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Chapter 35 : A Gene Odyssey: Exploring the Genomes of Endospore-Forming Bacteria

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Abstract:

This chapter provides hints about how much of the sporulation process and its regulation is conserved. The recent release of the complete bacterial genome of has provided data that are in general agreement with the conclusions of the chapter. It is noteworthy that this complex operon is fully conserved in , , , and , whereas it is absent from all other genomes sequenced so far. The current sequence data indicate that all the genes involved in the phosphorelay are present in and , with the possible exception of . It was reasonable to expect that many genes involved in the sporulation process would be highly specific to endospore formers. The most significant variations are seen when the interface between the bacterium and its environment is involved. The various and species inhabit a wide range of ecological niches, and it seems logical that environmental signals would be differentially relayed to SpoOA depending on their chemical nature, that hostile signals threatening spore viability would be countered with an adequate coat shell, and that germination signals would be detected by a specialized, niche-appropriate array of receptors. The conclusions suggested in this chapter are obviously tentative and doomed to be contradicted by the endless flow of incoming genomic data.

Citation: Stragier P. 2002. A Gene Odyssey: Exploring the Genomes of Endospore-Forming Bacteria, p 519-525. In Sonenshein A, Losick R, Hoch J (ed), and Its Closest Relatives. ASM Press, Washington, DC. doi: 10.1128/9781555817992.ch35

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Gene Expression and Regulation
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Cell Wall Biosynthesis
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Figures

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FIGURE 1

Gene organization around the locus of various endospore formers. Genes are shown as rectangles, and intergenic regions are shown as thin lines. Transcription goes from top to bottom. To emphasize the local synteny between (), (), (), and (), longer thin lines join two adjacent genes when additional genes are present in another species. For the sake of clarity, clusters of genes specific to one species are shown as a single larger rectangle. No inference should be drawn about the size of the genes and their operon structure. Genes are named from their orthologue (including those of unknown function with a y nomenclature), whereas genes with no orthologue are labeled . The genes discussed in the text are highlighted by a bold rectangle. The synteny between and spp. stops upstream of the gene and downstream of . The operon is located in another region of the chromosome.

Citation: Stragier P. 2002. A Gene Odyssey: Exploring the Genomes of Endospore-Forming Bacteria, p 519-525. In Sonenshein A, Losick R, Hoch J (ed), and Its Closest Relatives. ASM Press, Washington, DC. doi: 10.1128/9781555817992.ch35
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Tables

Generic image for table
TABLE 1

Conservation of developmental loci among endospore formers

Include , , , , , and .

Some genes conserved in Clostridium spp. and absent from Bacillus might be involved in sporulation but not yet identified.

Citation: Stragier P. 2002. A Gene Odyssey: Exploring the Genomes of Endospore-Forming Bacteria, p 519-525. In Sonenshein A, Losick R, Hoch J (ed), and Its Closest Relatives. ASM Press, Washington, DC. doi: 10.1128/9781555817992.ch35

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