, Totusek P, Kocmoud Z. 2002. Human Leukocyte Antigen Typing in -Positive Transplant Patients, p 196-199. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch35
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Image of FIGURE 2
FIGURE 2

HLA-B antigen frequency. , control group; , -positive patients.

Citation: Jaresova M, Bendukidze N, Ivaskova E, Striz I, Hlozanek I, Hatala M, Totusek P, Kocmoud Z. 2002. Human Leukocyte Antigen Typing in -Positive Transplant Patients, p 196-199. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch35
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References

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1. Beckers, M. C.,, S. Yoshida,, K. Morgan,, E. Skamene,, and P. Gros. 1995. Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene. Mamm. Genome 6:540545.
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9. Mahbubani, M. H.,, A. K. Bej,, R. Miller,, L. Haff,, J. DiCesare,, and R. M. Atlas. 1990. Detection of Legionella with polymerase chain reaction and gene probe methods. Mol. Cell. Probes 4:175187.
10. Rajalingam, R.,, N. K. Mehra,, S. Neolia,, R. C. Jain,, and J. N. Pande. 1997. HLA class I profile in Asian Indian patients with pulmonary tuberculosis. Indian J. Exp. Biol. 35:10551059.
11. Schneider, S.,, J.-M. Kueffer,, D. Roessli,, and L. Excoffier. 1997. A Software for Population Genetic Data Analysis. Genetics and Biometry Laboratory, University of Geneva, Geneva, Switzerland.

Tables

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TABLE 1

Comparison of antigen frequency: the test for comparison of a relative frequency with the underlying parameter

Citation: Jaresova M, Bendukidze N, Ivaskova E, Striz I, Hlozanek I, Hatala M, Totusek P, Kocmoud Z. 2002. Human Leukocyte Antigen Typing in -Positive Transplant Patients, p 196-199. In Marre R, Abu Kwaik Y, Bartlett C, Cianciotto N, Fields B, Frosch M, Hacker J, Lück P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817985.ch35

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